GB807638A - Substantially anhydrous ferrous fumarate and a method of preparing same - Google Patents
Substantially anhydrous ferrous fumarate and a method of preparing sameInfo
- Publication number
- GB807638A GB807638A GB8501/57A GB850157A GB807638A GB 807638 A GB807638 A GB 807638A GB 8501/57 A GB8501/57 A GB 8501/57A GB 850157 A GB850157 A GB 850157A GB 807638 A GB807638 A GB 807638A
- Authority
- GB
- United Kingdom
- Prior art keywords
- fumarate
- ferrous
- solution
- water
- anhydrous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- PMVSDNDAUGGCCE-TYYBGVCCSA-L Ferrous fumarate Chemical compound [Fe+2].[O-]C(=O)\C=C\C([O-])=O PMVSDNDAUGGCCE-TYYBGVCCSA-L 0.000 title abstract 10
- 239000011773 ferrous fumarate Substances 0.000 title abstract 10
- 229960000225 ferrous fumarate Drugs 0.000 title abstract 10
- 235000002332 ferrous fumarate Nutrition 0.000 title abstract 10
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 abstract 8
- 239000000243 solution Substances 0.000 abstract 8
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 abstract 4
- 239000001744 Sodium fumarate Substances 0.000 abstract 4
- MSJMDZAOKORVFC-SEPHDYHBSA-L disodium fumarate Chemical compound [Na+].[Na+].[O-]C(=O)\C=C\C([O-])=O MSJMDZAOKORVFC-SEPHDYHBSA-L 0.000 abstract 4
- 239000001530 fumaric acid Substances 0.000 abstract 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 4
- 229940005573 sodium fumarate Drugs 0.000 abstract 4
- 235000019294 sodium fumarate Nutrition 0.000 abstract 4
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 4
- 239000001828 Gelatine Substances 0.000 abstract 3
- 229920002472 Starch Polymers 0.000 abstract 3
- 239000011790 ferrous sulphate Substances 0.000 abstract 3
- 235000003891 ferrous sulphate Nutrition 0.000 abstract 3
- 229920000159 gelatin Polymers 0.000 abstract 3
- 235000019322 gelatine Nutrition 0.000 abstract 3
- 239000008107 starch Substances 0.000 abstract 3
- 235000019698 starch Nutrition 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 2
- 239000012736 aqueous medium Substances 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 239000011230 binding agent Substances 0.000 abstract 2
- 239000003937 drug carrier Substances 0.000 abstract 2
- 230000003179 granulation Effects 0.000 abstract 2
- 238000005469 granulation Methods 0.000 abstract 2
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 abstract 2
- 235000019359 magnesium stearate Nutrition 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000002002 slurry Substances 0.000 abstract 2
- 229910000029 sodium carbonate Inorganic materials 0.000 abstract 2
- 241000220479 Acacia Species 0.000 abstract 1
- 235000010643 Leucaena leucocephala Nutrition 0.000 abstract 1
- 235000021355 Stearic acid Nutrition 0.000 abstract 1
- FEERGWZZUUPUAN-SEPHDYHBSA-M [NH4+].[K+].[O-]C(=O)\C=C\C([O-])=O Chemical compound [NH4+].[K+].[O-]C(=O)\C=C\C([O-])=O FEERGWZZUUPUAN-SEPHDYHBSA-M 0.000 abstract 1
- MCDLETWIOVSGJT-UHFFFAOYSA-N acetic acid;iron Chemical compound [Fe].CC(O)=O.CC(O)=O MCDLETWIOVSGJT-UHFFFAOYSA-N 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 229960002089 ferrous chloride Drugs 0.000 abstract 1
- 239000000945 filler Substances 0.000 abstract 1
- 230000002984 haematinic effect Effects 0.000 abstract 1
- 229910052742 iron Inorganic materials 0.000 abstract 1
- NMCUIPGRVMDVDB-UHFFFAOYSA-L iron dichloride Chemical compound Cl[Fe]Cl NMCUIPGRVMDVDB-UHFFFAOYSA-L 0.000 abstract 1
- 239000000314 lubricant Substances 0.000 abstract 1
- 238000012423 maintenance Methods 0.000 abstract 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 abstract 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000008117 stearic acid Substances 0.000 abstract 1
- 239000000454 talc Substances 0.000 abstract 1
- 229910052623 talc Inorganic materials 0.000 abstract 1
- 235000012222 talc Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
- C07F15/025—Iron compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/30—Oligoelements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/295—Iron group metal compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Polymers & Plastics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Inorganic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Food Science & Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention comprises substantially anhydrous ferrous fumarate having the empirical formula FeC4H2O4. It may be obtained by mixing a water-soluble ferrous salt and a watersoluble salt of fumaric acid in an aqueous medium at a temperature above 70 DEG C. to precipitate the anhydrous ferrous fumarate which is then separated from the aqueous medium. It is preferred to use ferrous sulphate as the water-soluble ferrous salt but ferrous chloride and ferrous acetate are also suitable. The preferred water-soluble salt of fumaric acid is sodium fumarate but ammonium- and potassium-fumarate may also be used. The anhydrous ferrous fumarate product is substantially stable on exposure to moist air and has the empirical formula FeC4H2O4. In examples: (1) a solution of sodium fumarate is prepared by slowly adding fumaric acid to a solution of sodium carbonate in water, the pH being about 7, and a moderately hot clear solution of ferrous sulphate having a pH of 2.4 is added with mixing to the sodium fumarate solution which is maintained at 94-100 DEG C. during the addition, the resulting slurry is stirred for 30 minutes and is then filtered and the residue is washed with water in a centrifuge and then dried in trays for 17 hours at 115 DEG C. to yield anhydrous ferrous fumarate; (2) fumaric acid is added to an aqueous solution of sodium carbonate which is stirred and heated during the addition and the resulting solution of sodium fumarate (pH 6.8) is added to an aqueous solution of ferrous sulphate (pH 3.3) while maintaining both solutions at or near boiling temperature; the resulting slurry is then filtered and processed as in (1) except that the tray drying is for 15 hours at 110 DEG C. Examples are also given to illustrate the stability of the product on exposure to moist air. The product is stated to be valuable as a source of iron for medicinal purposes (see Group VI) or for agricultural purposes e.g. in the growing and maintenance of turf.ALSO:A haematinic composition in dosage form comprises substantially anhydrous ferrous fumarate (see Group IV (b)) and a pharmaceutical carrier. The composition may be in the form of tablets of the anhydrous ferrous fumarate and a pharmaceutical carrier such as a filler, binder, or lubricant, or in the form of hard gelatine capsules filled with the anhydrous ferrous fumarate. Specified solid carriers are starch, gelatine, talc, stearic acid, and magnesium stearate and specified binders are liquid glucose, starch paste, acacia solution, and gelatine solution. In examples: (1) a tablet granulation is prepared by moistening anhydrous ferrous fumarate with a mixture of equal parts of liquid glucose and water, magnesium stearate is mixed with the dried granulation and the mixture made into tablets each containing about 200 mg. of the anhydrous ferrous fumarate; and (2) as in (1) except that starch is also added.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US585633A US2848366A (en) | 1956-05-18 | 1956-05-18 | Non-hydrated ferrous fumarate and hematinic composition thereof |
| CH6212658A CH371558A (en) | 1956-05-18 | 1958-07-23 | Process for the production of organic ferrous salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB807638A true GB807638A (en) | 1959-01-21 |
Family
ID=25737741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB8501/57A Expired GB807638A (en) | 1956-05-18 | 1957-03-14 | Substantially anhydrous ferrous fumarate and a method of preparing same |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US2848366A (en) |
| BE (1) | BE569591A (en) |
| CA (1) | CA572556A (en) |
| CH (1) | CH371558A (en) |
| DE (1) | DE1087126B (en) |
| FR (1) | FR1175193A (en) |
| GB (1) | GB807638A (en) |
| IT (1) | IT573230A (en) |
| NL (1) | NL101664C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3125491A (en) * | 1962-04-06 | 1964-03-17 | Chew able hematinic vitamin tablet | |
| FR2068526A1 (en) * | 1969-08-28 | 1971-08-27 | Laso Martinez Victori O |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2985559A (en) * | 1958-01-27 | 1961-05-23 | Glaxo Lab Ltd | Stabilized therapeutic ferrous fumarate aqueous suspensions |
| US3259500A (en) * | 1961-10-11 | 1966-07-05 | Kentucky Res Foundation | Method for inhibiting anemia in young pigs by feeding the sow an iron agent |
| US3317386A (en) * | 1964-05-04 | 1967-05-02 | Burroughs Wellcome Co | Method of treating aplastic anaemia using a preparation containing the mitogenic component of phytohaemagglutinin |
| US3332778A (en) * | 1964-07-28 | 1967-07-25 | Nebraska Cons Mills Company | Supplying at least about 4% iron and a sweetening agent for the prevention of iron-deficiency anemia in baby pigs |
| SE340807B (en) * | 1966-05-06 | 1971-12-06 | Astra Ab | |
| CA885974A (en) * | 1968-04-02 | 1971-11-16 | R. Telfer William | Ferrous fumarate capsule and preparation |
| DE2814573A1 (en) * | 1978-04-05 | 1979-10-18 | Ruhr Stickstoff Ag | MINERAL ADDITIVES FOR ANIMAL FOOD |
| NO168152L (en) * | 1990-05-23 | 1991-10-14 | Norsk Hydro As | Fish feed |
| US7495117B2 (en) * | 2006-08-04 | 2009-02-24 | Kemin Industries, Inc. | Metal carboxylate salts |
| CN102370055B (en) * | 2010-08-24 | 2013-06-05 | 北京英惠尔生物技术有限公司 | Preparation method of feeding ferrous fumarate |
| CN105753686A (en) * | 2016-01-26 | 2016-07-13 | 苏州优合科技有限公司 | Process for preparing ferrous fumarate |
| CN111138271A (en) * | 2020-01-20 | 2020-05-12 | 太原理工大学 | Preparation method of organic metal salt additive |
| CN113264822B (en) * | 2021-05-15 | 2024-04-05 | 吉源(淮北)食品科技有限公司 | Preparation method of disodium fumarate |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2135031A (en) * | 1934-10-09 | 1938-11-01 | Brown Herman Elisha | Process for the manufacture of a therapeutic organic compound |
| DE682875C (en) * | 1935-02-07 | 1939-10-24 | Chem Fab Promonta G M B H | Process for the production of stable organic ferrous compounds |
| US2822317A (en) * | 1955-12-12 | 1958-02-04 | Smith Kline French Lab | Aqueous iron-ascorbic acid preparation |
-
0
- CA CA572556A patent/CA572556A/en not_active Expired
- NL NL101664D patent/NL101664C/xx active
- BE BE569591D patent/BE569591A/xx unknown
- IT IT573230D patent/IT573230A/it unknown
-
1956
- 1956-05-18 US US585633A patent/US2848366A/en not_active Expired - Lifetime
-
1957
- 1957-03-14 GB GB8501/57A patent/GB807638A/en not_active Expired
- 1957-05-15 FR FR1175193D patent/FR1175193A/en not_active Expired
- 1957-05-17 DE DEM34212A patent/DE1087126B/en active Pending
-
1958
- 1958-07-23 CH CH6212658A patent/CH371558A/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3125491A (en) * | 1962-04-06 | 1964-03-17 | Chew able hematinic vitamin tablet | |
| FR2068526A1 (en) * | 1969-08-28 | 1971-08-27 | Laso Martinez Victori O |
Also Published As
| Publication number | Publication date |
|---|---|
| FR1175193A (en) | 1959-03-20 |
| CH371558A (en) | 1963-08-31 |
| BE569591A (en) | |
| US2848366A (en) | 1958-08-19 |
| IT573230A (en) | |
| DE1087126B (en) | 1960-08-18 |
| CA572556A (en) | 1959-03-17 |
| NL101664C (en) |
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