IL313351A - New frameworks for antibodies - Google Patents
New frameworks for antibodiesInfo
- Publication number
- IL313351A IL313351A IL313351A IL31335124A IL313351A IL 313351 A IL313351 A IL 313351A IL 313351 A IL313351 A IL 313351A IL 31335124 A IL31335124 A IL 31335124A IL 313351 A IL313351 A IL 313351A
- Authority
- IL
- Israel
- Prior art keywords
- antibody
- sequence
- seq
- nucleic acid
- framework region
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Plant Pathology (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13003264 | 2013-06-26 | ||
| PCT/EP2014/001730 WO2014206561A1 (en) | 2013-06-26 | 2014-06-26 | Novel antibody frameworks |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL313351A true IL313351A (en) | 2024-08-01 |
Family
ID=48699516
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL313351A IL313351A (en) | 2013-06-26 | 2014-06-26 | New frameworks for antibodies |
| IL243311A IL243311B (en) | 2013-06-26 | 2014-06-26 | Novel antibody frameworks |
| IL293477A IL293477B2 (en) | 2013-06-26 | 2014-06-26 | New frameworks for antibodies |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL243311A IL243311B (en) | 2013-06-26 | 2014-06-26 | Novel antibody frameworks |
| IL293477A IL293477B2 (en) | 2013-06-26 | 2014-06-26 | New frameworks for antibodies |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US10174102B2 (enExample) |
| EP (1) | EP3013864A1 (enExample) |
| JP (4) | JP6708544B2 (enExample) |
| KR (4) | KR20240000622A (enExample) |
| CN (2) | CN113943366B (enExample) |
| AU (2) | AU2014301629B2 (enExample) |
| CA (1) | CA2914829A1 (enExample) |
| HK (1) | HK1218549A1 (enExample) |
| IL (3) | IL313351A (enExample) |
| NZ (1) | NZ714320A (enExample) |
| SG (2) | SG11201509899PA (enExample) |
| WO (1) | WO2014206561A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10174102B2 (en) | 2013-06-26 | 2019-01-08 | Numab Innovation Ag | Antibody frameworks |
| WO2016202457A1 (en) | 2015-06-15 | 2016-12-22 | Numab Ag | Hetero-dimeric multi-specific antibody format |
| US11434294B2 (en) | 2016-02-25 | 2022-09-06 | Cell Medica, Inc. | Binding members to PD-L1 |
| DK3219726T3 (da) | 2016-03-17 | 2020-12-07 | Tillotts Pharma Ag | Anti-TNF-alfa-antistoffer og funktionelle fragmenter deraf |
| BR112018017276A2 (pt) | 2016-03-17 | 2019-02-05 | Numab Innovation Ag | anticorpos anti-tnf-alfa e fragmentos funcionais dos mesmos |
| RS61412B1 (sr) | 2016-03-17 | 2021-03-31 | Tillotts Pharma Ag | Anti-tnf alfa-antitela i njihovi funkcionalni fragmenti |
| CA3016870A1 (en) | 2016-03-17 | 2017-09-21 | Numab Innovation Ag | Anti-tnf.alpha.-antibodies and functional fragments thereof |
| BR112018017165A2 (pt) | 2016-03-17 | 2019-01-02 | Numab Innovation Ag | anticorpos anti-tnf-alfa e fragmentos funcionais dos mesmos |
| GB201621591D0 (en) * | 2016-12-19 | 2017-02-01 | Ucb Biopharma Sprl | Antibody molecules and method |
| WO2018224441A1 (en) | 2017-06-05 | 2018-12-13 | Numab Innovation Ag | Novel anti-cd3 antibodies |
| KR102651965B1 (ko) | 2017-06-05 | 2024-03-28 | 누맙 세러퓨틱스 아게 | 신규 항 cd3 항체 |
| WO2018224443A1 (en) | 2017-06-05 | 2018-12-13 | Numab Innovation Ag | Hetero-dimeric multi-specific antibody format targeting at least cd3 and hsa |
| WO2018224439A1 (en) | 2017-06-05 | 2018-12-13 | Numab Innovation Ag | Novel anti-hsa antibodies |
| AU2018280679B2 (en) * | 2017-06-05 | 2025-04-24 | Numab Therapeutics AG | Novel anti-HSA antibodies |
| US11787863B2 (en) * | 2017-06-25 | 2023-10-17 | Systimmune, Inc. | Multi-specific antibodies and methods of making and using thereof |
| JP7474193B2 (ja) * | 2017-06-25 | 2024-04-24 | システィミューン， インク． | 多重特異性抗体とその作製及び使用方法 |
| EP3459968A1 (en) | 2017-09-20 | 2019-03-27 | Numab Innovation AG | Novel stable antibody variable domain framework combinations |
| IL320091A (en) | 2019-01-31 | 2025-06-01 | Numab Therapeutics AG | Multispecific antibodies having specificity for tnfa and il-17a, antibodies targeting il-17a, and methods of use thereof |
| EP3689907A1 (en) | 2019-01-31 | 2020-08-05 | Numab Therapeutics AG | Antibodies targeting il-17a and methods of use thereof |
| CA3203552A1 (en) * | 2020-12-30 | 2022-07-07 | Ascendo Biotechnology, Inc. | Monoclonal antibody against human mac-1 and uses thereof |
| KR20230146053A (ko) | 2021-02-12 | 2023-10-18 | 베링거 인겔하임 인터내셔날 게엠베하 | 보체 c3 항원 결합 단백질 |
| US12467094B2 (en) | 2021-03-11 | 2025-11-11 | IgGenix, Inc. | Methods and systems for predicting allergic response |
| JP2024546183A (ja) | 2021-12-22 | 2024-12-17 | ツェーデーエァ－ライフ アクチェンゲゼルシャフト | 抗ｃ３抗体及びその抗原結合性断片並びに眼科疾患又は眼疾患を処置するためのそれらの使用 |
| EP4611774A2 (en) * | 2022-11-04 | 2025-09-10 | MiNK Therapeutics, Inc. | B-cell maturation antigen (bcma) chimeric antigen receptor invariant natural killer t cells and uses thereof |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| DE19819846B4 (de) | 1998-05-05 | 2016-11-24 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Multivalente Antikörper-Konstrukte |
| US20050033031A1 (en) | 2003-08-07 | 2005-02-10 | Couto Fernando Jose Rebelo Do | Methods for humanizing rabbit monoclonal antibodies |
| WO2008004834A1 (en) | 2006-07-06 | 2008-01-10 | Isu Abxis Co., Ltd | Humanized monoclonal antibody highly binding to epidermal growth factor receptor, egf receptor |
| FR2910896B1 (fr) * | 2006-12-29 | 2012-11-16 | Lab Francais Du Fractionnement | Anticorps monoclonal dirige contre le recepteur humain des ldl |
| NZ581418A (en) | 2007-05-21 | 2012-08-31 | Alderbio Holdings Llc | Novel rabbit antibody humanization methods and humanized rabbit antibodies |
| JP5611820B2 (ja) | 2007-06-25 | 2014-10-22 | エスバテック − ア ノバルティスカンパニー エルエルシー | 抗体の修飾方法並びに改善された機能特性を有する修飾された抗体 |
| EP3628686B1 (en) | 2008-06-25 | 2021-07-21 | Novartis AG | Humanization of rabbit antibodies using a universal antibody framework |
| MX347972B (es) | 2008-06-25 | 2017-05-22 | Esbatech Alcon Biomed Res Unit | Anticuerpos estables y solubles que inhiben el vegf. |
| CA2727992C (en) | 2008-06-25 | 2017-10-17 | Esbatech, An Alcon Biomedical Research Unit Llc | Stable and soluble antibodies inhibiting tnf.alpha. |
| WO2010144780A1 (en) | 2009-06-12 | 2010-12-16 | University Of Kansas | Compositions and methods for establishing and maintaining stem cells in an undifferentiated state |
| KR20130098161A (ko) * | 2010-04-30 | 2013-09-04 | 알렉시온 파마슈티칼스, 인코포레이티드 | 인간에서 감소된 면역원성을 갖는 항체 |
| WO2012163519A1 (en) * | 2011-05-27 | 2012-12-06 | Dutalys | Antibodies with improved folding stability |
| US10174102B2 (en) | 2013-06-26 | 2019-01-08 | Numab Innovation Ag | Antibody frameworks |
| EP3459968A1 (en) | 2017-09-20 | 2019-03-27 | Numab Innovation AG | Novel stable antibody variable domain framework combinations |
-
2014
- 2014-06-26 US US14/900,550 patent/US10174102B2/en active Active
- 2014-06-26 KR KR1020237043185A patent/KR20240000622A/ko active Pending
- 2014-06-26 AU AU2014301629A patent/AU2014301629B2/en active Active
- 2014-06-26 KR KR1020167001339A patent/KR102286053B1/ko active Active
- 2014-06-26 KR KR1020227006072A patent/KR20220029763A/ko not_active Ceased
- 2014-06-26 IL IL313351A patent/IL313351A/en unknown
- 2014-06-26 CN CN202111136784.7A patent/CN113943366B/zh active Active
- 2014-06-26 SG SG11201509899PA patent/SG11201509899PA/en unknown
- 2014-06-26 IL IL243311A patent/IL243311B/en unknown
- 2014-06-26 IL IL293477A patent/IL293477B2/en unknown
- 2014-06-26 CA CA2914829A patent/CA2914829A1/en active Pending
- 2014-06-26 SG SG10201811017QA patent/SG10201811017QA/en unknown
- 2014-06-26 HK HK16106054.2A patent/HK1218549A1/zh unknown
- 2014-06-26 CN CN201480036689.1A patent/CN105579472B/zh active Active
- 2014-06-26 JP JP2016522319A patent/JP6708544B2/ja active Active
- 2014-06-26 NZ NZ714320A patent/NZ714320A/en unknown
- 2014-06-26 WO PCT/EP2014/001730 patent/WO2014206561A1/en not_active Ceased
- 2014-06-26 KR KR1020217024096A patent/KR20210097829A/ko not_active Ceased
- 2014-06-26 EP EP14737144.7A patent/EP3013864A1/en active Pending
-
2018
- 2018-10-10 US US16/156,036 patent/US11427628B2/en active Active
-
2019
- 2019-06-17 JP JP2019111990A patent/JP2019201643A/ja not_active Withdrawn
-
2020
- 2020-04-27 AU AU2020202770A patent/AU2020202770B2/en active Active
-
2021
- 2021-10-14 JP JP2021169020A patent/JP2022028659A/ja active Pending
-
2022
- 2022-08-29 US US17/822,959 patent/US20230212265A1/en active Pending
-
2023
- 2023-11-27 JP JP2023199881A patent/JP2024026176A/ja active Pending
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