IL326451A - הגנה תרמית ללא חומצה של אוליגונוקלאוטידים מוגני טריטיל - Google Patents
הגנה תרמית ללא חומצה של אוליגונוקלאוטידים מוגני טריטילInfo
- Publication number
- IL326451A IL326451A IL326451A IL32645126A IL326451A IL 326451 A IL326451 A IL 326451A IL 326451 A IL326451 A IL 326451A IL 32645126 A IL32645126 A IL 32645126A IL 326451 A IL326451 A IL 326451A
- Authority
- IL
- Israel
- Prior art keywords
- acid
- free thermal
- trityl protected
- protected oligonucleotides
- thermal deprotection
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202363534076P | 2023-08-22 | 2023-08-22 | |
| PCT/US2024/043206 WO2025042973A1 (en) | 2023-08-22 | 2024-08-21 | Acid-free thermal deprotection of trityl protected oligonucleotides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL326451A true IL326451A (he) | 2026-04-01 |
Family
ID=94732769
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL326451A IL326451A (he) | 2023-08-22 | 2024-08-21 | הגנה תרמית ללא חומצה של אוליגונוקלאוטידים מוגני טריטיל |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN121729274A (he) |
| IL (1) | IL326451A (he) |
| WO (1) | WO2025042973A1 (he) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6399765B1 (en) * | 1999-03-17 | 2002-06-04 | Isis Pharmaceuticals, Inc. | Methods for removing dimethoxytrityl groups from oligonucleotides |
| US11613554B2 (en) * | 2018-04-13 | 2023-03-28 | Bristol-Myers Squibb Company | Phosphorous (V)-based reagents, processes for the preparation thereof, and their use in making stereo-defined organophoshorous (V) compounds |
| AU2020309307B2 (en) * | 2019-07-09 | 2023-03-30 | F. Hoffmann-La Roche Ag | Process for the deprotection of oligonucleotides |
| AU2022224306A1 (en) * | 2021-02-17 | 2023-06-01 | F. Hoffmann-La Roche Ag | Process for the de-tritylation of oligonucleotides |
-
2024
- 2024-08-21 IL IL326451A patent/IL326451A/he unknown
- 2024-08-21 CN CN202480054488.8A patent/CN121729274A/zh active Pending
- 2024-08-21 WO PCT/US2024/043206 patent/WO2025042973A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2025042973A1 (en) | 2025-02-27 |
| CN121729274A (zh) | 2026-03-24 |
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