IL44117A - A method for determining the end point in immunochemical and serodiagnostic tests - Google Patents
A method for determining the end point in immunochemical and serodiagnostic testsInfo
- Publication number
- IL44117A IL44117A IL44117A IL4411774A IL44117A IL 44117 A IL44117 A IL 44117A IL 44117 A IL44117 A IL 44117A IL 4411774 A IL4411774 A IL 4411774A IL 44117 A IL44117 A IL 44117A
- Authority
- IL
- Israel
- Prior art keywords
- test
- serum
- agglutination
- antigen
- immunochemical
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 23
- 230000000984 immunochemical effect Effects 0.000 title claims abstract description 20
- 230000004520 agglutination Effects 0.000 claims abstract description 40
- 210000002700 urine Anatomy 0.000 claims description 25
- 239000000427 antigen Substances 0.000 claims description 21
- 102000036639 antigens Human genes 0.000 claims description 21
- 108091007433 antigens Proteins 0.000 claims description 21
- 239000002245 particle Substances 0.000 claims description 19
- 238000006243 chemical reaction Methods 0.000 claims description 18
- 239000011521 glass Substances 0.000 claims description 17
- 239000000203 mixture Substances 0.000 claims description 16
- 210000002966 serum Anatomy 0.000 claims description 15
- 229960004407 chorionic gonadotrophin Drugs 0.000 claims description 14
- 230000005764 inhibitory process Effects 0.000 claims description 14
- 239000007787 solid Substances 0.000 claims description 13
- 210000001124 body fluid Anatomy 0.000 claims description 12
- 239000010839 body fluid Substances 0.000 claims description 12
- 239000000975 dye Substances 0.000 claims description 10
- 239000004793 Polystyrene Substances 0.000 claims description 8
- 229920002223 polystyrene Polymers 0.000 claims description 8
- 230000035935 pregnancy Effects 0.000 claims description 8
- 210000003743 erythrocyte Anatomy 0.000 claims description 7
- 239000004033 plastic Substances 0.000 claims description 6
- 229920003023 plastic Polymers 0.000 claims description 6
- 238000003745 diagnosis Methods 0.000 claims description 4
- IINNWAYUJNWZRM-UHFFFAOYSA-L erythrosin B Chemical compound [Na+].[Na+].[O-]C(=O)C1=CC=CC=C1C1=C2C=C(I)C(=O)C(I)=C2OC2=C(I)C([O-])=C(I)C=C21 IINNWAYUJNWZRM-UHFFFAOYSA-L 0.000 claims description 2
- 229940011411 erythrosine Drugs 0.000 claims description 2
- 235000012732 erythrosine Nutrition 0.000 claims description 2
- 239000004174 erythrosine Substances 0.000 claims description 2
- JJCFRYNCJDLXIK-UHFFFAOYSA-N cyproheptadine Chemical compound C1CN(C)CCC1=C1C2=CC=CC=C2C=CC2=CC=CC=C21 JJCFRYNCJDLXIK-UHFFFAOYSA-N 0.000 claims 1
- 239000001046 green dye Substances 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 description 11
- 239000004816 latex Substances 0.000 description 9
- 229920000126 latex Polymers 0.000 description 9
- 239000007788 liquid Substances 0.000 description 8
- 210000002320 radius Anatomy 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 241000283973 Oryctolagus cuniculus Species 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 239000000872 buffer Substances 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 5
- 201000006747 infectious mononucleosis Diseases 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 230000003068 static effect Effects 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- 238000010998 test method Methods 0.000 description 5
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 238000009597 pregnancy test Methods 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000007853 buffer solution Substances 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 102000011022 Chorionic Gonadotropin Human genes 0.000 description 2
- 108010062540 Chorionic Gonadotropin Proteins 0.000 description 2
- 235000006679 Mentha X verticillata Nutrition 0.000 description 2
- 235000002899 Mentha suaveolens Nutrition 0.000 description 2
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- 210000000601 blood cell Anatomy 0.000 description 2
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 2
- 239000004327 boric acid Substances 0.000 description 2
- 239000006285 cell suspension Substances 0.000 description 2
- 238000002405 diagnostic procedure Methods 0.000 description 2
- 229940084986 human chorionic gonadotropin Drugs 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 2
- 239000004925 Acrylic resin Substances 0.000 description 1
- 229920000178 Acrylic resin Polymers 0.000 description 1
- 101710186708 Agglutinin Proteins 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101710146024 Horcolin Proteins 0.000 description 1
- 101710189395 Lectin Proteins 0.000 description 1
- 101710179758 Mannose-specific lectin Proteins 0.000 description 1
- 101710150763 Mannose-specific lectin 1 Proteins 0.000 description 1
- 101710150745 Mannose-specific lectin 2 Proteins 0.000 description 1
- GCKMFJBGXUYNAG-HLXURNFRSA-N Methyltestosterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@](C)(O)[C@@]1(C)CC2 GCKMFJBGXUYNAG-HLXURNFRSA-N 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000000910 agglutinin Substances 0.000 description 1
- 239000010425 asbestos Substances 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 229910021538 borax Inorganic materials 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 238000012754 cardiac puncture Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 230000003821 menstrual periods Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 229910052895 riebeckite Inorganic materials 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 229960000999 sodium citrate dihydrate Drugs 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 229940085503 testred Drugs 0.000 description 1
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/805—Optical property
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
- Y10S436/812—Infectious mononucleosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
- Y10S436/814—Pregnancy
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/328,219 US3955923A (en) | 1973-01-31 | 1973-01-31 | Serologic reaction method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL44117A0 IL44117A0 (en) | 1974-05-16 |
| IL44117A true IL44117A (en) | 1977-10-31 |
Family
ID=23280039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL44117A IL44117A (en) | 1973-01-31 | 1974-01-30 | A method for determining the end point in immunochemical and serodiagnostic tests |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US3955923A (cs) |
| JP (1) | JPS49102834A (cs) |
| AT (1) | ATA69974A (cs) |
| BE (1) | BE809171A (cs) |
| BR (1) | BR7400663D0 (cs) |
| CA (1) | CA1034492A (cs) |
| CH (1) | CH600338A5 (cs) |
| CS (1) | CS191906B2 (cs) |
| DE (1) | DE2404565A1 (cs) |
| ES (1) | ES422789A1 (cs) |
| FR (1) | FR2216879A5 (cs) |
| GB (1) | GB1457341A (cs) |
| IL (1) | IL44117A (cs) |
| NL (1) | NL7401068A (cs) |
| ZA (1) | ZA74633B (cs) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4138214A (en) * | 1977-12-19 | 1979-02-06 | American Home Products Corporation | Diagnostic test utilizing human chorionic gonadotropin |
| FI56905C (fi) * | 1978-02-28 | 1980-04-10 | Osmo A Suovaniemi | Foerfarande och anordning foer automatisk maetning av agglutinationsprov t ex i spektrofotometer adsoptionsfotometer fluorometer eller nefelometer |
| JPH0619348B2 (ja) * | 1984-06-15 | 1994-03-16 | マスト イミユノシステムズ インコ−ポレ−テツド | 発光特異結合検定に於いて外部光を抑制する減衰剤 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3415361A (en) * | 1966-12-22 | 1968-12-10 | Miles Lab | Test device and container therefor |
| US2041290A (en) * | 1935-01-12 | 1936-05-19 | Jackson William Peter | Agglutinating test plate |
| US3088875A (en) * | 1959-10-27 | 1963-05-07 | Hyland Lab | Immunological diagnostics utilizing polystyrene latex particles of 0.15 to 0.25 micron |
| FR95147E (fr) * | 1967-05-12 | 1970-07-24 | Centre Nat Rech Scient | Appareillage destiné plus particulierement a la détermination automatique des groupes sanguins. |
| US3655838A (en) * | 1969-03-20 | 1972-04-11 | Organon | Method of pelletizing analytical or immunological reagents |
-
1973
- 1973-01-31 US US05/328,219 patent/US3955923A/en not_active Expired - Lifetime
- 1973-12-18 FR FR7345314A patent/FR2216879A5/fr not_active Expired
- 1973-12-27 BE BE139332A patent/BE809171A/xx not_active IP Right Cessation
-
1974
- 1974-01-09 GB GB102574A patent/GB1457341A/en not_active Expired
- 1974-01-23 CA CA190,742A patent/CA1034492A/en not_active Expired
- 1974-01-25 NL NL7401068A patent/NL7401068A/xx not_active Application Discontinuation
- 1974-01-29 AT AT69974*#A patent/ATA69974A/de not_active IP Right Cessation
- 1974-01-29 JP JP49011515A patent/JPS49102834A/ja active Pending
- 1974-01-30 CS CS74629A patent/CS191906B2/cs unknown
- 1974-01-30 BR BR663/74A patent/BR7400663D0/pt unknown
- 1974-01-30 IL IL44117A patent/IL44117A/en unknown
- 1974-01-30 ZA ZA00740633A patent/ZA74633B/xx unknown
- 1974-01-30 ES ES422789A patent/ES422789A1/es not_active Expired
- 1974-01-31 DE DE2404565A patent/DE2404565A1/de not_active Withdrawn
- 1974-01-31 CH CH133774A patent/CH600338A5/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA1034492A (en) | 1978-07-11 |
| ES422789A1 (es) | 1976-08-01 |
| NL7401068A (cs) | 1974-08-02 |
| AU6449074A (en) | 1975-07-17 |
| US3955923A (en) | 1976-05-11 |
| CS191906B2 (en) | 1979-07-31 |
| CH600338A5 (cs) | 1978-06-15 |
| JPS49102834A (cs) | 1974-09-28 |
| GB1457341A (en) | 1976-12-01 |
| BE809171A (fr) | 1974-06-27 |
| DE2404565A1 (de) | 1974-08-01 |
| ATA69974A (de) | 1975-04-15 |
| FR2216879A5 (cs) | 1974-08-30 |
| BR7400663D0 (pt) | 1974-11-05 |
| ZA74633B (en) | 1975-09-24 |
| IL44117A0 (en) | 1974-05-16 |
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