IL300374A - A method for treating diseases related to WWOX - Google Patents
A method for treating diseases related to WWOXInfo
- Publication number
- IL300374A IL300374A IL300374A IL30037423A IL300374A IL 300374 A IL300374 A IL 300374A IL 300374 A IL300374 A IL 300374A IL 30037423 A IL30037423 A IL 30037423A IL 300374 A IL300374 A IL 300374A
- Authority
- IL
- Israel
- Prior art keywords
- wwox
- promoter
- gene
- brain
- mice
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063064181P | 2020-08-11 | 2020-08-11 | |
| US202163167277P | 2021-03-29 | 2021-03-29 | |
| PCT/IL2021/050982 WO2022034591A1 (en) | 2020-08-11 | 2021-08-11 | Method for the treatment of wwox associated diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL300374A true IL300374A (en) | 2023-04-01 |
Family
ID=77910831
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL300374A IL300374A (en) | 2020-08-11 | 2021-08-11 | A method for treating diseases related to WWOX |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20230293726A1 (enExample) |
| EP (2) | EP4582143A3 (enExample) |
| JP (1) | JP7850136B2 (enExample) |
| KR (1) | KR20230051223A (enExample) |
| AU (1) | AU2021324538A1 (enExample) |
| CA (1) | CA3188895A1 (enExample) |
| ES (1) | ES3032462T3 (enExample) |
| IL (1) | IL300374A (enExample) |
| WO (1) | WO2022034591A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116463413B (zh) * | 2023-06-12 | 2023-10-03 | 佛山科学技术学院 | 猪间性病相关的wwox基因分子标记及其应用 |
| WO2025264815A1 (en) * | 2024-06-18 | 2025-12-26 | Synaptec Network, Inc. | Systems and methods of exosome mediated delivery of antibodies |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7060811B2 (en) * | 2000-10-13 | 2006-06-13 | Board Of Regents, The University Of Texas System | WWOX: a tumor suppressor gene mutated in multiple cancers |
| US20090270484A1 (en) * | 2005-10-05 | 2009-10-29 | The Ohio State University Research Foundation | WWOX Vectors and Uses in Treatment of Cancer |
| DK2282779T3 (da) * | 2008-04-29 | 2013-05-27 | Pharnext | Nye terapeutiske fremgangsmåder til behandling af alzheimer sygdom og beslægtede lidelser gennem en modulation af cellestress-respons |
| EP2322163A1 (en) * | 2009-11-03 | 2011-05-18 | Pharnext | New therapeutics approaches for treating alzheimer disease |
| CN112301024A (zh) | 2013-03-15 | 2021-02-02 | 通用医疗公司 | 使用RNA引导的FokI核酸酶(RFN)提高RNA引导的基因组编辑的特异性 |
| WO2017147720A1 (en) * | 2016-03-04 | 2017-09-08 | Exerkine Corporation | Method for treating a central nervous system disorder |
| KR20210053877A (ko) * | 2018-06-26 | 2021-05-12 | 리보노바 인크. | 미토콘드리아 기능장애를 치료하는 방법 |
| KR20220094216A (ko) * | 2019-11-08 | 2022-07-05 | 코브 테라퓨틱스 | 변형된 아데노-관련 바이러스 벡터 및 이의 중추신경계로의 전달 |
-
2021
- 2021-08-11 US US18/020,734 patent/US20230293726A1/en active Pending
- 2021-08-11 CA CA3188895A patent/CA3188895A1/en active Pending
- 2021-08-11 EP EP25162633.9A patent/EP4582143A3/en active Pending
- 2021-08-11 IL IL300374A patent/IL300374A/en unknown
- 2021-08-11 KR KR1020237008228A patent/KR20230051223A/ko active Pending
- 2021-08-11 JP JP2023509534A patent/JP7850136B2/ja active Active
- 2021-08-11 WO PCT/IL2021/050982 patent/WO2022034591A1/en not_active Ceased
- 2021-08-11 EP EP21777373.8A patent/EP4196595B1/en active Active
- 2021-08-11 ES ES21777373T patent/ES3032462T3/es active Active
- 2021-08-11 AU AU2021324538A patent/AU2021324538A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ES3032462T3 (en) | 2025-07-18 |
| EP4582143A2 (en) | 2025-07-09 |
| KR20230051223A (ko) | 2023-04-17 |
| CA3188895A1 (en) | 2022-02-17 |
| EP4196595B1 (en) | 2025-03-12 |
| WO2022034591A1 (en) | 2022-02-17 |
| JP2023537093A (ja) | 2023-08-30 |
| EP4196595A1 (en) | 2023-06-21 |
| US20230293726A1 (en) | 2023-09-21 |
| JP7850136B2 (ja) | 2026-04-22 |
| EP4582143A3 (en) | 2025-10-22 |
| AU2021324538A1 (en) | 2023-03-09 |
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