IL301007B1 - GPR52 modulator compounds - Google Patents

GPR52 modulator compounds

Info

Publication number
IL301007B1
IL301007B1 IL301007A IL30100723A IL301007B1 IL 301007 B1 IL301007 B1 IL 301007B1 IL 301007 A IL301007 A IL 301007A IL 30100723 A IL30100723 A IL 30100723A IL 301007 B1 IL301007 B1 IL 301007B1
Authority
IL
Israel
Prior art keywords
gpr52
modulator compounds
modulator
compounds
gpr52 modulator
Prior art date
Application number
IL301007A
Other languages
English (en)
Hebrew (he)
Other versions
IL301007A (en
Original Assignee
Nxera Pharma Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nxera Pharma Uk Ltd filed Critical Nxera Pharma Uk Ltd
Publication of IL301007A publication Critical patent/IL301007A/en
Publication of IL301007B1 publication Critical patent/IL301007B1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • C07D491/044Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Amplifiers (AREA)
  • Optical Modulation, Optical Deflection, Nonlinear Optics, Optical Demodulation, Optical Logic Elements (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL301007A 2020-08-28 2021-08-31 GPR52 modulator compounds IL301007B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB2013558.8A GB202013558D0 (en) 2020-08-28 2020-08-28 GRP52 Modularor compounds
PCT/GB2021/052247 WO2022043714A1 (en) 2020-08-28 2021-08-31 Gpr52 modulator compounds

Publications (2)

Publication Number Publication Date
IL301007A IL301007A (en) 2023-05-01
IL301007B1 true IL301007B1 (en) 2026-04-01

Family

ID=72749711

Family Applications (1)

Application Number Title Priority Date Filing Date
IL301007A IL301007B1 (en) 2020-08-28 2021-08-31 GPR52 modulator compounds

Country Status (12)

Country Link
US (1) US20230348416A1 (https=)
EP (1) EP4204408A1 (https=)
JP (1) JP7761635B6 (https=)
KR (1) KR20230058132A (https=)
CN (1) CN116507622B (https=)
AU (1) AU2021330379A1 (https=)
BR (1) BR112023003696A2 (https=)
CA (1) CA3193487A1 (https=)
GB (1) GB202013558D0 (https=)
IL (1) IL301007B1 (https=)
MX (1) MX2023002389A (https=)
WO (1) WO2022043714A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202206413A (zh) 2020-04-22 2022-02-16 美商紐羅克里生物科學有限公司 Gpr52調節劑及其使用方法
WO2025117662A1 (en) * 2023-11-29 2025-06-05 Actio Biosciences, Inc. Heterocyclic compounds useful as kcnt1 inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180004193A (ko) * 2015-04-29 2018-01-10 아레나 파마슈티칼스, 인크. Gpr52와 관련된 장애의 치료 또는 예방을 위한 gpr52 조절제로서 1-헤테로아릴-인돌린-4-카르복스아미드
JP6859358B2 (ja) * 2015-11-02 2021-04-14 ゲナーゼ セラピューティクス ベー.フェー.Genase Therapeutics B.V. テトラヒドロインダゾール及びその医学的使用
WO2021009003A1 (en) * 2019-07-16 2021-01-21 Universität Hamburg Computer-based identification of types in the empirical sciences by tangle theory
CA3156474A1 (en) * 2019-11-08 2021-05-14 Heptares Therapeutics Limited GPR52 MODULATING COMPOUNDS

Also Published As

Publication number Publication date
JP7761635B6 (ja) 2025-11-27
EP4204408A1 (en) 2023-07-05
WO2022043714A1 (en) 2022-03-03
JP7761635B2 (ja) 2025-10-28
CN116507622A (zh) 2023-07-28
AU2021330379A1 (en) 2023-03-30
MX2023002389A (es) 2023-05-03
GB202013558D0 (en) 2020-10-14
IL301007A (en) 2023-05-01
KR20230058132A (ko) 2023-05-02
CN116507622B (zh) 2026-02-24
US20230348416A1 (en) 2023-11-02
CA3193487A1 (en) 2022-03-03
JP2023539336A (ja) 2023-09-13
BR112023003696A2 (pt) 2023-04-04

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