CL2023000946A1 - Modelado predictivo híbrido y el control de cultivo celular - Google Patents

Modelado predictivo híbrido y el control de cultivo celular

Info

Publication number
CL2023000946A1
CL2023000946A1 CL2023000946A CL2023000946A CL2023000946A1 CL 2023000946 A1 CL2023000946 A1 CL 2023000946A1 CL 2023000946 A CL2023000946 A CL 2023000946A CL 2023000946 A CL2023000946 A CL 2023000946A CL 2023000946 A1 CL2023000946 A1 CL 2023000946A1
Authority
CL
Chile
Prior art keywords
cell culture
controlling
inputs
predictive modeling
culture control
Prior art date
Application number
CL2023000946A
Other languages
English (en)
Inventor
KHODABANDEHLOU Hamid
Y Wang Tony
Tulsyan Aditya
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of CL2023000946A1 publication Critical patent/CL2023000946A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/32—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of substances in solution
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/02—Neural networks

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Computer Hardware Design (AREA)
  • Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • Computational Linguistics (AREA)
  • Biophysics (AREA)
  • Data Mining & Analysis (AREA)
  • Evolutionary Computation (AREA)
  • Molecular Biology (AREA)
  • Computing Systems (AREA)
  • General Physics & Mathematics (AREA)
  • Mathematical Physics (AREA)
  • Software Systems (AREA)
  • Artificial Intelligence (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Un método de control de un procedimiento de cultivo celular incluye, para cada intervalo de tiempo de uno o más intervalos de tiempo durante el procedimiento de cultivo celular, obtener valores actuales de uno o más atributos de cultivo celular asociados con un cultivo celular, predecir uno o más valores futuros de un atributo de cultivo celular particular asociado con el cultivo celular, y controlar una o más entradas físicas para el procedimiento de cultivo celular. Predecir el/los valor(es) futuro(s) incluye aplicar los valores actuales del/de los atributo(s) de cultivo celular y un valor anterior de al menos uno de los atributos de cultivo celular, como entradas para un modelo predictivo basado en datos usando datos históricos. Controlar la(s) entrada(s) física(s) incluye aplicar el/los valor(es) futuro(s) como entradas para un controlador predictivo de modelo.
CL2023000946A 2020-10-01 2023-03-30 Modelado predictivo híbrido y el control de cultivo celular CL2023000946A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US202063086417P 2020-10-01 2020-10-01

Publications (1)

Publication Number Publication Date
CL2023000946A1 true CL2023000946A1 (es) 2023-09-08

Family

ID=78599116

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2023000946A CL2023000946A1 (es) 2020-10-01 2023-03-30 Modelado predictivo híbrido y el control de cultivo celular

Country Status (11)

Country Link
US (1) US20230272331A1 (es)
EP (1) EP4204538A1 (es)
JP (1) JP2023544029A (es)
KR (1) KR20230076842A (es)
CN (1) CN116457453A (es)
AU (1) AU2021355381A1 (es)
CA (1) CA3196821A1 (es)
CL (1) CL2023000946A1 (es)
IL (1) IL301648A (es)
MX (1) MX2023003687A (es)
WO (1) WO2022072198A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024055008A1 (en) * 2022-09-09 2024-03-14 Genentech, Inc. Prediction of viability of cell culture during a biomolecule manufacturing process
CN116926241A (zh) * 2023-06-30 2023-10-24 广东美赛尔细胞生物科技有限公司 一种免疫细胞培养控制方法及系统
CN117235673B (zh) * 2023-11-15 2024-01-30 中南大学 一种细胞培养预测方法及装置、电子设备、存储介质

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3164481A4 (en) * 2014-07-02 2018-03-21 Biogen MA Inc. Cross-scale modeling of bioreactor cultures using raman spectroscopy
WO2019100040A1 (en) * 2017-11-20 2019-05-23 Lonza Ltd. Process and system for propagating cell cultures while preventing lactate accumulation
JP7092879B2 (ja) * 2017-12-29 2022-06-28 エフ．ホフマン－ラ ロシュ アーゲー 細胞培養物の代謝状態の予測
EP3841193A1 (en) * 2018-08-21 2021-06-30 Lonza Ltd. A process for creating reference data for predicting concentrations of quality attributes
BR112021007611A2 (pt) * 2018-10-23 2021-07-27 Amgen Inc. calibração automática e manutenção automática de modelos espectroscópicos raman para previsões em tempo real

Also Published As

Publication number Publication date
KR20230076842A (ko) 2023-05-31
MX2023003687A (es) 2023-04-20
JP2023544029A (ja) 2023-10-19
WO2022072198A1 (en) 2022-04-07
IL301648A (en) 2023-05-01
CN116457453A (zh) 2023-07-18
EP4204538A1 (en) 2023-07-05
AU2021355381A1 (en) 2023-05-04
US20230272331A1 (en) 2023-08-31
CA3196821A1 (en) 2022-04-07

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