IL314262A - Intermediates and processes for the preparation of ROCK inhibitors - Google Patents

Intermediates and processes for the preparation of ROCK inhibitors

Info

Publication number
IL314262A
IL314262A IL314262A IL31426224A IL314262A IL 314262 A IL314262 A IL 314262A IL 314262 A IL314262 A IL 314262A IL 31426224 A IL31426224 A IL 31426224A IL 314262 A IL314262 A IL 314262A
Authority
IL
Israel
Prior art keywords
compound
formula
alkyl
group
reacting
Prior art date
Application number
IL314262A
Other languages
English (en)
Hebrew (he)
Inventor
Scott Mcclure Michael
Francis MINKLER Daniel
Francis Nelson HAXELL Thomas
Original Assignee
Alcon Inc
Scott Mcclure Michael
Francis MINKLER Daniel
Francis Nelson HAXELL Thomas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc, Scott Mcclure Michael, Francis MINKLER Daniel, Francis Nelson HAXELL Thomas filed Critical Alcon Inc
Publication of IL314262A publication Critical patent/IL314262A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/03—Monoamines
    • C07C211/06—Monoamines containing only n- or iso-propyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
    • C07C211/35—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing only non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/62—Quaternary ammonium compounds
    • C07C211/63—Quaternary ammonium compounds having quaternised nitrogen atoms bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/62—Quaternary ammonium compounds
    • C07C211/64—Quaternary ammonium compounds having quaternised nitrogen atoms bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C68/00—Preparation of esters of carbonic or haloformic acids
    • C07C68/08—Purification; Separation; Stabilisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/023—Preparation; Separation; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Chemistry (AREA)
IL314262A 2022-01-12 2022-11-02 Intermediates and processes for the preparation of ROCK inhibitors IL314262A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202263298751P 2022-01-12 2022-01-12
PCT/US2022/079176 WO2023136942A1 (en) 2022-01-12 2022-11-02 Synthetic intermediates and improved processes for preparing rock inhibitors

Publications (1)

Publication Number Publication Date
IL314262A true IL314262A (en) 2024-09-01

Family

ID=84462734

Family Applications (1)

Application Number Title Priority Date Filing Date
IL314262A IL314262A (en) 2022-01-12 2022-11-02 Intermediates and processes for the preparation of ROCK inhibitors

Country Status (10)

Country Link
US (1) US20250109106A1 (cg-RX-API-DMAC7.html)
EP (1) EP4463439A1 (cg-RX-API-DMAC7.html)
JP (1) JP2025502210A (cg-RX-API-DMAC7.html)
KR (1) KR20240134342A (cg-RX-API-DMAC7.html)
CN (1) CN118696027A (cg-RX-API-DMAC7.html)
AU (1) AU2022433635B2 (cg-RX-API-DMAC7.html)
CA (1) CA3247774A1 (cg-RX-API-DMAC7.html)
IL (1) IL314262A (cg-RX-API-DMAC7.html)
MX (1) MX2024008610A (cg-RX-API-DMAC7.html)
WO (1) WO2023136942A1 (cg-RX-API-DMAC7.html)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4191829B2 (ja) * 1998-11-05 2008-12-03 大日本住友製薬株式会社 光学活性カルボン酸の製造方法
WO2010126626A2 (en) 2009-05-01 2010-11-04 Aerie Pharmaceuticals, Inc. Dual mechanism inhibitors for the treatment of disease
WO2017086941A1 (en) * 2015-11-17 2017-05-26 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
JP2021517137A (ja) * 2018-03-23 2021-07-15 フォチョン・ファーマシューティカルズ・リミテッドＦｏｃｈｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｌｔｄ． Ｒｏｃｋ阻害剤としての重水素化合物
EP3852790A4 (en) * 2018-09-19 2022-08-10 Forma Therapeutics, Inc. INHIBITION OF UBIQUITIN-SPECIFIC PEPTIDASE 9X

Also Published As

Publication number Publication date
WO2023136942A1 (en) 2023-07-20
AU2022433635A1 (en) 2024-07-04
MX2024008610A (es) 2024-07-23
EP4463439A1 (en) 2024-11-20
US20250109106A1 (en) 2025-04-03
KR20240134342A (ko) 2024-09-09
JP2025502210A (ja) 2025-01-24
AU2022433635B2 (en) 2025-12-18
CA3247774A1 (en) 2023-07-20
CN118696027A (zh) 2024-09-24

Similar Documents

Publication Publication Date Title
CN108601355B (zh) 制备激酶抑制剂及其中间体的方法
US9643927B1 (en) Process for the preparation of kinase inhibitors and intermediates thereof
JP5426560B2 (ja) 新規なヒストンデアセチラーゼインヒビター、その調製方法および使用
JPH11269146A (ja) 分化誘導剤
WO2012002538A1 (ja) 光学活性ジアミン誘導体の塩の製造方法
JP2023116769A (ja) エドキサバンの製造方法
US12247024B2 (en) Process for preparing aficamten
JP6873053B2 (ja) タンパク質脱アセチル化阻害剤の製造方法
CA3081558A1 (en) Anti-infective heterocyclic compounds and uses thereof
JP2014512392A (ja) 疼痛を治療するための脂肪酸アミド加水分解酵素阻害剤
JP6957595B2 (ja) 置換ｎ−［２−（４−フェノキシピペリジン−１−イル）−２−（１，３−チアゾール−５−イル）エチル］ベンズアミドおよびｎ−［２−（４−ベンジルオキシピペリジン−１−イル）−２−（１，３−チアゾール−５−イル）エチル］ベンズアミド誘導体ｐ２ｘ７受容体アンタゴニスト
AU2022433635B2 (en) Synthetic intermediates and improved processes for preparing rock inhibitors
RU2860908C2 (ru) Синтетические промежуточные продукты и усовершенствованные процессы получения ингибиторов rock
CN111205244B (zh) 噻唑并环类化合物、其制备方法、中间体和应用
RU2738937C2 (ru) Способ получения тиазольного производного
JP2009505961A (ja) ペプチドデホルミラーゼ阻害剤
JPH05294930A (ja) スチリル化合物
JP2023100917A (ja) プロリンアミド化合物の製造方法
IL292327A (en) Crystalline solids of 3-palmitoyl-amido-2,1-propanediol and 3-palmitoyl-amido-2-hydroxy-1-dimethoxytrinylmethylether-propane and methods for their preparation and use