IL40151A - Aminoglycoside antibiotics and a method for their preparation from the micromonosphere - Google Patents
Aminoglycoside antibiotics and a method for their preparation from the micromonosphereInfo
- Publication number
- IL40151A IL40151A IL40151A IL4015172A IL40151A IL 40151 A IL40151 A IL 40151A IL 40151 A IL40151 A IL 40151A IL 4015172 A IL4015172 A IL 4015172A IL 40151 A IL40151 A IL 40151A
- Authority
- IL
- Israel
- Prior art keywords
- antibiotic
- acid addition
- verdamicin
- process according
- pharmaceutically acceptable
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims 4
- 241000187708 Micromonospora Species 0.000 title claims 2
- 239000002647 aminoglycoside antibiotic agent Substances 0.000 title 1
- 238000000034 method Methods 0.000 claims 29
- LKKVGKXCMYHKSL-LLZRLKDCSA-N gentamycin A Chemical compound O[C@H]1[C@H](NC)[C@@H](O)CO[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)[C@@H](N)C[C@H]1N LKKVGKXCMYHKSL-LLZRLKDCSA-N 0.000 claims 22
- 239000002253 acid Substances 0.000 claims 21
- 150000003839 salts Chemical class 0.000 claims 21
- XUSXOPRDIDWMFO-CTMSJIKGSA-N (2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[[(2s,3r)-3-amino-6-[(1s)-1-aminoethyl]-3,4-dihydro-2h-pyran-2-yl]oxy]-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC=C(O2)[C@H](C)N)N)[C@@H](N)C[C@H]1N XUSXOPRDIDWMFO-CTMSJIKGSA-N 0.000 claims 19
- XUSXOPRDIDWMFO-UHFFFAOYSA-N Verdamicin Natural products O1CC(O)(C)C(NC)C(O)C1OC1C(O)C(OC2C(CC=C(O2)C(C)N)N)C(N)CC1N XUSXOPRDIDWMFO-UHFFFAOYSA-N 0.000 claims 19
- BRZYSWJRSDMWLG-DJWUNRQOSA-N (2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[(2s,3r,4r,5s,6r)-3-amino-4,5-dihydroxy-6-[(1r)-1-hydroxyethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H]([C@@H](C)O)O2)N)[C@@H](N)C[C@H]1N BRZYSWJRSDMWLG-DJWUNRQOSA-N 0.000 claims 18
- URWAJWIAIPFPJE-UHFFFAOYSA-N Rickamicin Natural products O1CC(O)(C)C(NC)C(O)C1OC1C(O)C(OC2C(CC=C(CN)O2)N)C(N)CC1N URWAJWIAIPFPJE-UHFFFAOYSA-N 0.000 claims 11
- 229930192786 Sisomicin Natural products 0.000 claims 11
- 239000000203 mixture Substances 0.000 claims 11
- 229960005456 sisomicin Drugs 0.000 claims 11
- URWAJWIAIPFPJE-YFMIWBNJSA-N sisomycin Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC=C(CN)O2)N)[C@@H](N)C[C@H]1N URWAJWIAIPFPJE-YFMIWBNJSA-N 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 7
- 239000013543 active substance Substances 0.000 claims 6
- 239000003242 anti bacterial agent Substances 0.000 claims 5
- 229940088710 antibiotic agent Drugs 0.000 claims 5
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 4
- 239000004480 active ingredient Substances 0.000 claims 4
- 230000003115 biocidal effect Effects 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 3
- 238000000855 fermentation Methods 0.000 claims 3
- 230000004151 fermentation Effects 0.000 claims 3
- 244000005700 microbiome Species 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 2
- XLYOFNOQVPJJNP-ZSJDYOACSA-N Heavy water Chemical compound [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 claims 2
- 101100505672 Podospora anserina grisea gene Proteins 0.000 claims 2
- 241000786363 Rhampholeon spectrum Species 0.000 claims 2
- 238000002329 infrared spectrum Methods 0.000 claims 2
- 239000002480 mineral oil Substances 0.000 claims 2
- 235000010446 mineral oil Nutrition 0.000 claims 2
- 235000015097 nutrients Nutrition 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- OKKJLVBELUTLKV-MICDWDOJSA-N deuteriomethanol Chemical compound [2H]CO OKKJLVBELUTLKV-MICDWDOJSA-N 0.000 claims 1
- 229960001760 dimethyl sulfoxide Drugs 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 229910021653 sulphate ion Inorganic materials 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
- C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19670771A | 1971-11-08 | 1971-11-08 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL40151A0 IL40151A0 (en) | 1972-10-29 |
| IL40151A true IL40151A (en) | 1976-01-30 |
Family
ID=22726520
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL40151A IL40151A (en) | 1971-11-08 | 1972-08-17 | Aminoglycoside antibiotics and a method for their preparation from the micromonosphere |
Country Status (20)
| Country | Link |
|---|---|
| JP (1) | JPS4852991A (cs) |
| AR (1) | AR193286A1 (cs) |
| AT (1) | AT319469B (cs) |
| BE (1) | BE787758A (cs) |
| CA (1) | CA972303A (cs) |
| CH (1) | CH586281A5 (cs) |
| CS (1) | CS163282B2 (cs) |
| DD (1) | DD102161A5 (cs) |
| DE (1) | DE2239964A1 (cs) |
| DK (1) | DK130847B (cs) |
| FR (1) | FR2159246A1 (cs) |
| IL (1) | IL40151A (cs) |
| LU (1) | LU65922A1 (cs) |
| NL (1) | NL7211265A (cs) |
| NO (1) | NO136050C (cs) |
| OA (1) | OA04260A (cs) |
| PH (1) | PH13016A (cs) |
| PL (1) | PL84893B1 (cs) |
| RO (1) | RO58761A (cs) |
| SE (1) | SE384691B (cs) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7313668A (cs) * | 1972-10-10 | 1974-04-16 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7012428A (cs) * | 1969-08-25 | 1971-03-01 | ||
| DE2130113C3 (de) * | 1970-06-22 | 1980-07-03 | Scherico Ltd., Luzern (Schweiz) | Gentamicin B, Gentamicin B1 und Gentamicin X, Verfahren zu deren Gewinnung und diese Gentamicine enthaltende pharmazeutische Zubereitungen |
-
0
- BE BE787758D patent/BE787758A/xx unknown
-
1972
- 1972-08-14 DE DE2239964A patent/DE2239964A1/de active Pending
- 1972-08-16 CH CH1211472A patent/CH586281A5/xx not_active IP Right Cessation
- 1972-08-17 PL PL1972157318A patent/PL84893B1/pl unknown
- 1972-08-17 SE SE7210703A patent/SE384691B/xx unknown
- 1972-08-17 IL IL40151A patent/IL40151A/en unknown
- 1972-08-17 RO RO71981A patent/RO58761A/ro unknown
- 1972-08-17 DD DD165307A patent/DD102161A5/xx unknown
- 1972-08-17 NO NO2955/72A patent/NO136050C/no unknown
- 1972-08-17 PH PH13813A patent/PH13016A/en unknown
- 1972-08-17 CA CA149,843A patent/CA972303A/en not_active Expired
- 1972-08-17 CS CS5710A patent/CS163282B2/cs unknown
- 1972-08-17 NL NL7211265A patent/NL7211265A/xx not_active Application Discontinuation
- 1972-08-17 DK DK407772AA patent/DK130847B/da unknown
- 1972-08-17 AT AT712272A patent/AT319469B/de not_active IP Right Cessation
- 1972-08-17 FR FR7229471A patent/FR2159246A1/fr active Granted
- 1972-08-18 OA OA54666A patent/OA04260A/xx unknown
- 1972-08-18 AR AR243622A patent/AR193286A1/es active
- 1972-08-18 LU LU65922A patent/LU65922A1/xx unknown
- 1972-08-18 JP JP47082680A patent/JPS4852991A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AR193286A1 (es) | 1973-04-11 |
| CA972303A (en) | 1975-08-05 |
| FR2159246B1 (cs) | 1976-03-05 |
| NO136050C (no) | 1977-07-13 |
| IL40151A0 (en) | 1972-10-29 |
| FR2159246A1 (en) | 1973-06-22 |
| NL7211265A (cs) | 1973-05-10 |
| LU65922A1 (cs) | 1973-01-15 |
| AT319469B (de) | 1974-12-27 |
| PL84893B1 (cs) | 1976-04-30 |
| DD102161A5 (cs) | 1973-12-05 |
| RO58761A (cs) | 1975-12-15 |
| DK130847B (da) | 1975-04-21 |
| DK130847C (cs) | 1975-09-29 |
| NO136050B (cs) | 1977-04-04 |
| JPS4852991A (cs) | 1973-07-25 |
| CH586281A5 (cs) | 1977-03-31 |
| PH13016A (en) | 1979-11-09 |
| OA04260A (fr) | 1979-12-31 |
| DE2239964A1 (de) | 1973-06-14 |
| BE787758A (fr) | 1973-02-19 |
| SE384691B (sv) | 1976-05-17 |
| CS163282B2 (cs) | 1975-08-29 |
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