IL307498A - Diagnosis and treatment of myeloid disorders and acute leukemia using antigens specific to new tumors - Google Patents

Diagnosis and treatment of myeloid disorders and acute leukemia using antigens specific to new tumors

Info

Publication number
IL307498A
IL307498A IL307498A IL30749823A IL307498A IL 307498 A IL307498 A IL 307498A IL 307498 A IL307498 A IL 307498A IL 30749823 A IL30749823 A IL 30749823A IL 307498 A IL307498 A IL 307498A
Authority
IL
Israel
Prior art keywords
diagnosis
treatment
specific antigens
tumor specific
acute leukemias
Prior art date
Application number
IL307498A
Other languages
English (en)
Hebrew (he)
Original Assignee
Altheia Science S R L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altheia Science S R L filed Critical Altheia Science S R L
Publication of IL307498A publication Critical patent/IL307498A/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/15Natural-killer [NK] cells; Natural-killer T [NKT] cells
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    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
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    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
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    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
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    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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    • C12Q1/6841In situ hybridisation
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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    • C12Q1/6874Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
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    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57505Immunoassay; Biospecific binding assay; Materials therefor for cancer of the blood, e.g. leukaemia
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    • A61K2239/48Blood cells, e.g. leukemia or lymphoma
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    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
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    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2319/00Fusion polypeptide
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IL307498A 2021-04-05 2022-04-05 Diagnosis and treatment of myeloid disorders and acute leukemia using antigens specific to new tumors IL307498A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163170976P 2021-04-05 2021-04-05
PCT/EP2022/059031 WO2022214499A2 (en) 2021-04-05 2022-04-05 Diagnosis and treatment of myeloid disorders and acute leukemias using novel tumor specific antigenscross-reference to related applications

Publications (1)

Publication Number Publication Date
IL307498A true IL307498A (en) 2023-12-01

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IL307498A IL307498A (en) 2021-04-05 2022-04-05 Diagnosis and treatment of myeloid disorders and acute leukemia using antigens specific to new tumors

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US (1) US20240180963A1 (enExample)
EP (1) EP4320154A2 (enExample)
JP (1) JP2024514830A (enExample)
KR (1) KR20240027578A (enExample)
CN (1) CN117881700A (enExample)
AU (1) AU2022255573A1 (enExample)
CA (1) CA3216175A1 (enExample)
IL (1) IL307498A (enExample)
MX (1) MX2023011766A (enExample)
WO (1) WO2022214499A2 (enExample)

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KR20250042204A (ko) * 2022-04-05 2025-03-26 알테이아 사이언스 에스.알.엘. 신규한 종양 특이적 항원을 표적으로 하는 골수성 질환 및 급성 백혈병의 치료
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Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4797368A (en) 1985-03-15 1989-01-10 The United States Of America As Represented By The Department Of Health And Human Services Adeno-associated virus as eukaryotic expression vector
US5139941A (en) 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors
US7361343B2 (en) * 2003-01-21 2008-04-22 Arius Research Inc. Cytotoxicity mediation of cells evidencing surface expression of CD63
US7361342B2 (en) * 2003-01-21 2008-04-22 Arius Research Inc. Cancerous disease modifying antibodies
US7750116B1 (en) 2006-02-18 2010-07-06 Seattle Genetics, Inc. Antibody drug conjugate metabolites
ES2800328T3 (es) * 2008-09-23 2020-12-29 Yeda Res And Development Company Ltd Métodos para diagnosticar y tratar la leucemia linfocítica crónica de linfocitos B en base a la detección e inhibición de CD84
EP3964237B1 (en) 2013-03-15 2026-02-18 Regeneron Pharmaceuticals, Inc. Biologically active molecules, conjugates thereof, and therapeutic uses
AU2015216875B2 (en) * 2014-02-14 2021-02-25 Cellectis Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells
WO2017118985A1 (en) * 2016-01-06 2017-07-13 Yeda Research And Development Co. Ltd. Compositions and methods for treating malignant, autoimmune and inflammatory diseases
JP2019524687A (ja) 2016-07-01 2019-09-05 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited 抗体薬物複合体およびこれを用いた治療方法
WO2020083406A1 (zh) * 2018-10-26 2020-04-30 科济生物医药(上海)有限公司 靶向cll1的抗体及其应用

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