IL301055A - Sulphamoyl urea derivatives containing alkyl-oxacycloalkyl moiety and uses thereof - Google Patents

Info

Publication number

IL301055A

IL301055A IL301055A IL30105523A IL301055A IL 301055 A IL301055 A IL 301055A IL 301055 A IL301055 A IL 301055A IL 30105523 A IL30105523 A IL 30105523A IL 301055 A IL301055 A IL 301055A

Authority

IL

Israel

Prior art keywords

compound

disease

disorder

pct

pharmaceutical composition

Prior art date

2020-09-04

Links

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• OJXASOYYODXRPT-UHFFFAOYSA-N sulfamoylurea Chemical class NC(=O)NS(N)(=O)=O OJXASOYYODXRPT-UHFFFAOYSA-N 0.000 title description 3
• 150000001875 compounds Chemical class 0.000 claims description 458
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 149
• 238000000034 method Methods 0.000 claims description 142
• 150000003839 salts Chemical class 0.000 claims description 109
• 201000010099 disease Diseases 0.000 claims description 84
• 208000035475 disorder Diseases 0.000 claims description 65
• 206010028980 Neoplasm Diseases 0.000 claims description 58
• 125000005842 heteroatom Chemical group 0.000 claims description 52
• 239000008194 pharmaceutical composition Substances 0.000 claims description 52
• 210000004027 cell Anatomy 0.000 claims description 50
• 208000022993 cryopyrin-associated periodic syndrome Diseases 0.000 claims description 49
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 49
• 239000000543 intermediate Substances 0.000 claims description 47
• 230000000694 effects Effects 0.000 claims description 45
• 229940002612 prodrug Drugs 0.000 claims description 42
• 239000000651 prodrug Substances 0.000 claims description 42
• 108010034143 Inflammasomes Proteins 0.000 claims description 41
• 239000012453 solvate Substances 0.000 claims description 39
• 239000003814 drug Substances 0.000 claims description 35
• 201000011510 cancer Diseases 0.000 claims description 33
• 206010052015 cytokine release syndrome Diseases 0.000 claims description 33
• 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims description 29
• 208000027866 inflammatory disease Diseases 0.000 claims description 26
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 25
• 238000001727 in vivo Methods 0.000 claims description 24
• 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims description 22
• 125000001412 tetrahydropyranyl group Chemical group 0.000 claims description 21
• 201000003176 Severe Acute Respiratory Syndrome Diseases 0.000 claims description 20
• 208000015181 infectious disease Diseases 0.000 claims description 18
• 230000002401 inhibitory effect Effects 0.000 claims description 18
• 238000004519 manufacturing process Methods 0.000 claims description 18
• 238000000338 in vitro Methods 0.000 claims description 17
• 206010016207 Familial Mediterranean fever Diseases 0.000 claims description 16
• 201000002795 Muckle-Wells syndrome Diseases 0.000 claims description 16
• 238000011467 adoptive cell therapy Methods 0.000 claims description 16
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• 108091008099 NLRP3 inflammasome Proteins 0.000 claims description 15
• 208000020832 chronic kidney disease Diseases 0.000 claims description 15
• 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims description 15
• 241000711573 Coronaviridae Species 0.000 claims description 14
• 208000035690 Familial cold urticaria Diseases 0.000 claims description 14
• 206010064570 familial cold autoinflammatory syndrome Diseases 0.000 claims description 14
• 125000006582 (C5-C6) heterocycloalkyl group Chemical group 0.000 claims description 13
• 210000001744 T-lymphocyte Anatomy 0.000 claims description 13
• 125000005843 halogen group Chemical group 0.000 claims description 13
• 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 12
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• 125000004093 cyano group Chemical group *C#N 0.000 claims description 12
• 230000004770 neurodegeneration Effects 0.000 claims description 12
• 208000015122 neurodegenerative disease Diseases 0.000 claims description 12
• 208000011580 syndromic disease Diseases 0.000 claims description 12
• 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims description 10
• 230000000155 isotopic effect Effects 0.000 claims description 10
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• 206010016654 Fibrosis Diseases 0.000 claims description 9
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• 230000004761 fibrosis Effects 0.000 claims description 9
• 201000006417 multiple sclerosis Diseases 0.000 claims description 9
• 235000020824 obesity Nutrition 0.000 claims description 9
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• 201000003274 CINCA syndrome Diseases 0.000 claims description 8
• 208000025721 COVID-19 Diseases 0.000 claims description 8
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• 208000002874 Acne Vulgaris Diseases 0.000 claims description 7
• 208000022715 Autoinflammatory syndrome Diseases 0.000 claims description 7
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• 230000003959 neuroinflammation Effects 0.000 claims description 7
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• 239000003085 diluting agent Substances 0.000 claims description 6
• 241001493065 dsRNA viruses Species 0.000 claims description 6
• 125000003226 pyrazolyl group Chemical group 0.000 claims description 6
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• 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 4
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• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 3
• 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 3
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• 235000013350 formula milk Nutrition 0.000 claims 6
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• 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 claims 1
• 230000001476 alcoholic effect Effects 0.000 claims 1
• 201000000459 head and neck squamous cell carcinoma Diseases 0.000 claims 1
• 235000002639 sodium chloride Nutrition 0.000 description 107
• -1 but not limited to Chemical group 0.000 description 96
• 239000000203 mixture Substances 0.000 description 91
• 239000000243 solution Substances 0.000 description 69
• XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 58
• WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 50
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 45
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• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 36
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• 238000011282 treatment Methods 0.000 description 34
• 229910052805 deuterium Inorganic materials 0.000 description 32
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 32
• 102100022691 NACHT, LRR and PYD domains-containing protein 3 Human genes 0.000 description 31
• YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 description 28
• 235000019439 ethyl acetate Nutrition 0.000 description 28
• 239000002904 solvent Substances 0.000 description 28
• YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical group C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 27
• 125000001424 substituent group Chemical group 0.000 description 27
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• 108010001946 Pyrin Domain-Containing 3 Protein NLR Family Proteins 0.000 description 26
• 230000004913 activation Effects 0.000 description 26
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 25
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• 241000282414 Homo sapiens Species 0.000 description 23
• 238000005481 NMR spectroscopy Methods 0.000 description 23
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• 125000006239 protecting group Chemical group 0.000 description 23
• 238000003556 assay Methods 0.000 description 22
• OKKJLVBELUTLKV-VMNATFBRSA-N methanol-d1 Chemical compound [2H]OC OKKJLVBELUTLKV-VMNATFBRSA-N 0.000 description 22
• ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 21
• 125000003118 aryl group Chemical group 0.000 description 21
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 20
• 206010027476 Metastases Diseases 0.000 description 20
• 125000004429 atom Chemical group 0.000 description 20
• 229910052708 sodium Inorganic materials 0.000 description 20
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• 238000003786 synthesis reaction Methods 0.000 description 20
• 230000001225 therapeutic effect Effects 0.000 description 20
• 150000001412 amines Chemical class 0.000 description 19
• 239000000872 buffer Substances 0.000 description 19
• 238000005160 1H NMR spectroscopy Methods 0.000 description 18
• YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 18
• JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 18
• 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 18
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• 125000000217 alkyl group Chemical group 0.000 description 17
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• 125000002887 hydroxy group Chemical group [H]O* 0.000 description 16
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• 238000002953 preparative HPLC Methods 0.000 description 16
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 16
• 125000003342 alkenyl group Chemical group 0.000 description 15
• 239000003795 chemical substances by application Substances 0.000 description 15
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 14
• BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 description 14
• XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 14
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