IL325432A - RNA therapeutic delivery using ring-shaped nucleic acids - Google Patents

RNA therapeutic delivery using ring-shaped nucleic acids

Info

Publication number
IL325432A
IL325432A IL325432A IL32543225A IL325432A IL 325432 A IL325432 A IL 325432A IL 325432 A IL325432 A IL 325432A IL 32543225 A IL32543225 A IL 32543225A IL 325432 A IL325432 A IL 325432A
Authority
IL
Israel
Prior art keywords
delivery
ring
nucleic acids
shaped nucleic
rna therapeutics
Prior art date
Application number
IL325432A
Other languages
English (en)
Hebrew (he)
Original Assignee
ARNAY Sciences LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ARNAY Sciences LLC filed Critical ARNAY Sciences LLC
Publication of IL325432A publication Critical patent/IL325432A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/17—Immunomodulatory nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/532—Closed or circular

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL325432A 2023-06-23 2025-12-18 RNA therapeutic delivery using ring-shaped nucleic acids IL325432A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202363522878P 2023-06-23 2023-06-23
US202363524009P 2023-06-29 2023-06-29
PCT/US2024/034985 WO2024263891A2 (en) 2023-06-23 2024-06-21 Delivery of rna therapeutics using ring-shaped nucleic acids

Publications (1)

Publication Number Publication Date
IL325432A true IL325432A (en) 2026-02-01

Family

ID=93936278

Family Applications (1)

Application Number Title Priority Date Filing Date
IL325432A IL325432A (en) 2023-06-23 2025-12-18 RNA therapeutic delivery using ring-shaped nucleic acids

Country Status (11)

Country Link
EP (1) EP4731768A2 (de)
JP (1) JP2026521760A (de)
KR (1) KR20260030126A (de)
CN (1) CN121620594A (de)
AU (1) AU2024312646A1 (de)
CL (1) CL2025004036A1 (de)
CO (1) CO2026000616A2 (de)
IL (1) IL325432A (de)
JO (1) JOP20250321A1 (de)
MX (1) MX2025015413A (de)
WO (1) WO2024263891A2 (de)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2675803B1 (fr) * 1991-04-25 1996-09-06 Genset Sa Oligonucleotides fermes, antisens et sens et leurs applications.
KR20240082367A (ko) * 2021-09-23 2024-06-10 아르네이 사이언시스 엘엘씨 치료학적 물질로서 고리형 구조의 올리고뉴클레오티드

Also Published As

Publication number Publication date
MX2025015413A (es) 2026-05-04
WO2024263891A3 (en) 2025-04-03
JP2026521760A (ja) 2026-07-01
JOP20250321A1 (ar) 2025-12-21
KR20260030126A (ko) 2026-03-05
CL2025004036A1 (es) 2026-05-15
AU2024312646A1 (en) 2026-01-08
CO2026000616A2 (es) 2026-02-13
EP4731768A2 (de) 2026-04-29
CN121620594A (zh) 2026-03-06
WO2024263891A2 (en) 2024-12-26

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