IL43008A - Dibenzazecines and processes for the production thereof - Google Patents
Dibenzazecines and processes for the production thereofInfo
- Publication number
- IL43008A IL43008A IL43008A IL4300873A IL43008A IL 43008 A IL43008 A IL 43008A IL 43008 A IL43008 A IL 43008A IL 4300873 A IL4300873 A IL 4300873A IL 43008 A IL43008 A IL 43008A
- Authority
- IL
- Israel
- Prior art keywords
- compound
- general
- represented
- pharmaceutical composition
- formula
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 33
- 238000004519 manufacturing process Methods 0.000 title claims 5
- 150000001875 compounds Chemical class 0.000 claims 34
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 238000009903 catalytic hydrogenation reaction Methods 0.000 claims 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 239000002262 Schiff base Substances 0.000 claims 3
- 150000004753 Schiff bases Chemical class 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 3
- -1 ethylenedioxy group Chemical group 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 229910052751 metal Inorganic materials 0.000 claims 3
- 239000002184 metal Substances 0.000 claims 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 2
- 125000001931 aliphatic group Chemical group 0.000 claims 2
- 229910052783 alkali metal Inorganic materials 0.000 claims 2
- 150000001340 alkali metals Chemical class 0.000 claims 2
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims 2
- 150000001342 alkaline earth metals Chemical class 0.000 claims 2
- 150000001728 carbonyl compounds Chemical class 0.000 claims 2
- 230000015556 catabolic process Effects 0.000 claims 2
- 230000003197 catalytic effect Effects 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 238000006731 degradation reaction Methods 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 230000003647 oxidation Effects 0.000 claims 2
- 238000007254 oxidation reaction Methods 0.000 claims 2
- 229910052697 platinum Inorganic materials 0.000 claims 2
- NDVLTYZPCACLMA-UHFFFAOYSA-N silver oxide Chemical compound [O-2].[Ag+].[Ag+] NDVLTYZPCACLMA-UHFFFAOYSA-N 0.000 claims 2
- 239000007858 starting material Substances 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 239000002585 base Substances 0.000 claims 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 238000006555 catalytic reaction Methods 0.000 claims 1
- 239000003874 central nervous system depressant Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 1
- 150000004820 halides Chemical class 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 230000007062 hydrolysis Effects 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- 230000003301 hydrolyzing effect Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000005342 ion exchange Methods 0.000 claims 1
- 229910052987 metal hydride Inorganic materials 0.000 claims 1
- 150000004681 metal hydrides Chemical class 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229910052759 nickel Inorganic materials 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- 229910052763 palladium Inorganic materials 0.000 claims 1
- 239000002798 polar solvent Substances 0.000 claims 1
- 239000011347 resin Substances 0.000 claims 1
- 229920005989 resin Polymers 0.000 claims 1
- 229910001923 silver oxide Inorganic materials 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8240072A JPS532878B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1972-08-17 | 1972-08-17 | |
| JP8239972A JPS532877B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1972-08-17 | 1972-08-17 | |
| JP9636872A JPS533398B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1972-09-26 | 1972-09-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL43008A true IL43008A (en) | 1976-07-30 |
Family
ID=27303905
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL43008A IL43008A (en) | 1972-08-17 | 1973-08-16 | Dibenzazecines and processes for the production thereof |
Country Status (12)
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3007710C2 (de) * | 1980-02-29 | 1982-04-15 | Gödecke AG, 1000 Berlin | 5,6;8,9-Tetrahydro-7H-dibenz(d,f)azonin-derivate, Verfahren zu deren Herstellung und Arzneimittel |
| US20020061339A1 (en) * | 2000-09-28 | 2002-05-23 | Martin Stogniew | Compositions and methods for use of extracts of rutaceae plants |
| WO2007006212A1 (en) * | 2005-07-08 | 2007-01-18 | Shanghai Institute Of Materia Medica, Chinese Academy Of Siences | Tetrahydroprotoberberine compounds, the synthetic method and the use thereof |
| CN1900076B (zh) * | 2005-07-08 | 2011-06-22 | 中国科学院上海药物研究所 | 四氢原小檗碱类化合物及其制备方法和用途 |
| US8003795B2 (en) | 2007-06-22 | 2011-08-23 | Cvi Pharmaceuticals Limited | Compounds and compositions for reducing lipid levels |
| US8710071B2 (en) | 2008-12-23 | 2014-04-29 | Cvi Pharmaceuticals Limited | Compounds, compositions and methods for reducing lipid levels |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3498988A (en) * | 1967-03-15 | 1970-03-03 | Sandoz Ag | Dibenz(c,f)azonines |
-
1973
- 1973-07-27 US US05/383,148 patent/US3932384A/en not_active Expired - Lifetime
- 1973-08-03 GB GB3754973A patent/GB1433227A/en not_active Expired
- 1973-08-13 CA CA178,612A patent/CA1005054A/en not_active Expired
- 1973-08-13 DE DE19732340846 patent/DE2340846A1/de active Pending
- 1973-08-16 CH CH1180873A patent/CH592630A5/xx not_active IP Right Cessation
- 1973-08-16 IL IL43008A patent/IL43008A/en unknown
- 1973-08-16 DD DD172934A patent/DD107921A5/xx unknown
- 1973-08-17 FR FR7330095A patent/FR2196175B1/fr not_active Expired
- 1973-08-17 PH PH14945A patent/PH10465A/en unknown
- 1973-08-17 NL NL7311419A patent/NL7311419A/xx not_active Application Discontinuation
- 1973-08-17 ES ES417971A patent/ES417971A1/es not_active Expired
-
1976
- 1976-03-09 SE SE7603122A patent/SE7603122L/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES417971A1 (es) | 1976-06-01 |
| PH10465A (en) | 1977-04-25 |
| CH592630A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1977-10-31 |
| US3932384A (en) | 1976-01-13 |
| DD107921A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1974-08-20 |
| FR2196175A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1974-03-15 |
| FR2196175B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1976-08-13 |
| CA1005054A (en) | 1977-02-08 |
| AU5895373A (en) | 1975-02-06 |
| NL7311419A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1974-02-19 |
| DE2340846A1 (de) | 1974-02-28 |
| GB1433227A (en) | 1976-04-22 |
| SE7603122L (sv) | 1976-03-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US3253037A (en) | N-2-alkynyl-amino-benzocylo-alkanes | |
| US9447025B2 (en) | Bicyclic analgesic compounds | |
| DE1668055B2 (de) | Basisch substituierte cyclopentylphenolaether, deren salze mit physiologisch vertraeglichen saeuren und verfahren zu deren herstellung | |
| DE2525512C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | ||
| IL43008A (en) | Dibenzazecines and processes for the production thereof | |
| DE2316727A1 (de) | Aminderivate, verfahren zu deren herstellung und sie enthaltende arzneimittel | |
| JPS5929190B2 (ja) | スルホンアミド化合物 | |
| CH626047A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | ||
| Brown et al. | Hydrogenation of nitroaromatics in the presence of the new platinum metal and carbon-supported platinum metal catalysts | |
| EP0067711B1 (en) | New 1-benzyl-3,4-dihydro-isoquinoline derivative | |
| GB1287664A (en) | Epierythromycylamine and epierythromycyl b amine | |
| GB811827A (en) | Reserpic acid derivative | |
| US3192113A (en) | N, n'-dialkylenediamines as antitubercular agents | |
| DE1770697C3 (de) | 2,2-(N-Methyl-2-azatetramethylen)- -adamantan, dessen Salze, Verfahren zu deren Herstellung und Arzneimittel | |
| US3541217A (en) | Omicron-chlorobenzylaminoguanidine for treating bovine ketosis | |
| US2923714A (en) | 1-picolinoyl-2-benzyl hydrazine and salts | |
| US3095448A (en) | Cycloalkyl-alkyl hydrazines | |
| DE1957490A1 (de) | 4-Amino-spiro [cyclohexan-1,9'-thioxanthen]-Verbindungen sowie Verfahren zu ihrer Herstellung | |
| US3492351A (en) | 1-(lower alkoxy-phenyl)-2-(lower alkyl-amino)- alkanones-(1) and salts | |
| DE2004301A1 (de) | Phenylserinderivate | |
| IL31513A (en) | Phenethylamine derivatives and process for the manufacture thereof | |
| SU427713A1 (ru) | Лекарственное средство | |
| GB1021858A (en) | Fumaramic acid derivatives | |
| SU803349A1 (ru) | Хлоргидраты N-адамантильных производных-1-(оксифенил)-2-аминоэтанола, обладающие местноанестезирующей и противоаритмической активностью | |
| US3406237A (en) | Composition and a method for relieving broncho-spasms which use 1-p-hydroxyphenyl - 2 - (beta - 3',5' - dihydroxyphenyl - beta-hydroxy)-ethylaminopropane |