CL2023000946A1 - Modelado predictivo híbrido y el control de cultivo celular - Google Patents
Modelado predictivo híbrido y el control de cultivo celularInfo
- Publication number
- CL2023000946A1 CL2023000946A1 CL2023000946A CL2023000946A CL2023000946A1 CL 2023000946 A1 CL2023000946 A1 CL 2023000946A1 CL 2023000946 A CL2023000946 A CL 2023000946A CL 2023000946 A CL2023000946 A CL 2023000946A CL 2023000946 A1 CL2023000946 A1 CL 2023000946A1
- Authority
- CL
- Chile
- Prior art keywords
- cell culture
- controlling
- inputs
- predictive modeling
- culture control
- Prior art date
Links
- 238000004113 cell culture Methods 0.000 title abstract 10
- 238000000034 method Methods 0.000 abstract 4
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/48—Automatic or computerized control
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/32—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of substances in solution
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
- G06N3/00—Computing arrangements based on biological models
- G06N3/02—Neural networks
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Computer Hardware Design (AREA)
- Physics & Mathematics (AREA)
- Theoretical Computer Science (AREA)
- Computational Linguistics (AREA)
- Biophysics (AREA)
- Data Mining & Analysis (AREA)
- Evolutionary Computation (AREA)
- Molecular Biology (AREA)
- Computing Systems (AREA)
- General Physics & Mathematics (AREA)
- Mathematical Physics (AREA)
- Software Systems (AREA)
- Artificial Intelligence (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Un método de control de un procedimiento de cultivo celular incluye, para cada intervalo de tiempo de uno o más intervalos de tiempo durante el procedimiento de cultivo celular, obtener valores actuales de uno o más atributos de cultivo celular asociados con un cultivo celular, predecir uno o más valores futuros de un atributo de cultivo celular particular asociado con el cultivo celular, y controlar una o más entradas físicas para el procedimiento de cultivo celular. Predecir el/los valor(es) futuro(s) incluye aplicar los valores actuales del/de los atributo(s) de cultivo celular y un valor anterior de al menos uno de los atributos de cultivo celular, como entradas para un modelo predictivo basado en datos usando datos históricos. Controlar la(s) entrada(s) física(s) incluye aplicar el/los valor(es) futuro(s) como entradas para un controlador predictivo de modelo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063086417P | 2020-10-01 | 2020-10-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2023000946A1 true CL2023000946A1 (es) | 2023-09-08 |
Family
ID=78599116
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2023000946A CL2023000946A1 (es) | 2020-10-01 | 2023-03-30 | Modelado predictivo híbrido y el control de cultivo celular |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20230272331A1 (es) |
| EP (1) | EP4204538A1 (es) |
| JP (1) | JP2023544029A (es) |
| KR (1) | KR20230076842A (es) |
| CN (1) | CN116457453A (es) |
| AU (1) | AU2021355381A1 (es) |
| CA (1) | CA3196821A1 (es) |
| CL (1) | CL2023000946A1 (es) |
| IL (1) | IL301648A (es) |
| MX (1) | MX2023003687A (es) |
| WO (1) | WO2022072198A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20240084240A1 (en) * | 2022-09-09 | 2024-03-14 | Genentech, Inc. | Prediction of viability of cell culture during a biomolecule manufacturing process |
| CN116926241A (zh) * | 2023-06-30 | 2023-10-24 | 广东美赛尔细胞生物科技有限公司 | 一种免疫细胞培养控制方法及系统 |
| CN117235673B (zh) * | 2023-11-15 | 2024-01-30 | 中南大学 | 一种细胞培养预测方法及装置、电子设备、存储介质 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3164481A4 (en) * | 2014-07-02 | 2018-03-21 | Biogen MA Inc. | Cross-scale modeling of bioreactor cultures using raman spectroscopy |
| CN111630148A (zh) * | 2017-11-20 | 2020-09-04 | 隆萨有限公司 | 在防止乳酸积累的同时繁殖细胞培养物的过程和系统 |
| CN112119306A (zh) * | 2017-12-29 | 2020-12-22 | 豪夫迈·罗氏有限公司 | 细胞培养物的代谢状态的预测 |
| WO2020041454A1 (en) * | 2018-08-21 | 2020-02-27 | Lonza Ltd | A process for creating reference data for predicting concentrations of quality attributes |
| WO2020086635A1 (en) * | 2018-10-23 | 2020-04-30 | Amgen Inc. | Automatic calibration and automatic maintenance of raman spectroscopic models for real-time predictions |
-
2021
- 2021-09-22 KR KR1020237014248A patent/KR20230076842A/ko unknown
- 2021-09-22 WO PCT/US2021/051570 patent/WO2022072198A1/en active Application Filing
- 2021-09-22 US US18/029,715 patent/US20230272331A1/en active Pending
- 2021-09-22 AU AU2021355381A patent/AU2021355381A1/en active Pending
- 2021-09-22 CA CA3196821A patent/CA3196821A1/en active Pending
- 2021-09-22 CN CN202180077069.2A patent/CN116457453A/zh active Pending
- 2021-09-22 JP JP2023519646A patent/JP2023544029A/ja active Pending
- 2021-09-22 IL IL301648A patent/IL301648A/en unknown
- 2021-09-22 EP EP21806433.5A patent/EP4204538A1/en active Pending
- 2021-09-22 MX MX2023003687A patent/MX2023003687A/es unknown
-
2023
- 2023-03-30 CL CL2023000946A patent/CL2023000946A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2023003687A (es) | 2023-04-20 |
| WO2022072198A1 (en) | 2022-04-07 |
| US20230272331A1 (en) | 2023-08-31 |
| AU2021355381A1 (en) | 2023-05-04 |
| CN116457453A (zh) | 2023-07-18 |
| EP4204538A1 (en) | 2023-07-05 |
| JP2023544029A (ja) | 2023-10-19 |
| CA3196821A1 (en) | 2022-04-07 |
| IL301648A (en) | 2023-05-01 |
| KR20230076842A (ko) | 2023-05-31 |
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