IL41440A - 1-(4-chlorobenzhydryl)-piperazine-4-spiro-1'-morpholinium salts,process for their preparation and pharmaceutical compositions containing them - Google Patents
1-(4-chlorobenzhydryl)-piperazine-4-spiro-1'-morpholinium salts,process for their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL41440A IL41440A IL41440A IL4144073A IL41440A IL 41440 A IL41440 A IL 41440A IL 41440 A IL41440 A IL 41440A IL 4144073 A IL4144073 A IL 4144073A IL 41440 A IL41440 A IL 41440A
- Authority
- IL
- Israel
- Prior art keywords
- composition
- compound
- formula
- active ingredient
- reacting
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 3
- 239000008194 pharmaceutical composition Substances 0.000 title claims 2
- DHCJDJGWWPYFRE-UHFFFAOYSA-N 9-[(4-chlorophenyl)-phenylmethyl]-4-oxa-1,9-diazaspiro[5.5]undecane Chemical class C1CN(CCC12COCCN2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl DHCJDJGWWPYFRE-UHFFFAOYSA-N 0.000 title 1
- 239000004480 active ingredient Substances 0.000 claims abstract 5
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 150000001875 compounds Chemical class 0.000 claims 15
- 239000000203 mixture Substances 0.000 claims 10
- 239000002253 acid Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002140 halogenating effect Effects 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000012442 inert solvent Substances 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 239000008024 pharmaceutical diluent Substances 0.000 claims 1
- 239000011591 potassium Substances 0.000 claims 1
- 229910052700 potassium Inorganic materials 0.000 claims 1
- CMXPERZAMAQXSF-UHFFFAOYSA-M sodium;1,4-bis(2-ethylhexoxy)-1,4-dioxobutane-2-sulfonate;1,8-dihydroxyanthracene-9,10-dione Chemical compound [Na+].O=C1C2=CC=CC(O)=C2C(=O)C2=C1C=CC=C2O.CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC CMXPERZAMAQXSF-UHFFFAOYSA-M 0.000 claims 1
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 claims 1
- 239000000824 cytostatic agent Substances 0.000 abstract 2
- 230000001085 cytostatic effect Effects 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 150000001450 anions Chemical group 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 230000002936 tranquilizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH142072A CH571004A5 (enrdf_load_stackoverflow) | 1972-02-01 | 1972-02-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL41440A0 IL41440A0 (en) | 1973-03-30 |
| IL41440A true IL41440A (en) | 1976-05-31 |
Family
ID=4210035
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL41440A IL41440A (en) | 1972-02-01 | 1973-01-31 | 1-(4-chlorobenzhydryl)-piperazine-4-spiro-1'-morpholinium salts,process for their preparation and pharmaceutical compositions containing them |
Country Status (14)
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2341110A1 (de) * | 1973-08-14 | 1975-02-27 | Crc Ricerca Chim | Verfahren zur herstellung von piperazinderivaten |
| DE2938557A1 (de) * | 1979-09-24 | 1981-04-23 | Isartaler Schraubenkompressoren Gmbh, 8192 Gertsried | Verdichteranlage |
| DK154078C (da) * | 1981-02-06 | 1989-05-22 | Ucb Sa | Analogifremgangsmaade til fremstilling af 2-(2-(4-(diphenyl-methyl)-1-piperazinyl)ethoxy)-acetamider eller syreadditionssalte heraf |
| JPS57134381U (enrdf_load_stackoverflow) * | 1981-02-17 | 1982-08-21 |
-
0
- BE BE794804D patent/BE794804A/xx unknown
-
1972
- 1972-02-01 CH CH142072A patent/CH571004A5/xx not_active IP Right Cessation
-
1973
- 1973-01-26 AT AT69973*#A patent/AT331250B/de not_active IP Right Cessation
- 1973-01-29 NO NO353/73A patent/NO138090C/no unknown
- 1973-01-30 HU HUCA342A patent/HU168740B/hu unknown
- 1973-01-31 DE DE2304708A patent/DE2304708A1/de active Pending
- 1973-01-31 IL IL41440A patent/IL41440A/en unknown
- 1973-01-31 CA CA162,943A patent/CA994772A/en not_active Expired
- 1973-01-31 ES ES411147A patent/ES411147A1/es not_active Expired
- 1973-02-01 ZA ZA730730A patent/ZA73730B/xx unknown
- 1973-02-01 JP JP1333973A patent/JPS5343511B2/ja not_active Expired
- 1973-02-01 FR FR7303599A patent/FR2173982B1/fr not_active Expired
- 1973-02-01 GB GB507673A patent/GB1424611A/en not_active Expired
- 1973-02-01 NL NL7301488A patent/NL7301488A/xx not_active Application Discontinuation
-
1974
- 1974-07-31 ZA ZA00744892A patent/ZA744892B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL41440A0 (en) | 1973-03-30 |
| NO138090B (no) | 1978-03-20 |
| NL7301488A (enrdf_load_stackoverflow) | 1973-08-03 |
| AT331250B (de) | 1976-08-10 |
| CH571004A5 (enrdf_load_stackoverflow) | 1975-12-31 |
| BE794804A (fr) | 1973-05-16 |
| NO138090C (no) | 1978-06-28 |
| HU168740B (enrdf_load_stackoverflow) | 1976-07-28 |
| FR2173982A1 (enrdf_load_stackoverflow) | 1973-10-12 |
| ZA744892B (en) | 1975-08-27 |
| JPS4881879A (enrdf_load_stackoverflow) | 1973-11-01 |
| DE2304708A1 (de) | 1973-08-23 |
| CA994772A (en) | 1976-08-10 |
| ATA69973A (de) | 1975-11-15 |
| GB1424611A (en) | 1976-02-11 |
| JPS5343511B2 (enrdf_load_stackoverflow) | 1978-11-20 |
| FR2173982B1 (enrdf_load_stackoverflow) | 1978-03-24 |
| ES411147A1 (es) | 1975-12-01 |
| ZA73730B (en) | 1974-04-24 |
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