IL38098A - Preparation of n-((1-ethyl-pyrrolidinyl-2)methyl)-2-methoxy-5-sulphamoylbenzamide - Google Patents
Preparation of n-((1-ethyl-pyrrolidinyl-2)methyl)-2-methoxy-5-sulphamoylbenzamideInfo
- Publication number
- IL38098A IL38098A IL38098A IL3809871A IL38098A IL 38098 A IL38098 A IL 38098A IL 38098 A IL38098 A IL 38098A IL 3809871 A IL3809871 A IL 3809871A IL 38098 A IL38098 A IL 38098A
- Authority
- IL
- Israel
- Prior art keywords
- methoxy
- ethyl
- pyrrolidinyl
- methyl
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
Description
Preparation of In a one litre flask with a a a thermometer and a dropping 27 g of and 560 ml of pyridine are The solution obtained is stirred and 6 g 04 of phosphorous loride dissolved in 64 ml pyridine are added drop whilst o taining the temperature at about 20 After stirring at for an g of acid are The mixture is heated four and a half hours and allowed to rest The pyridine is then removed by distillation under vacuum and the residue extracted with 200 ml of 10 hydrochloric There O O is obtained a precipitate which is heated to about 70 80 C and This solution is treated with 15 ml of concentrated ammonia The precipitate formed is washed with and o dried a drying chamber at 50 g with a melting point o of 178 C are is useful in the industry as an intermediary in particular for the manufacture of ceutical products for the treatment of sickness in the fields of enterology and insufficientOCRQuality
Claims (4)
1. Process for preparing -ethyl-pyrrolidinyl-2)methylJ" - 2 -methoxy- 5- sulphamoyl-benzamide comprising reacting l-ethyl-2-aminomethyl-pyrrolidine and 2-methoxy- 5- sulphamoyl-benzoic acid in the presence of phosphorous trichloride.
2. Process according to claim 1, in which pyridine is used as paction medium.
3. Process for preparing N- J(l -ethyl-pyrrolidinyl-2)-methyl j -2-methoxy-5-sulpharnoyl-benzamide substantially as hereinbefore descri
4. N- (1 - ethyl-pyrrolidinyl-2)-methyl -2-methoxy- 5- sulphamo enzamide whenever obtained by the process according to any preceding laim.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1226771A CH547797A (en) | 1971-08-20 | 1971-08-20 | PROCESS FOR THE PREPARATION OF N - ((1-AETHYL-PYRROLIDINYL2) -METHYL) -2-METHOXY-5-SULFAMOYL-BENZAMIDE. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL38098A0 IL38098A0 (en) | 1972-01-27 |
| IL38098A true IL38098A (en) | 1974-12-31 |
Family
ID=4381427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL38098A IL38098A (en) | 1971-08-20 | 1971-11-08 | Preparation of n-((1-ethyl-pyrrolidinyl-2)methyl)-2-methoxy-5-sulphamoylbenzamide |
Country Status (26)
| Country | Link |
|---|---|
| JP (1) | JPS4829764A (en) |
| KR (1) | KR780000067B1 (en) |
| AT (1) | AT311328B (en) |
| BE (1) | BE774104A (en) |
| CA (1) | CA928714A (en) |
| CH (1) | CH547797A (en) |
| CS (1) | CS177818B2 (en) |
| DE (1) | DE2152370A1 (en) |
| DK (1) | DK126325B (en) |
| ES (1) | ES396718A1 (en) |
| FR (1) | FR2111372A5 (en) |
| GB (1) | GB1328747A (en) |
| HU (1) | HU166567B (en) |
| IE (1) | IE35821B1 (en) |
| IL (1) | IL38098A (en) |
| LU (1) | LU64275A1 (en) |
| MC (1) | MC897A1 (en) |
| NL (1) | NL7114902A (en) |
| NO (1) | NO136460C (en) |
| OA (1) | OA03928A (en) |
| PL (1) | PL84446B1 (en) |
| RO (1) | RO62479A (en) |
| SE (1) | SE376914B (en) |
| YU (1) | YU34286B (en) |
| ZA (1) | ZA717543B (en) |
| ZM (1) | ZM17771A1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2252336B1 (en) * | 1973-11-27 | 1977-03-04 | Ile De France | |
| JPS5170235A (en) * | 1974-12-16 | 1976-06-17 | Toyo Aluminium Kk | |
| NZ186175A (en) * | 1977-01-27 | 1980-03-05 | Shionogi & Co | Meta-sulphonamidobenzamide derivatives |
| WO1991017144A1 (en) * | 1990-05-02 | 1991-11-14 | Yoshitomi Pharmaceutical Industries, Ltd. | Amide compound, pharmaceutical use thereof and novel 1-substituted pyrrolidinemethyl-amines |
-
1971
- 1971-08-20 CH CH1226771A patent/CH547797A/en not_active IP Right Cessation
- 1971-10-14 FR FR7136941A patent/FR2111372A5/fr not_active Expired
- 1971-10-18 BE BE774104A patent/BE774104A/en not_active IP Right Cessation
- 1971-10-21 DE DE19712152370 patent/DE2152370A1/en active Pending
- 1971-10-28 NL NL7114902A patent/NL7114902A/xx unknown
- 1971-11-05 ES ES396718A patent/ES396718A1/en not_active Expired
- 1971-11-08 IL IL38098A patent/IL38098A/en unknown
- 1971-11-08 CA CA127136A patent/CA928714A/en not_active Expired
- 1971-11-09 YU YU2821/71A patent/YU34286B/en unknown
- 1971-11-09 SE SE7114275A patent/SE376914B/xx unknown
- 1971-11-09 MC MC956A patent/MC897A1/en unknown
- 1971-11-09 ZA ZA717543A patent/ZA717543B/en unknown
- 1971-11-16 LU LU64275D patent/LU64275A1/xx unknown
- 1971-11-18 IE IE1459/71A patent/IE35821B1/en unknown
- 1971-11-29 DK DK584371AA patent/DK126325B/en not_active IP Right Cessation
- 1971-12-01 HU HUFA900A patent/HU166567B/hu unknown
- 1971-12-01 ZM ZM177/71*7A patent/ZM17771A1/xx unknown
- 1971-12-06 GB GB5649571A patent/GB1328747A/en not_active Expired
- 1971-12-06 KR KR7101750A patent/KR780000067B1/en active
- 1971-12-07 OA OA54434A patent/OA03928A/en unknown
- 1971-12-08 PL PL1971152013A patent/PL84446B1/pl unknown
- 1971-12-10 AT AT1064371A patent/AT311328B/en not_active IP Right Cessation
- 1971-12-29 JP JP47004153A patent/JPS4829764A/ja active Pending
- 1971-12-29 CS CS9068A patent/CS177818B2/cs unknown
- 1971-12-30 NO NO4949/71A patent/NO136460C/en unknown
-
1972
- 1972-01-15 RO RO7200069412A patent/RO62479A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL84446B1 (en) | 1976-04-30 |
| OA03928A (en) | 1975-08-14 |
| JPS4829764A (en) | 1973-04-19 |
| LU64275A1 (en) | 1972-06-02 |
| GB1328747A (en) | 1973-08-30 |
| YU34286B (en) | 1979-04-30 |
| NO136460B (en) | 1977-05-31 |
| FR2111372A5 (en) | 1972-06-02 |
| YU282171A (en) | 1978-10-31 |
| RO62479A (en) | 1978-02-15 |
| CS177818B2 (en) | 1977-08-31 |
| IE35821B1 (en) | 1976-05-26 |
| SE376914B (en) | 1975-06-16 |
| NL7114902A (en) | 1973-02-22 |
| ES396718A1 (en) | 1974-05-16 |
| MC897A1 (en) | 1972-06-22 |
| CA928714A (en) | 1973-06-19 |
| IE35821L (en) | 1973-02-20 |
| CH547797A (en) | 1974-04-11 |
| DE2152370A1 (en) | 1973-02-22 |
| ZA717543B (en) | 1972-08-30 |
| AT311328B (en) | 1973-11-12 |
| IL38098A0 (en) | 1972-01-27 |
| HU166567B (en) | 1975-04-28 |
| BE774104A (en) | 1972-04-18 |
| DK126325B (en) | 1973-07-02 |
| ZM17771A1 (en) | 1972-08-21 |
| KR780000067B1 (en) | 1978-03-30 |
| AU3572171A (en) | 1973-05-24 |
| NO136460C (en) | 1977-09-07 |
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