IL35862A - Substituted n-(substituted aminoalkyl)-benzamidines and their preparation - Google Patents
Substituted n-(substituted aminoalkyl)-benzamidines and their preparationInfo
- Publication number
- IL35862A IL35862A IL35862A IL3586267A IL35862A IL 35862 A IL35862 A IL 35862A IL 35862 A IL35862 A IL 35862A IL 3586267 A IL3586267 A IL 3586267A IL 35862 A IL35862 A IL 35862A
- Authority
- IL
- Israel
- Prior art keywords
- formula
- substituted
- compound
- preparation
- general
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims description 3
- 125000004103 aminoalkyl group Chemical group 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 10
- 150000003839 salts Chemical class 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 5
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- 229910052757 nitrogen Inorganic materials 0.000 claims description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 2
- 150000004985 diamines Chemical class 0.000 claims description 2
- 125000005843 halogen group Chemical group 0.000 claims description 2
- 125000005842 heteroatom Chemical group 0.000 claims description 2
- 125000000623 heterocyclic group Chemical group 0.000 claims description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 2
- 229910052760 oxygen Inorganic materials 0.000 claims description 2
- 239000001301 oxygen Substances 0.000 claims description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 239000002253 acid Substances 0.000 description 9
- 239000002904 solvent Substances 0.000 description 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 239000012458 free base Substances 0.000 description 3
- UDGSVBYJWHOHNN-UHFFFAOYSA-N n',n'-diethylethane-1,2-diamine Chemical compound CCN(CC)CCN UDGSVBYJWHOHNN-UHFFFAOYSA-N 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- -1 N-(2-diethylaminoethyl)-2-methoxy-4-nitro-5-chloro-benzamidine dihydrochloride Chemical compound 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- WTEOIRVLGSZEPR-UHFFFAOYSA-N boron trifluoride Chemical compound FB(F)F WTEOIRVLGSZEPR-UHFFFAOYSA-N 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 description 1
- CJNRGSHEMCMUOE-UHFFFAOYSA-N 2-piperidin-1-ylethanamine Chemical compound NCCN1CCCCC1 CJNRGSHEMCMUOE-UHFFFAOYSA-N 0.000 description 1
- 229910015900 BF3 Inorganic materials 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 239000012670 alkaline solution Substances 0.000 description 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000003474 anti-emetic effect Effects 0.000 description 1
- 230000002921 anti-spasmodic effect Effects 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 239000000812 cholinergic antagonist Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- RWIVICVCHVMHMU-UHFFFAOYSA-N n-aminoethylmorpholine Chemical compound NCCN1CCOCC1 RWIVICVCHVMHMU-UHFFFAOYSA-N 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP379166 | 1966-01-22 | ||
| JP378966 | 1966-01-22 | ||
| JP416366 | 1966-01-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL35862A true IL35862A (en) | 1971-05-26 |
Family
ID=27275970
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL35862A IL35862A (en) | 1966-01-22 | 1967-01-20 | Substituted n-(substituted aminoalkyl)-benzamidines and their preparation |
| IL27281A IL27281A (en) | 1966-01-22 | 1967-01-20 | Substituted benzonitriles and their preparation |
| IL35861A IL35861A (en) | 1966-01-22 | 1967-01-20 | Substituted benzimidic alkyl esters and their preparation |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL27281A IL27281A (en) | 1966-01-22 | 1967-01-20 | Substituted benzonitriles and their preparation |
| IL35861A IL35861A (en) | 1966-01-22 | 1967-01-20 | Substituted benzimidic alkyl esters and their preparation |
Country Status (13)
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4210754A (en) | 1977-02-01 | 1980-07-01 | Hoffmann-La Roche Inc. | Morpholino containing benzamides |
| US4808624A (en) * | 1984-06-28 | 1989-02-28 | Bristol-Myers Company | Pharmacologically active substituted benzamides |
-
1967
- 1967-01-16 ES ES336000A patent/ES336000A1/es not_active Expired
- 1967-01-16 BE BE692670D patent/BE692670A/xx not_active IP Right Cessation
- 1967-01-18 GR GR670132450A patent/GR32450B/el unknown
- 1967-01-18 FR FR91681A patent/FR1510299A/fr not_active Expired
- 1967-01-19 GB GB2933/67A patent/GB1170321A/en not_active Expired
- 1967-01-20 AT AT00026/69A patent/AT277969B/de not_active IP Right Cessation
- 1967-01-20 IL IL35862A patent/IL35862A/en unknown
- 1967-01-20 DK DK35167*#A patent/DK132794C/da active
- 1967-01-20 SE SE00881/67A patent/SE349024B/xx unknown
- 1967-01-20 AT AT00027/69A patent/AT277970B/de not_active IP Right Cessation
- 1967-01-20 FI FI670172A patent/FI51172C/fi active
- 1967-01-20 AT AT00613/67A patent/AT277214B/de not_active IP Right Cessation
- 1967-01-20 IL IL27281A patent/IL27281A/en unknown
- 1967-01-20 IL IL35861A patent/IL35861A/en unknown
- 1967-01-20 YU YU0096/67A patent/YU32358B/xx unknown
- 1967-01-21 BG BG007434A patent/BG15554A3/bg unknown
- 1967-01-23 CH CH93467A patent/CH478095A/fr not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| GR32450B (el) | 1967-07-05 |
| SE349024B (enrdf_load_stackoverflow) | 1972-09-18 |
| DK132794B (da) | 1976-02-09 |
| YU9667A (en) | 1974-04-30 |
| GB1170321A (en) | 1969-11-12 |
| IL35861A (en) | 1971-05-26 |
| YU32358B (en) | 1974-08-31 |
| AT277969B (de) | 1970-01-12 |
| AT277214B (de) | 1969-12-10 |
| DK132794C (da) | 1976-07-12 |
| ES336000A1 (es) | 1968-04-01 |
| BG15554A3 (bg) | 1972-05-20 |
| FI51172B (enrdf_load_stackoverflow) | 1976-08-02 |
| FR1510299A (fr) | 1968-01-19 |
| IL27281A (en) | 1971-05-26 |
| AT277970B (de) | 1970-01-12 |
| BE692670A (enrdf_load_stackoverflow) | 1967-07-17 |
| CH478095A (fr) | 1969-09-15 |
| FI51172C (fi) | 1976-11-10 |
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