CN116783184A - 含有烷基-氧杂环烷基部分的氨磺酰基脲衍生物及其用途 - Google Patents

含有烷基-氧杂环烷基部分的氨磺酰基脲衍生物及其用途 Download PDF

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Publication number
CN116783184A
CN116783184A CN202180074301.7A CN202180074301A CN116783184A CN 116783184 A CN116783184 A CN 116783184A CN 202180074301 A CN202180074301 A CN 202180074301A CN 116783184 A CN116783184 A CN 116783184A
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China
Prior art keywords
compound
disease
compound according
compounds
pharmaceutical composition
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Pending
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CN202180074301.7A
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English (en)
Chinese (zh)
Inventor
M·G·波克
D·哈里森
J·E·斯坎伦
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Northera Ltd
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Northera Ltd
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Publication of CN116783184A publication Critical patent/CN116783184A/zh
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/41551,2-Diazoles non condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05Isotopically modified compounds, e.g. labelled
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN202180074301.7A 2020-09-04 2021-09-03 含有烷基-氧杂环烷基部分的氨磺酰基脲衍生物及其用途 Pending CN116783184A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063074521P 2020-09-04 2020-09-04
US63/074521 2020-09-04
PCT/US2021/049001 WO2022051582A1 (en) 2020-09-04 2021-09-03 Sulphamoyl urea derivatives containing alkyl-oxacycloalkyl moiety and uses thereof

Publications (1)

Publication Number Publication Date
CN116783184A true CN116783184A (zh) 2023-09-19

Family

ID=77951864

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180074301.7A Pending CN116783184A (zh) 2020-09-04 2021-09-03 含有烷基-氧杂环烷基部分的氨磺酰基脲衍生物及其用途

Country Status (12)

Country Link
US (1) US20240043410A1 (https=)
EP (1) EP4208459A1 (https=)
JP (1) JP2023540733A (https=)
KR (1) KR20230061505A (https=)
CN (1) CN116783184A (https=)
AR (1) AR123435A1 (https=)
AU (1) AU2021336518A1 (https=)
BR (1) BR112023003792A2 (https=)
CA (1) CA3191410A1 (https=)
IL (1) IL301055A (https=)
MX (1) MX2023002686A (https=)
WO (1) WO2022051582A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201721185D0 (en) 2017-12-18 2018-01-31 Nodthera Ltd Sulphonyl urea derivatives
PL3983387T3 (pl) 2019-06-12 2024-08-19 NodThera Limited Pochodne sulfonylomocznika i ich zastosowania
WO2025104268A1 (en) 2023-11-17 2025-05-22 NodThera Limited Forms of urea derivatives and related uses
WO2025104244A1 (en) * 2023-11-17 2025-05-22 NodThera Limited Methods of preparing urea derivatives
WO2025153532A1 (en) * 2024-01-16 2025-07-24 NodThera Limited Nlrp3 inhibitors and glp-1 agonists combination therapies

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107428696A (zh) * 2015-02-16 2017-12-01 昆士兰大学 磺酰脲和相关化合物及其用途
WO2019121691A1 (en) * 2017-12-18 2019-06-27 NodThera Limited Sulphonyl urea derivatives as nlrp3 inflammasome modulators
WO2020035464A1 (en) * 2018-08-15 2020-02-20 Inflazome Limited Novel sulfonamideurea compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US5763263A (en) 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
PT1270565E (pt) 1997-01-29 2004-09-30 Pfizer Furano-2-sulfonamida 4-substituida e sua utilizacao na preparacao de derivados de sulfonilureia
ES2988798T3 (es) 2017-07-24 2024-11-21 Novartis Ag Compuestos y composiciones para el tratamiento de afecciones asociadas a la actividad de NLRP

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107428696A (zh) * 2015-02-16 2017-12-01 昆士兰大学 磺酰脲和相关化合物及其用途
WO2019121691A1 (en) * 2017-12-18 2019-06-27 NodThera Limited Sulphonyl urea derivatives as nlrp3 inflammasome modulators
WO2020035464A1 (en) * 2018-08-15 2020-02-20 Inflazome Limited Novel sulfonamideurea compounds

Also Published As

Publication number Publication date
JP2023540733A (ja) 2023-09-26
KR20230061505A (ko) 2023-05-08
WO2022051582A1 (en) 2022-03-10
MX2023002686A (es) 2023-04-03
IL301055A (en) 2023-05-01
AR123435A1 (es) 2022-11-30
EP4208459A1 (en) 2023-07-12
CA3191410A1 (en) 2022-03-10
US20240043410A1 (en) 2024-02-08
BR112023003792A2 (pt) 2023-03-28
AU2021336518A1 (en) 2023-03-23
TW202229265A (zh) 2022-08-01

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