IL303926A - Compounds comprising a protein ligand for fibroblast activation and its use - Google Patents

Compounds comprising a protein ligand for fibroblast activation and its use

Info

Publication number
IL303926A
IL303926A IL303926A IL30392623A IL303926A IL 303926 A IL303926 A IL 303926A IL 303926 A IL303926 A IL 303926A IL 30392623 A IL30392623 A IL 30392623A IL 303926 A IL303926 A IL 303926A
Authority
IL
Israel
Prior art keywords
cys
pro
compound
group
phe
Prior art date
Application number
IL303926A
Other languages
English (en)
Hebrew (he)
Inventor
Frank Osterkamp
Christian Haase
Eberhard Schneider
Jonas Proksch
Dirk Zboralski
Matthias Paschke
Christiane Smerling
Ulrich Reineke
Original Assignee
3B Pharmaceuticals Gmbh
Frank Osterkamp
Christian Haase
Eberhard Schneider
Jonas Proksch
Dirk Zboralski
Matthias Paschke
Christiane Smerling
Ulrich Reineke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3B Pharmaceuticals Gmbh, Frank Osterkamp, Christian Haase, Eberhard Schneider, Jonas Proksch, Dirk Zboralski, Matthias Paschke, Christiane Smerling, Ulrich Reineke filed Critical 3B Pharmaceuticals Gmbh
Publication of IL303926A publication Critical patent/IL303926A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/8103Exopeptidase (E.C. 3.4.11-19) inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64Cyclic peptides containing only normal peptide links
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Optics & Photonics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
IL303926A 2021-01-07 2022-01-07 Compounds comprising a protein ligand for fibroblast activation and its use IL303926A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP21150562.3A EP4050018A1 (en) 2021-01-07 2021-01-07 Compounds comprising a fibroblast activation protein ligand and use thereof
PCT/EP2022/050294 WO2022148851A1 (en) 2021-01-07 2022-01-07 Compounds comprising a fibroblast activation protein ligand and use thereof

Publications (1)

Publication Number Publication Date
IL303926A true IL303926A (en) 2023-08-01

Family

ID=74215696

Family Applications (1)

Application Number Title Priority Date Filing Date
IL303926A IL303926A (en) 2021-01-07 2022-01-07 Compounds comprising a protein ligand for fibroblast activation and its use

Country Status (9)

Country Link
US (1) US20240115745A1 (ja)
EP (2) EP4050018A1 (ja)
JP (1) JP2024503635A (ja)
KR (1) KR20230129260A (ja)
CN (1) CN116940586A (ja)
AU (1) AU2022205776A1 (ja)
CA (1) CA3206481A1 (ja)
IL (1) IL303926A (ja)
WO (1) WO2022148851A1 (ja)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118647415A (zh) 2022-02-09 2024-09-13 诺华股份有限公司 包含225锕标记的络合物和铋多价螯合剂的药物组合物
WO2023220836A1 (en) * 2022-05-20 2023-11-23 The Governors Of The University Of Alberta A new bifunctional linchpin that reacts selectively with cysteine residues to invoke cyclization while concurrently introducing a dotaga moiety for radiometal chelation
WO2024052431A1 (en) * 2022-09-07 2024-03-14 3B Pharmaceuticals Gmbh Prostate specific membrane antigen (psma) ligands and use thereof
WO2024165072A1 (zh) * 2023-02-10 2024-08-15 成都纽瑞特医疗科技股份有限公司 一种多肽化合物及其应用
CN118754936A (zh) * 2023-03-27 2024-10-11 晶核生物医药科技(南京)有限公司 环状多肽类化合物及其应用

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4885363A (en) 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
US5021556A (en) 1987-07-22 1991-06-04 Neorx Corporation Method of radiolabeling chelating compounds comprising sulfur atoms with metal radionuclides
US5075099A (en) 1988-05-31 1991-12-24 Neorx Corporation Metal radionuclide chelating compounds for improved chelation kinetics
US5364613A (en) 1989-04-07 1994-11-15 Sieving Paul F Polychelants containing macrocyclic chelant moieties
US5367080A (en) 1990-11-08 1994-11-22 Sterling Winthrop Inc. Complexing agents and targeting radioactive immunoreagents useful in therapeutic and diagnostic imaging compositions and methods
US5965107A (en) 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5886142A (en) 1997-05-20 1999-03-23 Thomas Jefferson University Radiolabeled thrombus imaging agents
AU743996B2 (en) 1997-09-29 2002-02-14 Point Therapeutics, Inc. Stimulation of hematopoietic cells in vitro
EP0953639A1 (en) 1998-04-30 1999-11-03 Boehringer Ingelheim International GmbH FAPalpha-specific antibody with improved producibility
US6890904B1 (en) 1999-05-25 2005-05-10 Point Therapeutics, Inc. Anti-tumor agents
AU2001256325A1 (en) 2000-03-17 2001-09-24 Boehringer Ingelheim Pharma Kg Human and humanized fap-alpha-specific antibodies
US7374898B2 (en) 2004-10-12 2008-05-20 The Research Foundation Of State University Of New York Peptide inhibitors against seprase
EP1943257A2 (en) 2005-05-19 2008-07-16 Genentech, Inc. Fibroblast activation protein inhibitor compounds and methods
US8933201B2 (en) 2006-06-07 2015-01-13 The Board Of Regents Of The University Of Oklahoma Substrates and inhibitors of antiplasmin cleaving enzyme and fibroblast activation protein and methods of use
US20100105753A1 (en) 2007-03-20 2010-04-29 Trustees Of Tufts College Inhibitors of Fibroblast Activation Protein, and Methods of Use Thereof
EP2100900A1 (en) 2008-03-07 2009-09-16 Universitätsspital Basel Bombesin analog peptide antagonist conjugates
CN102203061A (zh) 2008-09-25 2011-09-28 分子制药洞察公司 选择性seprase抑制剂
CA2776037A1 (en) 2009-10-02 2011-04-07 Ludwig Institute For Cancer Research Ltd Anti-fibroblast activation protein antibodies and methods and uses thereof
RS56702B1 (sr) 2010-08-13 2018-03-30 Roche Glycart Ag Anti-fap antitela i metode primene
EP2804859B1 (en) 2012-01-17 2019-06-12 Universiteit Antwerpen Novel fap inhibitors
UA118028C2 (uk) 2013-04-03 2018-11-12 Рош Глікарт Аг Біспецифічне антитіло, специфічне щодо fap і dr5, антитіло, специфічне щодо dr5, і спосіб їх застосування
GB201402006D0 (en) 2014-02-06 2014-03-26 Oncomatryx Biopharma S L Antibody-drug conjugates and immunotoxins
WO2016146174A1 (en) 2015-03-17 2016-09-22 Biontech Ag Compositions and methods for diagnosis and treatment of cancer
CN109689115A (zh) 2016-06-10 2019-04-26 拜耳制药股份公司 放射性药物配合物
JP2018035137A (ja) 2016-07-13 2018-03-08 マブイミューン ダイアグノスティックス エイジーMabimmune Diagnostics Ag 新規な抗線維芽細胞活性化タンパク質(fap)結合薬剤およびその使用
KR20200063230A (ko) 2017-10-23 2020-06-04 더 존스 홉킨스 유니버시티 섬유아세포 활성 단백질-α(FAP-α)를 표적하는 영상화 및 방사선치료제
BR112022000144A2 (pt) * 2019-07-08 2022-02-22 3B Pharmaceuticals Gmbh Compostos que compreendem um ligante de proteína de ativação de fibroblastos e uso dos mesmos
EP3763726A1 (en) * 2019-07-08 2021-01-13 3B Pharmaceuticals GmbH Compounds comprising a fibroblast activation protein ligand and use thereof

Also Published As

Publication number Publication date
EP4274836A1 (en) 2023-11-15
US20240115745A1 (en) 2024-04-11
CA3206481A1 (en) 2022-07-14
JP2024503635A (ja) 2024-01-26
EP4050018A1 (en) 2022-08-31
KR20230129260A (ko) 2023-09-07
WO2022148851A1 (en) 2022-07-14
CN116940586A (zh) 2023-10-24
AU2022205776A1 (en) 2023-07-27

Similar Documents

Publication Publication Date Title
US20220315554A1 (en) Compounds comprising a fibroblast activation protein ligand and use thereof
EP4050018A1 (en) Compounds comprising a fibroblast activation protein ligand and use thereof
US20220273831A1 (en) Compounds comprising a fibroblast activation protein ligand and use thereof
EP3763726A1 (en) Compounds comprising a fibroblast activation protein ligand and use thereof
US20230212549A1 (en) Compounds comprising a fibroblast activation protein ligand and use thereof
US20240335569A1 (en) Fibroblast activation protein inhibitors and use thereof
WO2022123462A1 (en) Radiolabelled prostate specific membrane antigen (psma) inhibitors and use thereof
TW202334177A (zh) 包含纖維母細胞活化蛋白配體之化合物和彼之用途
EP4448544A2 (en) Carbonic anhydrase ix ligands
WO2024052431A1 (en) Prostate specific membrane antigen (psma) ligands and use thereof