IL301648A - A predictive and control model in cell culture - Google Patents
A predictive and control model in cell cultureInfo
- Publication number
- IL301648A IL301648A IL301648A IL30164823A IL301648A IL 301648 A IL301648 A IL 301648A IL 301648 A IL301648 A IL 301648A IL 30164823 A IL30164823 A IL 30164823A IL 301648 A IL301648 A IL 301648A
- Authority
- IL
- Israel
- Prior art keywords
- cell culture
- attribute
- model
- time interval
- values
- Prior art date
Links
- 238000004113 cell culture Methods 0.000 title claims description 201
- 238000005259 measurement Methods 0.000 claims description 58
- 238000000034 method Methods 0.000 claims description 42
- 238000013528 artificial neural network Methods 0.000 claims description 39
- 239000002207 metabolite Substances 0.000 claims description 39
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 26
- 239000008103 glucose Substances 0.000 claims description 26
- 238000012545 processing Methods 0.000 claims description 16
- 238000001069 Raman spectroscopy Methods 0.000 claims description 14
- 230000035899 viability Effects 0.000 claims description 13
- 238000005070 sampling Methods 0.000 claims description 9
- 238000004088 simulation Methods 0.000 claims description 7
- 239000013598 vector Substances 0.000 description 17
- 238000012549 training Methods 0.000 description 15
- 230000008569 process Effects 0.000 description 12
- 230000006870 function Effects 0.000 description 11
- 239000000523 sample Substances 0.000 description 11
- 238000010586 diagram Methods 0.000 description 8
- 210000004027 cell Anatomy 0.000 description 7
- 238000005457 optimization Methods 0.000 description 7
- 238000004458 analytical method Methods 0.000 description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 5
- 238000013459 approach Methods 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 4
- 238000001802 infusion Methods 0.000 description 4
- 238000012544 monitoring process Methods 0.000 description 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 3
- 230000006399 behavior Effects 0.000 description 3
- 238000004422 calculation algorithm Methods 0.000 description 3
- 238000004891 communication Methods 0.000 description 3
- 230000001419 dependent effect Effects 0.000 description 3
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 3
- 229910052700 potassium Inorganic materials 0.000 description 3
- 239000011591 potassium Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 229960000074 biopharmaceutical Drugs 0.000 description 2
- 230000001066 destructive effect Effects 0.000 description 2
- 229940126534 drug product Drugs 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 238000010801 machine learning Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 101150008122 Bcan gene Proteins 0.000 description 1
- 241000270288 Gekko Species 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000008571 general function Effects 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000013178 mathematical model Methods 0.000 description 1
- 238000010946 mechanistic model Methods 0.000 description 1
- 239000012092 media component Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000005312 nonlinear dynamic Methods 0.000 description 1
- 238000004886 process control Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000013138 pruning Methods 0.000 description 1
- 238000004549 pulsed laser deposition Methods 0.000 description 1
- 238000007637 random forest analysis Methods 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/48—Automatic or computerized control
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/32—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of substances in solution
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
- G06N3/00—Computing arrangements based on biological models
- G06N3/02—Neural networks
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Computer Hardware Design (AREA)
- Physics & Mathematics (AREA)
- Theoretical Computer Science (AREA)
- Computational Linguistics (AREA)
- Biophysics (AREA)
- Data Mining & Analysis (AREA)
- Evolutionary Computation (AREA)
- Molecular Biology (AREA)
- Computing Systems (AREA)
- General Physics & Mathematics (AREA)
- Mathematical Physics (AREA)
- Software Systems (AREA)
- Artificial Intelligence (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063086417P | 2020-10-01 | 2020-10-01 | |
| PCT/US2021/051570 WO2022072198A1 (en) | 2020-10-01 | 2021-09-22 | Predictive modeling and control of cell culture |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL301648A true IL301648A (en) | 2023-05-01 |
Family
ID=78599116
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL301648A IL301648A (en) | 2020-10-01 | 2021-09-22 | A predictive and control model in cell culture |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20230272331A1 (es) |
| EP (1) | EP4204538A1 (es) |
| JP (1) | JP2023544029A (es) |
| KR (1) | KR20230076842A (es) |
| CN (1) | CN116457453A (es) |
| AU (1) | AU2021355381A1 (es) |
| CA (1) | CA3196821A1 (es) |
| CL (1) | CL2023000946A1 (es) |
| IL (1) | IL301648A (es) |
| MX (1) | MX2023003687A (es) |
| WO (1) | WO2022072198A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20240084240A1 (en) * | 2022-09-09 | 2024-03-14 | Genentech, Inc. | Prediction of viability of cell culture during a biomolecule manufacturing process |
| CN116926241B (zh) * | 2023-06-30 | 2024-07-19 | 广东美赛尔细胞生物科技有限公司 | 一种免疫细胞培养控制方法及系统 |
| CN117235673B (zh) * | 2023-11-15 | 2024-01-30 | 中南大学 | 一种细胞培养预测方法及装置、电子设备、存储介质 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10563163B2 (en) * | 2014-07-02 | 2020-02-18 | Biogen Ma Inc. | Cross-scale modeling of bioreactor cultures using Raman spectroscopy |
| EP3714036A1 (en) * | 2017-11-20 | 2020-09-30 | Lonza Ltd | Process and system for propagating cell cultures while preventing lactate accumulation |
| CN112119306B (zh) * | 2017-12-29 | 2024-09-03 | 豪夫迈·罗氏有限公司 | 细胞培养物的代谢状态的预测 |
| WO2020041454A1 (en) * | 2018-08-21 | 2020-02-27 | Lonza Ltd | A process for creating reference data for predicting concentrations of quality attributes |
| MX2021004510A (es) * | 2018-10-23 | 2021-06-08 | Amgen Inc | Calibracion automatica y mantenimiento automatico de modelos espectroscopicos de raman para predicciones en tiempo real. |
-
2021
- 2021-09-22 KR KR1020237014248A patent/KR20230076842A/ko active Search and Examination
- 2021-09-22 IL IL301648A patent/IL301648A/en unknown
- 2021-09-22 AU AU2021355381A patent/AU2021355381A1/en active Pending
- 2021-09-22 US US18/029,715 patent/US20230272331A1/en active Pending
- 2021-09-22 EP EP21806433.5A patent/EP4204538A1/en active Pending
- 2021-09-22 CA CA3196821A patent/CA3196821A1/en active Pending
- 2021-09-22 MX MX2023003687A patent/MX2023003687A/es unknown
- 2021-09-22 WO PCT/US2021/051570 patent/WO2022072198A1/en active Application Filing
- 2021-09-22 JP JP2023519646A patent/JP2023544029A/ja active Pending
- 2021-09-22 CN CN202180077069.2A patent/CN116457453A/zh active Pending
-
2023
- 2023-03-30 CL CL2023000946A patent/CL2023000946A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20230076842A (ko) | 2023-05-31 |
| US20230272331A1 (en) | 2023-08-31 |
| WO2022072198A1 (en) | 2022-04-07 |
| AU2021355381A1 (en) | 2023-05-04 |
| CA3196821A1 (en) | 2022-04-07 |
| CL2023000946A1 (es) | 2023-09-08 |
| JP2023544029A (ja) | 2023-10-19 |
| EP4204538A1 (en) | 2023-07-05 |
| MX2023003687A (es) | 2023-04-20 |
| CN116457453A (zh) | 2023-07-18 |
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