IL49897A - Pharmaceutical compositions for inhibiting phenylethanolamine n-methyl transferase containing tetrahydroisoquinolines - Google Patents

Pharmaceutical compositions for inhibiting phenylethanolamine n-methyl transferase containing tetrahydroisoquinolines

Info

Publication number
IL49897A
IL49897A IL49897A IL4989776A IL49897A IL 49897 A IL49897 A IL 49897A IL 49897 A IL49897 A IL 49897A IL 4989776 A IL4989776 A IL 4989776A IL 49897 A IL49897 A IL 49897A
Authority
IL
Israel
Prior art keywords
tetrahydroisoquinolines
pharmaceutical compositions
methyl transferase
phenylethanolamine
inhibiting
Prior art date
Application number
IL49897A
Other languages
English (en)
Other versions
IL49897A0 (en
Original Assignee
Smithkline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/590,772 external-priority patent/US3988339A/en
Application filed by Smithkline Corp filed Critical Smithkline Corp
Publication of IL49897A0 publication Critical patent/IL49897A0/xx
Publication of IL49897A publication Critical patent/IL49897A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/298—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with manganese derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/42—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrolysis
    • C07C45/43—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrolysis of >CX2 groups, X being halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
IL49897A 1975-06-26 1976-06-24 Pharmaceutical compositions for inhibiting phenylethanolamine n-methyl transferase containing tetrahydroisoquinolines IL49897A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/590,772 US3988339A (en) 1974-02-08 1975-06-26 Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase

Publications (2)

Publication Number Publication Date
IL49897A0 IL49897A0 (en) 1976-08-31
IL49897A true IL49897A (en) 1979-09-30

Family

ID=24363639

Family Applications (1)

Application Number Title Priority Date Filing Date
IL49897A IL49897A (en) 1975-06-26 1976-06-24 Pharmaceutical compositions for inhibiting phenylethanolamine n-methyl transferase containing tetrahydroisoquinolines

Country Status (12)

Country Link
US (1) US4062961A (xx)
JP (1) JPS527445A (xx)
AU (1) AU499217B2 (xx)
BE (1) BE843412A (xx)
CA (1) CA1069440A (xx)
DE (1) DE2628425A1 (xx)
FR (1) FR2315276A1 (xx)
GB (1) GB1561583A (xx)
IE (1) IE43794B1 (xx)
IL (1) IL49897A (xx)
NL (1) NL7606960A (xx)
ZA (1) ZA763806B (xx)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4258049A (en) * 1979-07-02 1981-03-24 Smithkline Corporation Inhibiting phenylethanolamine N-methyltransferase with thiadiazolo and oxadiazolotetrahydroisoquinolines
US4340600A (en) * 1980-05-22 1982-07-20 Smithkline Corporation Renal dilating methods and compositions using 4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3988339A (en) * 1974-02-08 1976-10-26 Smithkline Corporation Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase

Also Published As

Publication number Publication date
ZA763806B (en) 1977-05-25
IE43794L (en) 1976-12-26
AU1532376A (en) 1978-01-05
DE2628425A1 (de) 1977-01-20
FR2315276B1 (xx) 1980-03-14
IL49897A0 (en) 1976-08-31
BE843412A (fr) 1976-12-27
US4062961A (en) 1977-12-13
GB1561583A (en) 1980-02-27
FR2315276A1 (fr) 1977-01-21
AU499217B2 (en) 1979-04-12
JPS527445A (en) 1977-01-20
NL7606960A (nl) 1976-12-28
IE43794B1 (en) 1981-06-03
CA1069440A (en) 1980-01-08

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