IL42343A - N-substituted-n'-((benzoxazole-7-carboxamidoalkyl)benzene-sulfonyl)ureas and process for their manufacture - Google Patents
N-substituted-n'-((benzoxazole-7-carboxamidoalkyl)benzene-sulfonyl)ureas and process for their manufactureInfo
- Publication number
- IL42343A IL42343A IL42343A IL4234373A IL42343A IL 42343 A IL42343 A IL 42343A IL 42343 A IL42343 A IL 42343A IL 4234373 A IL4234373 A IL 4234373A IL 42343 A IL42343 A IL 42343A
- Authority
- IL
- Israel
- Prior art keywords
- ureas
- alkyl
- benzenesulfonyl
- substituted
- acid esters
- Prior art date
Links
- 235000013877 carbamide Nutrition 0.000 title claims 5
- 238000000034 method Methods 0.000 title claims 4
- 238000004519 manufacturing process Methods 0.000 title claims 3
- 150000003672 ureas Chemical class 0.000 title claims 2
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 title 1
- -1 alkyl radical Chemical group 0.000 claims abstract 12
- 150000003839 salts Chemical class 0.000 claims abstract 8
- 125000000217 alkyl group Chemical group 0.000 claims abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims abstract 3
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 claims abstract 2
- 239000003795 chemical substances by application Substances 0.000 claims abstract 2
- 125000000392 cycloalkenyl group Chemical group 0.000 claims abstract 2
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract 2
- 239000001257 hydrogen Substances 0.000 claims abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 2
- 239000008280 blood Substances 0.000 claims 3
- 210000004369 blood Anatomy 0.000 claims 3
- 206010012601 diabetes mellitus Diseases 0.000 claims 3
- 229940100389 Sulfonylurea Drugs 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 231100000252 nontoxic Toxicity 0.000 claims 2
- 230000003000 nontoxic effect Effects 0.000 claims 2
- QYCGBAJADAGLLK-UHFFFAOYSA-N 1-(cyclohepten-1-yl)cycloheptene Chemical group C1CCCCC=C1C1=CCCCCC1 QYCGBAJADAGLLK-UHFFFAOYSA-N 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 230000010933 acylation Effects 0.000 claims 1
- 238000005917 acylation reaction Methods 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- LSNDGFYQJRXEAR-UHFFFAOYSA-N benzenesulfonamidourea Chemical class NC(=O)NNS(=O)(=O)C1=CC=CC=C1 LSNDGFYQJRXEAR-UHFFFAOYSA-N 0.000 claims 1
- ALZKZGUTVJXYEF-UHFFFAOYSA-N benzenesulfonylcarbamic acid Chemical class OC(=O)NS(=O)(=O)C1=CC=CC=C1 ALZKZGUTVJXYEF-UHFFFAOYSA-N 0.000 claims 1
- GHDLZGOOOLEJKI-UHFFFAOYSA-N benzenesulfonylurea Chemical compound NC(=O)NS(=O)(=O)C1=CC=CC=C1 GHDLZGOOOLEJKI-UHFFFAOYSA-N 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 150000001714 carbamic acid halides Chemical class 0.000 claims 1
- 229940112021 centrally acting muscle relaxants carbamic acid ester Drugs 0.000 claims 1
- 239000007795 chemical reaction product Substances 0.000 claims 1
- 239000000460 chlorine Chemical group 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- ARUKYTASOALXFG-UHFFFAOYSA-N cycloheptylcycloheptane Chemical group C1CCCCCC1C1CCCCCC1 ARUKYTASOALXFG-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012948 isocyanate Substances 0.000 claims 1
- 150000002513 isocyanates Chemical class 0.000 claims 1
- UUFWPLHGJYIEBA-UHFFFAOYSA-N n-(iminomethylidene)benzenesulfonamide Chemical class N=C=NS(=O)(=O)C1=CC=CC=C1 UUFWPLHGJYIEBA-UHFFFAOYSA-N 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 125000003884 phenylalkyl group Chemical group 0.000 claims 1
- 229940124530 sulfonamide Drugs 0.000 claims 1
- 150000003456 sulfonamides Chemical class 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- JOYRKODLDBILNP-UHFFFAOYSA-N urethane group Chemical class NC(=O)OCC JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000005840 aryl radicals Chemical class 0.000 abstract 1
- 150000001602 bicycloalkyls Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005347 halocycloalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 230000002218 hypoglycaemic effect Effects 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 238000010561 standard procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D263/57—Aryl or substituted aryl radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2225544A DE2225544A1 (de) | 1972-05-26 | 1972-05-26 | Benzolsulfonylharnstoffe und verfahren zu ihrer herstellung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL42343A0 IL42343A0 (en) | 1973-07-30 |
| IL42343A true IL42343A (en) | 1976-03-31 |
Family
ID=5845890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL42343A IL42343A (en) | 1972-05-26 | 1973-05-24 | N-substituted-n'-((benzoxazole-7-carboxamidoalkyl)benzene-sulfonyl)ureas and process for their manufacture |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US3850950A (zh) |
| JP (1) | JPS4941369A (zh) |
| AT (1) | AT338817B (zh) |
| AU (1) | AU5612673A (zh) |
| BE (1) | BE800127A (zh) |
| CA (1) | CA1014162A (zh) |
| CH (3) | CH580609A5 (zh) |
| DE (1) | DE2225544A1 (zh) |
| ES (1) | ES414984A1 (zh) |
| FR (1) | FR2189029B1 (zh) |
| GB (1) | GB1429841A (zh) |
| IL (1) | IL42343A (zh) |
| NL (1) | NL7307062A (zh) |
| SE (1) | SE381048B (zh) |
| ZA (1) | ZA733572B (zh) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20070114748A (ko) * | 2005-02-17 | 2007-12-04 | 에이엠알 테크놀로지, 인크. | Ｃｉｎｖ 및 ｉｂｓｄ를 치료하기 위한 벤족사졸카복스아미드 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE34211B1 (en) * | 1969-05-09 | 1975-03-05 | Novo Terapeutisk Labor As | Improvements in or relating to sulphonylureas |
-
1972
- 1972-05-26 DE DE2225544A patent/DE2225544A1/de active Pending
-
1973
- 1973-05-21 NL NL7307062A patent/NL7307062A/xx not_active Application Discontinuation
- 1973-05-21 ES ES414984A patent/ES414984A1/es not_active Expired
- 1973-05-23 CH CH736273A patent/CH580609A5/xx not_active IP Right Cessation
- 1973-05-23 CH CH711676A patent/CH589071A5/xx not_active IP Right Cessation
- 1973-05-23 CH CH711776A patent/CH583718A5/xx not_active IP Right Cessation
- 1973-05-24 IL IL42343A patent/IL42343A/en unknown
- 1973-05-24 US US00363414A patent/US3850950A/en not_active Expired - Lifetime
- 1973-05-25 SE SE7307384A patent/SE381048B/xx unknown
- 1973-05-25 CA CA172,567A patent/CA1014162A/en not_active Expired
- 1973-05-25 ZA ZA733572A patent/ZA733572B/xx unknown
- 1973-05-25 AT AT459073A patent/AT338817B/de not_active IP Right Cessation
- 1973-05-25 GB GB2512873A patent/GB1429841A/en not_active Expired
- 1973-05-25 AU AU56126/73A patent/AU5612673A/en not_active Expired
- 1973-05-26 JP JP48058261A patent/JPS4941369A/ja active Pending
- 1973-05-28 FR FR7319339A patent/FR2189029B1/fr not_active Expired
- 1973-05-28 BE BE131596A patent/BE800127A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB1429841A (en) | 1976-03-31 |
| AT338817B (de) | 1977-09-12 |
| ES414984A1 (es) | 1976-02-16 |
| CH580609A5 (zh) | 1976-10-15 |
| NL7307062A (zh) | 1973-11-28 |
| CH583718A5 (zh) | 1977-01-14 |
| ATA459073A (de) | 1977-01-15 |
| US3850950A (en) | 1974-11-26 |
| DE2225544A1 (de) | 1973-12-13 |
| SE381048B (sv) | 1975-11-24 |
| ZA733572B (en) | 1974-04-24 |
| AU5612673A (en) | 1974-11-28 |
| BE800127A (fr) | 1973-11-28 |
| IL42343A0 (en) | 1973-07-30 |
| CH589071A5 (zh) | 1977-06-30 |
| FR2189029B1 (zh) | 1977-01-28 |
| FR2189029A1 (zh) | 1974-01-25 |
| CA1014162A (en) | 1977-07-19 |
| JPS4941369A (zh) | 1974-04-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4379785A (en) | Heterocyclic substituted sulfonyl ureas, and their use | |
| US4315940A (en) | Antidiabetic 1-piperidine-sulfonylureas | |
| IL42343A (en) | N-substituted-n'-((benzoxazole-7-carboxamidoalkyl)benzene-sulfonyl)ureas and process for their manufacture | |
| US3372164A (en) | Benzenesulfonyl semicarbazides | |
| US3919245A (en) | Benzenesulfonyl ureas | |
| US3504026A (en) | Benzenesulfonyl-ureas | |
| US3829434A (en) | Piperidinesulfonylurea derivatives | |
| US3843661A (en) | Benzene-sulfonyl semicarbazides | |
| US3108098A (en) | Novel nu-morpholinesulfonyl ureas | |
| US3835188A (en) | Benzenesulfonyl-ureas and process for their preparation | |
| GB1450801A (en) | Pyridinecarboxamide sulphonylurea hypoglycemic agents | |
| US3033902A (en) | Arylsulfonylureas | |
| US3928590A (en) | Ortho-mercaptoaroylamides and salts thereof as hypoglycemic agents | |
| US3305556A (en) | Novel hypoglycemic agents | |
| US4282239A (en) | Sulfonyl ureas and pharmaceutical preparations thereof | |
| CA2169695C (en) | Substituted benzenesulfonylureas and -thioureas, processes for their preparation, their use for the production of pharmaceutical preparations and medicaments containing them | |
| IL22148A (en) | Benzenesulfonyl ureas | |
| US3914426A (en) | Piperidinesulfonylurea derivatives for lowering blood sugar levels | |
| PL80492B1 (en) | N - (4-(beta-<2-methoxy-5-chloro-benzamido>-ethyl) - benzenesulfonyl)-n'-cyclopentyl-urea and process for its manufacture[us3754030a] | |
| US3100208A (en) | N1-(p-toluene sulfonyl)-n2-(alpha-tetrahydrofuryl methyl) urea | |
| US3856806A (en) | Thiazolecarboxamide sulfonylurea hypoglycemic agents | |
| US4166866A (en) | Immunosuppressive method with dithiocarbamates | |
| US4025519A (en) | Benzenesulfonyl-ureas | |
| KR800000451B1 (ko) | 벤젠설포닐-우레아의 제조방법 | |
| US3449417A (en) | Benzenesulphonyl-ureas and process for preparing them |