IL311945A - High-throughput methods for preparing lipid nanoparticles and uses thereof - Google Patents
High-throughput methods for preparing lipid nanoparticles and uses thereofInfo
- Publication number
- IL311945A IL311945A IL311945A IL31194524A IL311945A IL 311945 A IL311945 A IL 311945A IL 311945 A IL311945 A IL 311945A IL 31194524 A IL31194524 A IL 31194524A IL 311945 A IL311945 A IL 311945A
- Authority
- IL
- Israel
- Prior art keywords
- preparation
- lipid nanoparticles
- throughput methods
- throughput
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Nanotechnology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Optics & Photonics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Medical Informatics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicinal Preparation (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163272136P | 2021-10-26 | 2021-10-26 | |
| PCT/US2022/078710 WO2023076945A1 (en) | 2021-10-26 | 2022-10-26 | High-throughput methods for preparing lipid nanoparticles and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL311945A true IL311945A (en) | 2024-06-01 |
Family
ID=86158549
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL311945A IL311945A (en) | 2021-10-26 | 2022-10-26 | High-throughput methods for preparing lipid nanoparticles and uses thereof |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20240390287A1 (https=) |
| EP (1) | EP4422606A4 (https=) |
| JP (1) | JP2024541897A (https=) |
| KR (1) | KR20240090304A (https=) |
| CN (1) | CN118139616A (https=) |
| AR (1) | AR127469A1 (https=) |
| AU (1) | AU2022376919A1 (https=) |
| CA (1) | CA3233239A1 (https=) |
| IL (1) | IL311945A (https=) |
| MX (1) | MX2024004733A (https=) |
| TW (1) | TW202333653A (https=) |
| WO (1) | WO2023076945A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN120722759B (zh) * | 2025-08-28 | 2025-11-21 | 深圳市一五零生命科技有限公司 | 复方利多卡因纳米凝胶的制备工艺优化方法及系统 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN120392779A (zh) * | 2015-06-15 | 2025-08-01 | 华盛顿大学 | 用于延长血液和淋巴组织中的药物水平的多药脂质纳米颗粒组合物和相关方法 |
| WO2017223135A1 (en) * | 2016-06-24 | 2017-12-28 | Modernatx, Inc. | Lipid nanoparticles |
| US20230157955A1 (en) * | 2020-01-08 | 2023-05-25 | Puretech Lyt, Inc. | Vesicle compositions for oral delivery |
| TW202237068A (zh) * | 2020-12-09 | 2022-10-01 | 美商建南德克公司 | 製備脂質奈米顆粒的高通量方法及其用途 |
-
2022
- 2022-10-26 KR KR1020247014725A patent/KR20240090304A/ko active Pending
- 2022-10-26 TW TW111140749A patent/TW202333653A/zh unknown
- 2022-10-26 MX MX2024004733A patent/MX2024004733A/es unknown
- 2022-10-26 WO PCT/US2022/078710 patent/WO2023076945A1/en not_active Ceased
- 2022-10-26 CA CA3233239A patent/CA3233239A1/en active Pending
- 2022-10-26 AU AU2022376919A patent/AU2022376919A1/en active Pending
- 2022-10-26 CN CN202280070682.6A patent/CN118139616A/zh active Pending
- 2022-10-26 IL IL311945A patent/IL311945A/en unknown
- 2022-10-26 AR ARP220102913A patent/AR127469A1/es unknown
- 2022-10-26 EP EP22888463.1A patent/EP4422606A4/en active Pending
- 2022-10-26 JP JP2024524370A patent/JP2024541897A/ja active Pending
-
2024
- 2024-04-22 US US18/642,305 patent/US20240390287A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20240390287A1 (en) | 2024-11-28 |
| AR127469A1 (es) | 2024-01-31 |
| WO2023076945A1 (en) | 2023-05-04 |
| KR20240090304A (ko) | 2024-06-21 |
| EP4422606A4 (en) | 2025-09-17 |
| WO2023076945A9 (en) | 2025-02-13 |
| CA3233239A1 (en) | 2023-05-04 |
| JP2024541897A (ja) | 2024-11-13 |
| EP4422606A1 (en) | 2024-09-04 |
| TW202333653A (zh) | 2023-09-01 |
| CN118139616A (zh) | 2024-06-04 |
| AU2022376919A1 (en) | 2024-03-21 |
| MX2024004733A (es) | 2024-05-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL281615A (en) | Systems and methods for manufacturing lipid nanoparticles and liposomes | |
| IL282995A (en) | Lipid nanoparticle formulations | |
| EP3733211A4 (en) | LIPID NANOPARTICLE CONTAINING NUCLEIC ACID AND USE OF THE SAME | |
| PL3858333T3 (pl) | Wytwarzanie i przechowywanie liposomalnych preparatów rna odpowiednich do terapii | |
| ES3064716T3 (en) | Improved mrna-loaded lipid nanoparticles and processes of making the same | |
| EP3397264A4 (en) | METHOD FOR IMPROVED PREPARATION AND INSULATION OF CELL-DERIVED VESICLES | |
| PL3717102T3 (pl) | Oczyszczacz powietrza zespoły oraz sposoby zastosowania | |
| EP3538250A4 (en) | PC STRUCTURES WITH SUPPORTED POLYAMINES AND METHOD FOR PRODUCING THE SUPPORTED POLYAMINS | |
| IL257255B (en) | Method and device for continuous electrochemical manufacture of 3d structures | |
| PT3003286T (pt) | Método de preparação de nanopartículas sólidas com revestimento inorgânico e sua utilização | |
| DK3990028T3 (da) | Micellære nanopartikler og anvendelse deraf | |
| IL261517A (en) | Methods for modular synthesis of n-glycans and arrays thereof | |
| EP4201400A4 (en) | LIPID DNANOPARTICLES | |
| EP3603648A4 (en) | NUCLEIC ACID AND MULTIRAMIFIED LIPID DRUG COMPLEX | |
| UY34115A (es) | Ensayo de la lisil oxidasa-like 2 y sus métodos de empleo | |
| IL286492A (en) | Sialidase-resistant saccharide and method of making and using the same | |
| EP3417052A4 (en) | PROCESS FOR EXPANSION AND DIFFERENTIATION OF B-CELLS FOR ANTIBODY PRODUCTION | |
| BR112012033557A2 (pt) | instrumento e método para medição do fator de perda de um isolador | |
| EP3967649A4 (en) | LIPIDNANOPARTICLES | |
| EP3506254A4 (en) | SOUNDPROOF STRUCTURE | |
| EP3688246A4 (en) | PLASTER PLATES AND THEIR MANUFACTURING PROCESSES | |
| EP3505556A4 (en) | POLYIMIDE-FILM-FORMING COMPOSITION AND POLYIMIDE-FILM PRODUCED THEREOF | |
| EP3612169A4 (en) | NANOPARTICLES COATED WITH A LIPID MEMBRANE AND THEIR METHOD OF USE | |
| HUE054864T2 (hu) | In vitro módszer tüdõrák diagnosztizálására | |
| IT201700067430A1 (it) | Nanoparticelle quali veicoli di rilascio di principi attivi e metodi per la loro produzione |