IL313897A - Methods for reducing atopic dermatitis by administering an IL-4/IL-13 antagonist - Google Patents

Methods for reducing atopic dermatitis by administering an IL-4/IL-13 antagonist

Info

Publication number
IL313897A
IL313897A IL313897A IL31389724A IL313897A IL 313897 A IL313897 A IL 313897A IL 313897 A IL313897 A IL 313897A IL 31389724 A IL31389724 A IL 31389724A IL 313897 A IL313897 A IL 313897A
Authority
IL
Israel
Prior art keywords
attenuating
antagonist
administering
methods
atopic march
Prior art date
Application number
IL313897A
Other languages
English (en)
Hebrew (he)
Inventor
Gregory Geba
Dateng Li
Judy Xiang Li
Original Assignee
Regeneron Pharma
Gregory Geba
Dateng Li
Judy Xiang Li
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma, Gregory Geba, Dateng Li, Judy Xiang Li filed Critical Regeneron Pharma
Publication of IL313897A publication Critical patent/IL313897A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL313897A 2021-12-30 2022-12-29 Methods for reducing atopic dermatitis by administering an IL-4/IL-13 antagonist IL313897A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163295113P 2021-12-30 2021-12-30
PCT/US2022/082535 WO2023130010A1 (en) 2021-12-30 2022-12-29 Methods for attenuating atopic march by administering an il-4/il-13 antagonist

Publications (1)

Publication Number Publication Date
IL313897A true IL313897A (en) 2024-08-01

Family

ID=85199428

Family Applications (1)

Application Number Title Priority Date Filing Date
IL313897A IL313897A (en) 2021-12-30 2022-12-29 Methods for reducing atopic dermatitis by administering an IL-4/IL-13 antagonist

Country Status (10)

Country Link
US (1) US20230220089A1 (enExample)
EP (1) EP4457245A1 (enExample)
JP (1) JP2025501239A (enExample)
KR (1) KR20240135618A (enExample)
CN (1) CN118355034A (enExample)
AU (1) AU2022425608A1 (enExample)
CA (1) CA3241374A1 (enExample)
IL (1) IL313897A (enExample)
MX (1) MX2024006053A (enExample)
WO (1) WO2023130010A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102576903B1 (ko) 2012-09-07 2023-09-13 리제너론 파아마슈티컬스, 인크. Ｉｌ-4ｒ 길항제 투여로 아토피성 피부염을 치료하는 방법
EP4010373A1 (en) 2019-08-05 2022-06-15 Regeneron Pharmaceuticals, Inc. Methods for treating atopic dermatitis by administering an il-4r antagonist

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001092340A2 (en) 2000-05-26 2001-12-06 Immunex Corporation Use of interleukin-4 antagonists and compositions thereof
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
GB0407315D0 (en) 2003-07-15 2004-05-05 Cambridge Antibody Tech Human antibody molecules
NZ547588A (en) 2003-11-07 2009-05-31 Immunex Corp Antibodies that bind interleukin-4 receptor
JP4943161B2 (ja) 2003-12-23 2012-05-30 ジェネンテック， インコーポレイテッド 新規抗ｉｌ１３モノクローナル抗体での癌の処置
US7501121B2 (en) 2004-06-17 2009-03-10 Wyeth IL-13 binding agents
TWI307630B (en) 2004-07-01 2009-03-21 Glaxo Group Ltd Immunoglobulins
PE20060560A1 (es) 2004-08-03 2006-06-27 Novartis Ag Anticuerpos de interleucina-4 humana
WO2006124451A2 (en) 2005-05-11 2006-11-23 Centocor, Inc. Anti-il-13 antibodies, compositions, methods and uses
US7910708B2 (en) 2005-10-21 2011-03-22 Novartis Ag Anti-IL13 human antibodies
AU2007228943B2 (en) 2006-03-22 2012-03-22 Apogenix Gmbh Antibody specific for human IL-4 for the treament of cancer
PL3339445T3 (pl) 2006-09-08 2020-12-14 Abbvie Bahamas Ltd. Białka wiążące interleukinę 13
LT2769992T (lt) 2006-10-02 2021-04-12 Regeneron Pharmaceuticals, Inc. Didelio afiniškumo žmogaus antikūnai, atpažįstantys žmogaus il-4 receptorių
US7608693B2 (en) 2006-10-02 2009-10-27 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human IL-4 receptor
EP2050764A1 (en) 2007-10-15 2009-04-22 sanofi-aventis Novel polyvalent bispecific antibody format and uses thereof
EP2222709B1 (en) 2007-11-30 2016-11-23 Glaxo Group Limited Antigen-binding constructs
US8092804B2 (en) 2007-12-21 2012-01-10 Medimmune Limited Binding members for interleukin-4 receptor alpha (IL-4Rα)-173
GB0904214D0 (en) 2009-03-11 2009-04-22 Ucb Pharma Sa Biological products
CN106267189B (zh) 2010-10-06 2021-02-26 瑞泽恩制药公司 含有抗白介素-4受体(il-4r)的抗体的稳定制剂
CN103328506A (zh) 2010-10-15 2013-09-25 米迪缪尼有限公司 用于改善肺功能的疗法
KR102576903B1 (ko) * 2012-09-07 2023-09-13 리제너론 파아마슈티컬스, 인크. Ｉｌ-4ｒ 길항제 투여로 아토피성 피부염을 치료하는 방법
HK1220919A1 (zh) 2013-04-05 2017-05-19 F. Hoffmann-La Roche Ag 抗il-4抗体和双特异性抗体及其用途
EP2823841A1 (en) 2013-07-09 2015-01-14 Sanofi-Aventis Deutschland GmbH Autoinjector
TW201711716A (zh) 2015-06-03 2017-04-01 賽諾菲阿凡提斯德意志有限公司 護罩鎖
TW201709941A (zh) 2015-06-03 2017-03-16 賽諾菲阿凡提斯德意志有限公司 聲響指示器（二）
TW201707738A (zh) 2015-06-03 2017-03-01 賽諾菲阿凡提斯德意志有限公司 注射器支架及自動注射器（二）
TW201711713A (zh) 2015-06-03 2017-04-01 賽諾菲阿凡提斯德意志有限公司 藥物輸送裝置（五）
TW201707741A (zh) 2015-06-03 2017-03-01 賽諾菲阿凡提斯德意志有限公司 針頭護罩之抓握器、蓋子、自動注射器及製造抓握器之方法
CN113372446A (zh) 2016-06-08 2021-09-10 苏州康乃德生物医药有限公司 用于结合白细胞介素4受体的抗体
CN113166259A (zh) 2018-11-09 2021-07-23 亚洲大学校产学协力团 对人IL-4受体α具有高亲和力的人抗体及其用途
CN111686247B (zh) 2019-03-13 2022-07-29 苏州康乃德生物医药有限公司 包含人白介素-4受体α的抗体的液体组合物
CN112010977B (zh) 2019-05-29 2022-04-26 山东博安生物技术股份有限公司 抗白介素4受体(il-4r)的抗体及其应用
KR20220158821A (ko) * 2020-03-27 2022-12-01 리제너론 파아마슈티컬스, 인크. Il-4r 길항제를 투여함에 의해 아토피 피부염을 치료하기 위한 방법
CN113549151A (zh) 2020-04-24 2021-10-26 苏州康乃德生物医药有限公司 与人IL-4Rα中特定表位结合的抗体及其应用
TW202216782A (zh) 2020-09-10 2022-05-01 大陸商舒泰神（北京）生物製藥股份有限公司 特異性識別白細胞介素—４受體α的抗體及其用途
EP4019547A1 (en) 2020-12-23 2022-06-29 Numab Therapeutics AG Multispecific antibodies having specificity for il-4r and il-31
JP7846119B2 (ja) 2020-12-23 2026-04-14 ヌマブ セラピューティクス アクチェンゲゼルシャフト Ｉｌ－４ｒに結合する抗体可変ドメイン

Also Published As

Publication number Publication date
JP2025501239A (ja) 2025-01-17
CA3241374A1 (en) 2023-07-06
WO2023130010A1 (en) 2023-07-06
AU2022425608A1 (en) 2024-08-15
MX2024006053A (es) 2024-07-29
CN118355034A (zh) 2024-07-16
EP4457245A1 (en) 2024-11-06
WO2023130010A8 (en) 2023-08-10
US20230220089A1 (en) 2023-07-13
KR20240135618A (ko) 2024-09-11

Similar Documents

Publication Publication Date Title
IL289930A (en) Methods for treating atopic dermatitis using an IL-4R antagonist
SG11202009371WA (en) Methods for treating atopic dermatitis by administering an il-4r inhibitor
IL320913A (en) Spirocyclic dihydropyranopyrimidine KRAS inhibitors
IL274134A (en) Methods of treating or preventing asthma by administering an IL-4R agonist
PT3515465T (pt) Métodos para o tratamento de uma dermatite atópica grave mediante a administração de um inibidor de il-4r
IL326518A (en) Spirocyclic dihydropyranopyrimidine KRAS inhibitors
SG11202007123YA (en) Method and apparatus for pulse gas delivery with isolation valves
IL287902A (en) Methods of administering certain vmat2 inhibitors
IL287275A (en) Methods of treating or preventing asthma by administering an IL-33 agonist
SG11201510506RA (en) Apparatus and method for improved concealment of the adaptive codebook in acelp-like concealment employing improved pulse resynchronization
SG11201402490XA (en) Methods of treatment using an antibody against interferon gamma
PL4059029T3 (pl) Urządzenie do utrzymywania plazmy oraz sposób utrzymywania plazmy
IL265516A (en) Methods for treating severe allergic dermatitis by administering an il-4r inhibitor
PT3920912T (pt) Tratamento de ciliopatias usando inibidores da glucosilceramida sintase (gcs)
IL310962A (en) Methods for treating atopic dermatitis by administering an IL-4R antagonist
IL289731A (en) Methods for treating or preventing asthma by administering an antagonist to il-4r
IL277255A (en) Preparations and methods for assessing the attenuation and infectivity of Listeria strains
EP3784785A4 (en) DOWNREGULATION OF SNCA EXPRESSION BY TARGETED EDITING OF DNA METHYLATION
HK40111305A (en) Methods for attenuating atopic march by administering an il-4/il-13 antagonist
MX2024006053A (es) Metodos para atenuar la marcha atopica administrando un antagonista de il-4/il-13.
IL293544A (en) Methods for treating COPD by giving IL-33 antagonist
IL312187A (en) Methods for treating prurigo nodularis by administering an IL-4R antagonist
GB2586489B (en) Method and structures for coil adjustment
IL264463A (en) Device and method for disinfecting herbs using plasma
IL288288A (en) Method for providing safe administration of anti-cd40 antibody