IL326451A - הגנה תרמית ללא חומצה של אוליגונוקלאוטידים מוגני טריטיל - Google Patents
הגנה תרמית ללא חומצה של אוליגונוקלאוטידים מוגני טריטילInfo
- Publication number
- IL326451A IL326451A IL326451A IL32645126A IL326451A IL 326451 A IL326451 A IL 326451A IL 326451 A IL326451 A IL 326451A IL 32645126 A IL32645126 A IL 32645126A IL 326451 A IL326451 A IL 326451A
- Authority
- IL
- Israel
- Prior art keywords
- acid
- free thermal
- trityl protected
- protected oligonucleotides
- thermal deprotection
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202363534076P | 2023-08-22 | 2023-08-22 | |
| PCT/US2024/043206 WO2025042973A1 (en) | 2023-08-22 | 2024-08-21 | Acid-free thermal deprotection of trityl protected oligonucleotides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL326451A true IL326451A (he) | 2026-04-01 |
Family
ID=94732769
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL326451A IL326451A (he) | 2023-08-22 | 2024-08-21 | הגנה תרמית ללא חומצה של אוליגונוקלאוטידים מוגני טריטיל |
Country Status (4)
| Country | Link |
|---|---|
| KR (1) | KR20260056257A (he) |
| CN (1) | CN121729274A (he) |
| IL (1) | IL326451A (he) |
| WO (1) | WO2025042973A1 (he) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6399765B1 (en) * | 1999-03-17 | 2002-06-04 | Isis Pharmaceuticals, Inc. | Methods for removing dimethoxytrityl groups from oligonucleotides |
| CA3096682A1 (en) * | 2018-04-13 | 2019-10-17 | Bristol-Myers Squibb Company | Novel phosphorous (v)-based reagents, processes for the preparation thereof, and their use in making stereo-defined organophoshorous (v) compounds |
| AU2020309307B2 (en) * | 2019-07-09 | 2023-03-30 | F. Hoffmann-La Roche Ag | Process for the deprotection of oligonucleotides |
| EP4294818A1 (en) * | 2021-02-17 | 2023-12-27 | F. Hoffmann-La Roche AG | Process for the de-tritylation of oligonucleotides |
-
2024
- 2024-08-21 IL IL326451A patent/IL326451A/he unknown
- 2024-08-21 WO PCT/US2024/043206 patent/WO2025042973A1/en active Pending
- 2024-08-21 CN CN202480054488.8A patent/CN121729274A/zh active Pending
- 2024-08-21 KR KR1020267008702A patent/KR20260056257A/ko active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2025042973A1 (en) | 2025-02-27 |
| CN121729274A (zh) | 2026-03-24 |
| KR20260056257A (ko) | 2026-04-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017533721A5 (he) | ||
| JP2009524696A5 (he) | ||
| MX363110B (es) | Sintesis de ribonucleosidos deuterados, fosforamiditas n-protegidos, y oligonucleotidos. | |
| BR112013016982A2 (pt) | formas polimórficas de ácido 2-(5-bromo-4-(4-ciclopropilnaftalen-1-il)-4h-1,2,4-triazol-3-iltio)acético e usos destes | |
| CN106795198A (zh) | 用于制备吉西他滨‑[苯基(苄氧基‑l‑丙氨酸基)]磷酸酯的方法 | |
| Höbartner et al. | The synthesis of 2′-O-[(triisopropylsilyl) oxy] methyl (TOM) phosphoramidites of methylated ribonucleosides (m 1 G, m 2 G, m 2 2 G, m 1 I, m 3 U, m 4 C, m 6 A, m 6 2 A) for use in automated RNA solid-phase synthesis | |
| Gimenez Molina et al. | Assembly of short oligoribonucleotides from commercially available building blocks on a tetrapodal soluble support | |
| GB2606158B (en) | Amplification of single stranded DNA | |
| JP5194256B2 (ja) | ２’水酸基修飾リボヌクレオシド誘導体 | |
| JP2012510459A (ja) | Ｔｎｉｋ阻害剤およびその使用 | |
| IL304751A (he) | תהליך לדה-טריטילציה של אוליגונוקליאוטידים | |
| Wu et al. | Synthesis and biological evaluation of DAPY–DPEs hybrids as non-nucleoside inhibitors of HIV-1 reverse transcriptase | |
| IL197415A0 (en) | Azole nucleosides and use as inhibitors of rna and dna varial polymerases | |
| Bouton et al. | Efficient diastereoselective synthesis of a new class of azanucleosides: 2′-homoazanucleosides | |
| US20120108533A1 (en) | Novel phosphate modified nucleosides useful as substrates for polymerases and as antiviral agents | |
| Ohno et al. | Synthesis of photocaged 6-O-(2-nitrobenzyl) guanosine and 4-O-(2-nitrobenzyl) uridine triphosphates for photocontrol of the RNA transcription reaction | |
| IL289440A (he) | תהליך להסרת הגנה של אוליגונוקליאוטידים | |
| Poke et al. | Reversing aberrant methylation patterns in cancer | |
| CN105085595B (zh) | 一种脱酰基保护合成2,6‑位卤代嘌呤核苷的方法 | |
| Seth et al. | Synthesis and biophysical characterization of R-6′-Me-α-L-LNA modified oligonucleotides | |
| JP6950904B2 (ja) | ヌクレオチドの誘導体、及びｒｎａ誘導体若しくはｒｎａの製造方法 | |
| GB202203646D0 (en) | Read-as-x property for page of memory adress space | |
| Simeone et al. | N (3)‐Protection of Thymidine with Boc for an Easy Synthetic Access to Sugar‐Alkylated Nucleoside Analogs | |
| Du et al. | Synthetic approaches to bis-adenosine derivatives as potential bisubstrates of RNA methyltransferases | |
| EP2424874A1 (en) | Novel phosphate modified nucleosides useful as substrates for polymerases and as antiviral angents |