IL48544A - Tetrazolylalkyltriphenylphosphonium salt - Google Patents
Tetrazolylalkyltriphenylphosphonium saltInfo
- Publication number
- IL48544A IL48544A IL48544A IL4854472A IL48544A IL 48544 A IL48544 A IL 48544A IL 48544 A IL48544 A IL 48544A IL 4854472 A IL4854472 A IL 4854472A IL 48544 A IL48544 A IL 48544A
- Authority
- IL
- Israel
- Prior art keywords
- alpha
- double
- thp
- cis
- trans
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title description 2
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 claims abstract description 8
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 claims abstract description 8
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 235000019270 ammonium chloride Nutrition 0.000 claims abstract description 4
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 12
- 150000001875 compounds Chemical class 0.000 claims description 5
- GJVUAUBGMGCLEB-UHFFFAOYSA-M triphenyl-[4-(2h-tetrazol-5-yl)butyl]phosphanium;bromide Chemical compound [Br-].N=1N=NNC=1CCCC[P+](C=1C=CC=CC=1)(C=1C=CC=CC=1)C1=CC=CC=C1 GJVUAUBGMGCLEB-UHFFFAOYSA-M 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 2
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 abstract description 3
- 239000003153 chemical reaction reagent Substances 0.000 abstract description 2
- 150000003180 prostaglandins Chemical class 0.000 abstract description 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 208000026817 47,XYY syndrome Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
- -1 oct-1-yl Chemical class 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- 230000002997 prostaglandinlike Effects 0.000 abstract 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 abstract 1
- 230000001131 transforming effect Effects 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- NIIFINHILCUHNF-UHFFFAOYSA-M 4-cyanobutyl(triphenyl)phosphanium;bromide Chemical compound [Br-].C=1C=CC=CC=1[P+](C=1C=CC=CC=1)(CCCCC#N)C1=CC=CC=C1 NIIFINHILCUHNF-UHFFFAOYSA-M 0.000 description 1
- NWWWGAKVHCSAEU-UHFFFAOYSA-N 5-bromopentanenitrile Chemical compound BrCCCCC#N NWWWGAKVHCSAEU-UHFFFAOYSA-N 0.000 description 1
- 239000000538 analytical sample Substances 0.000 description 1
- MDKXBBPLEGPIRI-UHFFFAOYSA-N ethoxyethane;methanol Chemical compound OC.CCOCC MDKXBBPLEGPIRI-UHFFFAOYSA-N 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 150000002373 hemiacetals Chemical class 0.000 description 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 description 1
- 150000004714 phosphonium salts Chemical class 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 125000004299 tetrazol-5-yl group Chemical group [H]N1N=NC(*)=N1 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5407—Acyclic saturated phosphonium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17710271A | 1971-09-01 | 1971-09-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL48544A true IL48544A (en) | 1977-06-30 |
Family
ID=22647201
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL48544A IL48544A (en) | 1971-09-01 | 1972-08-22 | Tetrazolylalkyltriphenylphosphonium salt |
| IL40183A IL40183A (en) | 1971-09-01 | 1972-08-22 | Tetrazolyl derivatives of naturally occurring prostaglandins |
| IL48544A IL48544A0 (en) | 1971-09-01 | 1975-11-26 | A tetrazolylalkyltriphenylphosphonium salt |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL40183A IL40183A (en) | 1971-09-01 | 1972-08-22 | Tetrazolyl derivatives of naturally occurring prostaglandins |
| IL48544A IL48544A0 (en) | 1971-09-01 | 1975-11-26 | A tetrazolylalkyltriphenylphosphonium salt |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPS5724348B2 (fi) |
| AR (4) | AR197304A1 (fi) |
| AT (3) | ATA51974A (fi) |
| CA (1) | CA978939A (fi) |
| DK (1) | DK144730C (fi) |
| ES (3) | ES406250A1 (fi) |
| FI (1) | FI55497C (fi) |
| FR (3) | FR2283136A1 (fi) |
| IL (3) | IL48544A (fi) |
| PH (3) | PH10023A (fi) |
| SE (4) | SE409032B (fi) |
| ZA (1) | ZA725827B (fi) |
-
1972
- 1972-08-22 IL IL48544A patent/IL48544A/en unknown
- 1972-08-22 IL IL40183A patent/IL40183A/en unknown
- 1972-08-24 ZA ZA725827A patent/ZA725827B/xx unknown
- 1972-08-29 AT AT51974*A patent/ATA51974A/de not_active IP Right Cessation
- 1972-08-29 AT AT743472A patent/AT335079B/de not_active IP Right Cessation
- 1972-08-29 PH PH13850A patent/PH10023A/en unknown
- 1972-08-29 AT AT51974*7A patent/AT327219B/de not_active IP Right Cessation
- 1972-08-30 FI FI2387/72A patent/FI55497C/fi active
- 1972-08-30 SE SE7211233A patent/SE409032B/xx unknown
- 1972-08-31 DK DK430772A patent/DK144730C/da not_active IP Right Cessation
- 1972-08-31 CA CA150,669A patent/CA978939A/en not_active Expired
- 1972-08-31 AR AR243845A patent/AR197304A1/es active
- 1972-08-31 ES ES406250A patent/ES406250A1/es not_active Expired
- 1972-09-01 JP JP8784872A patent/JPS5724348B2/ja not_active Expired
-
1973
- 1973-06-22 AR AR248682A patent/AR199573A1/es active
- 1973-06-22 AR AR248681A patent/AR199784A1/es active
- 1973-06-22 AR AR248683A patent/AR199574A1/es active
- 1973-08-03 ES ES417557A patent/ES417557A1/es not_active Expired
- 1973-08-03 ES ES417558A patent/ES417558A1/es not_active Expired
-
1974
- 1974-06-03 PH PH15888A patent/PH10443A/en unknown
- 1974-06-03 PH PH15889A patent/PH10416A/en unknown
-
1975
- 1975-11-26 IL IL48544A patent/IL48544A0/xx unknown
- 1975-11-26 FR FR7536203A patent/FR2283136A1/fr active Granted
- 1975-11-26 FR FR7536205A patent/FR2283147A1/fr active Granted
- 1975-11-26 FR FR7536204A patent/FR2283134A1/fr active Granted
-
1976
- 1976-06-11 SE SE7606691A patent/SE424185B/xx unknown
- 1976-06-11 SE SE7606689A patent/SE421525B/xx unknown
- 1976-06-11 SE SE7606690A patent/SE421526B/xx unknown
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