IL305314A - Genetically modified bacteria for generating vaccines - Google Patents

Info

Publication number

IL305314A

IL305314A IL305314A IL30531423A IL305314A IL 305314 A IL305314 A IL 305314A IL 305314 A IL305314 A IL 305314A IL 30531423 A IL30531423 A IL 30531423A IL 305314 A IL305314 A IL 305314A

Authority

IL

Israel

Prior art keywords

bacteria

cancer

vaccine

breast

actinobacteria

Prior art date

2021-02-18

Links

• Espacenet
• Global Dossier
• Discuss

• 241000894006 Bacteria Species 0.000 title claims description 151
• 229960005486 vaccine Drugs 0.000 title claims description 63
• 238000004519 manufacturing process Methods 0.000 title description 7
• 206010028980 Neoplasm Diseases 0.000 claims description 140
• 210000000481 breast Anatomy 0.000 claims description 91
• 108091007433 antigens Proteins 0.000 claims description 83
• 102000036639 antigens Human genes 0.000 claims description 83
• 239000000427 antigen Substances 0.000 claims description 82
• 201000011510 cancer Diseases 0.000 claims description 82
• 108090000623 proteins and genes Proteins 0.000 claims description 28
• 201000001441 melanoma Diseases 0.000 claims description 26
• 208000005017 glioblastoma Diseases 0.000 claims description 22
• 102000004169 proteins and genes Human genes 0.000 claims description 19
• 239000002671 adjuvant Substances 0.000 claims description 16
• 206010009944 Colon cancer Diseases 0.000 claims description 14
• 108020004465 16S ribosomal RNA Proteins 0.000 claims description 11
• 208000003174 Brain Neoplasms Diseases 0.000 claims description 11
• 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 11
• 230000002238 attenuated effect Effects 0.000 claims description 11
• 206010033128 Ovarian cancer Diseases 0.000 claims description 10
• 206010061535 Ovarian neoplasm Diseases 0.000 claims description 10
• 208000020816 lung neoplasm Diseases 0.000 claims description 9
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 8
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 8
• 201000005202 lung cancer Diseases 0.000 claims description 8
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 8
• 201000002528 pancreatic cancer Diseases 0.000 claims description 8
• 208000008443 pancreatic carcinoma Diseases 0.000 claims description 8
• 241000894007 species Species 0.000 claims description 8
• 208000005718 Stomach Neoplasms Diseases 0.000 claims description 6
• 206010017758 gastric cancer Diseases 0.000 claims description 6
• 201000011549 stomach cancer Diseases 0.000 claims description 6
• 206010005949 Bone cancer Diseases 0.000 claims description 5
• 208000018084 Bone neoplasm Diseases 0.000 claims description 5
• 239000003937 drug carrier Substances 0.000 claims description 4
• 230000001225 therapeutic effect Effects 0.000 claims description 4
• 102000004127 Cytokines Human genes 0.000 claims description 3
• 108090000695 Cytokines Proteins 0.000 claims description 3
• 241000192125 Firmicutes Species 0.000 claims description 3
• 159000000013 aluminium salts Chemical class 0.000 claims description 2
• 229910000329 aluminium sulfate Inorganic materials 0.000 claims description 2
• 238000000034 method Methods 0.000 description 39
• 239000000203 mixture Substances 0.000 description 28
• 230000000813 microbial effect Effects 0.000 description 27
• 210000004027 cell Anatomy 0.000 description 25
• 210000004072 lung Anatomy 0.000 description 23
• 241000699670 Mus sp. Species 0.000 description 22
• 108090000765 processed proteins & peptides Chemical group 0.000 description 21
• 244000052616 bacterial pathogen Species 0.000 description 20
• 210000000496 pancreas Anatomy 0.000 description 20
• 241000191938 Micrococcus luteus Species 0.000 description 19
• 230000001580 bacterial effect Effects 0.000 description 18
• 238000002255 vaccination Methods 0.000 description 18
• 235000018102 proteins Nutrition 0.000 description 17
• 230000004614 tumor growth Effects 0.000 description 15
• 108091028043 Nucleic acid sequence Proteins 0.000 description 14
• 206010006187 Breast cancer Diseases 0.000 description 13
• 208000026310 Breast neoplasm Diseases 0.000 description 13
• 102000004196 processed proteins & peptides Human genes 0.000 description 13
• 241000699666 Mus <mouse, genus> Species 0.000 description 12
• 108010058846 Ovalbumin Proteins 0.000 description 12
• 201000010099 disease Diseases 0.000 description 12
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 12
• 241001112695 Clostridiales Species 0.000 description 11
• 241000191963 Staphylococcus epidermidis Species 0.000 description 11
• 210000000988 bone and bone Anatomy 0.000 description 11
• 239000012830 cancer therapeutic Substances 0.000 description 11
• 230000007774 longterm Effects 0.000 description 11
• 229940092253 ovalbumin Drugs 0.000 description 11
• 241000193833 Bacillales Species 0.000 description 10
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 10
• 210000001744 T-lymphocyte Anatomy 0.000 description 10
• 239000013612 plasmid Substances 0.000 description 10
• 239000000523 sample Substances 0.000 description 10
• 238000006467 substitution reaction Methods 0.000 description 10
• 241000186216 Corynebacterium Species 0.000 description 9
• 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 description 9
• 239000000306 component Substances 0.000 description 9
• 239000000463 material Substances 0.000 description 9
• 239000002609 medium Substances 0.000 description 9
• 238000002474 experimental method Methods 0.000 description 8
• 208000032839 leukemia Diseases 0.000 description 8
• 102000005962 receptors Human genes 0.000 description 8
• 108020003175 receptors Proteins 0.000 description 8
• 210000004988 splenocyte Anatomy 0.000 description 8
• 244000063299 Bacillus subtilis Species 0.000 description 7
• -1 CA 19-9 Proteins 0.000 description 7
• 241001134656 Staphylococcus lugdunensis Species 0.000 description 7
• 235000001014 amino acid Nutrition 0.000 description 7
• 150000001413 amino acids Chemical group 0.000 description 7
• 238000001943 fluorescence-activated cell sorting Methods 0.000 description 7
• 239000000126 substance Substances 0.000 description 7
• JVJGCCBAOOWGEO-RUTPOYCXSA-N (2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-4-amino-2-[[(2s,3s)-2-[[(2s,3s)-2-[[(2s)-2-azaniumyl-3-hydroxypropanoyl]amino]-3-methylpentanoyl]amino]-3-methylpentanoyl]amino]-4-oxobutanoyl]amino]-3-phenylpropanoyl]amino]-4-carboxylatobutanoyl]amino]-6-azaniumy Chemical compound OC[C@H](N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(O)=O)CC1=CC=CC=C1 JVJGCCBAOOWGEO-RUTPOYCXSA-N 0.000 description 6
• 241000192700 Cyanobacteria Species 0.000 description 6
• 241000282414 Homo sapiens Species 0.000 description 6
• 101150106931 IFNG gene Proteins 0.000 description 6
• 102000013691 Interleukin-17 Human genes 0.000 description 6
• 108050003558 Interleukin-17 Proteins 0.000 description 6
• 241001112724 Lactobacillales Species 0.000 description 6
• 241001493533 Streptophyta Species 0.000 description 6
• 210000003763 chloroplast Anatomy 0.000 description 6
• 239000002207 metabolite Substances 0.000 description 6
• 244000005700 microbiome Species 0.000 description 6
• 229920001184 polypeptide Chemical group 0.000 description 6
• 239000000047 product Substances 0.000 description 6
• 238000011002 quantification Methods 0.000 description 6
• 210000001519 tissue Anatomy 0.000 description 6
• 210000004881 tumor cell Anatomy 0.000 description 6
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
• 241000692822 Bacteroidales Species 0.000 description 5
• 102100025475 Carcinoembryonic antigen-related cell adhesion molecule 5 Human genes 0.000 description 5
• 108020004414 DNA Proteins 0.000 description 5
• 238000002965 ELISA Methods 0.000 description 5
• 102100028389 Melanoma antigen recognized by T-cells 1 Human genes 0.000 description 5
• 241001467578 Microbacterium Species 0.000 description 5
• 241000589516 Pseudomonas Species 0.000 description 5
• 229940024606 amino acid Drugs 0.000 description 5
• 239000002246 antineoplastic agent Substances 0.000 description 5
• 239000000872 buffer Substances 0.000 description 5
• 239000001963 growth medium Substances 0.000 description 5
• 230000002519 immonomodulatory effect Effects 0.000 description 5
• 230000006054 immunological memory Effects 0.000 description 5
• 210000004185 liver Anatomy 0.000 description 5
• 230000035772 mutation Effects 0.000 description 5
• 150000007523 nucleic acids Chemical class 0.000 description 5
• 210000001672 ovary Anatomy 0.000 description 5
• 241000203809 Actinomycetales Species 0.000 description 4
• 235000014469 Bacillus subtilis Nutrition 0.000 description 4
• 239000002028 Biomass Substances 0.000 description 4
• 102100025401 Breast cancer type 1 susceptibility protein Human genes 0.000 description 4
• 102100036850 C-C motif chemokine 23 Human genes 0.000 description 4
• 102100021942 C-C motif chemokine 28 Human genes 0.000 description 4
• 102000019034 Chemokines Human genes 0.000 description 4
• 108010012236 Chemokines Proteins 0.000 description 4
• 241001112696 Clostridia Species 0.000 description 4
• AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 4
• 241000588698 Erwinia Species 0.000 description 4
• 101000713081 Homo sapiens C-C motif chemokine 23 Proteins 0.000 description 4
• 101000897477 Homo sapiens C-C motif chemokine 28 Proteins 0.000 description 4
• 101000914324 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 5 Proteins 0.000 description 4
• 101000655352 Homo sapiens Telomerase reverse transcriptase Proteins 0.000 description 4
• 102000000588 Interleukin-2 Human genes 0.000 description 4
• 108010002350 Interleukin-2 Proteins 0.000 description 4
• 102000004889 Interleukin-6 Human genes 0.000 description 4
• 108090001005 Interleukin-6 Proteins 0.000 description 4
• 102100031413 L-dopachrome tautomerase Human genes 0.000 description 4
• 241001324870 Lactobacillus iners Species 0.000 description 4
• 239000006142 Luria-Bertani Agar Substances 0.000 description 4
• 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 description 4
• 102000007651 Macrophage Colony-Stimulating Factor Human genes 0.000 description 4
• CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
• 241000192041 Micrococcus Species 0.000 description 4
• 206010060862 Prostate cancer Diseases 0.000 description 4
• 108010072866 Prostate-Specific Antigen Proteins 0.000 description 4
• 102100038358 Prostate-specific antigen Human genes 0.000 description 4
• 208000000236 Prostatic Neoplasms Diseases 0.000 description 4
• 206010039491 Sarcoma Diseases 0.000 description 4
• 241000736131 Sphingomonas Species 0.000 description 4
• 241000960363 Streptococcus infantis Species 0.000 description 4
• 101800001271 Surface protein Proteins 0.000 description 4
• 241000644105 Tissierellaceae Species 0.000 description 4
• 102100040247 Tumor necrosis factor Human genes 0.000 description 4
• 230000001154 acute effect Effects 0.000 description 4
• 229960001212 bacterial vaccine Drugs 0.000 description 4
• 230000001332 colony forming effect Effects 0.000 description 4
• 230000004069 differentiation Effects 0.000 description 4
• 108010051081 dopachrome isomerase Proteins 0.000 description 4
• 239000003814 drug Substances 0.000 description 4
• 238000007710 freezing Methods 0.000 description 4
• 230000008014 freezing Effects 0.000 description 4
• 230000012010 growth Effects 0.000 description 4
• 230000002163 immunogen Effects 0.000 description 4
• 238000002347 injection Methods 0.000 description 4
• 239000007924 injection Substances 0.000 description 4
• 238000001990 intravenous administration Methods 0.000 description 4
• 239000003446 ligand Substances 0.000 description 4
• 244000052769 pathogen Species 0.000 description 4
• 238000003860 storage Methods 0.000 description 4
• 238000007920 subcutaneous administration Methods 0.000 description 4
• 238000012360 testing method Methods 0.000 description 4
• 230000035899 viability Effects 0.000 description 4
• 108700020463 BRCA1 Proteins 0.000 description 3
• 241001135755 Betaproteobacteria Species 0.000 description 3
• 241000186427 Cutibacterium acnes Species 0.000 description 3
• 241001464975 Cutibacterium granulosum Species 0.000 description 3
• 102100037985 Dickkopf-related protein 3 Human genes 0.000 description 3
• 241000291067 Enhydrobacter aerosaccus Species 0.000 description 3
• 102100023688 Eotaxin Human genes 0.000 description 3
• 208000000461 Esophageal Neoplasms Diseases 0.000 description 3
• 241001326555 Eurotiomycetes Species 0.000 description 3
• 241001617393 Finegoldia Species 0.000 description 3
• 102100030708 GTPase KRas Human genes 0.000 description 3
• 241000192128 Gammaproteobacteria Species 0.000 description 3
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
• 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 description 3
• 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 description 3
• 102100021866 Hepatocyte growth factor Human genes 0.000 description 3
• 101000914321 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 7 Proteins 0.000 description 3
• 101000584612 Homo sapiens GTPase KRas Proteins 0.000 description 3
• 101001133056 Homo sapiens Mucin-1 Proteins 0.000 description 3
• 102000000589 Interleukin-1 Human genes 0.000 description 3
• 108010002352 Interleukin-1 Proteins 0.000 description 3
• 102000003814 Interleukin-10 Human genes 0.000 description 3
• 108090000174 Interleukin-10 Proteins 0.000 description 3
• 102000013462 Interleukin-12 Human genes 0.000 description 3
• 108010065805 Interleukin-12 Proteins 0.000 description 3
• 102000003816 Interleukin-13 Human genes 0.000 description 3
• 108090000176 Interleukin-13 Proteins 0.000 description 3
• 102100039897 Interleukin-5 Human genes 0.000 description 3
• 108010002616 Interleukin-5 Proteins 0.000 description 3
• 108010010995 MART-1 Antigen Proteins 0.000 description 3
• 102000043129 MHC class I family Human genes 0.000 description 3
• 108091054437 MHC class I family Proteins 0.000 description 3
• 108091054438 MHC class II family Proteins 0.000 description 3
• 241000736262 Microbiota Species 0.000 description 3
• 102100034256 Mucin-1 Human genes 0.000 description 3
• 241001136170 Neisseria subflava Species 0.000 description 3
• 206010030155 Oesophageal carcinoma Diseases 0.000 description 3
• 241000611236 Paracoccus marcusii Species 0.000 description 3
• 241000605861 Prevotella Species 0.000 description 3
• 241000588770 Proteus mirabilis Species 0.000 description 3
• 241001248479 Pseudomonadales Species 0.000 description 3
• 241000589517 Pseudomonas aeruginosa Species 0.000 description 3
• 241000589157 Rhizobiales Species 0.000 description 3
• 241000607142 Salmonella Species 0.000 description 3
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
• 241000191940 Staphylococcus Species 0.000 description 3
• 241000192087 Staphylococcus hominis Species 0.000 description 3
• 241000861996 Staphylococcus succinus Species 0.000 description 3
• 241000194017 Streptococcus Species 0.000 description 3
• 102100021669 Stromal cell-derived factor 1 Human genes 0.000 description 3
• 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 description 3
• 102100031988 Tumor necrosis factor ligand superfamily member 6 Human genes 0.000 description 3
• 108090000435 Urokinase-type plasminogen activator Proteins 0.000 description 3
• 241001533204 Veillonella dispar Species 0.000 description 3
• 241001430183 Veillonellaceae Species 0.000 description 3
• 230000004075 alteration Effects 0.000 description 3
• 238000004458 analytical method Methods 0.000 description 3
• 210000000612 antigen-presenting cell Anatomy 0.000 description 3
• 108010018828 cadherin 5 Proteins 0.000 description 3
• 230000008859 change Effects 0.000 description 3
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
• 150000001875 compounds Chemical class 0.000 description 3
• 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 description 3
• 230000003111 delayed effect Effects 0.000 description 3
• 238000004520 electroporation Methods 0.000 description 3
• 201000004101 esophageal cancer Diseases 0.000 description 3
• 238000009472 formulation Methods 0.000 description 3
• 230000028993 immune response Effects 0.000 description 3
• 238000011534 incubation Methods 0.000 description 3
• 239000003112 inhibitor Substances 0.000 description 3
• 230000002401 inhibitory effect Effects 0.000 description 3
• 238000007918 intramuscular administration Methods 0.000 description 3
• 230000002601 intratumoral effect Effects 0.000 description 3
• 238000002372 labelling Methods 0.000 description 3
• 230000002906 microbiologic effect Effects 0.000 description 3
• 238000010369 molecular cloning Methods 0.000 description 3
• BSOQXXWZTUDTEL-ZUYCGGNHSA-N muramyl dipeptide Chemical group OC(=O)CC[C@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](O)[C@@H]1NC(C)=O BSOQXXWZTUDTEL-ZUYCGGNHSA-N 0.000 description 3
• 102000039446 nucleic acids Human genes 0.000 description 3
• 108020004707 nucleic acids Proteins 0.000 description 3
• 230000001717 pathogenic effect Effects 0.000 description 3
• 239000008194 pharmaceutical composition Substances 0.000 description 3
• 230000004481 post-translational protein modification Effects 0.000 description 3
• 238000004321 preservation Methods 0.000 description 3
• 230000028327 secretion Effects 0.000 description 3
• 210000002966 serum Anatomy 0.000 description 3
• 230000028070 sporulation Effects 0.000 description 3
• 102000003298 tumor necrosis factor receptor Human genes 0.000 description 3
• 239000013598 vector Substances 0.000 description 3
• 238000001262 western blot Methods 0.000 description 3
• 108091032973 (ribonucleotides)n+m Proteins 0.000 description 2
• INZOTETZQBPBCE-NYLDSJSYSA-N 3-sialyl lewis Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]([C@H](O)CO)[C@@H]([C@@H](NC(C)=O)C=O)O[C@H]1[C@H](O)[C@@H](O[C@]2(O[C@H]([C@H](NC(C)=O)[C@@H](O)C2)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O)[C@@H](CO)O1 INZOTETZQBPBCE-NYLDSJSYSA-N 0.000 description 2
• 102100030310 5,6-dihydroxyindole-2-carboxylic acid oxidase Human genes 0.000 description 2
• 102100026802 72 kDa type IV collagenase Human genes 0.000 description 2
• 108010011122 A Kinase Anchor Proteins Proteins 0.000 description 2
• 102000014022 A Kinase Anchor Proteins Human genes 0.000 description 2
• 108010042708 Acetylmuramyl-Alanyl-Isoglutamine Proteins 0.000 description 2
• 241000589291 Acinetobacter Species 0.000 description 2
• 241000202698 Agrococcus Species 0.000 description 2
• 102100023635 Alpha-fetoprotein Human genes 0.000 description 2
• 102100022987 Angiogenin Human genes 0.000 description 2
• 102100025674 Angiopoietin-related protein 4 Human genes 0.000 description 2
• 102000030431 Asparaginyl endopeptidase Human genes 0.000 description 2
• 102100035526 B melanoma antigen 1 Human genes 0.000 description 2
• 101150072950 BRCA1 gene Proteins 0.000 description 2
• 241000006381 Bacillus flexus Species 0.000 description 2
• 102100028239 Basal cell adhesion molecule Human genes 0.000 description 2
• 102100027314 Beta-2-microglobulin Human genes 0.000 description 2
• 102100023995 Beta-nerve growth factor Human genes 0.000 description 2
• 101800001382 Betacellulin Proteins 0.000 description 2
• 241001519635 Blastococcus Species 0.000 description 2
• 108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 description 2
• 108010049955 Bone Morphogenetic Protein 4 Proteins 0.000 description 2
• 108010049976 Bone Morphogenetic Protein 5 Proteins 0.000 description 2
• 108010049870 Bone Morphogenetic Protein 7 Proteins 0.000 description 2
• 102100024506 Bone morphogenetic protein 2 Human genes 0.000 description 2
• 102100024505 Bone morphogenetic protein 4 Human genes 0.000 description 2
• 102100022526 Bone morphogenetic protein 5 Human genes 0.000 description 2
• 102100022544 Bone morphogenetic protein 7 Human genes 0.000 description 2
• 102000004219 Brain-derived neurotrophic factor Human genes 0.000 description 2
• 108090000715 Brain-derived neurotrophic factor Proteins 0.000 description 2
• 102100023702 C-C motif chemokine 13 Human genes 0.000 description 2
• 101710112613 C-C motif chemokine 13 Proteins 0.000 description 2
• 102100023705 C-C motif chemokine 14 Human genes 0.000 description 2
• 102100023700 C-C motif chemokine 16 Human genes 0.000 description 2
• 102100023698 C-C motif chemokine 17 Human genes 0.000 description 2
• 102100021943 C-C motif chemokine 2 Human genes 0.000 description 2
• 102100036845 C-C motif chemokine 22 Human genes 0.000 description 2
• 102100021933 C-C motif chemokine 25 Human genes 0.000 description 2
• 102100021936 C-C motif chemokine 27 Human genes 0.000 description 2
• 102100032367 C-C motif chemokine 5 Human genes 0.000 description 2
• 102100032366 C-C motif chemokine 7 Human genes 0.000 description 2
• 102100034871 C-C motif chemokine 8 Human genes 0.000 description 2
• 102100025248 C-X-C motif chemokine 10 Human genes 0.000 description 2
• 101710098275 C-X-C motif chemokine 10 Proteins 0.000 description 2
• 102100025277 C-X-C motif chemokine 13 Human genes 0.000 description 2
• 102100025250 C-X-C motif chemokine 14 Human genes 0.000 description 2
• 102100036150 C-X-C motif chemokine 5 Human genes 0.000 description 2
• 102100036153 C-X-C motif chemokine 6 Human genes 0.000 description 2
• 102100036170 C-X-C motif chemokine 9 Human genes 0.000 description 2
• 102100031170 CCN family member 3 Human genes 0.000 description 2
• 102100031173 CCN family member 4 Human genes 0.000 description 2
• 101710137353 CCN family member 4 Proteins 0.000 description 2
• 102100024210 CD166 antigen Human genes 0.000 description 2
• 102100029761 Cadherin-5 Human genes 0.000 description 2
• 201000009030 Carcinoma Diseases 0.000 description 2
• 102100025064 Cellular tumor antigen p53 Human genes 0.000 description 2
• 241000186321 Cellulomonas Species 0.000 description 2
• 102000016950 Chemokine CXCL1 Human genes 0.000 description 2
• 108010014419 Chemokine CXCL1 Proteins 0.000 description 2
• 102100035167 Coiled-coil domain-containing protein 54 Human genes 0.000 description 2
• 102100027995 Collagenase 3 Human genes 0.000 description 2
• 241001518263 Corynebacterium tuberculostearicum Species 0.000 description 2
• 241001464974 Cutibacterium avidum Species 0.000 description 2
• 102100035784 Decorin Human genes 0.000 description 2
• 102100036462 Delta-like protein 1 Human genes 0.000 description 2
• 241000579717 Dermacoccus Species 0.000 description 2
• 102100030074 Dickkopf-related protein 1 Human genes 0.000 description 2
• 101710099518 Dickkopf-related protein 1 Proteins 0.000 description 2
• 101710099550 Dickkopf-related protein 3 Proteins 0.000 description 2
• 102100024361 Disintegrin and metalloproteinase domain-containing protein 9 Human genes 0.000 description 2
• 101710116121 Disintegrin and metalloproteinase domain-containing protein 9 Proteins 0.000 description 2
• 208000000471 Dysplastic Nevus Syndrome Diseases 0.000 description 2
• 108010024212 E-Selectin Proteins 0.000 description 2
• 102100023471 E-selectin Human genes 0.000 description 2
• 101150029707 ERBB2 gene Proteins 0.000 description 2
• 108010044063 Endocrine-Gland-Derived Vascular Endothelial Growth Factor Proteins 0.000 description 2
• 241000588914 Enterobacter Species 0.000 description 2
• 241000881810 Enterobacter asburiae Species 0.000 description 2
• 241000588697 Enterobacter cloacae Species 0.000 description 2
• 241000305071 Enterobacterales Species 0.000 description 2
• 101710139422 Eotaxin Proteins 0.000 description 2
• 108010066687 Epithelial Cell Adhesion Molecule Proteins 0.000 description 2
• 102000018651 Epithelial Cell Adhesion Molecule Human genes 0.000 description 2
• 241001468125 Exiguobacterium Species 0.000 description 2
• 108010039471 Fas Ligand Protein Proteins 0.000 description 2
• 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 description 2
• 102100031706 Fibroblast growth factor 1 Human genes 0.000 description 2
• 102100031734 Fibroblast growth factor 19 Human genes 0.000 description 2
• 108090000379 Fibroblast growth factor 2 Proteins 0.000 description 2
• 102100028072 Fibroblast growth factor 4 Human genes 0.000 description 2
• 108090000381 Fibroblast growth factor 4 Proteins 0.000 description 2
• 108090000385 Fibroblast growth factor 7 Proteins 0.000 description 2
• 102100035139 Folate receptor alpha Human genes 0.000 description 2
• 241001183197 Fusobacteriales Species 0.000 description 2
• 102000003688 G-Protein-Coupled Receptors Human genes 0.000 description 2
• 108090000045 G-Protein-Coupled Receptors Proteins 0.000 description 2
• 102000034615 Glial cell line-derived neurotrophic factor Human genes 0.000 description 2
• 108091010837 Glial cell line-derived neurotrophic factor Proteins 0.000 description 2
• 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 description 2
• 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 2
• 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 2
• 108010041834 Growth Differentiation Factor 15 Proteins 0.000 description 2
• 108010090290 Growth Differentiation Factor 2 Proteins 0.000 description 2
• 102100040896 Growth/differentiation factor 15 Human genes 0.000 description 2
• 102100040892 Growth/differentiation factor 2 Human genes 0.000 description 2
• 102210042925 HLA-A*02:01 Human genes 0.000 description 2
• 102400001369 Heparin-binding EGF-like growth factor Human genes 0.000 description 2
• 101800001649 Heparin-binding EGF-like growth factor Proteins 0.000 description 2
• 108010007712 Hepatitis A Virus Cellular Receptor 1 Proteins 0.000 description 2
• 102100034459 Hepatitis A virus cellular receptor 1 Human genes 0.000 description 2
• 102000018713 Histocompatibility Antigens Class II Human genes 0.000 description 2
• 208000017604 Hodgkin disease Diseases 0.000 description 2
• 101000978381 Homo sapiens C-C motif chemokine 14 Proteins 0.000 description 2
• 101000978375 Homo sapiens C-C motif chemokine 16 Proteins 0.000 description 2
• 101000978362 Homo sapiens C-C motif chemokine 17 Proteins 0.000 description 2
• 101000978371 Homo sapiens C-C motif chemokine 18 Proteins 0.000 description 2
• 101000858068 Homo sapiens C-X-C motif chemokine 14 Proteins 0.000 description 2
• 101000737052 Homo sapiens Coiled-coil domain-containing protein 54 Proteins 0.000 description 2
• 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 description 2
• 101001002470 Homo sapiens Interferon lambda-1 Proteins 0.000 description 2
• 101000578784 Homo sapiens Melanoma antigen recognized by T-cells 1 Proteins 0.000 description 2
• 101000824971 Homo sapiens Sperm surface protein Sp17 Proteins 0.000 description 2
• 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 description 2
• 102000037982 Immune checkpoint proteins Human genes 0.000 description 2
• 108091008036 Immune checkpoint proteins Proteins 0.000 description 2
• 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 2
• 102000004218 Insulin-Like Growth Factor I Human genes 0.000 description 2
• 102000048143 Insulin-Like Growth Factor II Human genes 0.000 description 2
• 108090001117 Insulin-Like Growth Factor II Proteins 0.000 description 2
• 102000004372 Insulin-like growth factor binding protein 2 Human genes 0.000 description 2
• 108090000964 Insulin-like growth factor binding protein 2 Proteins 0.000 description 2
• 102000004374 Insulin-like growth factor binding protein 3 Human genes 0.000 description 2
• 108090000965 Insulin-like growth factor binding protein 3 Proteins 0.000 description 2
• 102000004369 Insulin-like growth factor-binding protein 4 Human genes 0.000 description 2
• 108090000969 Insulin-like growth factor-binding protein 4 Proteins 0.000 description 2
• 102000004883 Insulin-like growth factor-binding protein 6 Human genes 0.000 description 2
• 108090001014 Insulin-like growth factor-binding protein 6 Proteins 0.000 description 2
• 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 description 2
• 108010064600 Intercellular Adhesion Molecule-3 Proteins 0.000 description 2
• 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 description 2
• 102100037872 Intercellular adhesion molecule 2 Human genes 0.000 description 2
• 101710148794 Intercellular adhesion molecule 2 Proteins 0.000 description 2
• 102100037871 Intercellular adhesion molecule 3 Human genes 0.000 description 2
• 108010078049 Interferon alpha-2 Proteins 0.000 description 2
• 102100020990 Interferon lambda-1 Human genes 0.000 description 2
• 108010074328 Interferon-gamma Proteins 0.000 description 2
• 108010050904 Interferons Proteins 0.000 description 2
• 102000014150 Interferons Human genes 0.000 description 2
• 102000003815 Interleukin-11 Human genes 0.000 description 2
• 108090000177 Interleukin-11 Proteins 0.000 description 2
• 102000003812 Interleukin-15 Human genes 0.000 description 2
• 108090000172 Interleukin-15 Proteins 0.000 description 2
• 102000049772 Interleukin-16 Human genes 0.000 description 2
• 101800003050 Interleukin-16 Proteins 0.000 description 2
• 102000003810 Interleukin-18 Human genes 0.000 description 2
• 108090000171 Interleukin-18 Proteins 0.000 description 2
• 102100021596 Interleukin-31 Human genes 0.000 description 2
• 101710181613 Interleukin-31 Proteins 0.000 description 2
• 102000017761 Interleukin-33 Human genes 0.000 description 2
• 108010067003 Interleukin-33 Proteins 0.000 description 2
• 102000004388 Interleukin-4 Human genes 0.000 description 2
• 108090000978 Interleukin-4 Proteins 0.000 description 2
• 102000000704 Interleukin-7 Human genes 0.000 description 2
• 108010002586 Interleukin-7 Proteins 0.000 description 2
• 102000004890 Interleukin-8 Human genes 0.000 description 2
• 108090001007 Interleukin-8 Proteins 0.000 description 2
• 102000000585 Interleukin-9 Human genes 0.000 description 2
• 108010002335 Interleukin-9 Proteins 0.000 description 2
• 102100033467 L-selectin Human genes 0.000 description 2
• 241000186660 Lactobacillus Species 0.000 description 2
• 206010024218 Lentigo maligna Diseases 0.000 description 2
• 108090000581 Leukemia inhibitory factor Proteins 0.000 description 2
• 102000013519 Lipocalin-2 Human genes 0.000 description 2
• 108010051335 Lipocalin-2 Proteins 0.000 description 2
• 108090001030 Lipoproteins Proteins 0.000 description 2
• 102000004895 Lipoproteins Human genes 0.000 description 2
• 206010025323 Lymphomas Diseases 0.000 description 2
• 102100020983 Lysosome membrane protein 2 Human genes 0.000 description 2
• 102100026553 Mannose-binding protein C Human genes 0.000 description 2
• 102000000380 Matrix Metalloproteinase 1 Human genes 0.000 description 2
• 108010016113 Matrix Metalloproteinase 1 Proteins 0.000 description 2
• 102100030412 Matrix metalloproteinase-9 Human genes 0.000 description 2
• 108010015302 Matrix metalloproteinase-9 Proteins 0.000 description 2
• MJVAVZPDRWSRRC-UHFFFAOYSA-N Menadione Chemical compound C1=CC=C2C(=O)C(C)=CC(=O)C2=C1 MJVAVZPDRWSRRC-UHFFFAOYSA-N 0.000 description 2
• 102100039364 Metalloproteinase inhibitor 1 Human genes 0.000 description 2
• 102100026262 Metalloproteinase inhibitor 2 Human genes 0.000 description 2
• 102100024289 Metalloproteinase inhibitor 4 Human genes 0.000 description 2
• 108050006579 Metalloproteinase inhibitor 4 Proteins 0.000 description 2
• 241000203578 Microbispora Species 0.000 description 2
• 101710151805 Mitochondrial intermediate peptidase 1 Proteins 0.000 description 2
• 241000186359 Mycobacterium Species 0.000 description 2
• 241000588674 Neisseria macacae Species 0.000 description 2
• 102000003729 Neprilysin Human genes 0.000 description 2
• 108090000028 Neprilysin Proteins 0.000 description 2
• 108010025020 Nerve Growth Factor Proteins 0.000 description 2
• 206010029260 Neuroblastoma Diseases 0.000 description 2
• 102100023181 Neurogenic locus notch homolog protein 1 Human genes 0.000 description 2
• 108090000742 Neurotrophin 3 Proteins 0.000 description 2
• 102100029268 Neurotrophin-3 Human genes 0.000 description 2
• 102000003683 Neurotrophin-4 Human genes 0.000 description 2
• 108090000099 Neurotrophin-4 Proteins 0.000 description 2
• 102100037369 Nidogen-1 Human genes 0.000 description 2
• 102100022396 Nucleosome assembly protein 1-like 4 Human genes 0.000 description 2
• 108090000630 Oncostatin M Proteins 0.000 description 2
• 102000008108 Osteoprotegerin Human genes 0.000 description 2
• 108010035042 Osteoprotegerin Proteins 0.000 description 2
• 102100025386 Oxidized low-density lipoprotein receptor 1 Human genes 0.000 description 2
• 108091008606 PDGF receptors Proteins 0.000 description 2
• 229930012538 Paclitaxel Natural products 0.000 description 2
• 108010089430 Phosphoproteins Proteins 0.000 description 2
• 102000007982 Phosphoproteins Human genes 0.000 description 2
• 206010035226 Plasma cell myeloma Diseases 0.000 description 2
• 108010022233 Plasminogen Activator Inhibitor 1 Proteins 0.000 description 2
• 102100039418 Plasminogen activator inhibitor 1 Human genes 0.000 description 2
• 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 description 2
• 102100030304 Platelet factor 4 Human genes 0.000 description 2
• 102000011653 Platelet-Derived Growth Factor Receptors Human genes 0.000 description 2
• 102100033237 Pro-epidermal growth factor Human genes 0.000 description 2
• 102100029837 Probetacellulin Human genes 0.000 description 2
• 102100040678 Programmed cell death protein 1 Human genes 0.000 description 2
• 101710089372 Programmed cell death protein 1 Proteins 0.000 description 2
• 102100040126 Prokineticin-1 Human genes 0.000 description 2
• 102100023832 Prolyl endopeptidase FAP Human genes 0.000 description 2
• 241001430313 Propionibacteriaceae Species 0.000 description 2
• 241000186429 Propionibacterium Species 0.000 description 2
• 238000012341 Quantitative reverse-transcriptase PCR Methods 0.000 description 2
• 108020004511 Recombinant DNA Proteins 0.000 description 2
• 102100038246 Retinol-binding protein 4 Human genes 0.000 description 2
• 241001185307 Rhodobacterales Species 0.000 description 2
• 241001227620 Roseomonas mucosa Species 0.000 description 2
• 241000203719 Rothia dentocariosa Species 0.000 description 2
• 241000157939 Rothia mucilaginosa Species 0.000 description 2
• OTKJDMGTUTTYMP-ROUUACIJSA-N Safingol ( L-threo-sphinganine) Chemical compound CCCCCCCCCCCCCCC[C@H](O)[C@@H](N)CO OTKJDMGTUTTYMP-ROUUACIJSA-N 0.000 description 2
• 101100117082 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) dnaG gene Proteins 0.000 description 2
• 102100030053 Secreted frizzled-related protein 3 Human genes 0.000 description 2
• 241000605036 Selenomonas Species 0.000 description 2
• 102100029965 Sialic acid-binding Ig-like lectin 9 Human genes 0.000 description 2
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
• 241000186547 Sporosarcina Species 0.000 description 2
• 241000191984 Staphylococcus haemolyticus Species 0.000 description 2
• 241000193998 Streptococcus pneumoniae Species 0.000 description 2
• 241000194051 Streptococcus vestibularis Species 0.000 description 2
• 101710088580 Stromal cell-derived factor 1 Proteins 0.000 description 2
• 102100030416 Stromelysin-1 Human genes 0.000 description 2
• 102100028848 Stromelysin-2 Human genes 0.000 description 2
• 206010042553 Superficial spreading melanoma stage unspecified Diseases 0.000 description 2
• 241000189180 Tepidimonas Species 0.000 description 2
• 102100031294 Thymic stromal lymphopoietin Human genes 0.000 description 2
• 102100030951 Tissue factor pathway inhibitor Human genes 0.000 description 2
• 102000002689 Toll-like receptor Human genes 0.000 description 2
• 108020000411 Toll-like receptor Proteins 0.000 description 2
• 102100024333 Toll-like receptor 2 Human genes 0.000 description 2
• 108700029229 Transcriptional Regulatory Elements Proteins 0.000 description 2
• 102100021393 Transcriptional repressor CTCFL Human genes 0.000 description 2
• 101710128101 Transcriptional repressor CTCFL Proteins 0.000 description 2
• 102000046299 Transforming Growth Factor beta1 Human genes 0.000 description 2
• 101800004564 Transforming growth factor alpha Proteins 0.000 description 2
• 101800002279 Transforming growth factor beta-1 Proteins 0.000 description 2
• 102000056172 Transforming growth factor beta-3 Human genes 0.000 description 2
• 108090000097 Transforming growth factor beta-3 Proteins 0.000 description 2
• 108010066451 Triggering Receptor Expressed on Myeloid Cells-1 Proteins 0.000 description 2
• 102100029681 Triggering receptor expressed on myeloid cells 1 Human genes 0.000 description 2
• 108060008682 Tumor Necrosis Factor Proteins 0.000 description 2
• 102100036922 Tumor necrosis factor ligand superfamily member 13B Human genes 0.000 description 2
• 102100029675 Tumor necrosis factor receptor superfamily member 13B Human genes 0.000 description 2
• 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 description 2
• 102100033726 Tumor necrosis factor receptor superfamily member 17 Human genes 0.000 description 2
• 102100022205 Tumor necrosis factor receptor superfamily member 21 Human genes 0.000 description 2
• 102100035284 Tumor necrosis factor receptor superfamily member 6B Human genes 0.000 description 2
• 102000003990 Urokinase-type plasminogen activator Human genes 0.000 description 2
• 102000008790 VE-cadherin Human genes 0.000 description 2
• 108010073923 Vascular Endothelial Growth Factor C Proteins 0.000 description 2
• 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 2
• 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 2
• 102100023543 Vascular cell adhesion protein 1 Human genes 0.000 description 2
• 102100038232 Vascular endothelial growth factor C Human genes 0.000 description 2
• 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 description 2
• 102100033179 Vascular endothelial growth factor receptor 3 Human genes 0.000 description 2
• 208000008383 Wilms tumor Diseases 0.000 description 2
• 230000002159 abnormal effect Effects 0.000 description 2
• 206010000583 acral lentiginous melanoma Diseases 0.000 description 2
• SMPZPKRDRQOOHT-UHFFFAOYSA-N acronycine Chemical compound CN1C2=CC=CC=C2C(=O)C2=C1C(C=CC(C)(C)O1)=C1C=C2OC SMPZPKRDRQOOHT-UHFFFAOYSA-N 0.000 description 2
• RJURFGZVJUQBHK-UHFFFAOYSA-N actinomycin D Natural products CC1OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C2CCCN2C(=O)C(C(C)C)NC(=O)C1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)NC4C(=O)NC(C(N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-UHFFFAOYSA-N 0.000 description 2
• 239000000443 aerosol Substances 0.000 description 2
• WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 2
• 125000000539 amino acid group Chemical group 0.000 description 2
• FRHBOQMZUOWXQL-UHFFFAOYSA-L ammonium ferric citrate Chemical compound [NH4+].[Fe+3].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FRHBOQMZUOWXQL-UHFFFAOYSA-L 0.000 description 2
• 230000003698 anagen phase Effects 0.000 description 2
• 108010072788 angiogenin Proteins 0.000 description 2
• 210000004102 animal cell Anatomy 0.000 description 2
• 230000000890 antigenic effect Effects 0.000 description 2
• 229940034982 antineoplastic agent Drugs 0.000 description 2
• 108010055066 asparaginylendopeptidase Proteins 0.000 description 2
• KQHXBDOEECKORE-UHFFFAOYSA-L beryllium sulfate Chemical compound [Be+2].[O-]S([O-])(=O)=O KQHXBDOEECKORE-UHFFFAOYSA-L 0.000 description 2
• 230000015572 biosynthetic process Effects 0.000 description 2
• 210000004369 blood Anatomy 0.000 description 2
• 239000008280 blood Substances 0.000 description 2
• 210000004899 c-terminal region Anatomy 0.000 description 2
• 108091006374 cAMP receptor proteins Proteins 0.000 description 2
• ZCCIPPOKBCJFDN-UHFFFAOYSA-N calcium nitrate Chemical compound [Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ZCCIPPOKBCJFDN-UHFFFAOYSA-N 0.000 description 2
• 208000035269 cancer or benign tumor Diseases 0.000 description 2
• 229940041514 candida albicans extract Drugs 0.000 description 2
• 108010079058 casein hydrolysate Proteins 0.000 description 2
• 230000010261 cell growth Effects 0.000 description 2
• 230000005754 cellular signaling Effects 0.000 description 2
• 238000005119 centrifugation Methods 0.000 description 2
• 208000019065 cervical carcinoma Diseases 0.000 description 2
• 238000010367 cloning Methods 0.000 description 2
• 239000002299 complementary DNA Substances 0.000 description 2
• 238000005138 cryopreservation Methods 0.000 description 2
• 238000012258 culturing Methods 0.000 description 2
• 238000001514 detection method Methods 0.000 description 2
• 238000001035 drying Methods 0.000 description 2
• 239000012636 effector Substances 0.000 description 2
• 239000000839 emulsion Substances 0.000 description 2
• 239000002158 endotoxin Substances 0.000 description 2
• 239000000284 extract Substances 0.000 description 2
• 238000001125 extrusion Methods 0.000 description 2
• 229960004642 ferric ammonium citrate Drugs 0.000 description 2
• 238000004108 freeze drying Methods 0.000 description 2
• 230000004927 fusion Effects 0.000 description 2
• SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 description 2
• 230000002068 genetic effect Effects 0.000 description 2
• 239000008103 glucose Substances 0.000 description 2
• 206010073071 hepatocellular carcinoma Diseases 0.000 description 2
• 238000011493 immune profiling Methods 0.000 description 2
• 210000000987 immune system Anatomy 0.000 description 2
• 230000036039 immunity Effects 0.000 description 2
• 239000004615 ingredient Substances 0.000 description 2
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
• 229940079322 interferon Drugs 0.000 description 2
• 102000003898 interleukin-24 Human genes 0.000 description 2
• 108090000237 interleukin-24 Proteins 0.000 description 2
• 229940100601 interleukin-6 Drugs 0.000 description 2
• 239000004313 iron ammonium citrate Substances 0.000 description 2
• 235000000011 iron ammonium citrate Nutrition 0.000 description 2
• 230000002147 killing effect Effects 0.000 description 2
• 208000011080 lentigo maligna melanoma Diseases 0.000 description 2
• 230000000670 limiting effect Effects 0.000 description 2
• 108010013555 lipoprotein-associated coagulation inhibitor Proteins 0.000 description 2
• 239000007788 liquid Substances 0.000 description 2
• 208000014018 liver neoplasm Diseases 0.000 description 2
• 229910052943 magnesium sulfate Inorganic materials 0.000 description 2
• 235000019341 magnesium sulphate Nutrition 0.000 description 2
• 238000004949 mass spectrometry Methods 0.000 description 2
• 238000002156 mixing Methods 0.000 description 2
• 201000000050 myeloid neoplasm Diseases 0.000 description 2
• 208000004649 neutrophil actin dysfunction Diseases 0.000 description 2
• 108010008217 nidogen Proteins 0.000 description 2
• 201000000032 nodular malignant melanoma Diseases 0.000 description 2
• 239000002773 nucleotide Substances 0.000 description 2
• 125000003729 nucleotide group Chemical group 0.000 description 2
• 235000015097 nutrients Nutrition 0.000 description 2
• 229960001592 paclitaxel Drugs 0.000 description 2
• 239000008188 pellet Substances 0.000 description 2
• 230000000144 pharmacologic effect Effects 0.000 description 2
• 201000005825 prostate adenocarcinoma Diseases 0.000 description 2
• RXWNCPJZOCPEPQ-NVWDDTSBSA-N puromycin Chemical compound C1=CC(OC)=CC=C1C[C@H](N)C(=O)N[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(=C3N=C2)N(C)C)O[C@@H]1CO RXWNCPJZOCPEPQ-NVWDDTSBSA-N 0.000 description 2
• 239000001397 quillaja saponaria molina bark Chemical class 0.000 description 2
• 238000003753 real-time PCR Methods 0.000 description 2
• 238000011084 recovery Methods 0.000 description 2
• 230000004044 response Effects 0.000 description 2
• 238000007480 sanger sequencing Methods 0.000 description 2
• 229930182490 saponin Chemical class 0.000 description 2
• 150000007949 saponins Chemical class 0.000 description 2
• 208000011581 secondary neoplasm Diseases 0.000 description 2
• 150000003384 small molecules Chemical class 0.000 description 2
• 210000000952 spleen Anatomy 0.000 description 2
• 206010041823 squamous cell carcinoma Diseases 0.000 description 2
• 238000010186 staining Methods 0.000 description 2
• PVYJZLYGTZKPJE-UHFFFAOYSA-N streptonigrin Chemical compound C=1C=C2C(=O)C(OC)=C(N)C(=O)C2=NC=1C(C=1N)=NC(C(O)=O)=C(C)C=1C1=CC=C(OC)C(OC)=C1O PVYJZLYGTZKPJE-UHFFFAOYSA-N 0.000 description 2
• 208000030457 superficial spreading melanoma Diseases 0.000 description 2
• 208000024891 symptom Diseases 0.000 description 2
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 2
• 229940124597 therapeutic agent Drugs 0.000 description 2
• 108010014402 tyrosinase-related protein-1 Proteins 0.000 description 2
• 239000012138 yeast extract Substances 0.000 description 2
• HZSBSRAVNBUZRA-RQDPQJJXSA-J (1r,2r)-cyclohexane-1,2-diamine;tetrachloroplatinum(2+) Chemical compound Cl[Pt+2](Cl)(Cl)Cl.N[C@@H]1CCCC[C@H]1N HZSBSRAVNBUZRA-RQDPQJJXSA-J 0.000 description 1
• PCTMTFRHKVHKIS-BMFZQQSSSA-N (1s,3r,4e,6e,8e,10e,12e,14e,16e,18s,19r,20r,21s,25r,27r,30r,31r,33s,35r,37s,38r)-3-[(2r,3s,4s,5s,6r)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-19,25,27,30,31,33,35,37-octahydroxy-18,20,21-trimethyl-23-oxo-22,39-dioxabicyclo[33.3.1]nonatriaconta-4,6,8,10 Chemical compound C1C=C2C[C@@H](OS(O)(=O)=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2.O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 PCTMTFRHKVHKIS-BMFZQQSSSA-N 0.000 description 1
• MNHVIVWFCMBFCV-AVGNSLFASA-N (2S)-2-[[(2S)-2-[[(4S)-4-amino-4-carboxybutanoyl]amino]-6-diazo-5-oxohexanoyl]amino]-6-diazo-5-oxohexanoic acid Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CCC(=O)C=[N+]=[N-])C(=O)N[C@@H](CCC(=O)C=[N+]=[N-])C(O)=O MNHVIVWFCMBFCV-AVGNSLFASA-N 0.000 description 1
• PAYBYKKERMGTSS-MNCSTQPFSA-N (2r,3r,3as,9ar)-7-fluoro-2-(hydroxymethyl)-6-imino-2,3,3a,9a-tetrahydrofuro[1,2][1,3]oxazolo[3,4-a]pyrimidin-3-ol Chemical compound N=C1C(F)=CN2[C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3OC2=N1 PAYBYKKERMGTSS-MNCSTQPFSA-N 0.000 description 1
• JPSHPWJJSVEEAX-OWPBQMJCSA-N (2s)-2-amino-4-fluoranylpentanedioic acid Chemical compound OC(=O)[C@@H](N)CC([18F])C(O)=O JPSHPWJJSVEEAX-OWPBQMJCSA-N 0.000 description 1
• NAALWFYYHHJEFQ-ZASNTINBSA-N (2s,5r,6r)-6-[[(2r)-2-[[6-[4-[bis(2-hydroxyethyl)sulfamoyl]phenyl]-2-oxo-1h-pyridine-3-carbonyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Chemical compound N([C@@H](C(=O)N[C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C=1C=CC(O)=CC=1)C(=O)C(C(N1)=O)=CC=C1C1=CC=C(S(=O)(=O)N(CCO)CCO)C=C1 NAALWFYYHHJEFQ-ZASNTINBSA-N 0.000 description 1
• ASWBNKHCZGQVJV-UHFFFAOYSA-N (3-hexadecanoyloxy-2-hydroxypropyl) 2-(trimethylazaniumyl)ethyl phosphate Chemical class CCCCCCCCCCCCCCCC(=O)OCC(O)COP([O-])(=O)OCC[N+](C)(C)C ASWBNKHCZGQVJV-UHFFFAOYSA-N 0.000 description 1
• DNXIKVLOVZVMQF-UHFFFAOYSA-N (3beta,16beta,17alpha,18beta,20alpha)-17-hydroxy-11-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-yohimban-16-carboxylic acid, methyl ester Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(C(=O)OC)C(O)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 DNXIKVLOVZVMQF-UHFFFAOYSA-N 0.000 description 1
• NMWKYTGJWUAZPZ-WWHBDHEGSA-N (4S)-4-[[(4R,7S,10S,16S,19S,25S,28S,31R)-31-[[(2S)-2-[[(1R,6R,9S,12S,18S,21S,24S,27S,30S,33S,36S,39S,42R,47R,53S,56S,59S,62S,65S,68S,71S,76S,79S,85S)-47-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-phenylpropanoyl]amino]-4-oxobutanoyl]amino]-3-carboxypropanoyl]amino]-18-(4-aminobutyl)-27,68-bis(3-amino-3-oxopropyl)-36,71,76-tribenzyl-39-(3-carbamimidamidopropyl)-24-(2-carboxyethyl)-21,56-bis(carboxymethyl)-65,85-bis[(1R)-1-hydroxyethyl]-59-(hydroxymethyl)-62,79-bis(1H-imidazol-4-ylmethyl)-9-methyl-33-(2-methylpropyl)-8,11,17,20,23,26,29,32,35,38,41,48,54,57,60,63,66,69,72,74,77,80,83,86-tetracosaoxo-30-propan-2-yl-3,4,44,45-tetrathia-7,10,16,19,22,25,28,31,34,37,40,49,55,58,61,64,67,70,73,75,78,81,84,87-tetracosazatetracyclo[40.31.14.012,16.049,53]heptaoctacontane-6-carbonyl]amino]-3-methylbutanoyl]amino]-7-(3-carbamimidamidopropyl)-25-(hydroxymethyl)-19-[(4-hydroxyphenyl)methyl]-28-(1H-imidazol-4-ylmethyl)-10-methyl-6,9,12,15,18,21,24,27,30-nonaoxo-16-propan-2-yl-1,2-dithia-5,8,11,14,17,20,23,26,29-nonazacyclodotriacontane-4-carbonyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-3-carboxy-1-[[(2S)-1-[[(2S)-1-[[(1S)-1-carboxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid Chemical compound CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc4c[nH]cn4)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](Cc4c[nH]cn4)NC(=O)[C@H](Cc4ccccc4)NC3=O)[C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N3CCC[C@H]3C(=O)N[C@@H](C)C(=O)N2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1)C(=O)N[C@@H](C)C(O)=O NMWKYTGJWUAZPZ-WWHBDHEGSA-N 0.000 description 1
• SWXOGPJRIDTIRL-DOUNNPEJSA-N (4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-n-[(2s)-1-amino-3-(1h-indol-3-yl)-1-oxopropan-2-yl]-19-[[(2r)-2-amino-3-phenylpropanoyl]amino]-16-[(4-hydroxyphenyl)methyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-7-propan-2-yl-1,2-dithia-5,8,11,14,17-pent Chemical compound C([C@H]1C(=O)N[C@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)[C@H](N)CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(N)=O)=O)C(C)C)C1=CC=C(O)C=C1 SWXOGPJRIDTIRL-DOUNNPEJSA-N 0.000 description 1
• POVNCJSPYFCWJR-USZUGGBUSA-N (4s)-4-[[(2s)-2-[[(2s)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-5-[(2s)-2-[[2-[(2s)-2-[[(2s)-1-[[(2s,3r)-1-[[(1s)-1-carboxy-2-methylpropyl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1- Chemical compound C([C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N1[C@@H](CCC1)C(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(O)=O)C1=CC=C(O)C=C1 POVNCJSPYFCWJR-USZUGGBUSA-N 0.000 description 1
• YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 1
• MWWSFMDVAYGXBV-FGBSZODSSA-N (7s,9s)-7-[(2r,4s,5r,6s)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7h-tetracene-5,12-dione;hydron;chloride Chemical compound Cl.O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 MWWSFMDVAYGXBV-FGBSZODSSA-N 0.000 description 1
• RCFNNLSZHVHCEK-YGCMNLPTSA-N (7s,9s)-7-[(2s,4r,6s)-4-amino-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7h-tetracene-5,12-dione;hydrochloride Chemical compound Cl.O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)C[C@H](C)O1 RCFNNLSZHVHCEK-YGCMNLPTSA-N 0.000 description 1
• FDKXTQMXEQVLRF-ZHACJKMWSA-N (E)-dacarbazine Chemical compound CN(C)\N=N\c1[nH]cnc1C(N)=O FDKXTQMXEQVLRF-ZHACJKMWSA-N 0.000 description 1
• LKJPYSCBVHEWIU-KRWDZBQOSA-N (R)-bicalutamide Chemical compound C([C@@](O)(C)C(=O)NC=1C=C(C(C#N)=CC=1)C(F)(F)F)S(=O)(=O)C1=CC=C(F)C=C1 LKJPYSCBVHEWIU-KRWDZBQOSA-N 0.000 description 1
• OJRZEKJECRTBPJ-NGAMADIESA-N (z,5s)-5-acetamido-1-diazonio-6-hydroxy-6-oxohex-1-en-2-olate Chemical compound CC(=O)N[C@H](C(O)=O)CC\C([O-])=C\[N+]#N OJRZEKJECRTBPJ-NGAMADIESA-N 0.000 description 1
• FONKWHRXTPJODV-DNQXCXABSA-N 1,3-bis[2-[(8s)-8-(chloromethyl)-4-hydroxy-1-methyl-7,8-dihydro-3h-pyrrolo[3,2-e]indole-6-carbonyl]-1h-indol-5-yl]urea Chemical compound C1([C@H](CCl)CN2C(=O)C=3NC4=CC=C(C=C4C=3)NC(=O)NC=3C=C4C=C(NC4=CC=3)C(=O)N3C4=CC(O)=C5NC=C(C5=C4[C@H](CCl)C3)C)=C2C=C(O)C2=C1C(C)=CN2 FONKWHRXTPJODV-DNQXCXABSA-N 0.000 description 1
• OUPZKGBUJRBPGC-HLTSFMKQSA-N 1,5-bis[[(2r)-oxiran-2-yl]methyl]-3-[[(2s)-oxiran-2-yl]methyl]-1,3,5-triazinane-2,4,6-trione Chemical compound O=C1N(C[C@H]2OC2)C(=O)N(C[C@H]2OC2)C(=O)N1C[C@H]1CO1 OUPZKGBUJRBPGC-HLTSFMKQSA-N 0.000 description 1
• UOAFGUOASVSLPK-UHFFFAOYSA-N 1-(2-chloroethyl)-3-(2,2-dimethylpropyl)-1-nitrosourea Chemical compound CC(C)(C)CNC(=O)N(N=O)CCCl UOAFGUOASVSLPK-UHFFFAOYSA-N 0.000 description 1
• JQJSFAJISYZPER-UHFFFAOYSA-N 1-(4-chlorophenyl)-3-(2,3-dihydro-1h-inden-5-ylsulfonyl)urea Chemical compound C1=CC(Cl)=CC=C1NC(=O)NS(=O)(=O)C1=CC=C(CCC2)C2=C1 JQJSFAJISYZPER-UHFFFAOYSA-N 0.000 description 1
• SNYUHPPZINRDSG-UHFFFAOYSA-N 1-(oxiran-2-ylmethyl)-4-[1-(oxiran-2-ylmethyl)piperidin-4-yl]piperidine Chemical compound C1CC(C2CCN(CC3OC3)CC2)CCN1CC1CO1 SNYUHPPZINRDSG-UHFFFAOYSA-N 0.000 description 1
• ZKFNOUUKULVDOB-UHFFFAOYSA-N 1-amino-1-phenylmethyl phosphonic acid Chemical compound OP(=O)(O)C(N)C1=CC=CC=C1 ZKFNOUUKULVDOB-UHFFFAOYSA-N 0.000 description 1
• IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical class CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
• 102000010400 1-phosphatidylinositol-3-kinase activity proteins Human genes 0.000 description 1
• FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Chemical class OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
• 108020004463 18S ribosomal RNA Proteins 0.000 description 1
• OOMDVERDMZLRFX-UHFFFAOYSA-N 2,2-bis(aminomethyl)propane-1,3-diol;cyclobutane-1,1-dicarboxylic acid;platinum Chemical compound [Pt].NCC(CN)(CO)CO.OC(=O)C1(C(O)=O)CCC1 OOMDVERDMZLRFX-UHFFFAOYSA-N 0.000 description 1
• VKDGNNYJFSHYKD-UHFFFAOYSA-N 2,5-diamino-2-(difluoromethyl)pentanoic acid;hydron;chloride Chemical compound Cl.NCCCC(N)(C(F)F)C(O)=O VKDGNNYJFSHYKD-UHFFFAOYSA-N 0.000 description 1
• SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 description 1
• NJWBUDCAWGTQAS-UHFFFAOYSA-N 2-(chrysen-6-ylmethylamino)-2-methylpropane-1,3-diol;methanesulfonic acid Chemical compound CS(O)(=O)=O.C1=CC=C2C(CNC(CO)(CO)C)=CC3=C(C=CC=C4)C4=CC=C3C2=C1 NJWBUDCAWGTQAS-UHFFFAOYSA-N 0.000 description 1
• QXLQZLBNPTZMRK-UHFFFAOYSA-N 2-[(dimethylamino)methyl]-1-(2,4-dimethylphenyl)prop-2-en-1-one Chemical compound CN(C)CC(=C)C(=O)C1=CC=C(C)C=C1C QXLQZLBNPTZMRK-UHFFFAOYSA-N 0.000 description 1
• KPRFMAZESAKTEJ-UHFFFAOYSA-N 2-[1-amino-4-[2,5-dioxo-4-(1-phenylethyl)pyrrolidin-3-yl]-1-oxobutan-2-yl]-5-carbamoylheptanedioic acid;azane Chemical compound [NH4+].[NH4+].C=1C=CC=CC=1C(C)C1C(CCC(C(CCC(CC([O-])=O)C(N)=O)C([O-])=O)C(N)=O)C(=O)NC1=O KPRFMAZESAKTEJ-UHFFFAOYSA-N 0.000 description 1
• JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
• VKUYLANQOAKALN-UHFFFAOYSA-N 2-[benzyl-(4-methoxyphenyl)sulfonylamino]-n-hydroxy-4-methylpentanamide Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N(C(CC(C)C)C(=O)NO)CC1=CC=CC=C1 VKUYLANQOAKALN-UHFFFAOYSA-N 0.000 description 1
• BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 description 1
• QCXJFISCRQIYID-IAEPZHFASA-N 2-amino-1-n-[(3s,6s,7r,10s,16s)-3-[(2s)-butan-2-yl]-7,11,14-trimethyl-2,5,9,12,15-pentaoxo-10-propan-2-yl-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]-4,6-dimethyl-3-oxo-9-n-[(3s,6s,7r,10s,16s)-7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propa Chemical compound C[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@H](C(C)C)NC(=O)[C@H]1NC(=O)C1=C(N=C2C(C(=O)N[C@@H]3C(=O)N[C@H](C(N4CCC[C@H]4C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]3C)=O)[C@@H](C)CC)=C(N)C(=O)C(C)=C2O2)C2=C(C)C=C1 QCXJFISCRQIYID-IAEPZHFASA-N 0.000 description 1
• DSWLRNLRVBAVFC-UHFFFAOYSA-N 2-methylsulfinyl-1-pyridin-2-ylethanone Chemical compound CS(=O)CC(=O)C1=CC=CC=N1 DSWLRNLRVBAVFC-UHFFFAOYSA-N 0.000 description 1
• NDMPLJNOPCLANR-UHFFFAOYSA-N 3,4-dihydroxy-15-(4-hydroxy-18-methoxycarbonyl-5,18-seco-ibogamin-18-yl)-16-methoxy-1-methyl-6,7-didehydro-aspidospermidine-3-carboxylic acid methyl ester Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 NDMPLJNOPCLANR-UHFFFAOYSA-N 0.000 description 1
• GRLUHXSUZYFZCW-UHFFFAOYSA-N 3-(8,8-diethyl-2-aza-8-germaspiro[4.5]decan-2-yl)-n,n-dimethylpropan-1-amine;dihydrochloride Chemical compound Cl.Cl.C1C[Ge](CC)(CC)CCC11CN(CCCN(C)C)CC1 GRLUHXSUZYFZCW-UHFFFAOYSA-N 0.000 description 1
• GTJXPMSTODOYNP-BTKVJIOYSA-N 3-[(e)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C=1C=CC=CC=1C(/CC)=C(C=1C=C(O)C=CC=1)\C1=CC=C(OCCN(C)C)C=C1 GTJXPMSTODOYNP-BTKVJIOYSA-N 0.000 description 1
• UZFPOOOQHWICKY-UHFFFAOYSA-N 3-[13-[1-[1-[8,12-bis(2-carboxyethyl)-17-(1-hydroxyethyl)-3,7,13,18-tetramethyl-21,24-dihydroporphyrin-2-yl]ethoxy]ethyl]-18-(2-carboxyethyl)-8-(1-hydroxyethyl)-3,7,12,17-tetramethyl-22,23-dihydroporphyrin-2-yl]propanoic acid Chemical compound N1C(C=C2C(=C(CCC(O)=O)C(C=C3C(=C(C)C(C=C4N5)=N3)CCC(O)=O)=N2)C)=C(C)C(C(C)O)=C1C=C5C(C)=C4C(C)OC(C)C1=C(N2)C=C(N3)C(C)=C(C(O)C)C3=CC(C(C)=C3CCC(O)=O)=NC3=CC(C(CCC(O)=O)=C3C)=NC3=CC2=C1C UZFPOOOQHWICKY-UHFFFAOYSA-N 0.000 description 1
• QNKJFXARIMSDBR-UHFFFAOYSA-N 3-[2-[bis(2-chloroethyl)amino]ethyl]-1,3-diazaspiro[4.5]decane-2,4-dione Chemical compound O=C1N(CCN(CCCl)CCCl)C(=O)NC11CCCCC1 QNKJFXARIMSDBR-UHFFFAOYSA-N 0.000 description 1
• WUIABRMSWOKTOF-OYALTWQYSA-O 3-[[2-[2-[2-[[(2s,3r)-2-[[(2s,3s,4r)-4-[[(2s,3r)-2-[[6-amino-2-[(1s)-3-amino-1-[[(2s)-2,3-diamino-3-oxopropyl]amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[(2r,3s,4s,5s,6s)-3-[(2r,3s,4s,5r,6r)-4-carbamoyloxy-3,5-dihydroxy-6-(hydroxymethyl)ox Chemical compound OS(O)(=O)=O.N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C WUIABRMSWOKTOF-OYALTWQYSA-O 0.000 description 1
• CLPFFLWZZBQMAO-UHFFFAOYSA-N 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile Chemical compound C1=CC(C#N)=CC=C1C1N2C=NC=C2CCC1 CLPFFLWZZBQMAO-UHFFFAOYSA-N 0.000 description 1
• AKJHMTWEGVYYSE-AIRMAKDCSA-N 4-HPR Chemical compound C=1C=C(O)C=CC=1NC(=O)/C=C(\C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C AKJHMTWEGVYYSE-AIRMAKDCSA-N 0.000 description 1
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
• PXLPCZJACKUXGP-UHFFFAOYSA-N 5-(3,4-dichlorophenyl)-6-ethylpyrimidine-2,4-diamine Chemical compound CCC1=NC(N)=NC(N)=C1C1=CC=C(Cl)C(Cl)=C1 PXLPCZJACKUXGP-UHFFFAOYSA-N 0.000 description 1
• IDPUKCWIGUEADI-UHFFFAOYSA-N 5-[bis(2-chloroethyl)amino]uracil Chemical compound ClCCN(CCCl)C1=CNC(=O)NC1=O IDPUKCWIGUEADI-UHFFFAOYSA-N 0.000 description 1
• XAUDJQYHKZQPEU-KVQBGUIXSA-N 5-aza-2'-deoxycytidine Chemical compound O=C1N=C(N)N=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 XAUDJQYHKZQPEU-KVQBGUIXSA-N 0.000 description 1
• NMUSYJAQQFHJEW-KVTDHHQDSA-N 5-azacytidine Chemical compound O=C1N=C(N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NMUSYJAQQFHJEW-KVTDHHQDSA-N 0.000 description 1
• DQOGWKZQQBYYMW-LQGIGNHCSA-N 5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline-2,4-diamine;(2s,3s,4s,5r,6s)-3,4,5,6-tetrahydroxyoxane-2-carboxylic acid Chemical compound O[C@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O.COC1=C(OC)C(OC)=CC(NCC=2C(=C3C(N)=NC(N)=NC3=CC=2)C)=C1 DQOGWKZQQBYYMW-LQGIGNHCSA-N 0.000 description 1
• WYWHKKSPHMUBEB-UHFFFAOYSA-N 6-Mercaptoguanine Natural products N1C(N)=NC(=S)C2=C1N=CN2 WYWHKKSPHMUBEB-UHFFFAOYSA-N 0.000 description 1
• OTSZCHORPMQCBZ-UHFFFAOYSA-N 6-[(3-chlorophenyl)-imidazol-1-ylmethyl]-1h-benzimidazole;hydron;chloride Chemical compound Cl.ClC1=CC=CC(C(C=2C=C3NC=NC3=CC=2)N2C=NC=C2)=C1 OTSZCHORPMQCBZ-UHFFFAOYSA-N 0.000 description 1
• KXBCLNRMQPRVTP-UHFFFAOYSA-N 6-amino-1,5-dihydroimidazo[4,5-c]pyridin-4-one Chemical compound O=C1NC(N)=CC2=C1N=CN2 KXBCLNRMQPRVTP-UHFFFAOYSA-N 0.000 description 1
• ZNTIXVYOBQDFFV-UHFFFAOYSA-N 6-amino-1,5-dihydroimidazo[4,5-c]pyridin-4-one;methanesulfonic acid Chemical compound CS(O)(=O)=O.O=C1NC(N)=CC2=C1N=CN2 ZNTIXVYOBQDFFV-UHFFFAOYSA-N 0.000 description 1
• KABRXLINDSPGDF-UHFFFAOYSA-N 7-bromoisoquinoline Chemical compound C1=CN=CC2=CC(Br)=CC=C21 KABRXLINDSPGDF-UHFFFAOYSA-N 0.000 description 1
• 101710151806 72 kDa type IV collagenase Proteins 0.000 description 1
• LPDLEICKXUVJHW-QJILNLRNSA-N 78nz2pmp25 Chemical compound OS(O)(=O)=O.O([C@]12[C@H](OC(C)=O)[C@]3(CC)C=CCN4CC[C@@]5([C@H]34)[C@H]1N(C)C1=C5C=C(C(=C1)OC)[C@]1(C(=O)OC)C3=C(C4=CC=CC=C4N3)CCN3C[C@H](C1)C[C@@](C3)(O)CC)C(=O)N(CCCl)C2=O LPDLEICKXUVJHW-QJILNLRNSA-N 0.000 description 1
• ZKRFOXLVOKTUTA-KQYNXXCUSA-N 9-(5-phosphoribofuranosyl)-6-mercaptopurine Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]1N1C(NC=NC2=S)=C2N=C1 ZKRFOXLVOKTUTA-KQYNXXCUSA-N 0.000 description 1
• 102100026381 ADP-dependent glucokinase Human genes 0.000 description 1
• 108010058598 ADP-dependent glucokinase Proteins 0.000 description 1
• 101150054149 ANGPTL4 gene Proteins 0.000 description 1
• 241001600692 Acidovorax temperans Species 0.000 description 1
• 241000122231 Acinetobacter radioresistens Species 0.000 description 1
• 241001556024 Acinetobacter ursingii Species 0.000 description 1
• 208000020154 Acnes Diseases 0.000 description 1
• 241001156739 Actinobacteria <phylum> Species 0.000 description 1
• 241000186046 Actinomyces Species 0.000 description 1
• 241000132734 Actinomyces oris Species 0.000 description 1
• 241000203716 Actinomycetaceae Species 0.000 description 1
• 108010075348 Activated-Leukocyte Cell Adhesion Molecule Proteins 0.000 description 1
• 102100034540 Adenomatous polyposis coli protein Human genes 0.000 description 1
• 102100026423 Adhesion G protein-coupled receptor E5 Human genes 0.000 description 1
• 241000193792 Aerococcus viridans Species 0.000 description 1
• 229920001817 Agar Polymers 0.000 description 1
• 102000054930 Agouti-Related Human genes 0.000 description 1
• 101710127426 Agouti-related protein Proteins 0.000 description 1
• 102100027211 Albumin Human genes 0.000 description 1
• 108010088751 Albumins Proteins 0.000 description 1
• 241000588813 Alcaligenes faecalis Species 0.000 description 1
• 241000186033 Alloiococcus Species 0.000 description 1
• 241001135756 Alphaproteobacteria Species 0.000 description 1
• 239000005995 Aluminium silicate Substances 0.000 description 1
• 108010065511 Amylases Proteins 0.000 description 1
• 102100034594 Angiopoietin-1 Human genes 0.000 description 1
• 108010048154 Angiopoietin-1 Proteins 0.000 description 1
• 102100034608 Angiopoietin-2 Human genes 0.000 description 1
• 108010048036 Angiopoietin-2 Proteins 0.000 description 1
• 102100033402 Angiopoietin-4 Human genes 0.000 description 1
• 108700042530 Angiopoietin-Like Protein 4 Proteins 0.000 description 1
• 102400000068 Angiostatin Human genes 0.000 description 1
• 108010079709 Angiostatins Proteins 0.000 description 1
• 102100027153 Ankyrin repeat and sterile alpha motif domain-containing protein 1B Human genes 0.000 description 1
• 101710149294 Ankyrin repeat and sterile alpha motif domain-containing protein 1B Proteins 0.000 description 1
• 101710145634 Antigen 1 Proteins 0.000 description 1
• 102100040197 Apolipoprotein A-V Human genes 0.000 description 1
• 108010061118 Apolipoprotein A-V Proteins 0.000 description 1
• 241000186063 Arthrobacter Species 0.000 description 1
• 241000235349 Ascomycota Species 0.000 description 1
• 108010024976 Asparaginase Proteins 0.000 description 1
• 102000015790 Asparaginase Human genes 0.000 description 1
• 241000122821 Aspergillus kawachii Species 0.000 description 1
• 241000228245 Aspergillus niger Species 0.000 description 1
• 241000374462 Aspergillus pseudoglaucus Species 0.000 description 1
• 108700032558 Aspergillus restrictus MITF Proteins 0.000 description 1
• 108090000461 Aurora Kinase A Proteins 0.000 description 1
• 102100032311 Aurora kinase A Human genes 0.000 description 1
• 101710131520 B melanoma antigen 1 Proteins 0.000 description 1
• 108010028006 B-Cell Activating Factor Proteins 0.000 description 1
• 108010008014 B-Cell Maturation Antigen Proteins 0.000 description 1
• 241000193830 Bacillus <bacterium> Species 0.000 description 1
• 241001328122 Bacillus clausii Species 0.000 description 1
• 241000495374 Bacillus foraminis Species 0.000 description 1
• 241000078022 Bacillus muralis Species 0.000 description 1
• 241000210691 Bacillus nealsonii Species 0.000 description 1
• 241000730261 Bacillus subtilis PY79 Species 0.000 description 1
• 241000276408 Bacillus subtilis subsp. subtilis str. 168 Species 0.000 description 1
• 241000606125 Bacteroides Species 0.000 description 1
• 241001105998 Bacteroides dorei Species 0.000 description 1
• 101710172654 Basal cell adhesion molecule Proteins 0.000 description 1
• 206010004146 Basal cell carcinoma Diseases 0.000 description 1
• 108010081589 Becaplermin Proteins 0.000 description 1
• 206010005003 Bladder cancer Diseases 0.000 description 1
• 108010006654 Bleomycin Proteins 0.000 description 1
• 241000588832 Bordetella pertussis Species 0.000 description 1
• 241000218943 Brachybacterium conglomeratum Species 0.000 description 1
• CIUUIPMOFZIWIZ-UHFFFAOYSA-N Bropirimine Chemical compound NC1=NC(O)=C(Br)C(C=2C=CC=CC=2)=N1 CIUUIPMOFZIWIZ-UHFFFAOYSA-N 0.000 description 1
• 208000011691 Burkitt lymphomas Diseases 0.000 description 1
• COVZYZSDYWQREU-UHFFFAOYSA-N Busulfan Chemical compound CS(=O)(=O)OCCCCOS(C)(=O)=O COVZYZSDYWQREU-UHFFFAOYSA-N 0.000 description 1
• 102100023703 C-C motif chemokine 15 Human genes 0.000 description 1
• 102100023701 C-C motif chemokine 18 Human genes 0.000 description 1
• 102100036842 C-C motif chemokine 19 Human genes 0.000 description 1
• 101710112622 C-C motif chemokine 19 Proteins 0.000 description 1
• 101710155857 C-C motif chemokine 2 Proteins 0.000 description 1
• 102100036848 C-C motif chemokine 20 Human genes 0.000 description 1
• 102100036846 C-C motif chemokine 21 Human genes 0.000 description 1
• 102100036849 C-C motif chemokine 24 Human genes 0.000 description 1
• 101710112540 C-C motif chemokine 25 Proteins 0.000 description 1
• 102100021935 C-C motif chemokine 26 Human genes 0.000 description 1
• 101710112538 C-C motif chemokine 27 Proteins 0.000 description 1
• 102100031102 C-C motif chemokine 4 Human genes 0.000 description 1
• 101710155834 C-C motif chemokine 7 Proteins 0.000 description 1
• 101710155833 C-C motif chemokine 8 Proteins 0.000 description 1
• 102100025279 C-X-C motif chemokine 11 Human genes 0.000 description 1
• 101710098272 C-X-C motif chemokine 11 Proteins 0.000 description 1
• 101710098309 C-X-C motif chemokine 13 Proteins 0.000 description 1
• 102100039396 C-X-C motif chemokine 16 Human genes 0.000 description 1
• 101710085495 C-X-C motif chemokine 5 Proteins 0.000 description 1
• 101710085504 C-X-C motif chemokine 6 Proteins 0.000 description 1
• 101710085500 C-X-C motif chemokine 9 Proteins 0.000 description 1
• 102000002086 C-type lectin-like Human genes 0.000 description 1
• 108050009406 C-type lectin-like Proteins 0.000 description 1
• 238000011740 C57BL/6 mouse Methods 0.000 description 1
• 101710134031 CCAAT/enhancer-binding protein beta Proteins 0.000 description 1
• 108700013048 CCL2 Proteins 0.000 description 1
• 101710137351 CCN family member 3 Proteins 0.000 description 1
• 101710164718 CD166 antigen Proteins 0.000 description 1
• 108010029697 CD40 Ligand Proteins 0.000 description 1
• 101150013553 CD40 gene Proteins 0.000 description 1
• 102100032937 CD40 ligand Human genes 0.000 description 1
• 108091016585 CD44 antigen Proteins 0.000 description 1
• 210000001266 CD8-positive T-lymphocyte Anatomy 0.000 description 1
• 101150004010 CXCR3 gene Proteins 0.000 description 1
• FVLVBPDQNARYJU-XAHDHGMMSA-N C[C@H]1CCC(CC1)NC(=O)N(CCCl)N=O Chemical compound C[C@H]1CCC(CC1)NC(=O)N(CCCl)N=O FVLVBPDQNARYJU-XAHDHGMMSA-N 0.000 description 1
• 102000000905 Cadherin Human genes 0.000 description 1
• 108050007957 Cadherin Proteins 0.000 description 1
• 101100436100 Caenorhabditis elegans asp-6 gene Proteins 0.000 description 1
• UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
• 102100025570 Cancer/testis antigen 1 Human genes 0.000 description 1
• 102100039510 Cancer/testis antigen 2 Human genes 0.000 description 1
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
• 190000008236 Carboplatin Chemical compound 0.000 description 1
• 108010022366 Carcinoembryonic Antigen Proteins 0.000 description 1
• 102100024533 Carcinoembryonic antigen-related cell adhesion molecule 1 Human genes 0.000 description 1
• DLGOEMSEDOSKAD-UHFFFAOYSA-N Carmustine Chemical compound ClCCNC(=O)N(N=O)CCCl DLGOEMSEDOSKAD-UHFFFAOYSA-N 0.000 description 1
• 102400001321 Cathepsin L Human genes 0.000 description 1
• 108090000624 Cathepsin L Proteins 0.000 description 1
• 102100037182 Cation-independent mannose-6-phosphate receptor Human genes 0.000 description 1
• 101710145225 Cation-independent mannose-6-phosphate receptor Proteins 0.000 description 1
• 102100023441 Centromere protein J Human genes 0.000 description 1
• 108010082548 Chemokine CCL11 Proteins 0.000 description 1
• 108010083702 Chemokine CCL21 Proteins 0.000 description 1
• 108010083701 Chemokine CCL22 Proteins 0.000 description 1
• 108010083647 Chemokine CCL24 Proteins 0.000 description 1
• 108010083698 Chemokine CCL26 Proteins 0.000 description 1
• 108010055166 Chemokine CCL5 Proteins 0.000 description 1
• 108010055124 Chemokine CCL7 Proteins 0.000 description 1
• 108010055204 Chemokine CCL8 Proteins 0.000 description 1
• 108010008951 Chemokine CXCL12 Proteins 0.000 description 1
• 108010014423 Chemokine CXCL6 Proteins 0.000 description 1
• JWBOIMRXGHLCPP-UHFFFAOYSA-N Chloditan Chemical compound C=1C=CC=C(Cl)C=1C(C(Cl)Cl)C1=CC=C(Cl)C=C1 JWBOIMRXGHLCPP-UHFFFAOYSA-N 0.000 description 1
• 102000009016 Cholera Toxin Human genes 0.000 description 1
• 108010049048 Cholera Toxin Proteins 0.000 description 1
• 108010062540 Chorionic Gonadotropin Proteins 0.000 description 1
• 102000011022 Chorionic Gonadotropin Human genes 0.000 description 1
• 241000789822 Chryseomicrobium Species 0.000 description 1
• 241001295415 Chryseomicrobium imtechense Species 0.000 description 1
• 241000588919 Citrobacter freundii Species 0.000 description 1
• PPASFTRHCXASPY-UHFFFAOYSA-N Cl.Cl.NCCCNc1ccc2c3c(nn2CCNCCO)c4c(O)ccc(O)c4C(=O)c13 Chemical compound Cl.Cl.NCCCNc1ccc2c3c(nn2CCNCCO)c4c(O)ccc(O)c4C(=O)c13 PPASFTRHCXASPY-UHFFFAOYSA-N 0.000 description 1
• PTOAARAWEBMLNO-KVQBGUIXSA-N Cladribine Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)O1 PTOAARAWEBMLNO-KVQBGUIXSA-N 0.000 description 1
• 101100018293 Clostridioides difficile pflE gene Proteins 0.000 description 1
• 241000193403 Clostridium Species 0.000 description 1
• 102000003780 Clusterin Human genes 0.000 description 1
• 108090000197 Clusterin Proteins 0.000 description 1
• 108050005238 Collagenase 3 Proteins 0.000 description 1
• 108010078546 Complement C5a Proteins 0.000 description 1
• 102000003706 Complement factor D Human genes 0.000 description 1
• 108090000059 Complement factor D Proteins 0.000 description 1
• 241000186308 Corynebacterium stationis Species 0.000 description 1
• 241000186244 Corynebacterium variabile Species 0.000 description 1
• CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 1
• 102000012192 Cystatin C Human genes 0.000 description 1
• 108010061642 Cystatin C Proteins 0.000 description 1
• UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 description 1
• 102000005754 Cytokine Receptor gp130 Human genes 0.000 description 1
• 108010006197 Cytokine Receptor gp130 Proteins 0.000 description 1
• 101710199286 Cytosol aminopeptidase Proteins 0.000 description 1
• SPKNARKFCOPTSY-UHFFFAOYSA-N D-asperlin Natural products CC1OC1C1C(OC(C)=O)C=CC(=O)O1 SPKNARKFCOPTSY-UHFFFAOYSA-N 0.000 description 1
• WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
• 230000004544 DNA amplification Effects 0.000 description 1
• 108010092160 Dactinomycin Proteins 0.000 description 1
• 101100481408 Danio rerio tie2 gene Proteins 0.000 description 1
• 108090000738 Decorin Proteins 0.000 description 1
• 241000192093 Deinococcus Species 0.000 description 1
• 101710112750 Delta-like protein 1 Proteins 0.000 description 1
• 241001508502 Dermabacter Species 0.000 description 1
• 208000008334 Dermatofibrosarcoma Diseases 0.000 description 1
• 206010057070 Dermatofibrosarcoma protuberans Diseases 0.000 description 1
• 241000205646 Devosia Species 0.000 description 1
• 229920002307 Dextran Polymers 0.000 description 1
• 241001524109 Dietzia Species 0.000 description 1
• MWWSFMDVAYGXBV-RUELKSSGSA-N Doxorubicin hydrochloride Chemical compound Cl.O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 MWWSFMDVAYGXBV-RUELKSSGSA-N 0.000 description 1
• ZQZFYGIXNQKOAV-OCEACIFDSA-N Droloxifene Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=C(O)C=CC=1)\C1=CC=C(OCCN(C)C)C=C1 ZQZFYGIXNQKOAV-OCEACIFDSA-N 0.000 description 1
• 206010062805 Dysplastic naevus Diseases 0.000 description 1
• 101710197780 E3 ubiquitin-protein ligase LAP Proteins 0.000 description 1
• 102000001301 EGF receptor Human genes 0.000 description 1
• 108060006698 EGF receptor Proteins 0.000 description 1
• 241000588878 Eikenella corrodens Species 0.000 description 1
• 102100023795 Elafin Human genes 0.000 description 1
• 208000001976 Endocrine Gland Neoplasms Diseases 0.000 description 1
• 102100037241 Endoglin Human genes 0.000 description 1
• 108010036395 Endoglin Proteins 0.000 description 1
• 206010014733 Endometrial cancer Diseases 0.000 description 1
• 206010014759 Endometrial neoplasm Diseases 0.000 description 1
• 241001552883 Enhydrobacter Species 0.000 description 1
• NBEALWAVEGMZQY-UHFFFAOYSA-N Enpromate Chemical compound C=1C=CC=CC=1C(C#C)(C=1C=CC=CC=1)OC(=O)NC1CCCCC1 NBEALWAVEGMZQY-UHFFFAOYSA-N 0.000 description 1
• 241000588921 Enterobacteriaceae Species 0.000 description 1
• 241000194033 Enterococcus Species 0.000 description 1
• 241000194030 Enterococcus gallinarum Species 0.000 description 1
• 102000004190 Enzymes Human genes 0.000 description 1
• 108090000790 Enzymes Proteins 0.000 description 1
• 206010014950 Eosinophilia Diseases 0.000 description 1
• 101800003838 Epidermal growth factor Proteins 0.000 description 1
• 241000368135 Erythrobacteraceae Species 0.000 description 1
• 241000588722 Escherichia Species 0.000 description 1
• 241000670472 Exiguobacterium mexicanum Species 0.000 description 1
• 241000952638 Exiguobacterium profundum Species 0.000 description 1
• 102000018700 F-Box Proteins Human genes 0.000 description 1
• 108010066805 F-Box Proteins Proteins 0.000 description 1
• 241000605980 Faecalibacterium prausnitzii Species 0.000 description 1
• 102000030914 Fatty Acid-Binding Human genes 0.000 description 1
• 102100026748 Fatty acid-binding protein, intestinal Human genes 0.000 description 1
• 101710153349 Fibroblast growth factor 19 Proteins 0.000 description 1
• 102000003974 Fibroblast growth factor 2 Human genes 0.000 description 1
• 102100024785 Fibroblast growth factor 2 Human genes 0.000 description 1
• 102100028043 Fibroblast growth factor 3 Human genes 0.000 description 1
• 102000003972 Fibroblast growth factor 7 Human genes 0.000 description 1
• 102100028071 Fibroblast growth factor 7 Human genes 0.000 description 1
• 201000008808 Fibrosarcoma Diseases 0.000 description 1
• 108010040721 Flagellin Proteins 0.000 description 1
• 241001141128 Flavobacteriales Species 0.000 description 1
• GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 1
• 108050001931 Folate receptor alpha Proteins 0.000 description 1
• 102000012673 Follicle Stimulating Hormone Human genes 0.000 description 1
• 108010079345 Follicle Stimulating Hormone Proteins 0.000 description 1
• 102000016970 Follistatin Human genes 0.000 description 1
• 108010014612 Follistatin Proteins 0.000 description 1
• 108090001126 Furin Proteins 0.000 description 1
• 102100035233 Furin Human genes 0.000 description 1
• 241000605986 Fusobacterium nucleatum Species 0.000 description 1
• 101710142641 G-protein coupled receptor-associated sorting protein 1 Proteins 0.000 description 1
• 101710142639 G-protein coupled receptor-associated sorting protein 2 Proteins 0.000 description 1
• 102000040452 GAGE family Human genes 0.000 description 1
• 108091072337 GAGE family Proteins 0.000 description 1
• 102100039788 GTPase NRas Human genes 0.000 description 1
• 108010001517 Galectin 3 Proteins 0.000 description 1
• 102100039558 Galectin-3 Human genes 0.000 description 1
• 102000044465 Galectin-7 Human genes 0.000 description 1
• 102100028652 Gamma-enolase Human genes 0.000 description 1
• 101710115997 Gamma-tubulin complex component 2 Proteins 0.000 description 1
• 241001674568 Georgenia Species 0.000 description 1
• 208000021309 Germ cell tumor Diseases 0.000 description 1
• 201000010915 Glioblastoma multiforme Diseases 0.000 description 1
• 201000005618 Glomus Tumor Diseases 0.000 description 1
• 241000201858 Granulicatella adiacens Species 0.000 description 1
• 102100039619 Granulocyte colony-stimulating factor Human genes 0.000 description 1
• 108010051696 Growth Hormone Proteins 0.000 description 1
• 102000006354 HLA-DR Antigens Human genes 0.000 description 1
• 108010058597 HLA-DR Antigens Proteins 0.000 description 1
• 101100406392 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) omp26 gene Proteins 0.000 description 1
• 206010019043 Hair follicle tumour benign Diseases 0.000 description 1
• 102000008055 Heparan Sulfate Proteoglycans Human genes 0.000 description 1
• 229920002971 Heparan sulfate Polymers 0.000 description 1
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
• 206010073069 Hepatic cancer Diseases 0.000 description 1
• 108090000100 Hepatocyte Growth Factor Proteins 0.000 description 1
• 208000021519 Hodgkin lymphoma Diseases 0.000 description 1
• 208000010747 Hodgkins lymphoma Diseases 0.000 description 1
• 241000282412 Homo Species 0.000 description 1
• 101000718243 Homo sapiens Adhesion G protein-coupled receptor E5 Proteins 0.000 description 1
• 101000693076 Homo sapiens Angiopoietin-related protein 4 Proteins 0.000 description 1
• 101000874316 Homo sapiens B melanoma antigen 1 Proteins 0.000 description 1
• 101000935638 Homo sapiens Basal cell adhesion molecule Proteins 0.000 description 1
• 101000766294 Homo sapiens Branched-chain-amino-acid aminotransferase, mitochondrial Proteins 0.000 description 1
• 101000934870 Homo sapiens Breast cancer type 1 susceptibility protein Proteins 0.000 description 1
• 101000978376 Homo sapiens C-C motif chemokine 15 Proteins 0.000 description 1
• 101000713099 Homo sapiens C-C motif chemokine 20 Proteins 0.000 description 1
• 101000897494 Homo sapiens C-C motif chemokine 27 Proteins 0.000 description 1
• 101000777471 Homo sapiens C-C motif chemokine 4 Proteins 0.000 description 1
• 101000797762 Homo sapiens C-C motif chemokine 5 Proteins 0.000 description 1
• 101000889133 Homo sapiens C-X-C motif chemokine 16 Proteins 0.000 description 1
• 101000947186 Homo sapiens C-X-C motif chemokine 5 Proteins 0.000 description 1
• 101000947172 Homo sapiens C-X-C motif chemokine 9 Proteins 0.000 description 1
• 101000856237 Homo sapiens Cancer/testis antigen 1 Proteins 0.000 description 1
• 101000889345 Homo sapiens Cancer/testis antigen 2 Proteins 0.000 description 1
• 101000981093 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 1 Proteins 0.000 description 1
• 101000928537 Homo sapiens Delta-like protein 1 Proteins 0.000 description 1
• 101001048718 Homo sapiens Elafin Proteins 0.000 description 1
• 101000911337 Homo sapiens Fatty acid-binding protein, intestinal Proteins 0.000 description 1
• 101000846394 Homo sapiens Fibroblast growth factor 19 Proteins 0.000 description 1
• 101001023230 Homo sapiens Folate receptor alpha Proteins 0.000 description 1
• 101000744505 Homo sapiens GTPase NRas Proteins 0.000 description 1
• 101000608772 Homo sapiens Galectin-7 Proteins 0.000 description 1
• 101000746367 Homo sapiens Granulocyte colony-stimulating factor Proteins 0.000 description 1
• 101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 description 1
• 101001076292 Homo sapiens Insulin-like growth factor II Proteins 0.000 description 1
• 101001053423 Homo sapiens Integrator complex subunit 11 Proteins 0.000 description 1
• 101001076407 Homo sapiens Interleukin-1 receptor antagonist protein Proteins 0.000 description 1
• 101001091232 Homo sapiens Kinesin-like protein KIF18B Proteins 0.000 description 1
• 101001018097 Homo sapiens L-selectin Proteins 0.000 description 1
• 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 description 1
• 101000716481 Homo sapiens Lysosome membrane protein 2 Proteins 0.000 description 1
• 101000991061 Homo sapiens MHC class I polypeptide-related sequence B Proteins 0.000 description 1
• 101000669513 Homo sapiens Metalloproteinase inhibitor 1 Proteins 0.000 description 1
• 101000645296 Homo sapiens Metalloproteinase inhibitor 2 Proteins 0.000 description 1
• 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 description 1
• 101000623900 Homo sapiens Mucin-13 Proteins 0.000 description 1
• 101000972284 Homo sapiens Mucin-3A Proteins 0.000 description 1
• 101000972286 Homo sapiens Mucin-4 Proteins 0.000 description 1
• 101000978766 Homo sapiens Neurogenic locus notch homolog protein 1 Proteins 0.000 description 1
• 101000973997 Homo sapiens Nucleosome assembly protein 1-like 4 Proteins 0.000 description 1
• 101001098352 Homo sapiens OX-2 membrane glycoprotein Proteins 0.000 description 1
• 101001001487 Homo sapiens Phosphatidylinositol-glycan biosynthesis class F protein Proteins 0.000 description 1
• 101000595923 Homo sapiens Placenta growth factor Proteins 0.000 description 1
• 101000947178 Homo sapiens Platelet basic protein Proteins 0.000 description 1
• 101000617725 Homo sapiens Pregnancy-specific beta-1-glycoprotein 2 Proteins 0.000 description 1
• 101000684208 Homo sapiens Prolyl endopeptidase FAP Proteins 0.000 description 1
• 101000668165 Homo sapiens RNA-binding motif, single-stranded-interacting protein 1 Proteins 0.000 description 1
• 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 description 1
• 101000665882 Homo sapiens Retinol-binding protein 4 Proteins 0.000 description 1
• 101001094545 Homo sapiens Retrotransposon-like protein 1 Proteins 0.000 description 1
• 101000711796 Homo sapiens Sclerostin Proteins 0.000 description 1
• 101000984753 Homo sapiens Serine/threonine-protein kinase B-raf Proteins 0.000 description 1
• 101000863883 Homo sapiens Sialic acid-binding Ig-like lectin 9 Proteins 0.000 description 1
• 101000835745 Homo sapiens Teratocarcinoma-derived growth factor 1 Proteins 0.000 description 1
• 101000845170 Homo sapiens Thymic stromal lymphopoietin Proteins 0.000 description 1
• 101000831567 Homo sapiens Toll-like receptor 2 Proteins 0.000 description 1
• 101000904724 Homo sapiens Transmembrane glycoprotein NMB Proteins 0.000 description 1
• 101000795167 Homo sapiens Tumor necrosis factor receptor superfamily member 13B Proteins 0.000 description 1
• 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 description 1
• 101000597785 Homo sapiens Tumor necrosis factor receptor superfamily member 6B Proteins 0.000 description 1
• 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 description 1
• 101000851007 Homo sapiens Vascular endothelial growth factor receptor 2 Proteins 0.000 description 1
• 101000851030 Homo sapiens Vascular endothelial growth factor receptor 3 Proteins 0.000 description 1
• VSNHCAURESNICA-UHFFFAOYSA-N Hydroxyurea Chemical compound NC(=O)NO VSNHCAURESNICA-UHFFFAOYSA-N 0.000 description 1
• 206010020649 Hyperkeratosis Diseases 0.000 description 1
• 101150009416 INTS11 gene Proteins 0.000 description 1
• XDXDZDZNSLXDNA-TZNDIEGXSA-N Idarubicin Chemical compound C1[C@H](N)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2C[C@@](O)(C(C)=O)C1 XDXDZDZNSLXDNA-TZNDIEGXSA-N 0.000 description 1
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
• 102000004877 Insulin Human genes 0.000 description 1
• 108090001061 Insulin Proteins 0.000 description 1
• 102100039688 Insulin-like growth factor 1 receptor Human genes 0.000 description 1
• 101710184277 Insulin-like growth factor 1 receptor Proteins 0.000 description 1
• 102100037852 Insulin-like growth factor I Human genes 0.000 description 1
• 102100025947 Insulin-like growth factor II Human genes 0.000 description 1
• 102000004375 Insulin-like growth factor-binding protein 1 Human genes 0.000 description 1
• 108090000957 Insulin-like growth factor-binding protein 1 Proteins 0.000 description 1
• 102100024370 Integrator complex subunit 11 Human genes 0.000 description 1
• 108050002021 Integrator complex subunit 2 Proteins 0.000 description 1
• 108010054698 Interferon Alfa-n3 Proteins 0.000 description 1
• 102100037850 Interferon gamma Human genes 0.000 description 1
• 102100020989 Interferon lambda-2 Human genes 0.000 description 1
• 101710099622 Interferon lambda-2 Proteins 0.000 description 1
• 102000008070 Interferon-gamma Human genes 0.000 description 1
• 229940119178 Interleukin 1 receptor antagonist Drugs 0.000 description 1
• 102100020881 Interleukin-1 alpha Human genes 0.000 description 1
• 102000019223 Interleukin-1 receptor Human genes 0.000 description 1
• 108050006617 Interleukin-1 receptor Proteins 0.000 description 1
• 102000051628 Interleukin-1 receptor antagonist Human genes 0.000 description 1
• 102100035014 Interleukin-17 receptor B Human genes 0.000 description 1
• 101710186071 Interleukin-17 receptor B Proteins 0.000 description 1
• 102100033096 Interleukin-17D Human genes 0.000 description 1
• 108010082786 Interleukin-1alpha Proteins 0.000 description 1
• 102100030703 Interleukin-22 Human genes 0.000 description 1
• 108010065637 Interleukin-23 Proteins 0.000 description 1
• 102000013264 Interleukin-23 Human genes 0.000 description 1
• 108010066979 Interleukin-27 Proteins 0.000 description 1
• 108010002386 Interleukin-3 Proteins 0.000 description 1
• 102000015696 Interleukins Human genes 0.000 description 1
• 108010063738 Interleukins Proteins 0.000 description 1
• 101710198693 Invasin Proteins 0.000 description 1
• 108090000862 Ion Channels Proteins 0.000 description 1
• 102000004310 Ion Channels Human genes 0.000 description 1
• 241000520764 Janibacter Species 0.000 description 1
• 102100023437 Junctional adhesion molecule-like Human genes 0.000 description 1
• 239000007836 KH2PO4 Substances 0.000 description 1
• 229940126685 KRAS G12R Drugs 0.000 description 1
• 102100038298 Kallikrein-14 Human genes 0.000 description 1
• 101710115806 Kallikrein-14 Proteins 0.000 description 1
• 102100023012 Kallistatin Human genes 0.000 description 1
• 208000008839 Kidney Neoplasms Diseases 0.000 description 1
• 101150104818 Kif18b gene Proteins 0.000 description 1
• 102100034896 Kinesin-like protein KIF18B Human genes 0.000 description 1
• 102100035792 Kininogen-1 Human genes 0.000 description 1
• 101710111227 Kininogen-1 Proteins 0.000 description 1
• 241000588748 Klebsiella Species 0.000 description 1
• 241000588915 Klebsiella aerogenes Species 0.000 description 1
• 241000588749 Klebsiella oxytoca Species 0.000 description 1
• 241000588747 Klebsiella pneumoniae Species 0.000 description 1
• 241000579722 Kocuria Species 0.000 description 1
• 241000281703 Kocuria atrinae Species 0.000 description 1
• 102100039020 Kunitz-type protease inhibitor 2 Human genes 0.000 description 1
• 101710165138 Kunitz-type protease inhibitor 2 Proteins 0.000 description 1
• 108010092694 L-Selectin Proteins 0.000 description 1
• IFQSXNOEEPCSLW-DKWTVANSSA-N L-cysteine hydrochloride Chemical compound Cl.SC[C@H](N)C(O)=O IFQSXNOEEPCSLW-DKWTVANSSA-N 0.000 description 1
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
• FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
• 102000017578 LAG3 Human genes 0.000 description 1
• 108010007622 LDL Lipoproteins Proteins 0.000 description 1
• 102000007330 LDL Lipoproteins Human genes 0.000 description 1
• 241001112693 Lachnospiraceae Species 0.000 description 1
• 102000004407 Lactalbumin Human genes 0.000 description 1
• 108090000942 Lactalbumin Proteins 0.000 description 1
• 241000194036 Lactococcus Species 0.000 description 1
• 101150030213 Lag3 gene Proteins 0.000 description 1
• 235000019687 Lamb Nutrition 0.000 description 1
• 239000004166 Lanolin Chemical class 0.000 description 1
• 102000004856 Lectins Human genes 0.000 description 1
• 108090001090 Lectins Proteins 0.000 description 1
• 108010092277 Leptin Proteins 0.000 description 1
• 102000016267 Leptin Human genes 0.000 description 1
• 241001453171 Leptotrichia Species 0.000 description 1
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
• 102000004058 Leukemia inhibitory factor Human genes 0.000 description 1
• 102100032352 Leukemia inhibitory factor Human genes 0.000 description 1
• 108010000817 Leuprolide Proteins 0.000 description 1
• HLFSDGLLUJUHTE-SNVBAGLBSA-N Levamisole Chemical compound C1([C@H]2CN3CCSC3=N2)=CC=CC=C1 HLFSDGLLUJUHTE-SNVBAGLBSA-N 0.000 description 1
• 201000011062 Li-Fraumeni syndrome Diseases 0.000 description 1
• GQYIWUVLTXOXAJ-UHFFFAOYSA-N Lomustine Chemical compound ClCCN(N=O)C(=O)NC1CCCCC1 GQYIWUVLTXOXAJ-UHFFFAOYSA-N 0.000 description 1
• 241001647883 Luteimonas Species 0.000 description 1
• 102100026849 Lymphatic vessel endothelial hyaluronic acid receptor 1 Human genes 0.000 description 1
• 101710178181 Lymphatic vessel endothelial hyaluronic acid receptor 1 Proteins 0.000 description 1
• 102100020862 Lymphocyte activation gene 3 protein Human genes 0.000 description 1
• 102100035304 Lymphotactin Human genes 0.000 description 1
• 102100026238 Lymphotoxin-alpha Human genes 0.000 description 1
• 108090000542 Lymphotoxin-alpha Proteins 0.000 description 1
• 102100026894 Lymphotoxin-beta Human genes 0.000 description 1
• 108090000362 Lymphotoxin-beta Proteins 0.000 description 1
• 208000001567 Lynch Syndrome II Diseases 0.000 description 1
• 101710204480 Lysosomal acid phosphatase Proteins 0.000 description 1
• 101710165448 Lysosome membrane protein 2 Proteins 0.000 description 1
• 102100030300 MHC class I polypeptide-related sequence B Human genes 0.000 description 1
• 102000043131 MHC class II family Human genes 0.000 description 1
• 102000034655 MIF Human genes 0.000 description 1
• 108010009474 Macrophage Inflammatory Proteins Proteins 0.000 description 1
• 102000009571 Macrophage Inflammatory Proteins Human genes 0.000 description 1
• 108010048043 Macrophage Migration-Inhibitory Factors Proteins 0.000 description 1
• 102100037791 Macrophage migration inhibitory factor Human genes 0.000 description 1
• 101710167885 Major outer membrane protein P.IB Proteins 0.000 description 1
• 229910021380 Manganese Chloride Inorganic materials 0.000 description 1
• GLFNIEUTAYBVOC-UHFFFAOYSA-L Manganese chloride Chemical compound Cl[Mn]Cl GLFNIEUTAYBVOC-UHFFFAOYSA-L 0.000 description 1
• 108010087870 Mannose-Binding Lectin Proteins 0.000 description 1
• 108010090665 Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase Proteins 0.000 description 1
• 241001358049 Massilia Species 0.000 description 1
• 241000215495 Massilia timonae Species 0.000 description 1
• 108010076497 Matrix Metalloproteinase 10 Proteins 0.000 description 1
• 108010076503 Matrix Metalloproteinase 13 Proteins 0.000 description 1
• 108010016165 Matrix Metalloproteinase 2 Proteins 0.000 description 1
• 108010016160 Matrix Metalloproteinase 3 Proteins 0.000 description 1
• 229930126263 Maytansine Natural products 0.000 description 1
• 208000000172 Medulloblastoma Diseases 0.000 description 1
• 206010027145 Melanocytic naevus Diseases 0.000 description 1
• 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 description 1
• 102000012750 Membrane Glycoproteins Human genes 0.000 description 1
• 108010090054 Membrane Glycoproteins Proteins 0.000 description 1
• 102000018697 Membrane Proteins Human genes 0.000 description 1
• 108010052285 Membrane Proteins Proteins 0.000 description 1
• 102000003939 Membrane transport proteins Human genes 0.000 description 1
• 108090000301 Membrane transport proteins Proteins 0.000 description 1
• 241000253389 Methylobacteriaceae Species 0.000 description 1
• 241001535042 Methylobacterium mesophilicum Species 0.000 description 1
• 241000192017 Micrococcaceae Species 0.000 description 1
• 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
• 229930192392 Mitomycin Natural products 0.000 description 1
• HRHKSTOGXBBQCB-UHFFFAOYSA-N Mitomycin E Natural products O=C1C(N)=C(C)C(=O)C2=C1C(COC(N)=O)C1(OC)C3N(C)C3CN12 HRHKSTOGXBBQCB-UHFFFAOYSA-N 0.000 description 1
• 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 description 1
• 102100023124 Mucin-13 Human genes 0.000 description 1
• 102100022497 Mucin-3A Human genes 0.000 description 1
• 102100022693 Mucin-4 Human genes 0.000 description 1
• 208000034578 Multiple myelomas Diseases 0.000 description 1
• 101100481410 Mus musculus Tek gene Proteins 0.000 description 1
• 101000904718 Mus musculus Transmembrane glycoprotein NMB Proteins 0.000 description 1
• NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 description 1
• USVMJSALORZVDV-SDBHATRESA-N N(6)-(Delta(2)-isopentenyl)adenosine Chemical compound C1=NC=2C(NCC=C(C)C)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O USVMJSALORZVDV-SDBHATRESA-N 0.000 description 1
• 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
• PIJXCSUPSNFXNE-QRZOAFCBSA-N N-acetyl-4-(N-acetylglucosaminyl)muramoyl-L-alanyl-D-isoglutamine Chemical compound OC(=O)CC[C@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@@H]1[C@@H](NC(C)=O)[C@H](O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 PIJXCSUPSNFXNE-QRZOAFCBSA-N 0.000 description 1
• 102100030397 N-acetylmuramoyl-L-alanine amidase Human genes 0.000 description 1
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 description 1
• LYPFDBRUNKHDGX-SOGSVHMOSA-N N1C2=CC=C1\C(=C1\C=CC(=N1)\C(=C1\C=C/C(/N1)=C(/C1=N/C(/CC1)=C2/C1=CC(O)=CC=C1)C1=CC(O)=CC=C1)\C1=CC(O)=CC=C1)C1=CC(O)=CC=C1 Chemical compound N1C2=CC=C1\C(=C1\C=CC(=N1)\C(=C1\C=C/C(/N1)=C(/C1=N/C(/CC1)=C2/C1=CC(O)=CC=C1)C1=CC(O)=CC=C1)\C1=CC(O)=CC=C1)C1=CC(O)=CC=C1 LYPFDBRUNKHDGX-SOGSVHMOSA-N 0.000 description 1
• 238000005481 NMR spectroscopy Methods 0.000 description 1
• 101150031836 NRCAM gene Proteins 0.000 description 1
• 241000588656 Neisseriaceae Species 0.000 description 1
• 206010061309 Neoplasm progression Diseases 0.000 description 1
• 208000034176 Neoplasms, Germ Cell and Embryonal Diseases 0.000 description 1
• 108010032605 Nerve Growth Factor Receptors Proteins 0.000 description 1
• 108010069196 Neural Cell Adhesion Molecules Proteins 0.000 description 1
• 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 description 1
• 108050003738 Neural cell adhesion molecule 1 Proteins 0.000 description 1
• 102100023616 Neural cell adhesion molecule L1-like protein Human genes 0.000 description 1
• 108700037638 Neurogenic locus notch homolog protein 1 Proteins 0.000 description 1
• 102100021852 Neuronal cell adhesion molecule Human genes 0.000 description 1
• 101710130688 Neuronal cell adhesion molecule Proteins 0.000 description 1
• 102100030411 Neutrophil collagenase Human genes 0.000 description 1
• 101710118230 Neutrophil collagenase Proteins 0.000 description 1
• 108030001564 Neutrophil collagenases Proteins 0.000 description 1
• 102000056189 Neutrophil collagenases Human genes 0.000 description 1
• 208000007256 Nevus Diseases 0.000 description 1
• KYRVNWMVYQXFEU-UHFFFAOYSA-N Nocodazole Chemical compound C1=C2NC(NC(=O)OC)=NC2=CC=C1C(=O)C1=CC=CS1 KYRVNWMVYQXFEU-UHFFFAOYSA-N 0.000 description 1
• KGTDRFCXGRULNK-UHFFFAOYSA-N Nogalamycin Natural products COC1C(OC)(C)C(OC)C(C)OC1OC1C2=C(O)C(C(=O)C3=C(O)C=C4C5(C)OC(C(C(C5O)N(C)C)O)OC4=C3C3=O)=C3C=C2C(C(=O)OC)C(C)(O)C1 KGTDRFCXGRULNK-UHFFFAOYSA-N 0.000 description 1
• 208000015914 Non-Hodgkin lymphomas Diseases 0.000 description 1
• 101710192965 Nucleosome assembly protein 1-like 4 Proteins 0.000 description 1
• 108010079246 OMPA outer membrane proteins Proteins 0.000 description 1
• 102100037589 OX-2 membrane glycoprotein Human genes 0.000 description 1
• 241000352063 Oerskovia Species 0.000 description 1
• 108700028353 OmpC Proteins 0.000 description 1
• 102000004140 Oncostatin M Human genes 0.000 description 1
• 241000572528 Ornithinimicrobium Species 0.000 description 1
• 102100040557 Osteopontin Human genes 0.000 description 1
• 108010081689 Osteopontin Proteins 0.000 description 1
• 101710116435 Outer membrane protein Proteins 0.000 description 1
• 241001277521 Oxalobacteraceae Species 0.000 description 1
• 101710199789 Oxidized low-density lipoprotein receptor 1 Proteins 0.000 description 1
• 108091007960 PI3Ks Proteins 0.000 description 1
• 229910019142 PO4 Inorganic materials 0.000 description 1
• 241000157908 Paenarthrobacter aurescens Species 0.000 description 1
• 208000031463 Palmoplantar Diffuse Keratoderma Diseases 0.000 description 1
• 241001057811 Paracoccus <mealybug> Species 0.000 description 1
• 241001478310 Paracoccus aminovorans Species 0.000 description 1
• 241001068919 Paracoccus chinensis Species 0.000 description 1
• 206010061332 Paraganglion neoplasm Diseases 0.000 description 1
• 108010057150 Peplomycin Proteins 0.000 description 1
• 108010047320 Pepsinogen A Proteins 0.000 description 1
• 239000001888 Peptone Substances 0.000 description 1
• 108010080698 Peptones Proteins 0.000 description 1
• 102000012288 Phosphopyruvate Hydratase Human genes 0.000 description 1
• 108010022181 Phosphopyruvate Hydratase Proteins 0.000 description 1
• 241000914635 Phylus Species 0.000 description 1
• 208000009077 Pigmented Nevus Diseases 0.000 description 1
• 208000007913 Pituitary Neoplasms Diseases 0.000 description 1
• 102100035194 Placenta growth factor Human genes 0.000 description 1
• 108010069381 Platelet Endothelial Cell Adhesion Molecule-1 Proteins 0.000 description 1
• 101710204736 Platelet endothelial cell adhesion molecule Proteins 0.000 description 1
• 108090000778 Platelet factor 4 Proteins 0.000 description 1
• 102100026547 Platelet-derived growth factor receptor beta Human genes 0.000 description 1
• 101710164680 Platelet-derived growth factor receptor beta Proteins 0.000 description 1
• 102100040990 Platelet-derived growth factor subunit B Human genes 0.000 description 1
• 101710103494 Platelet-derived growth factor subunit B Proteins 0.000 description 1
• 241000566598 Podomys floridanus Species 0.000 description 1
• RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
• HFVNWDWLWUCIHC-GUPDPFMOSA-N Prednimustine Chemical compound O=C([C@@]1(O)CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)[C@@H](O)C[C@@]21C)COC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 HFVNWDWLWUCIHC-GUPDPFMOSA-N 0.000 description 1
• 241001135223 Prevotella melaninogenica Species 0.000 description 1
• 101710089118 Probable cytosol aminopeptidase Proteins 0.000 description 1
• 108010048233 Procalcitonin Proteins 0.000 description 1
• 102000003946 Prolactin Human genes 0.000 description 1
• 108010057464 Prolactin Proteins 0.000 description 1
• 102000016971 Proto-Oncogene Proteins c-kit Human genes 0.000 description 1
• 108010014608 Proto-Oncogene Proteins c-kit Proteins 0.000 description 1
• 102000008022 Proto-Oncogene Proteins c-met Human genes 0.000 description 1
• 108010089836 Proto-Oncogene Proteins c-met Proteins 0.000 description 1
• 102100032350 Protransforming growth factor alpha Human genes 0.000 description 1
• 241000947836 Pseudomonadaceae Species 0.000 description 1
• 241000857755 Pseudomonas argentinensis Species 0.000 description 1
• 241000948631 Pseudomonas baetica Species 0.000 description 1
• 241000589755 Pseudomonas mendocina Species 0.000 description 1
• 241000588671 Psychrobacter Species 0.000 description 1
• XESARGFCSKSFID-UHFFFAOYSA-N Pyrazofurin Natural products OC1=C(C(=O)N)NN=C1C1C(O)C(O)C(CO)O1 XESARGFCSKSFID-UHFFFAOYSA-N 0.000 description 1
• 102000014128 RANK Ligand Human genes 0.000 description 1
• 108010025832 RANK Ligand Proteins 0.000 description 1
• 241001513398 Ralstonia mannitolilytica Species 0.000 description 1
• 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 description 1
• 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 description 1
• 102100029986 Receptor tyrosine-protein kinase erbB-3 Human genes 0.000 description 1
• 102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 description 1
• 208000015634 Rectal Neoplasms Diseases 0.000 description 1
• 206010038389 Renal cancer Diseases 0.000 description 1
• 208000006265 Renal cell carcinoma Diseases 0.000 description 1
• LCQMZZCPPSWADO-UHFFFAOYSA-N Reserpilin Natural products COC(=O)C1COCC2CN3CCc4c([nH]c5cc(OC)c(OC)cc45)C3CC12 LCQMZZCPPSWADO-UHFFFAOYSA-N 0.000 description 1
• QEVHRUUCFGRFIF-SFWBKIHZSA-N Reserpine Natural products O=C(OC)[C@@H]1[C@H](OC)[C@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)C[C@H]2[C@@H]1C[C@H]1N(C2)CCc2c3c([nH]c12)cc(OC)cc3 QEVHRUUCFGRFIF-SFWBKIHZSA-N 0.000 description 1
• 102100024735 Resistin Human genes 0.000 description 1
• 108010047909 Resistin Proteins 0.000 description 1
• 201000000582 Retinoblastoma Diseases 0.000 description 1
• 102100033914 Retinoic acid receptor responder protein 2 Human genes 0.000 description 1
• 101710170513 Retinoic acid receptor responder protein 2 Proteins 0.000 description 1
• 101710137011 Retinol-binding protein 4 Proteins 0.000 description 1
• 208000008938 Rhabdoid tumor Diseases 0.000 description 1
• 241001430267 Rhodobacteraceae Species 0.000 description 1
• 241000187561 Rhodococcus erythropolis Species 0.000 description 1
• 241001185316 Rhodospirillales Species 0.000 description 1
• 241000572738 Roseomonas Species 0.000 description 1
• 239000006146 Roswell Park Memorial Institute medium Substances 0.000 description 1
• 241000095588 Ruminococcaceae Species 0.000 description 1
• 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
• 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 1
• 241000235342 Saccharomycetes Species 0.000 description 1
• 101100406813 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) pagC gene Proteins 0.000 description 1
• 101100311026 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) ssaV gene Proteins 0.000 description 1
• 102100034201 Sclerostin Human genes 0.000 description 1
• 102100030054 Secreted frizzled-related protein 2 Human genes 0.000 description 1
• 108050007987 Secreted frizzled-related protein 2 Proteins 0.000 description 1
• 108050007990 Secreted frizzled-related protein 3 Proteins 0.000 description 1
• 102000012152 Securin Human genes 0.000 description 1
• 108010061477 Securin Proteins 0.000 description 1
• 102100034801 Serine protease hepsin Human genes 0.000 description 1
• 101710111478 Serine protease hepsin Proteins 0.000 description 1
• 102100027103 Serine/threonine-protein kinase B-raf Human genes 0.000 description 1
• 241001388028 Shewanella decolorationis Species 0.000 description 1
• 241000607768 Shigella Species 0.000 description 1
• 102100029957 Sialic acid-binding Ig-like lectin 5 Human genes 0.000 description 1
• 101710110535 Sialic acid-binding Ig-like lectin 5 Proteins 0.000 description 1
• 101710110541 Sialic acid-binding Ig-like lectin 9 Proteins 0.000 description 1
• VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
• 208000021712 Soft tissue sarcoma Diseases 0.000 description 1
• 240000002825 Solanum vestissimum Species 0.000 description 1
• 102100038803 Somatotropin Human genes 0.000 description 1
• 102400000673 Sonic hedgehog protein N-product Human genes 0.000 description 1
• 101800001400 Sonic hedgehog protein N-product Proteins 0.000 description 1
• 241001185305 Sphingomonadales Species 0.000 description 1
• 241001411857 Sphingomonas desiccabilis Species 0.000 description 1
• 241001220764 Sphingomonas yunnanensis Species 0.000 description 1
• 241000589970 Spirochaetales Species 0.000 description 1
• 241000295644 Staphylococcaceae Species 0.000 description 1
• 241001147698 Staphylococcus cohnii Species 0.000 description 1
• 241000193817 Staphylococcus pasteuri Species 0.000 description 1
• 241000192086 Staphylococcus warneri Species 0.000 description 1
• 229920002472 Starch Polymers 0.000 description 1
• 241000194018 Streptococcaceae Species 0.000 description 1
• 241000194008 Streptococcus anginosus Species 0.000 description 1
• 241000194025 Streptococcus oralis Species 0.000 description 1
• 241000194023 Streptococcus sanguinis Species 0.000 description 1
• 101710108790 Stromelysin-1 Proteins 0.000 description 1
• 101710108792 Stromelysin-2 Proteins 0.000 description 1
• 102000003705 Syndecan-1 Human genes 0.000 description 1
• 108090000058 Syndecan-1 Proteins 0.000 description 1
• 108090000054 Syndecan-2 Proteins 0.000 description 1
• 230000024932 T cell mediated immunity Effects 0.000 description 1
• 108091008874 T cell receptors Proteins 0.000 description 1
• 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 1
• 208000029052 T-cell acute lymphoblastic leukemia Diseases 0.000 description 1
• 108010000449 TNF-Related Apoptosis-Inducing Ligand Receptors Proteins 0.000 description 1
• 102000002259 TNF-Related Apoptosis-Inducing Ligand Receptors Human genes 0.000 description 1
• 108091007178 TNFRSF10A Proteins 0.000 description 1
• 102100026404 Teratocarcinoma-derived growth factor 1 Human genes 0.000 description 1
• 241000846120 Terribacillus Species 0.000 description 1
• 208000024313 Testicular Neoplasms Diseases 0.000 description 1
• 206010057644 Testis cancer Diseases 0.000 description 1
• BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 1
• FOCVUCIESVLUNU-UHFFFAOYSA-N Thiotepa Chemical compound C1CN1P(N1CC1)(=S)N1CC1 FOCVUCIESVLUNU-UHFFFAOYSA-N 0.000 description 1
• 102100026966 Thrombomodulin Human genes 0.000 description 1
• 108010079274 Thrombomodulin Proteins 0.000 description 1
• 102000036693 Thrombopoietin Human genes 0.000 description 1
• 108010041111 Thrombopoietin Proteins 0.000 description 1
• 102100034195 Thrombopoietin Human genes 0.000 description 1
• 102000006601 Thymidine Kinase Human genes 0.000 description 1
• 108020004440 Thymidine kinase Proteins 0.000 description 1
• 102000009843 Thyroglobulin Human genes 0.000 description 1
• 108010034949 Thyroglobulin Proteins 0.000 description 1
• 108010031374 Tissue Inhibitor of Metalloproteinase-1 Proteins 0.000 description 1
• 108010031372 Tissue Inhibitor of Metalloproteinase-2 Proteins 0.000 description 1
• 108010060888 Toll-like receptor 2 Proteins 0.000 description 1
• IWEQQRMGNVVKQW-OQKDUQJOSA-N Toremifene citrate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C1=CC(OCCN(C)C)=CC=C1C(\C=1C=CC=CC=1)=C(\CCCl)C1=CC=CC=C1 IWEQQRMGNVVKQW-OQKDUQJOSA-N 0.000 description 1
• 102000004338 Transferrin Human genes 0.000 description 1
• 108090000901 Transferrin Proteins 0.000 description 1
• 102000006747 Transforming Growth Factor alpha Human genes 0.000 description 1
• 102000011117 Transforming Growth Factor beta2 Human genes 0.000 description 1
• 101800000304 Transforming growth factor beta-2 Proteins 0.000 description 1
• 108060008539 Transglutaminase Proteins 0.000 description 1
• 102100023935 Transmembrane glycoprotein NMB Human genes 0.000 description 1
• 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 description 1
• 108010050144 Triptorelin Pamoate Proteins 0.000 description 1
• 108010065729 Troponin I Proteins 0.000 description 1
• 102000013394 Troponin I Human genes 0.000 description 1
• 241000460694 Trueperella Species 0.000 description 1
• 108010065323 Tumor Necrosis Factor Ligand Superfamily Member 13 Proteins 0.000 description 1
• 108010078814 Tumor Suppressor Protein p53 Proteins 0.000 description 1
• 102100024585 Tumor necrosis factor ligand superfamily member 13 Human genes 0.000 description 1
• 108050002568 Tumor necrosis factor ligand superfamily member 6 Proteins 0.000 description 1
• 102100040113 Tumor necrosis factor receptor superfamily member 10A Human genes 0.000 description 1
• 102100040110 Tumor necrosis factor receptor superfamily member 10D Human genes 0.000 description 1
• 101710178277 Tumor necrosis factor receptor superfamily member 10D Proteins 0.000 description 1
• 101710178302 Tumor necrosis factor receptor superfamily member 13B Proteins 0.000 description 1
• 101710187780 Tumor necrosis factor receptor superfamily member 14 Proteins 0.000 description 1
• 102100033725 Tumor necrosis factor receptor superfamily member 16 Human genes 0.000 description 1
• 101710187885 Tumor necrosis factor receptor superfamily member 17 Proteins 0.000 description 1
• 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 description 1
• 101710187751 Tumor necrosis factor receptor superfamily member 21 Proteins 0.000 description 1
• 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 description 1
• 101710187622 Tumor necrosis factor receptor superfamily member 6B Proteins 0.000 description 1
• 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 description 1
• 102000003425 Tyrosinase Human genes 0.000 description 1
• 108060008724 Tyrosinase Proteins 0.000 description 1
• 102100037236 Tyrosine-protein kinase receptor UFO Human genes 0.000 description 1
• 101710192735 Tyrosine-protein kinase receptor UFO Proteins 0.000 description 1
• VGQOVCHZGQWAOI-UHFFFAOYSA-N UNPD55612 Natural products N1C(O)C2CC(C=CC(N)=O)=CN2C(=O)C2=CC=C(C)C(O)=C12 VGQOVCHZGQWAOI-UHFFFAOYSA-N 0.000 description 1
• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
• 108010000134 Vascular Cell Adhesion Molecule-1 Proteins 0.000 description 1
• 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 description 1
• 108010073919 Vascular Endothelial Growth Factor D Proteins 0.000 description 1
• 108010053099 Vascular Endothelial Growth Factor Receptor-2 Proteins 0.000 description 1
• 108010053100 Vascular Endothelial Growth Factor Receptor-3 Proteins 0.000 description 1
• 101710160666 Vascular cell adhesion protein 1 Proteins 0.000 description 1
• 102100038234 Vascular endothelial growth factor D Human genes 0.000 description 1
• 241001148135 Veillonella parvula Species 0.000 description 1
• JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 description 1
• FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Chemical class OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
• 102100020722 WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 Human genes 0.000 description 1
• 101710160039 WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 Proteins 0.000 description 1
• 102100036021 WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 Human genes 0.000 description 1
• 101710160038 WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 Proteins 0.000 description 1
• 241000709812 Wautersiella Species 0.000 description 1
• 101100056949 Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) ansA gene Proteins 0.000 description 1
• 241000567083 Xanthomonas arboricola Species 0.000 description 1
• VUPBDWQPEOWRQP-RTUCOMKBSA-N [(2R,3S,4S,5R,6R)-2-[(2R,3S,4S,5S,6S)-2-[(1S,2S)-3-[[(2R,3S)-5-[[(2S,3R)-1-[[2-[4-[4-[[4-amino-6-[3-(4-aminobutylamino)propylamino]-6-oxohexyl]carbamoyl]-1,3-thiazol-2-yl]-1,3-thiazol-2-yl]-1-[(2S,3R,4R,5S,6S)-5-amino-3,4-dihydroxy-6-methyloxan-2-yl]oxy-2-hydroxyethyl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-hydroxy-5-oxopentan-2-yl]amino]-2-[[6-amino-2-[(1S)-3-amino-1-[[(2S)-2,3-diamino-3-oxopropyl]amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-1-(1H-imidazol-5-yl)-3-oxopropoxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl] carbamate Chemical compound C[C@@H](O)[C@H](NC(=O)C[C@H](O)[C@@H](C)NC(=O)[C@@H](NC(=O)c1nc(nc(N)c1C)[C@H](CC(N)=O)NC[C@H](N)C(N)=O)[C@H](O[C@@H]1O[C@@H](CO)[C@@H](O)[C@H](O)[C@@H]1O[C@H]1O[C@H](CO)[C@@H](O)[C@H](OC(N)=O)[C@@H]1O)c1cnc[nH]1)C(=O)NC(O[C@@H]1O[C@@H](C)[C@@H](N)[C@@H](O)[C@H]1O)C(O)c1nc(cs1)-c1nc(cs1)C(=O)NCCCC(N)CC(=O)NCCCNCCCCN VUPBDWQPEOWRQP-RTUCOMKBSA-N 0.000 description 1
• SPKNARKFCOPTSY-XWPZMVOTSA-N [(2r,3s)-2-[(2s,3r)-3-methyloxiran-2-yl]-6-oxo-2,3-dihydropyran-3-yl] acetate Chemical compound C[C@H]1O[C@@H]1[C@H]1[C@@H](OC(C)=O)C=CC(=O)O1 SPKNARKFCOPTSY-XWPZMVOTSA-N 0.000 description 1
• IVCRCPJOLWECJU-XQVQQVTHSA-N [(7r,8r,9s,10r,13s,14s,17s)-7,13-dimethyl-3-oxo-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-17-yl] acetate Chemical compound C1C[C@]2(C)[C@@H](OC(C)=O)CC[C@H]2[C@@H]2[C@H](C)CC3=CC(=O)CC[C@@H]3[C@H]21 IVCRCPJOLWECJU-XQVQQVTHSA-N 0.000 description 1
• KMLCRELJHYKIIL-UHFFFAOYSA-N [1-(azanidylmethyl)cyclohexyl]methylazanide;platinum(2+);sulfuric acid Chemical compound [Pt+2].OS(O)(=O)=O.[NH-]CC1(C[NH-])CCCCC1 KMLCRELJHYKIIL-UHFFFAOYSA-N 0.000 description 1
• ODEDPKNSRBCSDO-UHFFFAOYSA-N [2-(hexadecylsulfanylmethyl)-3-methoxypropyl] 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CCCCCCCCCCCCCCCCSCC(COC)COP([O-])(=O)OCC[N+](C)(C)C ODEDPKNSRBCSDO-UHFFFAOYSA-N 0.000 description 1
• NAFFDQVVNWTDJD-UHFFFAOYSA-L [4-(azanidylmethyl)oxan-4-yl]methylazanide;cyclobutane-1,1-dicarboxylate;platinum(4+) Chemical compound [Pt+4].[NH-]CC1(C[NH-])CCOCC1.[O-]C(=O)C1(C([O-])=O)CCC1 NAFFDQVVNWTDJD-UHFFFAOYSA-L 0.000 description 1
• JURAJLFHWXNPHG-UHFFFAOYSA-N [acetyl(methylcarbamoyl)amino] n-methylcarbamate Chemical compound CNC(=O)ON(C(C)=O)C(=O)NC JURAJLFHWXNPHG-UHFFFAOYSA-N 0.000 description 1
• 230000001594 aberrant effect Effects 0.000 description 1
• RUGAHXUZHWYHNG-NLGNTGLNSA-N acetic acid;(4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-n-[(2s,3r)-1-amino-3-hydroxy-1-oxobutan-2-yl]-19-[[(2r)-2-amino-3-naphthalen-2-ylpropanoyl]amino]-16-[(4-hydroxyphenyl)methyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-7-propan-2-yl-1,2-dithia-5, Chemical compound CC(O)=O.CC(O)=O.CC(O)=O.CC(O)=O.CC(O)=O.C([C@H]1C(=O)N[C@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)[C@H](N)CC=1C=C2C=CC=CC2=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(N)=O)=O)C(C)C)C1=CC=C(O)C=C1.C([C@H]1C(=O)N[C@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)[C@H](N)CC=1C=C2C=CC=CC2=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(N)=O)=O)C(C)C)C1=CC=C(O)C=C1 RUGAHXUZHWYHNG-NLGNTGLNSA-N 0.000 description 1
• IGCAUIJHGNYDKE-UHFFFAOYSA-N acetic acid;1,4-bis[2-(2-hydroxyethylamino)ethylamino]anthracene-9,10-dione Chemical compound CC([O-])=O.CC([O-])=O.O=C1C2=CC=CC=C2C(=O)C2=C1C(NCC[NH2+]CCO)=CC=C2NCC[NH2+]CCO IGCAUIJHGNYDKE-UHFFFAOYSA-N 0.000 description 1
• 230000002378 acidificating effect Effects 0.000 description 1
• QAWIHIJWNYOLBE-OKKQSCSOSA-N acivicin Chemical compound OC(=O)[C@@H](N)[C@@H]1CC(Cl)=NO1 QAWIHIJWNYOLBE-OKKQSCSOSA-N 0.000 description 1
• 229950008427 acivicin Drugs 0.000 description 1
• USZYSDMBJDPRIF-SVEJIMAYSA-N aclacinomycin A Chemical compound O([C@H]1[C@@H](O)C[C@@H](O[C@H]1C)O[C@H]1[C@H](C[C@@H](O[C@H]1C)O[C@H]1C[C@]([C@@H](C2=CC=3C(=O)C4=CC=CC(O)=C4C(=O)C=3C(O)=C21)C(=O)OC)(O)CC)N(C)C)[C@H]1CCC(=O)[C@H](C)O1 USZYSDMBJDPRIF-SVEJIMAYSA-N 0.000 description 1
• 229960004176 aclarubicin Drugs 0.000 description 1
• 229950000616 acronine Drugs 0.000 description 1
• RJURFGZVJUQBHK-IIXSONLDSA-N actinomycin D Chemical compound C[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](C(C)C)NC(=O)[C@H]1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)N[C@@H]4C(=O)N[C@@H](C(N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-IIXSONLDSA-N 0.000 description 1
• 230000004913 activation Effects 0.000 description 1
• 230000003044 adaptive effect Effects 0.000 description 1
• 101150063416 add gene Proteins 0.000 description 1
• 229950004955 adozelesin Drugs 0.000 description 1
• BYRVKDUQDLJUBX-JJCDCTGGSA-N adozelesin Chemical compound C1=CC=C2OC(C(=O)NC=3C=C4C=C(NC4=CC=3)C(=O)N3C[C@H]4C[C@]44C5=C(C(C=C43)=O)NC=C5C)=CC2=C1 BYRVKDUQDLJUBX-JJCDCTGGSA-N 0.000 description 1
• 208000020990 adrenal cortex carcinoma Diseases 0.000 description 1
• 208000007128 adrenocortical carcinoma Diseases 0.000 description 1
• 229940009456 adriamycin Drugs 0.000 description 1
• 241001148470 aerobic bacillus Species 0.000 description 1
• 239000008272 agar Substances 0.000 description 1
• 108700025316 aldesleukin Proteins 0.000 description 1
• 229960005310 aldesleukin Drugs 0.000 description 1
• FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical class OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
• 102000012005 alpha-2-HS-Glycoprotein Human genes 0.000 description 1
• 108010075843 alpha-2-HS-Glycoprotein Proteins 0.000 description 1
• 108010026331 alpha-Fetoproteins Proteins 0.000 description 1
• 229960000473 altretamine Drugs 0.000 description 1
• 229940037003 alum Drugs 0.000 description 1
• 229910052782 aluminium Inorganic materials 0.000 description 1
• XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
• ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 description 1
• 235000012211 aluminium silicate Nutrition 0.000 description 1
• 229940103272 aluminum potassium sulfate Drugs 0.000 description 1
• 229950004821 ambomycin Drugs 0.000 description 1
• 229960003437 aminoglutethimide Drugs 0.000 description 1
• ROBVIMPUHSLWNV-UHFFFAOYSA-N aminoglutethimide Chemical compound C=1C=C(N)C=CC=1C1(CC)CCC(=O)NC1=O ROBVIMPUHSLWNV-UHFFFAOYSA-N 0.000 description 1
• 229960001220 amsacrine Drugs 0.000 description 1
• XCPGHVQEEXUHNC-UHFFFAOYSA-N amsacrine Chemical compound COC1=CC(NS(C)(=O)=O)=CC=C1NC1=C(C=CC=C2)C2=NC2=CC=CC=C12 XCPGHVQEEXUHNC-UHFFFAOYSA-N 0.000 description 1
• 229960002932 anastrozole Drugs 0.000 description 1
• YBBLVLTVTVSKRW-UHFFFAOYSA-N anastrozole Chemical compound N#CC(C)(C)C1=CC(C(C)(C#N)C)=CC(CN2N=CN=C2)=C1 YBBLVLTVTVSKRW-UHFFFAOYSA-N 0.000 description 1
• 108010069801 angiopoietin 4 Proteins 0.000 description 1
• 101150082095 ansB gene Proteins 0.000 description 1
• VGQOVCHZGQWAOI-HYUHUPJXSA-N anthramycin Chemical compound N1[C@@H](O)[C@@H]2CC(\C=C\C(N)=O)=CN2C(=O)C2=CC=C(C)C(O)=C12 VGQOVCHZGQWAOI-HYUHUPJXSA-N 0.000 description 1
• 239000003242 anti bacterial agent Substances 0.000 description 1
• 229940088710 antibiotic agent Drugs 0.000 description 1
• 230000006907 apoptotic process Effects 0.000 description 1
• 229960003272 asparaginase Drugs 0.000 description 1
• DCXYFEDJOCDNAF-UHFFFAOYSA-M asparaginate Chemical compound [O-]C(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-M 0.000 description 1
• FZCSTZYAHCUGEM-UHFFFAOYSA-N aspergillomarasmine B Natural products OC(=O)CNC(C(O)=O)CNC(C(O)=O)CC(O)=O FZCSTZYAHCUGEM-UHFFFAOYSA-N 0.000 description 1
• 238000003556 assay Methods 0.000 description 1
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
• 229960002756 azacitidine Drugs 0.000 description 1
• HRXVDDOKERXBEY-UHFFFAOYSA-N azatepa Chemical compound C1CN1P(=O)(N1CC1)N(CC)C1=NN=CS1 HRXVDDOKERXBEY-UHFFFAOYSA-N 0.000 description 1
• 229950004295 azotomycin Drugs 0.000 description 1
• 239000000688 bacterial toxin Substances 0.000 description 1
• XFILPEOLDIKJHX-QYZOEREBSA-N batimastat Chemical compound C([C@@H](C(=O)NC)NC(=O)[C@H](CC(C)C)[C@H](CSC=1SC=CC=1)C(=O)NO)C1=CC=CC=C1 XFILPEOLDIKJHX-QYZOEREBSA-N 0.000 description 1
• 229950001858 batimastat Drugs 0.000 description 1
• 239000011324 bead Substances 0.000 description 1
• 235000015278 beef Nutrition 0.000 description 1
• 230000008901 benefit Effects 0.000 description 1
• 229950005567 benzodepa Drugs 0.000 description 1
• MMIMIFULGMZVPO-UHFFFAOYSA-N benzyl 3-bromo-2,6-dinitro-5-phenylmethoxybenzoate Chemical compound [O-][N+](=O)C1=C(C(=O)OCC=2C=CC=CC=2)C([N+](=O)[O-])=C(Br)C=C1OCC1=CC=CC=C1 MMIMIFULGMZVPO-UHFFFAOYSA-N 0.000 description 1
• VFIUCBTYGKMLCM-UHFFFAOYSA-N benzyl n-[bis(aziridin-1-yl)phosphoryl]carbamate Chemical compound C=1C=CC=CC=1COC(=O)NP(=O)(N1CC1)N1CC1 VFIUCBTYGKMLCM-UHFFFAOYSA-N 0.000 description 1
• 108010081355 beta 2-Microglobulin Proteins 0.000 description 1
• SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 description 1
• 229960000997 bicalutamide Drugs 0.000 description 1
• 238000001574 biopsy Methods 0.000 description 1
• 229950008548 bisantrene Drugs 0.000 description 1
• 229950006844 bizelesin Drugs 0.000 description 1
• 229960004395 bleomycin sulfate Drugs 0.000 description 1
• 210000004204 blood vessel Anatomy 0.000 description 1
• 210000001185 bone marrow Anatomy 0.000 description 1
• 210000004556 brain Anatomy 0.000 description 1
• 229940077737 brain-derived neurotrophic factor Drugs 0.000 description 1
• PZOHOALJQOFNTB-UHFFFAOYSA-M brequinar sodium Chemical compound [Na+].N1=C2C=CC(F)=CC2=C(C([O-])=O)C(C)=C1C(C=C1)=CC=C1C1=CC=CC=C1F PZOHOALJQOFNTB-UHFFFAOYSA-M 0.000 description 1
• 229950009494 bropirimine Drugs 0.000 description 1
• 239000008366 buffered solution Substances 0.000 description 1
• 108700002839 cactinomycin Proteins 0.000 description 1
• 229950009908 cactinomycin Drugs 0.000 description 1
• 239000001110 calcium chloride Substances 0.000 description 1
• 229910001628 calcium chloride Inorganic materials 0.000 description 1
• 238000004364 calculation method Methods 0.000 description 1
• IVFYLRMMHVYGJH-PVPPCFLZSA-N calusterone Chemical compound C1C[C@]2(C)[C@](O)(C)CC[C@H]2[C@@H]2[C@@H](C)CC3=CC(=O)CC[C@]3(C)[C@H]21 IVFYLRMMHVYGJH-PVPPCFLZSA-N 0.000 description 1
• 229950009823 calusterone Drugs 0.000 description 1
• 229950009338 caracemide Drugs 0.000 description 1
• 229950005155 carbetimer Drugs 0.000 description 1
• 150000001720 carbohydrates Chemical class 0.000 description 1
• 235000014633 carbohydrates Nutrition 0.000 description 1
• 229910052799 carbon Inorganic materials 0.000 description 1
• 229960004562 carboplatin Drugs 0.000 description 1
• XREUEWVEMYWFFA-CSKJXFQVSA-N carminomycin Chemical compound C1[C@H](N)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1C2=C(O)C(C(=O)C3=C(O)C=CC=C3C3=O)=C3C(O)=C2C[C@@](O)(C(C)=O)C1 XREUEWVEMYWFFA-CSKJXFQVSA-N 0.000 description 1
• 229960005243 carmustine Drugs 0.000 description 1
• QRYRORQUOLYVBU-VBKZILBWSA-N carnosic acid Chemical compound CC([C@@H]1CC2)(C)CCC[C@]1(C(O)=O)C1=C2C=C(C(C)C)C(O)=C1O QRYRORQUOLYVBU-VBKZILBWSA-N 0.000 description 1
• 210000000845 cartilage Anatomy 0.000 description 1
• 229950001725 carubicin Drugs 0.000 description 1
• BBZDXMBRAFTCAA-AREMUKBSSA-N carzelesin Chemical compound C1=2NC=C(C)C=2C([C@H](CCl)CN2C(=O)C=3NC4=CC=C(C=C4C=3)NC(=O)C3=CC4=CC=C(C=C4O3)N(CC)CC)=C2C=C1OC(=O)NC1=CC=CC=C1 BBZDXMBRAFTCAA-AREMUKBSSA-N 0.000 description 1
• 229950007509 carzelesin Drugs 0.000 description 1
• 229950010667 cedefingol Drugs 0.000 description 1
• 238000004113 cell culture Methods 0.000 description 1
• 210000000170 cell membrane Anatomy 0.000 description 1
• 230000001413 cellular effect Effects 0.000 description 1
• 201000007455 central nervous system cancer Diseases 0.000 description 1
• OWSKEUBOCMEJMI-KPXOXKRLSA-N chembl2105946 Chemical compound [N-]=[N+]=CC(=O)CC[C@H](NC(=O)[C@@H](N)C)C(=O)N[C@H](CCC(=O)C=[N+]=[N-])C(O)=O OWSKEUBOCMEJMI-KPXOXKRLSA-N 0.000 description 1
• 239000003638 chemical reducing agent Substances 0.000 description 1
• 239000003795 chemical substances by application Substances 0.000 description 1
• 229960004630 chlorambucil Drugs 0.000 description 1
• JCKYGMPEJWAADB-UHFFFAOYSA-N chlorambucil Chemical compound OC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 JCKYGMPEJWAADB-UHFFFAOYSA-N 0.000 description 1
• 229960005091 chloramphenicol Drugs 0.000 description 1
• WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
• BFPSDSIWYFKGBC-UHFFFAOYSA-N chlorotrianisene Chemical compound C1=CC(OC)=CC=C1C(Cl)=C(C=1C=CC(OC)=CC=1)C1=CC=C(OC)C=C1 BFPSDSIWYFKGBC-UHFFFAOYSA-N 0.000 description 1
• 230000001684 chronic effect Effects 0.000 description 1
• 229950011359 cirolemycin Drugs 0.000 description 1
• DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 1
• 229960004316 cisplatin Drugs 0.000 description 1
• 229960002436 cladribine Drugs 0.000 description 1
• 208000029742 colonic neoplasm Diseases 0.000 description 1
• 201000002758 colorectal adenoma Diseases 0.000 description 1
• 238000004737 colorimetric analysis Methods 0.000 description 1
• 210000002808 connective tissue Anatomy 0.000 description 1
• 238000011109 contamination Methods 0.000 description 1
• 229920001577 copolymer Polymers 0.000 description 1
• 229960004397 cyclophosphamide Drugs 0.000 description 1
• 229960002433 cysteine Drugs 0.000 description 1
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
• 235000018417 cysteine Nutrition 0.000 description 1
• 229960000684 cytarabine Drugs 0.000 description 1
• 210000000172 cytosol Anatomy 0.000 description 1
• YCWXIQRLONXJLF-PFFGJIDWSA-N d06307 Chemical compound OS(O)(=O)=O.C([C@]1([C@@H]2O1)CC)N(CCC=1C3=CC=CC=C3NC=11)C[C@H]2C[C@]1(C(=O)OC)C1=CC([C@]23[C@H]([C@@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC.C([C@]1([C@@H]2O1)CC)N(CCC=1C3=CC=CC=C3NC=11)C[C@H]2C[C@]1(C(=O)OC)C1=CC([C@]23[C@H]([C@@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC YCWXIQRLONXJLF-PFFGJIDWSA-N 0.000 description 1
• 229960003901 dacarbazine Drugs 0.000 description 1
• 229960000640 dactinomycin Drugs 0.000 description 1
• 229960003109 daunorubicin hydrochloride Drugs 0.000 description 1
• 229960003603 decitabine Drugs 0.000 description 1
• 238000000432 density-gradient centrifugation Methods 0.000 description 1
• 230000001419 dependent effect Effects 0.000 description 1
• 238000011161 development Methods 0.000 description 1
• 230000018109 developmental process Effects 0.000 description 1
• VPOCYEOOFRNHNL-RQDPQJJXSA-J dexormaplatin Chemical compound Cl[Pt](Cl)(Cl)Cl.N[C@@H]1CCCC[C@H]1N VPOCYEOOFRNHNL-RQDPQJJXSA-J 0.000 description 1
• 229950001640 dexormaplatin Drugs 0.000 description 1
• 239000008121 dextrose Substances 0.000 description 1
• 229950010621 dezaguanine Drugs 0.000 description 1
• 238000003745 diagnosis Methods 0.000 description 1
• WVYXNIXAMZOZFK-UHFFFAOYSA-N diaziquone Chemical compound O=C1C(NC(=O)OCC)=C(N2CC2)C(=O)C(NC(=O)OCC)=C1N1CC1 WVYXNIXAMZOZFK-UHFFFAOYSA-N 0.000 description 1
• 229950002389 diaziquone Drugs 0.000 description 1
• 238000009792 diffusion process Methods 0.000 description 1
• OTKJDMGTUTTYMP-UHFFFAOYSA-N dihydrosphingosine Natural products CCCCCCCCCCCCCCCC(O)C(N)CO OTKJDMGTUTTYMP-UHFFFAOYSA-N 0.000 description 1
• 238000010790 dilution Methods 0.000 description 1
• 239000012895 dilution Substances 0.000 description 1
• AIUDWMLXCFRVDR-UHFFFAOYSA-N dimethyl 2-(3-ethyl-3-methylpentyl)propanedioate Chemical compound CCC(C)(CC)CCC(C(=O)OC)C(=O)OC AIUDWMLXCFRVDR-UHFFFAOYSA-N 0.000 description 1
• ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
• 229910000396 dipotassium phosphate Inorganic materials 0.000 description 1
• 235000019797 dipotassium phosphate Nutrition 0.000 description 1
• WDRWZVWLVBXVOI-QTNFYWBSSA-L dipotassium;(2s)-2-aminopentanedioate Chemical compound [K+].[K+].[O-]C(=O)[C@@H](N)CCC([O-])=O WDRWZVWLVBXVOI-QTNFYWBSSA-L 0.000 description 1
• CZLKTMHQYXYHOO-QTNFYWBSSA-L disodium;(2s)-2-[(2-phosphonatoacetyl)amino]butanedioic acid Chemical compound [Na+].[Na+].OC(=O)C[C@@H](C(O)=O)NC(=O)CP([O-])([O-])=O CZLKTMHQYXYHOO-QTNFYWBSSA-L 0.000 description 1
• SVJSWELRJWVPQD-KJWOGLQMSA-L disodium;(2s)-2-[[4-[2-[(6r)-2-amino-4-oxo-5,6,7,8-tetrahydro-1h-pyrido[2,3-d]pyrimidin-6-yl]ethyl]benzoyl]amino]pentanedioate Chemical compound [Na+].[Na+].C([C@@H]1CC=2C(=O)N=C(NC=2NC1)N)CC1=CC=C(C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)C=C1 SVJSWELRJWVPQD-KJWOGLQMSA-L 0.000 description 1
• 229960003668 docetaxel Drugs 0.000 description 1
• PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 1
• 239000002552 dosage form Substances 0.000 description 1
• 229960004679 doxorubicin Drugs 0.000 description 1
• 229960002918 doxorubicin hydrochloride Drugs 0.000 description 1
• 229950004203 droloxifene Drugs 0.000 description 1
• NOTIQUSPUUHHEH-UXOVVSIBSA-N dromostanolone propionate Chemical compound C([C@@H]1CC2)C(=O)[C@H](C)C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](OC(=O)CC)[C@@]2(C)CC1 NOTIQUSPUUHHEH-UXOVVSIBSA-N 0.000 description 1
• 229950004683 drostanolone propionate Drugs 0.000 description 1
• 229940079593 drug Drugs 0.000 description 1
• 238000009510 drug design Methods 0.000 description 1
• 229950005133 duazomycin Drugs 0.000 description 1
• 229930192837 duazomycin Natural products 0.000 description 1
• 239000000975 dye Substances 0.000 description 1
• FSIRXIHZBIXHKT-MHTVFEQDSA-N edatrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CC(CC)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FSIRXIHZBIXHKT-MHTVFEQDSA-N 0.000 description 1
• 229950006700 edatrexate Drugs 0.000 description 1
• 229960002046 eflornithine hydrochloride Drugs 0.000 description 1
• MDCUNMLZLNGCQA-HWOAGHQOSA-N elafin Chemical compound N([C@H](C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H]1C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]2CSSC[C@H]3C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CSSC[C@H]4C(=O)N5CCC[C@H]5C(=O)NCC(=O)N[C@H](C(N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]5N(CCC5)C(=O)[C@H]5N(CCC5)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@H](C)NC2=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N4)C(=O)N[C@@H](CSSC1)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N3)=O)[C@@H](C)CC)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(N)=O)C(O)=O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(C)C)C(C)C)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)N MDCUNMLZLNGCQA-HWOAGHQOSA-N 0.000 description 1
• MGQRRMONVLMKJL-KWJIQSIXSA-N elsamitrucin Chemical compound O1[C@H](C)[C@H](O)[C@H](OC)[C@@H](N)[C@H]1O[C@@H]1[C@](O)(C)[C@@H](O)[C@@H](C)O[C@H]1OC1=CC=CC2=C(O)C(C(O3)=O)=C4C5=C3C=CC(C)=C5C(=O)OC4=C12 MGQRRMONVLMKJL-KWJIQSIXSA-N 0.000 description 1
• 229950002339 elsamitrucin Drugs 0.000 description 1
• 201000011523 endocrine gland cancer Diseases 0.000 description 1
• 201000003914 endometrial carcinoma Diseases 0.000 description 1
• 230000003511 endothelial effect Effects 0.000 description 1
• 238000005516 engineering process Methods 0.000 description 1
• 229950010625 enloplatin Drugs 0.000 description 1
• 229950001022 enpromate Drugs 0.000 description 1
• 230000007613 environmental effect Effects 0.000 description 1
• 229940088598 enzyme Drugs 0.000 description 1
• 229940116977 epidermal growth factor Drugs 0.000 description 1
• 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 description 1
• 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 description 1
• 229950004926 epipropidine Drugs 0.000 description 1
• 229960003265 epirubicin hydrochloride Drugs 0.000 description 1
• 210000000981 epithelium Anatomy 0.000 description 1
• 229950001426 erbulozole Drugs 0.000 description 1
• KLEPCGBEXOCIGS-QPPBQGQZSA-N erbulozole Chemical compound C1=CC(NC(=O)OCC)=CC=C1SC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C=CC(OC)=CC=2)OC1 KLEPCGBEXOCIGS-QPPBQGQZSA-N 0.000 description 1
• HCZKYJDFEPMADG-UHFFFAOYSA-N erythro-nordihydroguaiaretic acid Natural products C=1C=C(O)C(O)=CC=1CC(C)C(C)CC1=CC=C(O)C(O)=C1 HCZKYJDFEPMADG-UHFFFAOYSA-N 0.000 description 1
• 210000003743 erythrocyte Anatomy 0.000 description 1
• 229960001842 estramustine Drugs 0.000 description 1
• FRPJXPJMRWBBIH-RBRWEJTLSA-N estramustine Chemical compound ClCCN(CCCl)C(=O)OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 FRPJXPJMRWBBIH-RBRWEJTLSA-N 0.000 description 1
• 229960001766 estramustine phosphate sodium Drugs 0.000 description 1
• IIUMCNJTGSMNRO-VVSKJQCTSA-L estramustine sodium phosphate Chemical compound [Na+].[Na+].ClCCN(CCCl)C(=O)OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)OP([O-])([O-])=O)[C@@H]4[C@@H]3CCC2=C1 IIUMCNJTGSMNRO-VVSKJQCTSA-L 0.000 description 1
• WCDWBPCFGJXFJZ-UHFFFAOYSA-N etanidazole Chemical compound OCCNC(=O)CN1C=CN=C1[N+]([O-])=O WCDWBPCFGJXFJZ-UHFFFAOYSA-N 0.000 description 1
• 229950006566 etanidazole Drugs 0.000 description 1
• HZQPPNNARUQMJA-IMIWJGOWSA-N ethyl n-[4-[[(2r,4r)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methylsulfanyl]phenyl]carbamate;hydrochloride Chemical compound Cl.C1=CC(NC(=O)OCC)=CC=C1SC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 HZQPPNNARUQMJA-IMIWJGOWSA-N 0.000 description 1
• 229960005420 etoposide Drugs 0.000 description 1
• VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 description 1
• 229960000752 etoposide phosphate Drugs 0.000 description 1
• LIQODXNTTZAGID-OCBXBXKTSA-N etoposide phosphate Chemical compound COC1=C(OP(O)(O)=O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 LIQODXNTTZAGID-OCBXBXKTSA-N 0.000 description 1
• 238000001704 evaporation Methods 0.000 description 1
• 230000008020 evaporation Effects 0.000 description 1
• 230000001747 exhibiting effect Effects 0.000 description 1
• 229950011548 fadrozole Drugs 0.000 description 1
• 208000025697 familial rhabdoid tumor Diseases 0.000 description 1
• 108091022862 fatty acid binding Proteins 0.000 description 1
• 230000002349 favourable effect Effects 0.000 description 1
• NMUSYJAQQFHJEW-ARQDHWQXSA-N fazarabine Chemical compound O=C1N=C(N)N=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 NMUSYJAQQFHJEW-ARQDHWQXSA-N 0.000 description 1
• 229950005096 fazarabine Drugs 0.000 description 1
• 229950003662 fenretinide Drugs 0.000 description 1
• 239000000945 filler Substances 0.000 description 1
• 239000012467 final product Substances 0.000 description 1
• 238000000684 flow cytometry Methods 0.000 description 1
• 229960000961 floxuridine Drugs 0.000 description 1
• ODKNJVUHOIMIIZ-RRKCRQDMSA-N floxuridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(F)=C1 ODKNJVUHOIMIIZ-RRKCRQDMSA-N 0.000 description 1
• GIUYCYHIANZCFB-FJFJXFQQSA-N fludarabine phosphate Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O GIUYCYHIANZCFB-FJFJXFQQSA-N 0.000 description 1
• 239000007850 fluorescent dye Substances 0.000 description 1
• 229960002949 fluorouracil Drugs 0.000 description 1
• 229950005682 flurocitabine Drugs 0.000 description 1
• 108010003374 fms-Like Tyrosine Kinase 3 Proteins 0.000 description 1
• 229940028334 follicle stimulating hormone Drugs 0.000 description 1
• UXTSQCOOUJTIAC-UHFFFAOYSA-N fosquidone Chemical compound C=1N2CC3=CC=CC=C3C(C)C2=C(C(C2=CC=C3)=O)C=1C(=O)C2=C3OP(O)(=O)OCC1=CC=CC=C1 UXTSQCOOUJTIAC-UHFFFAOYSA-N 0.000 description 1
• 229950005611 fosquidone Drugs 0.000 description 1
• 239000012634 fragment Substances 0.000 description 1
• 230000037433 frameshift Effects 0.000 description 1
• 108010018632 frizzled related protein-3 Proteins 0.000 description 1
• 229960005277 gemcitabine Drugs 0.000 description 1
• 229960005144 gemcitabine hydrochloride Drugs 0.000 description 1
• 239000000122 growth hormone Substances 0.000 description 1
• 230000036541 health Effects 0.000 description 1
• 238000010438 heat treatment Methods 0.000 description 1
• BTIJJDXEELBZFS-UHFFFAOYSA-K hemin Chemical compound [Cl-].[Fe+3].[N-]1C(C=C2C(=C(C)C(C=C3C(=C(C)C(=C4)[N-]3)C=C)=N2)C=C)=C(C)C(CCC(O)=O)=C1C=C1C(CCC(O)=O)=C(C)C4=N1 BTIJJDXEELBZFS-UHFFFAOYSA-K 0.000 description 1
• 229960002897 heparin Drugs 0.000 description 1
• 229920000669 heparin Polymers 0.000 description 1
• 208000006359 hepatoblastoma Diseases 0.000 description 1
• 231100000844 hepatocellular carcinoma Toxicity 0.000 description 1
• UUVWYPNAQBNQJQ-UHFFFAOYSA-N hexamethylmelamine Chemical compound CN(C)C1=NC(N(C)C)=NC(N(C)C)=N1 UUVWYPNAQBNQJQ-UHFFFAOYSA-N 0.000 description 1
• 229940084986 human chorionic gonadotropin Drugs 0.000 description 1
• SOCGJDYHNGLZEC-UHFFFAOYSA-N hydron;n-methyl-n-[4-[(7-methyl-3h-imidazo[4,5-f]quinolin-9-yl)amino]phenyl]acetamide;chloride Chemical compound Cl.C1=CC(N(C(C)=O)C)=CC=C1NC1=CC(C)=NC2=CC=C(NC=N3)C3=C12 SOCGJDYHNGLZEC-UHFFFAOYSA-N 0.000 description 1
• 229960001330 hydroxycarbamide Drugs 0.000 description 1
• 229960001176 idarubicin hydrochloride Drugs 0.000 description 1
• 229960001101 ifosfamide Drugs 0.000 description 1
• HOMGKSMUEGBAAB-UHFFFAOYSA-N ifosfamide Chemical compound ClCCNP1(=O)OCCCN1CCCl HOMGKSMUEGBAAB-UHFFFAOYSA-N 0.000 description 1
• 229950006905 ilmofosine Drugs 0.000 description 1
• 210000001822 immobilized cell Anatomy 0.000 description 1
• 230000005934 immune activation Effects 0.000 description 1
• 210000002865 immune cell Anatomy 0.000 description 1
• 230000003053 immunization Effects 0.000 description 1
• 238000002649 immunization Methods 0.000 description 1
• 238000003018 immunoassay Methods 0.000 description 1
• 230000005847 immunogenicity Effects 0.000 description 1
• 230000001976 improved effect Effects 0.000 description 1
• 238000001727 in vivo Methods 0.000 description 1
• 238000011065 in-situ storage Methods 0.000 description 1
• 229940125396 insulin Drugs 0.000 description 1
• 229940068935 insulin-like growth factor 2 Drugs 0.000 description 1
• 102000028416 insulin-like growth factor binding Human genes 0.000 description 1
• 108091022911 insulin-like growth factor binding Proteins 0.000 description 1
• 230000010354 integration Effects 0.000 description 1
• 230000003993 interaction Effects 0.000 description 1
• 229960003521 interferon alfa-2a Drugs 0.000 description 1
• 229960003507 interferon alfa-2b Drugs 0.000 description 1
• 229960004061 interferon alfa-n1 Drugs 0.000 description 1
• 108010006088 interferon alfa-n1 Proteins 0.000 description 1
• 229940109242 interferon alfa-n3 Drugs 0.000 description 1
• 229960003130 interferon gamma Drugs 0.000 description 1
• 239000003407 interleukin 1 receptor blocking agent Substances 0.000 description 1
• 102000009634 interleukin-1 receptor antagonist activity proteins Human genes 0.000 description 1
• 108040001669 interleukin-1 receptor antagonist activity proteins Proteins 0.000 description 1
• 229940076144 interleukin-10 Drugs 0.000 description 1
• 229940074383 interleukin-11 Drugs 0.000 description 1
• 229940117681 interleukin-12 Drugs 0.000 description 1
• 102000053460 interleukin-17 receptor activity proteins Human genes 0.000 description 1
• 108040001304 interleukin-17 receptor activity proteins Proteins 0.000 description 1
• 102000044166 interleukin-18 binding protein Human genes 0.000 description 1
• 108010070145 interleukin-18 binding protein Proteins 0.000 description 1
• 108010074108 interleukin-21 Proteins 0.000 description 1
• 102000008640 interleukin-21 receptor activity proteins Human genes 0.000 description 1
• 108040002099 interleukin-21 receptor activity proteins Proteins 0.000 description 1
• 229940028885 interleukin-4 Drugs 0.000 description 1
• 229940100602 interleukin-5 Drugs 0.000 description 1
• 229940100994 interleukin-7 Drugs 0.000 description 1
• 229940096397 interleukin-8 Drugs 0.000 description 1
• XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 description 1
• 229940118526 interleukin-9 Drugs 0.000 description 1
• 238000001361 intraarterial administration Methods 0.000 description 1
• 238000007912 intraperitoneal administration Methods 0.000 description 1
• 238000007913 intrathecal administration Methods 0.000 description 1
• 230000009545 invasion Effects 0.000 description 1
• 229950010897 iproplatin Drugs 0.000 description 1
• 229960000779 irinotecan hydrochloride Drugs 0.000 description 1
• GURKHSYORGJETM-WAQYZQTGSA-N irinotecan hydrochloride (anhydrous) Chemical compound Cl.C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 GURKHSYORGJETM-WAQYZQTGSA-N 0.000 description 1
• BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 1
• 229910000359 iron(II) sulfate Inorganic materials 0.000 description 1
• 238000002955 isolation Methods 0.000 description 1
• 108010050180 kallistatin Proteins 0.000 description 1
• NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
• 201000010982 kidney cancer Diseases 0.000 description 1
• 235000019388 lanolin Nutrition 0.000 description 1
• 229940039717 lanolin Drugs 0.000 description 1
• 108010021336 lanreotide Proteins 0.000 description 1
• 229960001739 lanreotide acetate Drugs 0.000 description 1
• 239000002523 lectin Substances 0.000 description 1
• 229940039781 leptin Drugs 0.000 description 1
• NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 description 1
• 229960003881 letrozole Drugs 0.000 description 1
• HPJKCIUCZWXJDR-UHFFFAOYSA-N letrozole Chemical compound C1=CC(C#N)=CC=C1C(N1N=CN=C1)C1=CC=C(C#N)C=C1 HPJKCIUCZWXJDR-UHFFFAOYSA-N 0.000 description 1
• GFIJNRVAKGFPGQ-LIJARHBVSA-N leuprolide Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 GFIJNRVAKGFPGQ-LIJARHBVSA-N 0.000 description 1
• 229960004338 leuprorelin Drugs 0.000 description 1
• KDQAABAKXDWYSZ-SDCRJXSCSA-N leurosidine sulfate Chemical compound OS(O)(=O)=O.C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 KDQAABAKXDWYSZ-SDCRJXSCSA-N 0.000 description 1
• 229960001614 levamisole Drugs 0.000 description 1
• HEHQDWUWJVPREQ-XQJZMFRCSA-N lipid X Chemical compound CCCCCCCCCCC[C@@H](O)CC(=O)N[C@H]1[C@@H](OP(O)(O)=O)O[C@H](CO)[C@@H](O)[C@@H]1OC(=O)C[C@H](O)CCCCCCCCCCC HEHQDWUWJVPREQ-XQJZMFRCSA-N 0.000 description 1
• 229920006008 lipopolysaccharide Polymers 0.000 description 1
• 206010024627 liposarcoma Diseases 0.000 description 1
• 201000007270 liver cancer Diseases 0.000 description 1
• 238000011068 loading method Methods 0.000 description 1
• 229960002247 lomustine Drugs 0.000 description 1
• XDMHALQMTPSGEA-UHFFFAOYSA-N losoxantrone hydrochloride Chemical compound Cl.Cl.OCCNCCN1N=C2C3=CC=CC(O)=C3C(=O)C3=C2C1=CC=C3NCCNCCO XDMHALQMTPSGEA-UHFFFAOYSA-N 0.000 description 1
• 101150040799 luxI gene Proteins 0.000 description 1
• 210000001165 lymph node Anatomy 0.000 description 1
• 210000001077 lymphatic endothelium Anatomy 0.000 description 1
• 108010019677 lymphotactin Proteins 0.000 description 1
• 239000012139 lysis buffer Substances 0.000 description 1
• 102000049853 macrophage stimulating protein Human genes 0.000 description 1
• 108010053292 macrophage stimulating protein Proteins 0.000 description 1
• 230000014759 maintenance of location Effects 0.000 description 1
• 210000003794 male germ cell Anatomy 0.000 description 1
• 239000011565 manganese chloride Substances 0.000 description 1
• 235000002867 manganese chloride Nutrition 0.000 description 1
• 229960003951 masoprocol Drugs 0.000 description 1
• HCZKYJDFEPMADG-TXEJJXNPSA-N masoprocol Chemical compound C([C@H](C)[C@H](C)CC=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 HCZKYJDFEPMADG-TXEJJXNPSA-N 0.000 description 1
• 208000000516 mast-cell leukemia Diseases 0.000 description 1
• WKPWGQKGSOKKOO-RSFHAFMBSA-N maytansine Chemical compound CO[C@@H]([C@@]1(O)C[C@](OC(=O)N1)([C@H]([C@@H]1O[C@@]1(C)[C@@H](OC(=O)[C@H](C)N(C)C(C)=O)CC(=O)N1C)C)[H])\C=C\C=C(C)\CC2=CC(OC)=C(Cl)C1=C2 WKPWGQKGSOKKOO-RSFHAFMBSA-N 0.000 description 1
• AEUKDPKXTPNBNY-XEYRWQBLSA-N mcp 2 Chemical compound C([C@@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)C1=CC=CC=C1 AEUKDPKXTPNBNY-XEYRWQBLSA-N 0.000 description 1
• 238000005259 measurement Methods 0.000 description 1
• 229960002868 mechlorethamine hydrochloride Drugs 0.000 description 1
• QZIQJVCYUQZDIR-UHFFFAOYSA-N mechlorethamine hydrochloride Chemical compound Cl.ClCCN(C)CCCl QZIQJVCYUQZDIR-UHFFFAOYSA-N 0.000 description 1
• 230000001404 mediated effect Effects 0.000 description 1
• 239000012533 medium component Substances 0.000 description 1
• 239000013028 medium composition Substances 0.000 description 1
• 229960004296 megestrol acetate Drugs 0.000 description 1
• RQZAXGRLVPAYTJ-GQFGMJRRSA-N megestrol acetate Chemical compound C1=C(C)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 RQZAXGRLVPAYTJ-GQFGMJRRSA-N 0.000 description 1
• 210000002752 melanocyte Anatomy 0.000 description 1
• 201000002699 melanoma in congenital melanocytic nevus Diseases 0.000 description 1
• 229960003846 melengestrol acetate Drugs 0.000 description 1
• 229960001924 melphalan Drugs 0.000 description 1
• SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 description 1
• 230000015654 memory Effects 0.000 description 1
• 206010027191 meningioma Diseases 0.000 description 1
• LWYJUZBXGAFFLP-OCNCTQISSA-N menogaril Chemical compound O1[C@@]2(C)[C@H](O)[C@@H](N(C)C)[C@H](O)[C@@H]1OC1=C3C(=O)C(C=C4C[C@@](C)(O)C[C@H](C4=C4O)OC)=C4C(=O)C3=C(O)C=C12 LWYJUZBXGAFFLP-OCNCTQISSA-N 0.000 description 1
• 229950002676 menogaril Drugs 0.000 description 1
• GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 description 1
• 229960001428 mercaptopurine Drugs 0.000 description 1
• 229910052751 metal Inorganic materials 0.000 description 1
• 239000002184 metal Substances 0.000 description 1
• 239000003475 metalloproteinase inhibitor Substances 0.000 description 1
• KPQJSSLKKBKWEW-RKDOVGOJSA-N methanesulfonic acid;5-nitro-2-[(2r)-1-[2-[[(2r)-2-(5-nitro-1,3-dioxobenzo[de]isoquinolin-2-yl)propyl]amino]ethylamino]propan-2-yl]benzo[de]isoquinoline-1,3-dione Chemical compound CS(O)(=O)=O.CS(O)(=O)=O.[O-][N+](=O)C1=CC(C(N([C@@H](CNCCNC[C@@H](C)N2C(C=3C=C(C=C4C=CC=C(C=34)C2=O)[N+]([O-])=O)=O)C)C2=O)=O)=C3C2=CC=CC3=C1 KPQJSSLKKBKWEW-RKDOVGOJSA-N 0.000 description 1
• 229960000485 methotrexate Drugs 0.000 description 1
• BKBBTCORRZMASO-ZOWNYOTGSA-M methotrexate monosodium Chemical compound [Na+].C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C([O-])=O)C=C1 BKBBTCORRZMASO-ZOWNYOTGSA-M 0.000 description 1
• 229960003058 methotrexate sodium Drugs 0.000 description 1
• HRHKSTOGXBBQCB-VFWICMBZSA-N methylmitomycin Chemical compound O=C1C(N)=C(C)C(=O)C2=C1[C@@H](COC(N)=O)[C@@]1(OC)[C@H]3N(C)[C@H]3CN12 HRHKSTOGXBBQCB-VFWICMBZSA-N 0.000 description 1
• VQJHOPSWBGJHQS-UHFFFAOYSA-N metoprine, methodichlorophen Chemical compound CC1=NC(N)=NC(N)=C1C1=CC=C(Cl)C(Cl)=C1 VQJHOPSWBGJHQS-UHFFFAOYSA-N 0.000 description 1
• QTFKTBRIGWJQQL-UHFFFAOYSA-N meturedepa Chemical compound C1C(C)(C)N1P(=O)(NC(=O)OCC)N1CC1(C)C QTFKTBRIGWJQQL-UHFFFAOYSA-N 0.000 description 1
• 229950009847 meturedepa Drugs 0.000 description 1
• 239000010445 mica Substances 0.000 description 1
• 229910052618 mica group Inorganic materials 0.000 description 1
• HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 description 1
• 238000010208 microarray analysis Methods 0.000 description 1
• 229940016286 microcrystalline cellulose Drugs 0.000 description 1
• 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
• 239000008108 microcrystalline cellulose Substances 0.000 description 1
• 238000007431 microscopic evaluation Methods 0.000 description 1
• 208000022499 mismatch repair cancer syndrome Diseases 0.000 description 1
• CFCUWKMKBJTWLW-BKHRDMLASA-N mithramycin Chemical compound O([C@@H]1C[C@@H](O[C@H](C)[C@H]1O)OC=1C=C2C=C3C[C@H]([C@@H](C(=O)C3=C(O)C2=C(O)C=1C)O[C@@H]1O[C@H](C)[C@@H](O)[C@H](O[C@@H]2O[C@H](C)[C@H](O)[C@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@@](C)(O)C3)C2)C1)[C@H](OC)C(=O)[C@@H](O)[C@@H](C)O)[C@H]1C[C@@H](O)[C@H](O)[C@@H](C)O1 CFCUWKMKBJTWLW-BKHRDMLASA-N 0.000 description 1
• DRCJGCOYHLTVNR-ZUIZSQJWSA-N mitindomide Chemical compound C1=C[C@@H]2[C@@H]3[C@H]4C(=O)NC(=O)[C@H]4[C@@H]3[C@H]1[C@@H]1C(=O)NC(=O)[C@H]21 DRCJGCOYHLTVNR-ZUIZSQJWSA-N 0.000 description 1
• 229950001314 mitindomide Drugs 0.000 description 1
• 229950002137 mitocarcin Drugs 0.000 description 1
• 229950000911 mitogillin Drugs 0.000 description 1
• 108010026677 mitomalcin Proteins 0.000 description 1
• 229950007612 mitomalcin Drugs 0.000 description 1
• 229960004857 mitomycin Drugs 0.000 description 1
• 229950005715 mitosper Drugs 0.000 description 1
• 229960000350 mitotane Drugs 0.000 description 1
• ZAHQPTJLOCWVPG-UHFFFAOYSA-N mitoxantrone dihydrochloride Chemical compound Cl.Cl.O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(NCCNCCO)=CC=C2NCCNCCO ZAHQPTJLOCWVPG-UHFFFAOYSA-N 0.000 description 1
• 229960004169 mitoxantrone hydrochloride Drugs 0.000 description 1
• 235000013919 monopotassium glutamate Nutrition 0.000 description 1
• 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
• 235000019796 monopotassium phosphate Nutrition 0.000 description 1
• 238000010172 mouse model Methods 0.000 description 1
• 210000004877 mucosa Anatomy 0.000 description 1
• 206010051747 multiple endocrine neoplasia Diseases 0.000 description 1
• 210000003205 muscle Anatomy 0.000 description 1
• 229960000951 mycophenolic acid Drugs 0.000 description 1
• HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 description 1
• 208000001611 myxosarcoma Diseases 0.000 description 1
• CRJGESKKUOMBCT-PMACEKPBSA-N n-[(2s,3s)-1,3-dihydroxyoctadecan-2-yl]acetamide Chemical compound CCCCCCCCCCCCCCC[C@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-PMACEKPBSA-N 0.000 description 1
• NKFHKYQGZDAKMX-PPRKPIOESA-N n-[(e)-1-[(2s,4s)-4-[(2r,4s,5s,6s)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-3,4-dihydro-1h-tetracen-2-yl]ethylideneamino]benzamide;hydrochloride Chemical compound Cl.O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(\C)=N\NC(=O)C=1C=CC=CC=1)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 NKFHKYQGZDAKMX-PPRKPIOESA-N 0.000 description 1
• NJSMWLQOCQIOPE-OCHFTUDZSA-N n-[(e)-[10-[(e)-(4,5-dihydro-1h-imidazol-2-ylhydrazinylidene)methyl]anthracen-9-yl]methylideneamino]-4,5-dihydro-1h-imidazol-2-amine Chemical compound N1CCN=C1N\N=C\C(C1=CC=CC=C11)=C(C=CC=C2)C2=C1\C=N\NC1=NCCN1 NJSMWLQOCQIOPE-OCHFTUDZSA-N 0.000 description 1
• YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 description 1
• WRINSSLBPNLASA-FOCLMDBBSA-N n-methyl-n-[(e)-(n-methylanilino)diazenyl]aniline Chemical compound C=1C=CC=CC=1N(C)\N=N\N(C)C1=CC=CC=C1 WRINSSLBPNLASA-FOCLMDBBSA-N 0.000 description 1
• QZGIWPZCWHMVQL-UIYAJPBUSA-N neocarzinostatin chromophore Chemical compound O1[C@H](C)[C@H](O)[C@H](O)[C@@H](NC)[C@H]1O[C@@H]1C/2=C/C#C[C@H]3O[C@@]3([C@@H]3OC(=O)OC3)C#CC\2=C[C@H]1OC(=O)C1=C(O)C=CC2=C(C)C=C(OC)C=C12 QZGIWPZCWHMVQL-UIYAJPBUSA-N 0.000 description 1
• 229940053128 nerve growth factor Drugs 0.000 description 1
• 229940032018 neurotrophin 3 Drugs 0.000 description 1
• 229940097998 neurotrophin 4 Drugs 0.000 description 1
• 238000007481 next generation sequencing Methods 0.000 description 1
• 229950006344 nocodazole Drugs 0.000 description 1
• KGTDRFCXGRULNK-JYOBTZKQSA-N nogalamycin Chemical compound CO[C@@H]1[C@@](OC)(C)[C@@H](OC)[C@H](C)O[C@H]1O[C@@H]1C2=C(O)C(C(=O)C3=C(O)C=C4[C@@]5(C)O[C@H]([C@H]([C@@H]([C@H]5O)N(C)C)O)OC4=C3C3=O)=C3C=C2[C@@H](C(=O)OC)[C@@](C)(O)C1 KGTDRFCXGRULNK-JYOBTZKQSA-N 0.000 description 1
• 229950009266 nogalamycin Drugs 0.000 description 1
• 201000006079 nonepidermolytic palmoplantar keratoderma Diseases 0.000 description 1
• 238000007899 nucleic acid hybridization Methods 0.000 description 1
• 239000006916 nutrient agar Substances 0.000 description 1
• XXUPLYBCNPLTIW-UHFFFAOYSA-N octadec-7-ynoic acid Chemical compound CCCCCCCCCCC#CCCCCCC(O)=O XXUPLYBCNPLTIW-UHFFFAOYSA-N 0.000 description 1
• 238000006384 oligomerization reaction Methods 0.000 description 1
• 238000002515 oligonucleotide synthesis Methods 0.000 description 1
• 231100000590 oncogenic Toxicity 0.000 description 1
• 230000002246 oncogenic effect Effects 0.000 description 1
• 229950008017 ormaplatin Drugs 0.000 description 1
• 230000003204 osmotic effect Effects 0.000 description 1
• 201000008968 osteosarcoma Diseases 0.000 description 1
• 230000002611 ovarian Effects 0.000 description 1
• 229950000370 oxisuran Drugs 0.000 description 1
• 239000001301 oxygen Substances 0.000 description 1
• 229910052760 oxygen Inorganic materials 0.000 description 1
• 230000009996 pancreatic endocrine effect Effects 0.000 description 1
• 208000007312 paraganglioma Diseases 0.000 description 1
• 230000036961 partial effect Effects 0.000 description 1
• 229960001744 pegaspargase Drugs 0.000 description 1
• 108010001564 pegaspargase Proteins 0.000 description 1
• 229950006960 peliomycin Drugs 0.000 description 1
• 229950003180 peplomycin Drugs 0.000 description 1
• QIMGFXOHTOXMQP-GFAGFCTOSA-N peplomycin Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCCN[C@@H](C)C=1C=CC=CC=1)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1NC=NC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C QIMGFXOHTOXMQP-GFAGFCTOSA-N 0.000 description 1
• 235000019319 peptone Nutrition 0.000 description 1
• VPAWVRUHMJVRHU-VGDKGRGNSA-N perfosfamide Chemical compound OO[C@@H]1CCO[P@@](=O)(N(CCCl)CCCl)N1 VPAWVRUHMJVRHU-VGDKGRGNSA-N 0.000 description 1
• 229950009351 perfosfamide Drugs 0.000 description 1
• 239000000825 pharmaceutical preparation Substances 0.000 description 1
• 238000002205 phenol-chloroform extraction Methods 0.000 description 1
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
• 239000010452 phosphate Substances 0.000 description 1
• 230000026731 phosphorylation Effects 0.000 description 1
• 238000006366 phosphorylation reaction Methods 0.000 description 1
• 208000001095 pilomatrixoma Diseases 0.000 description 1
• MXXWOMGUGJBKIW-YPCIICBESA-N piperine Chemical compound C=1C=C2OCOC2=CC=1/C=C/C=C/C(=O)N1CCCCC1 MXXWOMGUGJBKIW-YPCIICBESA-N 0.000 description 1
• 229940075559 piperine Drugs 0.000 description 1
• WVWHRXVVAYXKDE-UHFFFAOYSA-N piperine Natural products O=C(C=CC=Cc1ccc2OCOc2c1)C3CCCCN3 WVWHRXVVAYXKDE-UHFFFAOYSA-N 0.000 description 1
• 235000019100 piperine Nutrition 0.000 description 1
• 229960000952 pipobroman Drugs 0.000 description 1
• NJBFOOCLYDNZJN-UHFFFAOYSA-N pipobroman Chemical compound BrCCC(=O)N1CCN(C(=O)CCBr)CC1 NJBFOOCLYDNZJN-UHFFFAOYSA-N 0.000 description 1
• NUKCGLDCWQXYOQ-UHFFFAOYSA-N piposulfan Chemical compound CS(=O)(=O)OCCC(=O)N1CCN(C(=O)CCOS(C)(=O)=O)CC1 NUKCGLDCWQXYOQ-UHFFFAOYSA-N 0.000 description 1
• 229950001100 piposulfan Drugs 0.000 description 1
• XESARGFCSKSFID-FLLFQEBCSA-N pirazofurin Chemical compound OC1=C(C(=O)N)NN=C1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 XESARGFCSKSFID-FLLFQEBCSA-N 0.000 description 1
• 208000010916 pituitary tumor Diseases 0.000 description 1
• 108010017843 platelet-derived growth factor A Proteins 0.000 description 1
• 108010000685 platelet-derived growth factor AB Proteins 0.000 description 1
• 229960003171 plicamycin Drugs 0.000 description 1
• JKPDEYAOCSQBSZ-OEUJLIAZSA-N plomestane Chemical compound O=C1CC[C@]2(CC#C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 JKPDEYAOCSQBSZ-OEUJLIAZSA-N 0.000 description 1
• 229950004541 plomestane Drugs 0.000 description 1
• 229920001992 poloxamer 407 Polymers 0.000 description 1
• 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
• 229920000053 polysorbate 80 Polymers 0.000 description 1
• 229960004293 porfimer sodium Drugs 0.000 description 1
• 229950004406 porfiromycin Drugs 0.000 description 1
• GRLPQNLYRHEGIJ-UHFFFAOYSA-J potassium aluminium sulfate Chemical compound [Al+3].[K+].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O GRLPQNLYRHEGIJ-UHFFFAOYSA-J 0.000 description 1
• GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
• 239000000843 powder Substances 0.000 description 1
• 229960004694 prednimustine Drugs 0.000 description 1
• CWCXERYKLSEGEZ-KDKHKZEGSA-N procalcitonin Chemical compound C([C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)NCC(O)=O)[C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@H]1NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@@H](N)CSSC1)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 CWCXERYKLSEGEZ-KDKHKZEGSA-N 0.000 description 1
• 229960001586 procarbazine hydrochloride Drugs 0.000 description 1
• 238000012545 processing Methods 0.000 description 1
• 229940097325 prolactin Drugs 0.000 description 1
• 230000035755 proliferation Effects 0.000 description 1
• 230000001902 propagating effect Effects 0.000 description 1
• 238000012514 protein characterization Methods 0.000 description 1
• 238000001742 protein purification Methods 0.000 description 1
• 229950010131 puromycin Drugs 0.000 description 1
• MKSVFGKWZLUTTO-FZFAUISWSA-N puromycin dihydrochloride Chemical compound Cl.Cl.C1=CC(OC)=CC=C1C[C@H](N)C(=O)N[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(=C3N=C2)N(C)C)O[C@@H]1CO MKSVFGKWZLUTTO-FZFAUISWSA-N 0.000 description 1
• 102000016914 ras Proteins Human genes 0.000 description 1
• 230000008707 rearrangement Effects 0.000 description 1
• 108091006084 receptor activators Proteins 0.000 description 1
• 206010038038 rectal cancer Diseases 0.000 description 1
• 201000001275 rectum cancer Diseases 0.000 description 1
• 230000002829 reductive effect Effects 0.000 description 1
• 230000001105 regulatory effect Effects 0.000 description 1
• 238000009877 rendering Methods 0.000 description 1
• BJOIZNZVOZKDIG-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C([C]5C=CC(OC)=CC5=N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 BJOIZNZVOZKDIG-MDEJGZGSSA-N 0.000 description 1
• 229960003147 reserpine Drugs 0.000 description 1
• 201000009410 rhabdomyosarcoma Diseases 0.000 description 1
• 229960004356 riboprine Drugs 0.000 description 1
• QXKJWHWUDVQATH-UHFFFAOYSA-N rogletimide Chemical compound C=1C=NC=CC=1C1(CC)CCC(=O)NC1=O QXKJWHWUDVQATH-UHFFFAOYSA-N 0.000 description 1
• 229950005230 rogletimide Drugs 0.000 description 1
• MDMGHDFNKNZPAU-UHFFFAOYSA-N roserpine Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(OC(C)=O)C(OC)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 MDMGHDFNKNZPAU-UHFFFAOYSA-N 0.000 description 1
• 102200006532 rs112445441 Human genes 0.000 description 1
• 102200055464 rs113488022 Human genes 0.000 description 1
• 102200124924 rs11554290 Human genes 0.000 description 1
• 102200085789 rs121913279 Human genes 0.000 description 1
• 102200006539 rs121913529 Human genes 0.000 description 1
• 102200006540 rs121913530 Human genes 0.000 description 1
• 102200158819 rs63751148 Human genes 0.000 description 1
• 229950008902 safingol Drugs 0.000 description 1
• 108091005418 scavenger receptor class E Proteins 0.000 description 1
• 229960003440 semustine Drugs 0.000 description 1
• 238000002864 sequence alignment Methods 0.000 description 1
• 208000028467 sex cord-stromal tumor Diseases 0.000 description 1
• 230000035939 shock Effects 0.000 description 1
• SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 description 1
• 230000019491 signal transduction Effects 0.000 description 1
• 239000000377 silicon dioxide Substances 0.000 description 1
• 229950009089 simtrazene Drugs 0.000 description 1
• 210000003491 skin Anatomy 0.000 description 1
• 101150038679 skp gene Proteins 0.000 description 1
• 208000000587 small cell lung carcinoma Diseases 0.000 description 1
• 239000011734 sodium Substances 0.000 description 1
• 229910052708 sodium Inorganic materials 0.000 description 1
• 239000001632 sodium acetate Substances 0.000 description 1
• 235000017281 sodium acetate Nutrition 0.000 description 1
• 239000000661 sodium alginate Substances 0.000 description 1
• 235000010413 sodium alginate Nutrition 0.000 description 1
• 229940005550 sodium alginate Drugs 0.000 description 1
• 239000011780 sodium chloride Substances 0.000 description 1
• 239000001509 sodium citrate Substances 0.000 description 1
• AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
• XBUIKNRVGYFSHL-IAVQPKKASA-M sodium;[(1e,3r,4r,6r,7z,9z,11e)-3,6,13-trihydroxy-3-methyl-1-[(2r)-6-oxo-2,3-dihydropyran-2-yl]trideca-1,7,9,11-tetraen-4-yl] hydrogen phosphate Chemical compound [Na+].OC/C=C/C=C\C=C/[C@H](O)C[C@@H](OP(O)([O-])=O)[C@@](O)(C)\C=C\[C@H]1CC=CC(=O)O1 XBUIKNRVGYFSHL-IAVQPKKASA-M 0.000 description 1
• MIXCUJKCXRNYFM-UHFFFAOYSA-M sodium;diiodomethanesulfonate;n-propyl-n-[2-(2,4,6-trichlorophenoxy)ethyl]imidazole-1-carboxamide Chemical compound [Na+].[O-]S(=O)(=O)C(I)I.C1=CN=CN1C(=O)N(CCC)CCOC1=C(Cl)C=C(Cl)C=C1Cl MIXCUJKCXRNYFM-UHFFFAOYSA-M 0.000 description 1
• 239000000243 solution Substances 0.000 description 1
• 238000000638 solvent extraction Methods 0.000 description 1
• 229950009641 sparsomycin Drugs 0.000 description 1
• XKLZIVIOZDNKEQ-CLQLPEFOSA-N sparsomycin Chemical compound CSC[S@](=O)C[C@H](CO)NC(=O)\C=C\C1=C(C)NC(=O)NC1=O XKLZIVIOZDNKEQ-CLQLPEFOSA-N 0.000 description 1
• XKLZIVIOZDNKEQ-UHFFFAOYSA-N sparsomycin Natural products CSCS(=O)CC(CO)NC(=O)C=CC1=C(C)NC(=O)NC1=O XKLZIVIOZDNKEQ-UHFFFAOYSA-N 0.000 description 1
• 101150082315 spas-1 gene Proteins 0.000 description 1
• 238000002798 spectrophotometry method Methods 0.000 description 1
• 229950006050 spiromustine Drugs 0.000 description 1
• 229950004330 spiroplatin Drugs 0.000 description 1
• 239000007921 spray Substances 0.000 description 1
• 238000001694 spray drying Methods 0.000 description 1
• 229940031439 squalene Drugs 0.000 description 1
• TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
• 235000019698 starch Nutrition 0.000 description 1
• 239000008107 starch Substances 0.000 description 1
• 230000004936 stimulating effect Effects 0.000 description 1
• 230000000638 stimulation Effects 0.000 description 1
• 229960001052 streptozocin Drugs 0.000 description 1
• ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 description 1
• 238000013337 sub-cultivation Methods 0.000 description 1
• 210000001768 subcellular fraction Anatomy 0.000 description 1
• 238000000859 sublimation Methods 0.000 description 1
• 230000008022 sublimation Effects 0.000 description 1
• 235000000346 sugar Nutrition 0.000 description 1
• 229950007841 sulofenur Drugs 0.000 description 1
• 239000006228 supernatant Substances 0.000 description 1
• 239000000725 suspension Substances 0.000 description 1
• 230000009885 systemic effect Effects 0.000 description 1
• 108700003774 talisomycin Proteins 0.000 description 1
• 229950002687 talisomycin Drugs 0.000 description 1
• 230000008685 targeting Effects 0.000 description 1
• URLYINUFLXOMHP-HTVVRFAVSA-N tcn-p Chemical compound C=12C3=NC=NC=1N(C)N=C(N)C2=CN3[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O URLYINUFLXOMHP-HTVVRFAVSA-N 0.000 description 1
• 229960001674 tegafur Drugs 0.000 description 1
• WFWLQNSHRPWKFK-ZCFIWIBFSA-N tegafur Chemical compound O=C1NC(=O)C(F)=CN1[C@@H]1OCCC1 WFWLQNSHRPWKFK-ZCFIWIBFSA-N 0.000 description 1
• RNVNXVVEDMSRJE-UHFFFAOYSA-N teloxantrone hydrochloride Chemical compound Cl.Cl.OCCNCCN1NC2=C3C(=O)C=CC(=O)C3=C(O)C3=C2C1=CC=C3NCCNC RNVNXVVEDMSRJE-UHFFFAOYSA-N 0.000 description 1
• 229960002197 temoporfin Drugs 0.000 description 1
• NRUKOCRGYNPUPR-QBPJDGROSA-N teniposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@@H](OC[C@H]4O3)C=3SC=CC=3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 NRUKOCRGYNPUPR-QBPJDGROSA-N 0.000 description 1
• 229960001278 teniposide Drugs 0.000 description 1
• 229950008703 teroxirone Drugs 0.000 description 1
• 201000003120 testicular cancer Diseases 0.000 description 1
• 210000001550 testis Anatomy 0.000 description 1
• 229960005353 testolactone Drugs 0.000 description 1
• BPEWUONYVDABNZ-DZBHQSCQSA-N testolactone Chemical compound O=C1C=C[C@]2(C)[C@H]3CC[C@](C)(OC(=O)CC4)[C@@H]4[C@@H]3CCC2=C1 BPEWUONYVDABNZ-DZBHQSCQSA-N 0.000 description 1
• ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 1
• 229940022511 therapeutic cancer vaccine Drugs 0.000 description 1
• 229960001196 thiotepa Drugs 0.000 description 1
• 108010029307 thymic stromal lymphopoietin Proteins 0.000 description 1
• 229960002175 thyroglobulin Drugs 0.000 description 1
• 210000001685 thyroid gland Anatomy 0.000 description 1
• YFTWHEBLORWGNI-UHFFFAOYSA-N tiamiprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC(N)=NC2=C1NC=N2 YFTWHEBLORWGNI-UHFFFAOYSA-N 0.000 description 1
• 229950011457 tiamiprine Drugs 0.000 description 1
• 229960003087 tioguanine Drugs 0.000 description 1
• MNRILEROXIRVNJ-UHFFFAOYSA-N tioguanine Chemical compound N1C(N)=NC(=S)C2=NC=N[C]21 MNRILEROXIRVNJ-UHFFFAOYSA-N 0.000 description 1
• 229950002376 tirapazamine Drugs 0.000 description 1
• QVMPZNRFXAKISM-UHFFFAOYSA-N tirapazamine Chemical compound C1=CC=C2[N+]([O-])=NC(=N)N(O)C2=C1 QVMPZNRFXAKISM-UHFFFAOYSA-N 0.000 description 1
• 238000011200 topical administration Methods 0.000 description 1
• 230000000699 topical effect Effects 0.000 description 1
• UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 description 1
• 229960002190 topotecan hydrochloride Drugs 0.000 description 1
• 229960004167 toremifene citrate Drugs 0.000 description 1
• 231100000419 toxicity Toxicity 0.000 description 1
• 230000001988 toxicity Effects 0.000 description 1
• 239000003053 toxin Substances 0.000 description 1
• 231100000765 toxin Toxicity 0.000 description 1
• 108700012359 toxins Proteins 0.000 description 1
• 238000013518 transcription Methods 0.000 description 1
• 230000035897 transcription Effects 0.000 description 1
• 239000012581 transferrin Substances 0.000 description 1
• 230000009466 transformation Effects 0.000 description 1
• 238000000844 transformation Methods 0.000 description 1
• 229940099456 transforming growth factor beta 1 Drugs 0.000 description 1
• 229940072041 transforming growth factor beta 2 Drugs 0.000 description 1
• 102000003601 transglutaminase Human genes 0.000 description 1
• 238000013519 translation Methods 0.000 description 1
• 229960001099 trimetrexate Drugs 0.000 description 1
• NOYPYLRCIDNJJB-UHFFFAOYSA-N trimetrexate Chemical compound COC1=C(OC)C(OC)=CC(NCC=2C(=C3C(N)=NC(N)=NC3=CC=2)C)=C1 NOYPYLRCIDNJJB-UHFFFAOYSA-N 0.000 description 1
• 229960000538 trimetrexate glucuronate Drugs 0.000 description 1
• 208000022679 triple-negative breast carcinoma Diseases 0.000 description 1
• VXKHXGOKWPXYNA-PGBVPBMZSA-N triptorelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 VXKHXGOKWPXYNA-PGBVPBMZSA-N 0.000 description 1
• 229960004824 triptorelin Drugs 0.000 description 1
• HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
• 229940038773 trisodium citrate Drugs 0.000 description 1
• 230000005751 tumor progression Effects 0.000 description 1
• 241001148471 unidentified anaerobic bacterium Species 0.000 description 1
• 238000011144 upstream manufacturing Methods 0.000 description 1
• 229960001055 uracil mustard Drugs 0.000 description 1
• SPDZFJLQFWSJGA-UHFFFAOYSA-N uredepa Chemical compound C1CN1P(=O)(NC(=O)OCC)N1CC1 SPDZFJLQFWSJGA-UHFFFAOYSA-N 0.000 description 1
• 229950006929 uredepa Drugs 0.000 description 1
• 201000005112 urinary bladder cancer Diseases 0.000 description 1
• VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
• 229960005356 urokinase Drugs 0.000 description 1
• 102000009816 urokinase plasminogen activator receptor activity proteins Human genes 0.000 description 1
• 108040001269 urokinase plasminogen activator receptor activity proteins Proteins 0.000 description 1
• 229960002730 vapreotide Drugs 0.000 description 1
• 108700029852 vapreotide Proteins 0.000 description 1
• 230000002792 vascular Effects 0.000 description 1
• 239000003981 vehicle Substances 0.000 description 1
• 229960001722 verapamil Drugs 0.000 description 1
• ZQFGRJWRSLZCSQ-ZSFNYQMMSA-N verteporfin Chemical compound C=1C([C@@]2([C@H](C(=O)OC)C(=CC=C22)C(=O)OC)C)=NC2=CC(C(=C2C=C)C)=NC2=CC(C(=C2CCC(O)=O)C)=NC2=CC2=NC=1C(C)=C2CCC(=O)OC ZQFGRJWRSLZCSQ-ZSFNYQMMSA-N 0.000 description 1
• 229960003895 verteporfin Drugs 0.000 description 1
• 229960004982 vinblastine sulfate Drugs 0.000 description 1
• KDQAABAKXDWYSZ-PNYVAJAMSA-N vinblastine sulfate Chemical compound OS(O)(=O)=O.C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 KDQAABAKXDWYSZ-PNYVAJAMSA-N 0.000 description 1
• AQTQHPDCURKLKT-JKDPCDLQSA-N vincristine sulfate Chemical compound OS(O)(=O)=O.C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C=O)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 AQTQHPDCURKLKT-JKDPCDLQSA-N 0.000 description 1
• 229960002110 vincristine sulfate Drugs 0.000 description 1
• 229960004355 vindesine Drugs 0.000 description 1
• UGGWPQSBPIFKDZ-KOTLKJBCSA-N vindesine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(N)=O)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1N=C1[C]2C=CC=C1 UGGWPQSBPIFKDZ-KOTLKJBCSA-N 0.000 description 1
• 229960005212 vindesine sulfate Drugs 0.000 description 1
• BCXOZISMDZTYHW-IFQBWSDRSA-N vinepidine sulfate Chemical compound OS(O)(=O)=O.C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C=O)C=2)OC)C[C@@H](C2)CC)N2CCC2=C1NC1=CC=CC=C21 BCXOZISMDZTYHW-IFQBWSDRSA-N 0.000 description 1
• 229960002166 vinorelbine tartrate Drugs 0.000 description 1
• GBABOYUKABKIAF-IWWDSPBFSA-N vinorelbinetartrate Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC(C23[C@H]([C@@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-IWWDSPBFSA-N 0.000 description 1
• 230000001018 virulence Effects 0.000 description 1
• 239000000304 virulence factor Substances 0.000 description 1
• 230000007923 virulence factor Effects 0.000 description 1
• 235000019155 vitamin A Nutrition 0.000 description 1
• 239000011719 vitamin A Chemical class 0.000 description 1
• 235000012711 vitamin K3 Nutrition 0.000 description 1
• 239000011652 vitamin K3 Substances 0.000 description 1
• 229940045997 vitamin a Drugs 0.000 description 1
• 229940041603 vitamin k 3 Drugs 0.000 description 1
• 229960001771 vorozole Drugs 0.000 description 1
• XLMPPFTZALNBFS-INIZCTEOSA-N vorozole Chemical compound C1([C@@H](C2=CC=C3N=NN(C3=C2)C)N2N=CN=C2)=CC=C(Cl)C=C1 XLMPPFTZALNBFS-INIZCTEOSA-N 0.000 description 1
• 239000011534 wash buffer Substances 0.000 description 1
• 238000005406 washing Methods 0.000 description 1
• DVPVGSLIUJPOCJ-XXRQFBABSA-N x1j761618a Chemical compound OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(=O)CN(C)C)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21.C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(=O)CN(C)C)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 DVPVGSLIUJPOCJ-XXRQFBABSA-N 0.000 description 1
• 229950003017 zeniplatin Drugs 0.000 description 1
• 229950009268 zinostatin Drugs 0.000 description 1
• 235000021241 α-lactalbumin Nutrition 0.000 description 1