IL41792A - Acne preparation for oral administration and process for preparing same - Google Patents
Acne preparation for oral administration and process for preparing sameInfo
- Publication number
- IL41792A IL41792A IL41792A IL4179273A IL41792A IL 41792 A IL41792 A IL 41792A IL 41792 A IL41792 A IL 41792A IL 4179273 A IL4179273 A IL 4179273A IL 41792 A IL41792 A IL 41792A
- Authority
- IL
- Israel
- Prior art keywords
- composition
- acnes
- corynebacterium
- accordance
- oral administration
- Prior art date
Links
- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract 6
- 206010000496 acne Diseases 0.000 title claims abstract 6
- 238000002360 preparation method Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 claims abstract 13
- 230000002503 metabolic effect Effects 0.000 claims abstract 2
- 241000186427 Cutibacterium acnes Species 0.000 claims 9
- 239000000470 constituent Substances 0.000 claims 3
- 239000002671 adjuvant Substances 0.000 claims 2
- 230000003053 immunization Effects 0.000 claims 2
- 231100000252 nontoxic Toxicity 0.000 claims 2
- 230000003000 nontoxic effect Effects 0.000 claims 2
- 208000020154 Acnes Diseases 0.000 claims 1
- 241000186216 Corynebacterium Species 0.000 claims 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 239000004202 carbamide Substances 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 244000005700 microbiome Species 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 241000894006 Bacteria Species 0.000 abstract 2
- 230000002238 attenuated effect Effects 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 238000004113 cell culture Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Cosmetics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Acne bacteria which have been attenuated by cell culture passages are cultivated under anaerobic conditions in a weakly acid medium. A composition which contains attenuated acne bacteria and metabolic products thereof is obtained. This composition can be processed to preparations for the treatment of acne vulgaris which can be administered orally and induce no additional allergization.
[GB1413419A]
Claims (1)
1. WHAT IS CLAIMED IS; 1. A composition for oral administration in the treatment of acne, which composition comprises corynebacterium acnes as an immunizing constituent and a non-toxic adjuvant, the composition containing an. excess of the number of said microorganisms which would be toJerated upon injection thereof. as claimed in claim 1 2. An acne composition for oral administration,/ comprising corynebacterium acnes as an immunizing constituent and /me€a6ofic°produc¾§ of corynebacterium acnes as a desensitizing constituent. 3. A composition in accordance with Claim 1 or 2 wherein the corynebacterium acnes are inactivated corynebacterium acnes selected from the group consisting of Gerrath, Beck and Vogel strains and combinations thereof. k A composition in accordance with Claim 1 or 2 wherein the metabolic products of corynebacterium acnes are antigens contained In the nutrient medium in which said corynebacterium acnes are cultivated. 5. A composition in accordance with Claim 1 or 2 which additionally contains urea as an immuno-ad uvant · 6. A composition in accordance with Claim 1 or 2 wherein the corynebaoterium acnes are in freeze-dried form. 7· A composition in accordance with Claim 1 or 2 wherein the corynebacterium acnes are in the form of a suspension. 8. A therapeutic composition for oral administration in unit dosage form comprising at least 1 billion of corynebacterium acnes and non-toxic adjuvant material. 9. A composition as defined in Claim 8 in which the corynebacterium strain is Gerrath. 16
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2213677A DE2213677C3 (en) | 1972-03-21 | 1972-03-21 | Orally administered acne preparation |
| DE2306223A DE2306223C2 (en) | 1973-02-08 | 1973-02-08 | Orally administered acne preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL41792A0 IL41792A0 (en) | 1973-05-31 |
| IL41792A true IL41792A (en) | 1976-09-30 |
Family
ID=25762926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL41792A IL41792A (en) | 1972-03-21 | 1973-03-16 | Acne preparation for oral administration and process for preparing same |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JPS496117A (en) |
| AR (1) | AR194533A1 (en) |
| AT (1) | AT320859B (en) |
| BG (1) | BG25659A3 (en) |
| CA (1) | CA1021262A (en) |
| CH (1) | CH608031A5 (en) |
| DD (1) | DD102915A5 (en) |
| ES (1) | ES412785A1 (en) |
| FI (1) | FI51274C (en) |
| FR (1) | FR2183687B1 (en) |
| GB (1) | GB1413419A (en) |
| HU (1) | HU171517B (en) |
| IE (1) | IE37401B1 (en) |
| IL (1) | IL41792A (en) |
| IN (1) | IN138803B (en) |
| NL (1) | NL7303883A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4314072A (en) | 1978-07-19 | 1982-02-02 | Shell Oil Company | 2-[2-(2,2-Dihalovinyl)-3,3-dimethylcyclopropyl]ethylidene diacetates |
-
1973
- 1973-03-12 IE IE402/73A patent/IE37401B1/en unknown
- 1973-03-15 DD DD169470A patent/DD102915A5/xx unknown
- 1973-03-15 IN IN591/CAL/73A patent/IN138803B/en unknown
- 1973-03-16 CA CA166,281A patent/CA1021262A/en not_active Expired
- 1973-03-16 IL IL41792A patent/IL41792A/en unknown
- 1973-03-17 ES ES412785A patent/ES412785A1/en not_active Expired
- 1973-03-19 BG BG023029A patent/BG25659A3/en unknown
- 1973-03-20 FI FI730870A patent/FI51274C/en active
- 1973-03-20 GB GB1332673A patent/GB1413419A/en not_active Expired
- 1973-03-20 HU HU73SI00001304A patent/HU171517B/en unknown
- 1973-03-20 NL NL7303883A patent/NL7303883A/xx not_active Application Discontinuation
- 1973-03-20 CH CH405073A patent/CH608031A5/en not_active IP Right Cessation
- 1973-03-20 JP JP48032526A patent/JPS496117A/ja active Pending
- 1973-03-20 AT AT247773A patent/AT320859B/en not_active IP Right Cessation
- 1973-03-21 AR AR247161A patent/AR194533A1/en active
- 1973-03-21 FR FR7310186A patent/FR2183687B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IE37401B1 (en) | 1977-07-20 |
| FR2183687B1 (en) | 1975-11-21 |
| FI51274C (en) | 1976-12-10 |
| GB1413419A (en) | 1975-11-12 |
| FR2183687A1 (en) | 1973-12-21 |
| JPS496117A (en) | 1974-01-19 |
| IN138803B (en) | 1976-04-03 |
| HU171517B (en) | 1978-01-28 |
| IL41792A0 (en) | 1973-05-31 |
| CA1021262A (en) | 1977-11-22 |
| FI51274B (en) | 1976-08-31 |
| DD102915A5 (en) | 1974-01-05 |
| AR194533A1 (en) | 1973-07-23 |
| AU5351173A (en) | 1974-09-26 |
| NL7303883A (en) | 1973-09-25 |
| AT320859B (en) | 1975-03-10 |
| CH608031A5 (en) | 1978-12-15 |
| BG25659A3 (en) | 1978-11-10 |
| ES412785A1 (en) | 1976-09-01 |
| IE37401L (en) | 1973-09-21 |
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