IL41868A - Pharmaceutical preparations containing d-penicillamine - Google Patents
Pharmaceutical preparations containing d-penicillamineInfo
- Publication number
- IL41868A IL41868A IL41868A IL4186873A IL41868A IL 41868 A IL41868 A IL 41868A IL 41868 A IL41868 A IL 41868A IL 4186873 A IL4186873 A IL 4186873A IL 41868 A IL41868 A IL 41868A
- Authority
- IL
- Israel
- Prior art keywords
- composition
- composition according
- penicillamine
- compositions
- tablet
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
Abstract
1424432 Compositions containing synthetic D-penicillamine DEUTSCHE GOLD-UND SILBER - SOHEIDEANSTALT 23 March 1973 [25 March 1972 11 July 1972] 14158/73 Heading A5B [Also in Division C2] A pharmaceutical composition comprises fully synthetic D-penicillamine obtained by resolution of a D, L-penicillamine derivative of general formula: in which Ac represents an acyl group, Z represents H or together with Ac represents a diacyl radical, R represents H, a benzyl radical or an acyl group and R<SP>1</SP> and R<SP>2</SP> which may be the same or different, each represent H, C 1 -C<SP>8</SP> alkyl or a cycloalkyl or aryl radical, with an optically active base and converting the D-isomer obtained to D-penicillamine, together with at least one pharmaceutically acceptable additive or excipient. The compositions may be made up in forms suitable for oral, parenteral, rectal, vaginal or local administration or may be in the form of an inhalation. The compositions may contain other active ingredients such as analgesics, antihistamines, antiphlogistics, spasmolytics, geriatics, liver therapeutics, vitamins, trace elements and steroids. In examples salicylamide, α-tocopherol and ascorbic acid may be present.
[GB1424432A]
Claims (1)
1. IS CLAIMED A medicinal composition containing completely synthetic or a pharmaceutically acceptable salt thereof and a pharmacologically acceptable said composition having less allergenic and side effects than a comparable composition containing natural A medicinal composition according to claim 1 including the disodium salt of tetraacetic A composition according to claim 2 including at least one of the following pharmaceutical a alginic calcium pectic di or tricalcium calcium cellulose sodium carboxymethyl gum gum vinyl acetate high magnesium ethylene solid or cetyl alcohol and hard fat having a hydroxy1 number of 1 to A composition in accordance with claim 1 in the form of a tablet or composition according to claim wherein the tablet or capsule has a gastric juice soluble A composition according to claim wherein the coating comprises an alkyl cellulose or hydroxyalkyl A composition according to claim 4 wherein the tablet or capsule has a gastric juice resistant A composition according to claim 7 wherein the coating comprises acylated A composition accordin to claim 1 comprising or a pharmaceutically acceptable salt thereof together with at least one non toxic solvent which is a partial ether of a polyhydric alcohol and a lower alkanolj a partial ester of a polyhydric alcohol with a lower aliphatic carboxylic an aliphatic carbonamide having 1 to 10 carbon atoms or an aliphatic A composition prepared from the composition of claim 1 and A suppository comprising the composition claim 1 and a hard A salve containing the composition of claim A composition according to l A composition according to claim 1 wherein the or salt thereof is formed by racemate a completely synthetically produced derivative of the where R is benzyl or and Ac is an group and and are of 1 to 8 carbon aryl or and Z stands for a hydrogen or together Ac may be a diacyl especially phthaly with an optically active A composition to claim wherein the derivative is or and the base is or A composition according to claim 14 wherein Ac is nitrophenyl or lower 34 A process for preparation of compositions acoarding to any one of to the la granulated vith known solid in the of a solu ion essentially of For insufficientOCRQuality
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2214814A DE2214814A1 (en) | 1972-03-25 | 1972-03-25 | Synthetic d-penicillamine prepns - useful against fibrosis polyarthritis aggressive hepatitis etc |
DE19722233993 DE2233993A1 (en) | 1972-07-11 | 1972-07-11 | Synthetic D-penicillamine prepns - obtd by optical resolution |
Publications (2)
Publication Number | Publication Date |
---|---|
IL41868A0 IL41868A0 (en) | 1973-05-31 |
IL41868A true IL41868A (en) | 1976-02-29 |
Family
ID=25762971
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL41868A IL41868A (en) | 1972-03-25 | 1973-03-25 | Pharmaceutical preparations containing d-penicillamine |
Country Status (5)
Country | Link |
---|---|
FR (1) | FR2182892B1 (en) |
GB (1) | GB1424432A (en) |
IL (1) | IL41868A (en) |
NL (1) | NL7304113A (en) |
OA (1) | OA04527A (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2304055C3 (en) * | 1973-01-27 | 1982-04-29 | Degussa Ag, 6000 Frankfurt | Process for the production of D-penicillamine |
DE2304054C3 (en) * | 1973-01-27 | 1982-04-08 | Degussa Ag, 6000 Frankfurt | Process for obtaining D-penicillamine |
ATE73995T1 (en) * | 1985-06-08 | 1992-04-15 | Asta Medica Ag | USE OF PENICILLAMIN TO TREAT IMMUNE DEFICIENCY DISEASES. |
ES2739352T3 (en) | 2009-02-26 | 2020-01-30 | Glaxo Group Ltd | Pharmaceutical formulations comprising 4 - {(1R) -2 - [(6- {2 - [(2,6-dichlorobenzyl) oxy] ethoxy} hexyl) amino] -1-hydroxyethyl} -2- (hydroxymethyl) phenol |
GB0921075D0 (en) | 2009-12-01 | 2010-01-13 | Glaxo Group Ltd | Novel combination of the therapeutic agents |
WO2019111193A1 (en) * | 2017-12-09 | 2019-06-13 | Kashiv Pharma Llc | A stable pharmaceutical composition comprising penicillamine |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1015108A (en) * | 1946-03-22 | 1952-08-27 | Merck & Co Inc | Process for the preparation of penicillin derivatives and products resulting therefrom |
BE786964A (en) * | 1971-07-30 | 1973-01-29 | Degussa | PROCEDURE FOR OBTAINING D-PENICILLAMINE |
-
1973
- 1973-03-23 GB GB1415873A patent/GB1424432A/en not_active Expired
- 1973-03-23 FR FR7310473A patent/FR2182892B1/fr not_active Expired
- 1973-03-23 NL NL7304113A patent/NL7304113A/xx active Search and Examination
- 1973-03-24 OA OA54862A patent/OA04527A/en unknown
- 1973-03-25 IL IL41868A patent/IL41868A/en unknown
Also Published As
Publication number | Publication date |
---|---|
IL41868A0 (en) | 1973-05-31 |
FR2182892B1 (en) | 1976-11-05 |
OA04527A (en) | 1980-03-30 |
NL7304113A (en) | 1973-09-27 |
AU5367973A (en) | 1974-09-26 |
GB1424432A (en) | 1976-02-11 |
FR2182892A1 (en) | 1973-12-14 |
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