IL42707A - Device for the administration of medicaments by oral inhalation - Google Patents

Device for the administration of medicaments by oral inhalation

Info

Publication number
IL42707A
IL42707A IL42707A IL4270773A IL42707A IL 42707 A IL42707 A IL 42707A IL 42707 A IL42707 A IL 42707A IL 4270773 A IL4270773 A IL 4270773A IL 42707 A IL42707 A IL 42707A
Authority
IL
Israel
Prior art keywords
housing
capsule
vents
vent
holder
Prior art date
Application number
IL42707A
Other versions
IL42707A0 (en
Original Assignee
Beecham Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Ltd filed Critical Beecham Group Ltd
Publication of IL42707A0 publication Critical patent/IL42707A0/en
Publication of IL42707A publication Critical patent/IL42707A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0031—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up by bursting or breaking the package, i.e. without cutting or piercing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0035—Piercing means
    • A61M15/0036—Piercing means hollow piercing means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0041—Details of the piercing or cutting means with movable piercing or cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

1404338 Administering medicines BEECHAM GROUP Ltd 2 Aug 1973 [4 Aug 1972] 36428/72 Heading A5T A device for the oral inhalation of finely divided solid medicaments comprises a hollow housing and a capsule holder fixed to an elongated vibratable member which is fixed at one end within the housing at a point remote from the capsule holder, the housing having inlet and outlet vents permitting air to flow through the housing, and means causing the member to vibrate, the outlet vents being adapted for application to or insertion into the mouth, and positioned such that the finely divided medicament is carried through the outlet vents at the intake of breath by the user of the device. As shown in Fig. 1, a hollow, generally cylindrical housing 1 has a flat reed 4 mounted on a projection 5 at the end of the housing. A capsule 3, containing finely divided medicament, is held in a holder 2 at the other end of reed 4. In use, the patient inhales at the outlet vents 7, so that air flows in through vents 6 to baffles 8 in the body and baffle 9 on reed 4. The baffles 8, 9 are arranged with a small gap between them, so that turbulence occurs in their vicinity. The reed is vibrated, and powder is shaken out of the capsule, which is pierced for the purpose, before loading or in situ. A constriction 10 is formed near the capsule to provide for low pressure to help disperse the powder. The housing 1 is made in two parts, with screw threads or a snap fastening at X, for placing the capsule in holder 2. Vents 6 may be omitted and air enters by a single vent or opposed vents in the side of the housing, co-operating with the reed or baffles mounted on opposite sides of the reed parallel to the housing walls. Vents 7 may be replaced by a plug drilled with a hole which has a cross-sectional area approximately equal to the area of the annular gap between a side vent and the reed at their greatest separation. In another embodiment, Fig. 6, air enters by tangential vents 406 (see also Fig. 7, not shown), and a vent 406a. A piercing member 421 slides coaxially in housing 401. As the patient inhales through the vent 407, a vortex is formed around holder 402, which rotates orbitally and strikes the inside of housing 401 successive light blows. Air is also drawn through vent 406a, passing partly through passage 417 and through capsule 403, adding to the turbulence. Consequently, powder issues from the capsule in a helical path. Lighter particles are inhaled through the vent 407; heavier particles whirl round in a trough 422 surrounding vent 407 until they are abraded to a size such that they also pass out through vent 407. The vibrating rod may be mounted on a spring-biassed pushbutton, and the capsule impaled on a hollow piercing member of the holder, so that it may be pushed on to a second piercing member by pressing the button. Where the patient is unable to suck sufficiently hard, his efforts may be supplemented by a rubber squeeze bulb. [GB1404338A]

Claims (26)

1. A device for the oral inhalation of finely divided solid., medicaments which device comprises a hollow housing and a capsule holder fixed to an elongate vibratable member, which member is fixed at one end within the housing at a point remote from the capsule holder, said housing having inlet and outlet vents permitting air to flow through the housing and a means for causing, said member to vibrate, the outlet vents being adapted for application to or insertion into- the mouth, and positioned such that the finely divided medicament is carried from a pierced capsule when present in the capsule holder through said outlet vents at the intake of breath by the user.
2. A device according to claim 1 wherein the means for vibrating said elongate member is provided by a turbulent air stream caused to flow between the inlet and outlet vents at the. intake of breathe by the user of the device,
3. A device according to claim 2 wherein turbulence is imparted to said air stream by the construction and arrangement of the interior of the housing of the device.
4. A device according to claim 2 wherein turbulence is imparted to the air stream by the construction and arrangement of the irOBt vents.
5. A device according to claim 2 wherein turbulence is imparted to the air stream by the construction and arrangement of both the interior of the housing of the device and the inlet vents·
6. A device according to any of the claims 1-5 which device has only one outlet vent.
7. A device according to any of the claims 1-5 wherein the elongate vibratable member is in the form of a rod which is f able to vibrate in any direction at right angles to its long axis.
8. M. 42707/2
9. A device according to any of the claims 1-6 wherein the vibrmtable member is in the form of a long narrowflat strip such that its primary component of vibration is inua single plane.
10. A device according to either claim 7 or claim 8 wherein the housing is provided with a pluralit of inlet vents in the region of the capsule holder.
11. A device according to claim 10 wherein said inlet vents are angled such that incoming air Is directed to a circular path.
12. A device according to claim 10 wherein said inlet vents are positioned adjacent internal angled barriers such that incoming air is directed to a circula path,
13. 15. A device according to claim 9 wherein the cross-sectional area of the outlet vent is of the same general magnitude as the total cross-sectional area of the inlet vents.
14. · A device according to any one of claims 1-13 wherein the capsule holder is provided with a protuberance adapted to strike the inner walls of the housing when the vibratable member vibrates,
15. device according to any one of claims 1-14 wherein the capsule holder is in the form of a cup adapted to securely carry a capsule.
16. A device according to any one of claims 1-15 wherein the capsule holder has a passage to allo a flow of air from within., the hollow housing to one end of the major axis of the capsule.
17. · A device according to any one o claims 1-16 which device is provided with means for piercing the capsule in situ in the device.
18. A device according to claim 17 which device is provided 42707/2 axis thereof.
19. A device according to claim 18 wherein the means of piercing the end of the capsule nearest to the o let vent is in the form of a sharpened piercing member mounted within the hollow housing coaxial with the capsule holder,
20. A device according to claim 19 wherein the sharpened piercing member is slidably mounted within the housing,
21. A device according to claim 18 wherein the sharpened piercing member is fixed within the housing and the device is provided with means for moving the capsule holder towards the piercing member.
22. A device according to any one of claims 18*21 wherein the means for piercing the end of the capsule furthest from the outlet vent is in the form of a sharpened hollow piercing membe attached-to the capsule holder onto which a capsule may be impaled.
23. * A device according to any one of claims 1-21 wherein the housing is separable into two parts.
24. A device according to claim 2 wherein the two parts of the housing are adapted to be reassembled by means of a screw thread.
25. device according to claim 7 substantially^as herei described with reference to any one of Figs 6, 9, 12 and 13 of the accompanying drawings.
26. A device according to claim 9 substantially as herei described with reference to any one of Figs 1, 2, 4 and -5. o the accompanying drawings. A
IL42707A 1972-08-04 1973-07-10 Device for the administration of medicaments by oral inhalation IL42707A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3642872A GB1404338A (en) 1972-08-04 1972-08-04 Device for the inhalation of medicaments

Publications (2)

Publication Number Publication Date
IL42707A0 IL42707A0 (en) 1973-10-25
IL42707A true IL42707A (en) 1976-06-30

Family

ID=10388056

Family Applications (1)

Application Number Title Priority Date Filing Date
IL42707A IL42707A (en) 1972-08-04 1973-07-10 Device for the administration of medicaments by oral inhalation

Country Status (20)

Country Link
AR (1) AR196538A1 (en)
AT (1) AT346466B (en)
BE (1) BE802702A (en)
BR (1) BR7305927D0 (en)
CA (1) CA1006060A (en)
CH (1) CH553579A (en)
DE (1) DE2335122C3 (en)
ES (1) ES193872Y (en)
FI (1) FI58076C (en)
FR (1) FR2194454B1 (en)
GB (1) GB1404338A (en)
IE (1) IE38212B1 (en)
IL (1) IL42707A (en)
IT (1) IT990115B (en)
LU (1) LU68151A1 (en)
NL (1) NL7310742A (en)
NO (1) NO133013C (en)
SE (1) SE392215B (en)
YU (1) YU36613B (en)
ZA (1) ZA735066B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE395611B (en) * 1975-12-12 1977-08-22 Draco Ab AEROSOL INHALATION DEVICE INTENDED FOR INHALATION THROUGH AN INHALATION MOUTH OF PHARMACOLOGICALLY ACTIVE SUBSTANCES
IT1116047B (en) * 1979-04-27 1986-02-10 Sigma Tau Ind Farmaceuti DEVICE FOR THE QUICK INHALATION OF POWDER DRUGS BY PERSONS SUFFERING FROM ASTHMA
DE3050005A1 (en) * 1979-10-30 1982-03-18 Riker Laboratories Inc BREATH ACTUATED DEVICES FOR ADMINISTERING POWDERED MEDICAMENTS
BR8007911A (en) * 1979-12-06 1981-06-16 Glaxo Group Ltd PERFECTED INHALER
GB9021433D0 (en) * 1990-10-02 1990-11-14 Atomic Energy Authority Uk Power inhaler
PL370286A1 (en) * 2004-09-23 2006-04-03 Glaxosmithkline Pharmaceuticals Spółka Akcyjna Powder inhaler - capsules opening and emptying system
GB2489383A (en) * 2009-12-30 2012-09-26 Vijayan Thirumalai Anandampillai An improved dry powder inhaler
WO2011080747A2 (en) * 2010-01-27 2011-07-07 Aespira Ltd. Dry powder inhaler
TW201340894A (en) * 2011-12-20 2013-10-16 British American Tobacco Co Smoking articles and other flow delivery articles
EP3934720B1 (en) * 2019-03-05 2023-05-03 Philip Morris Products S.A. Holder for inhaler article

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2519555A (en) * 1945-08-31 1950-08-22 Abbott Lab Sterile medicament insufflator cartridge and insufflator
GB1301856A (en) * 1965-03-19 1973-01-04 Fisons Pharmaceuticals Ltd Dispensing device
US2946332A (en) * 1957-12-23 1960-07-26 Nysco Lab Inc Insufflator
GB1122284A (en) * 1965-03-19 1968-08-07 Fisons Pharmaceuticals Ltd Inhalation device
GB1295081A (en) * 1969-01-08 1972-11-01 Fisons Pharmaceuticals Ltd A method and device for dispensing particulate medicament material from a container
GB1118341A (en) * 1965-04-20 1968-07-03 Fisons Pharmaceuticals Ltd Inhalation device
GB1182779A (en) * 1966-09-17 1970-03-04 Fisons Pharmaceuticals Ltd Inhalation Device
DE1566604C3 (en) * 1966-09-17 1980-10-23 Fisons Pharmaceuticals Ltd., Loughborough, Leicestershire (Ver. Koenigreich) Device for the oral inhalation of medication in finely divided form
GB1268051A (en) * 1968-06-07 1972-03-22 Fisons Pharmaceuticals Ltd Inhalation device
GB1338254A (en) * 1970-03-25 1973-11-21 Fisons Ltd Powder blowing device
IT941426B (en) * 1971-07-17 1973-03-01 Isf Spa SWIRL-CHAMBER INHALER FOR POWDER-SHAPING MEDICINAL SUBSTANCES

Also Published As

Publication number Publication date
GB1404338A (en) 1975-08-28
DE2335122C3 (en) 1981-08-06
IE38212L (en) 1974-02-04
AR196538A1 (en) 1974-02-06
YU211373A (en) 1982-06-18
ES193872Y (en) 1975-03-16
CH553579A (en) 1974-09-13
NO133013C (en) 1976-02-25
ES193872U (en) 1974-12-01
IE38212B1 (en) 1978-01-18
DE2335122B2 (en) 1980-10-23
AT346466B (en) 1978-11-10
ATA664073A (en) 1978-03-15
IL42707A0 (en) 1973-10-25
CA1006060A (en) 1977-03-01
FR2194454B1 (en) 1979-07-20
FR2194454A1 (en) 1974-03-01
IT990115B (en) 1975-06-20
NL7310742A (en) 1974-02-06
SE392215B (en) 1977-03-21
BE802702A (en) 1974-01-23
DE2335122A1 (en) 1974-02-14
FI58076B (en) 1980-08-29
YU36613B (en) 1984-08-31
BR7305927D0 (en) 1974-08-29
FI58076C (en) 1980-12-10
NO133013B (en) 1975-11-17
ZA735066B (en) 1974-07-31
LU68151A1 (en) 1973-10-15

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