IL300310A - Preparations and methods for treating diseases and disorders - Google Patents

Info

Publication number

IL300310A

IL300310A IL300310A IL30031023A IL300310A IL 300310 A IL300310 A IL 300310A IL 300310 A IL300310 A IL 300310A IL 30031023 A IL30031023 A IL 30031023A IL 300310 A IL300310 A IL 300310A

Authority

IL

Israel

Prior art keywords

compound

subject

pharmaceutical composition

administering

disease

Prior art date

2020-08-03

Links

• Espacenet
• Global Dossier
• Discuss

• 238000000034 method Methods 0.000 title claims description 267
• 239000000203 mixture Substances 0.000 title description 47
• 208000037765 diseases and disorders Diseases 0.000 title description 3
• 150000001875 compounds Chemical class 0.000 claims description 261
• 239000008194 pharmaceutical composition Substances 0.000 claims description 128
• 229940125904 compound 1 Drugs 0.000 claims description 98
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 94
• 208000024908 graft versus host disease Diseases 0.000 claims description 67
• 206010028980 Neoplasm Diseases 0.000 claims description 66
• 238000011319 anticancer therapy Methods 0.000 claims description 65
• 150000003839 salts Chemical class 0.000 claims description 63
• 201000010099 disease Diseases 0.000 claims description 60
• 208000002250 Hematologic Neoplasms Diseases 0.000 claims description 57
• 206010066476 Haematological malignancy Diseases 0.000 claims description 52
• 230000004044 response Effects 0.000 claims description 51
• 238000011282 treatment Methods 0.000 claims description 50
• 239000002177 L01XE27 - Ibrutinib Substances 0.000 claims description 46
• XYFPWWZEPKGCCK-GOSISDBHSA-N ibrutinib Chemical group C1=2C(N)=NC=NC=2N([C@H]2CN(CCC2)C(=O)C=C)N=C1C(C=C1)=CC=C1OC1=CC=CC=C1 XYFPWWZEPKGCCK-GOSISDBHSA-N 0.000 claims description 46
• 229960001507 ibrutinib Drugs 0.000 claims description 46
• 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims description 41
• 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims description 39
• 208000009329 Graft vs Host Disease Diseases 0.000 claims description 37
• 239000003814 drug Substances 0.000 claims description 36
• 229960004641 rituximab Drugs 0.000 claims description 35
• 208000035475 disorder Diseases 0.000 claims description 34
• 239000002552 dosage form Substances 0.000 claims description 34
• 208000033559 Waldenström macroglobulinemia Diseases 0.000 claims description 32
• 229940124291 BTK inhibitor Drugs 0.000 claims description 30
• 201000011510 cancer Diseases 0.000 claims description 29
• 229940079593 drug Drugs 0.000 claims description 29
• 208000031261 Acute myeloid leukaemia Diseases 0.000 claims description 25
• 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims description 24
• 201000007924 marginal zone B-cell lymphoma Diseases 0.000 claims description 22
• 208000021937 marginal zone lymphoma Diseases 0.000 claims description 22
• 208000027866 inflammatory disease Diseases 0.000 claims description 21
• 230000036961 partial effect Effects 0.000 claims description 21
• RNOAOAWBMHREKO-QFIPXVFZSA-N (7S)-2-(4-phenoxyphenyl)-7-(1-prop-2-enoylpiperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide Chemical compound C(C=C)(=O)N1CCC(CC1)[C@@H]1CCNC=2N1N=C(C=2C(=O)N)C1=CC=C(C=C1)OC1=CC=CC=C1 RNOAOAWBMHREKO-QFIPXVFZSA-N 0.000 claims description 20
• 230000035772 mutation Effects 0.000 claims description 20
• 229950007153 zanubrutinib Drugs 0.000 claims description 20
• 208000016800 primary central nervous system lymphoma Diseases 0.000 claims description 19
• -1 IMO-08400 Chemical compound 0.000 claims description 18
• 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims description 18
• 102100024134 Myeloid differentiation primary response protein MyD88 Human genes 0.000 claims description 17
• WDENQIQQYWYTPO-IBGZPJMESA-N acalabrutinib Chemical compound CC#CC(=O)N1CCC[C@H]1C1=NC(C=2C=CC(=CC=2)C(=O)NC=2N=CC=CC=2)=C2N1C=CN=C2N WDENQIQQYWYTPO-IBGZPJMESA-N 0.000 claims description 17
• 229950009821 acalabrutinib Drugs 0.000 claims description 17
• 210000004027 cell Anatomy 0.000 claims description 17
• 201000007919 lymphoplasmacytic lymphoma Diseases 0.000 claims description 17
• 241000282414 Homo sapiens Species 0.000 claims description 16
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 16
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
• 239000003085 diluting agent Substances 0.000 claims description 15
• CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims description 14
• 239000002775 capsule Substances 0.000 claims description 14
• 230000001684 chronic effect Effects 0.000 claims description 14
• 229960004397 cyclophosphamide Drugs 0.000 claims description 14
• 229960003957 dexamethasone Drugs 0.000 claims description 14
• UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims description 14
• 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims description 13
• 229960001467 bortezomib Drugs 0.000 claims description 13
• GXJABQQUPOEUTA-RDJZCZTQSA-N bortezomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)B(O)O)NC(=O)C=1N=CC=NC=1)C1=CC=CC=C1 GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 claims description 13
• 201000003444 follicular lymphoma Diseases 0.000 claims description 13
• 208000021173 high grade B-cell lymphoma Diseases 0.000 claims description 13
• 206010007953 Central nervous system lymphoma Diseases 0.000 claims description 12
• 239000002253 acid Substances 0.000 claims description 12
• HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 12
• 201000003791 MALT lymphoma Diseases 0.000 claims description 11
• 239000000314 lubricant Substances 0.000 claims description 11
• 238000002560 therapeutic procedure Methods 0.000 claims description 11
• UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 claims description 10
• 206010025323 Lymphomas Diseases 0.000 claims description 10
• 201000003793 Myelodysplastic syndrome Diseases 0.000 claims description 10
• DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 10
• GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 10
• 208000007502 anemia Diseases 0.000 claims description 10
• 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 10
• 239000012664 BCL-2-inhibitor Substances 0.000 claims description 9
• 229940123711 Bcl2 inhibitor Drugs 0.000 claims description 9
• 229920002785 Croscarmellose sodium Polymers 0.000 claims description 9
• 229940124650 anti-cancer therapies Drugs 0.000 claims description 9
• 230000001363 autoimmune Effects 0.000 claims description 9
• 239000011230 binding agent Substances 0.000 claims description 9
• 239000004094 surface-active agent Substances 0.000 claims description 9
• 239000000454 talc Substances 0.000 claims description 9
• 229910052623 talc Inorganic materials 0.000 claims description 9
• AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims description 8
• 206010020751 Hypersensitivity Diseases 0.000 claims description 8
• 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims description 8
• 239000004141 Sodium laurylsulphate Substances 0.000 claims description 8
• 208000026935 allergic disease Diseases 0.000 claims description 8
• 238000011861 anti-inflammatory therapy Methods 0.000 claims description 8
• 210000001185 bone marrow Anatomy 0.000 claims description 8
• 239000007884 disintegrant Substances 0.000 claims description 8
• 229960000390 fludarabine Drugs 0.000 claims description 8
• GIUYCYHIANZCFB-FJFJXFQQSA-N fludarabine phosphate Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O GIUYCYHIANZCFB-FJFJXFQQSA-N 0.000 claims description 8
• 230000011664 signaling Effects 0.000 claims description 8
• 210000000130 stem cell Anatomy 0.000 claims description 8
• 150000003431 steroids Chemical class 0.000 claims description 8
• 229960001183 venetoclax Drugs 0.000 claims description 8
• LQBVNQSMGBZMKD-UHFFFAOYSA-N venetoclax Chemical compound C=1C=C(Cl)C=CC=1C=1CC(C)(C)CCC=1CN(CC1)CCN1C(C=C1OC=2C=C3C=CNC3=NC=2)=CC=C1C(=O)NS(=O)(=O)C(C=C1[N+]([O-])=O)=CC=C1NCC1CCOCC1 LQBVNQSMGBZMKD-UHFFFAOYSA-N 0.000 claims description 8
• WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 claims description 7
• 208000036170 B-Cell Marginal Zone Lymphoma Diseases 0.000 claims description 7
• 206010061850 Extranodal marginal zone B-cell lymphoma (MALT type) Diseases 0.000 claims description 7
• 102000000589 Interleukin-1 Human genes 0.000 claims description 7
• 108010002352 Interleukin-1 Proteins 0.000 claims description 7
• 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 7
• DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 7
• 229960002707 bendamustine Drugs 0.000 claims description 7
• YTKUWDBFDASYHO-UHFFFAOYSA-N bendamustine Chemical compound ClCCN(CCCl)C1=CC=C2N(C)C(CCCC(O)=O)=NC2=C1 YTKUWDBFDASYHO-UHFFFAOYSA-N 0.000 claims description 7
• 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims description 7
• 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 7
• 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 7
• 229940016286 microcrystalline cellulose Drugs 0.000 claims description 7
• 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 7
• 239000008108 microcrystalline cellulose Substances 0.000 claims description 7
• 208000025113 myeloid leukemia Diseases 0.000 claims description 7
• 229960004618 prednisone Drugs 0.000 claims description 7
• XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 claims description 7
• UEJJHQNACJXSKW-UHFFFAOYSA-N 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O UEJJHQNACJXSKW-UHFFFAOYSA-N 0.000 claims description 6
• SEJLPXCPMNSRAM-GOSISDBHSA-N 6-amino-9-[(3r)-1-but-2-ynoylpyrrolidin-3-yl]-7-(4-phenoxyphenyl)purin-8-one Chemical compound C1N(C(=O)C#CC)CC[C@H]1N1C(=O)N(C=2C=CC(OC=3C=CC=CC=3)=CC=2)C2=C(N)N=CN=C21 SEJLPXCPMNSRAM-GOSISDBHSA-N 0.000 claims description 6
• 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 claims description 6
• PTOAARAWEBMLNO-KVQBGUIXSA-N Cladribine Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)O1 PTOAARAWEBMLNO-KVQBGUIXSA-N 0.000 claims description 6
• 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims description 6
• 230000007815 allergy Effects 0.000 claims description 6
• ABSXPNGWJFAPRT-UHFFFAOYSA-N benzenesulfonic acid;n-[3-[[5-fluoro-2-[4-(2-methoxyethoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound OS(=O)(=O)C1=CC=CC=C1.C1=CC(OCCOC)=CC=C1NC1=NC=C(F)C(NC=2C=C(NC(=O)C=C)C=CC=2)=N1 ABSXPNGWJFAPRT-UHFFFAOYSA-N 0.000 claims description 6
• 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims description 6
• 229960002436 cladribine Drugs 0.000 claims description 6
• 229960001681 croscarmellose sodium Drugs 0.000 claims description 6
• 230000016396 cytokine production Effects 0.000 claims description 6
• 230000007423 decrease Effects 0.000 claims description 6
• VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims description 6
• 229960005420 etoposide Drugs 0.000 claims description 6
• QUIWHXQETADMGN-UHFFFAOYSA-N evobrutinib Chemical compound C=1C=C(OC=2C=CC=CC=2)C=CC=1C=1C(N)=NC=NC=1NCC1CCN(C(=O)C=C)CC1 QUIWHXQETADMGN-UHFFFAOYSA-N 0.000 claims description 6
• 229950003411 evobrutinib Drugs 0.000 claims description 6
• 229940075628 hypomethylating agent Drugs 0.000 claims description 6
• 239000012678 infectious agent Substances 0.000 claims description 6
• 229940043355 kinase inhibitor Drugs 0.000 claims description 6
• 235000019359 magnesium stearate Nutrition 0.000 claims description 6
• 239000003757 phosphotransferase inhibitor Substances 0.000 claims description 6
• 229950002089 spebrutinib Drugs 0.000 claims description 6
• 229960003433 thalidomide Drugs 0.000 claims description 6
• 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims description 5
• 101100087590 Homo sapiens RICTOR gene Proteins 0.000 claims description 5
• 239000004372 Polyvinyl alcohol Substances 0.000 claims description 5
• 102000046941 Rapamycin-Insensitive Companion of mTOR Human genes 0.000 claims description 5
• 108700019586 Rapamycin-Insensitive Companion of mTOR Proteins 0.000 claims description 5
• 241000700605 Viruses Species 0.000 claims description 5
• 230000008859 change Effects 0.000 claims description 5
• 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 claims description 5
• 210000003958 hematopoietic stem cell Anatomy 0.000 claims description 5
• 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 5
• 229960001021 lactose monohydrate Drugs 0.000 claims description 5
• 229920002451 polyvinyl alcohol Polymers 0.000 claims description 5
• 239000004408 titanium dioxide Substances 0.000 claims description 5
• 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims description 4
• 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims description 4
• 208000023275 Autoimmune disease Diseases 0.000 claims description 4
• 208000011691 Burkitt lymphomas Diseases 0.000 claims description 4
• 208000015943 Coeliac disease Diseases 0.000 claims description 4
• 206010009900 Colitis ulcerative Diseases 0.000 claims description 4
• 206010009944 Colon cancer Diseases 0.000 claims description 4
• 206010010741 Conjunctivitis Diseases 0.000 claims description 4
• 206010050685 Cytokine storm Diseases 0.000 claims description 4
• 201000005569 Gout Diseases 0.000 claims description 4
• 208000029523 Interstitial Lung disease Diseases 0.000 claims description 4
• 208000003456 Juvenile Arthritis Diseases 0.000 claims description 4
• 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims description 4
• 208000034578 Multiple myelomas Diseases 0.000 claims description 4
• 201000002481 Myositis Diseases 0.000 claims description 4
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 4
• 206010033645 Pancreatitis Diseases 0.000 claims description 4
• 201000011152 Pemphigus Diseases 0.000 claims description 4
• 206010035226 Plasma cell myeloma Diseases 0.000 claims description 4
• 206010035664 Pneumonia Diseases 0.000 claims description 4
• 206010060862 Prostate cancer Diseases 0.000 claims description 4
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 4
• 201000001263 Psoriatic Arthritis Diseases 0.000 claims description 4
• 208000036824 Psoriatic arthropathy Diseases 0.000 claims description 4
• 206010039710 Scleroderma Diseases 0.000 claims description 4
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
• 208000005718 Stomach Neoplasms Diseases 0.000 claims description 4
• 208000025865 Ulcer Diseases 0.000 claims description 4
• 201000006704 Ulcerative Colitis Diseases 0.000 claims description 4
• 206010047115 Vasculitis Diseases 0.000 claims description 4
• 208000006673 asthma Diseases 0.000 claims description 4
• 229960004630 chlorambucil Drugs 0.000 claims description 4
• JCKYGMPEJWAADB-UHFFFAOYSA-N chlorambucil Chemical compound OC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 JCKYGMPEJWAADB-UHFFFAOYSA-N 0.000 claims description 4
• 208000029742 colonic neoplasm Diseases 0.000 claims description 4
• 208000022993 cryopyrin-associated periodic syndrome Diseases 0.000 claims description 4
• 206010052015 cytokine release syndrome Diseases 0.000 claims description 4
• 201000001981 dermatomyositis Diseases 0.000 claims description 4
• MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical group CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 claims description 4
• 229960004679 doxorubicin Drugs 0.000 claims description 4
• 230000003628 erosive effect Effects 0.000 claims description 4
• 201000001155 extrinsic allergic alveolitis Diseases 0.000 claims description 4
• 238000009093 first-line therapy Methods 0.000 claims description 4
• 206010017758 gastric cancer Diseases 0.000 claims description 4
• 208000014829 head and neck neoplasm Diseases 0.000 claims description 4
• 208000022098 hypersensitivity pneumonitis Diseases 0.000 claims description 4
• 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims description 4
• 208000017169 kidney disease Diseases 0.000 claims description 4
• 208000003747 lymphoid leukemia Diseases 0.000 claims description 4
• 230000036210 malignancy Effects 0.000 claims description 4
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 4
• 206010028417 myasthenia gravis Diseases 0.000 claims description 4
• 201000008383 nephritis Diseases 0.000 claims description 4
• 201000002528 pancreatic cancer Diseases 0.000 claims description 4
• 208000008443 pancreatic carcinoma Diseases 0.000 claims description 4
• 206010039073 rheumatoid arthritis Diseases 0.000 claims description 4
• 201000009890 sinusitis Diseases 0.000 claims description 4
• 201000011549 stomach cancer Diseases 0.000 claims description 4
• 229960004528 vincristine Drugs 0.000 claims description 4
• OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 claims description 4
• OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 claims description 4
• 241000894006 Bacteria Species 0.000 claims description 3
• 229940124130 Bcl inhibitor Drugs 0.000 claims description 3
• DLGOEMSEDOSKAD-UHFFFAOYSA-N Carmustine Chemical compound ClCCNC(=O)N(N=O)CCCl DLGOEMSEDOSKAD-UHFFFAOYSA-N 0.000 claims description 3
• UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 claims description 3
• 206010061818 Disease progression Diseases 0.000 claims description 3
• 101000653374 Homo sapiens Methylcytosine dioxygenase TET2 Proteins 0.000 claims description 3
• 102100030803 Methylcytosine dioxygenase TET2 Human genes 0.000 claims description 3
• 208000002193 Pain Diseases 0.000 claims description 3
• 230000001154 acute effect Effects 0.000 claims description 3
• 229960005243 carmustine Drugs 0.000 claims description 3
• 230000003750 conditioning effect Effects 0.000 claims description 3
• 239000001767 crosslinked sodium carboxy methyl cellulose Substances 0.000 claims description 3
• 229960000684 cytarabine Drugs 0.000 claims description 3
• 230000005750 disease progression Effects 0.000 claims description 3
• 210000001280 germinal center Anatomy 0.000 claims description 3
• 229960003943 hypromellose Drugs 0.000 claims description 3
• HOMGKSMUEGBAAB-UHFFFAOYSA-N ifosfamide Chemical compound ClCCNP1(=O)OCCCN1CCCl HOMGKSMUEGBAAB-UHFFFAOYSA-N 0.000 claims description 3
• 229960001101 ifosfamide Drugs 0.000 claims description 3
• 208000032839 leukemia Diseases 0.000 claims description 3
• SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 claims description 3
• 229960001924 melphalan Drugs 0.000 claims description 3
• QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical group CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 3
• 210000001550 testis Anatomy 0.000 claims description 3
• 231100000402 unacceptable toxicity Toxicity 0.000 claims description 3
• 206010056508 Acquired epidermolysis bullosa Diseases 0.000 claims description 2
• 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims description 2
• 208000026872 Addison Disease Diseases 0.000 claims description 2
• 208000022309 Alcoholic Liver disease Diseases 0.000 claims description 2
• 206010001889 Alveolitis Diseases 0.000 claims description 2
• 206010002198 Anaphylactic reaction Diseases 0.000 claims description 2
• 208000032467 Aplastic anaemia Diseases 0.000 claims description 2
• 206010003011 Appendicitis Diseases 0.000 claims description 2
• 208000009137 Behcet syndrome Diseases 0.000 claims description 2
• 208000008439 Biliary Liver Cirrhosis Diseases 0.000 claims description 2
• 208000033222 Biliary cirrhosis primary Diseases 0.000 claims description 2
• 206010005003 Bladder cancer Diseases 0.000 claims description 2
• 201000004940 Bloch-Sulzberger syndrome Diseases 0.000 claims description 2
• 208000003174 Brain Neoplasms Diseases 0.000 claims description 2
• 206010006187 Breast cancer Diseases 0.000 claims description 2
• 208000026310 Breast neoplasm Diseases 0.000 claims description 2
• 206010006448 Bronchiolitis Diseases 0.000 claims description 2
• 206010006811 Bursitis Diseases 0.000 claims description 2
• 206010007558 Cardiac failure chronic Diseases 0.000 claims description 2
• 206010007572 Cardiac hypertrophy Diseases 0.000 claims description 2
• 208000006029 Cardiomegaly Diseases 0.000 claims description 2
• 208000002177 Cataract Diseases 0.000 claims description 2
• 206010008342 Cervix carcinoma Diseases 0.000 claims description 2
• 206010008909 Chronic Hepatitis Diseases 0.000 claims description 2
• 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims description 2
• 208000023890 Complex Regional Pain Syndromes Diseases 0.000 claims description 2
• 206010010744 Conjunctivitis allergic Diseases 0.000 claims description 2
• 241000711573 Coronaviridae Species 0.000 claims description 2
• 208000011231 Crohn disease Diseases 0.000 claims description 2
• PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims description 2
• 229930105110 Cyclosporin A Natural products 0.000 claims description 2
• 108010036949 Cyclosporine Proteins 0.000 claims description 2
• 201000003883 Cystic fibrosis Diseases 0.000 claims description 2
• 102100025621 Cytochrome b-245 heavy chain Human genes 0.000 claims description 2
• 239000012625 DNA intercalator Substances 0.000 claims description 2
• 206010011841 Dacryoadenitis acquired Diseases 0.000 claims description 2
• 201000004624 Dermatitis Diseases 0.000 claims description 2
• 206010012438 Dermatitis atopic Diseases 0.000 claims description 2
• 206010012468 Dermatitis herpetiformis Diseases 0.000 claims description 2
• 208000003556 Dry Eye Syndromes Diseases 0.000 claims description 2
• 206010013774 Dry eye Diseases 0.000 claims description 2
• 206010058314 Dysplasia Diseases 0.000 claims description 2
• 201000009273 Endometriosis Diseases 0.000 claims description 2
• 208000004145 Endometritis Diseases 0.000 claims description 2
• 208000004232 Enteritis Diseases 0.000 claims description 2
• 206010014950 Eosinophilia Diseases 0.000 claims description 2
• 201000011275 Epicondylitis Diseases 0.000 claims description 2
• 206010015150 Erythema Diseases 0.000 claims description 2
• 206010016228 Fasciitis Diseases 0.000 claims description 2
• 208000001362 Fetal Growth Retardation Diseases 0.000 claims description 2
• 208000001640 Fibromyalgia Diseases 0.000 claims description 2
• 206010070531 Foetal growth restriction Diseases 0.000 claims description 2
• 208000007882 Gastritis Diseases 0.000 claims description 2
• 208000005577 Gastroenteritis Diseases 0.000 claims description 2
• 208000010412 Glaucoma Diseases 0.000 claims description 2
• 208000022461 Glomerular disease Diseases 0.000 claims description 2
• 206010018364 Glomerulonephritis Diseases 0.000 claims description 2
• 229940121727 Glutaminase inhibitor Drugs 0.000 claims description 2
• 206010018634 Gouty Arthritis Diseases 0.000 claims description 2
• 208000003807 Graves Disease Diseases 0.000 claims description 2
• 208000015023 Graves' disease Diseases 0.000 claims description 2
• 206010019233 Headaches Diseases 0.000 claims description 2
• 201000004331 Henoch-Schoenlein purpura Diseases 0.000 claims description 2
• 206010019617 Henoch-Schonlein purpura Diseases 0.000 claims description 2
• 206010019755 Hepatitis chronic active Diseases 0.000 claims description 2
• 208000000203 Hyaline Membrane Disease Diseases 0.000 claims description 2
• 208000035150 Hypercholesterolemia Diseases 0.000 claims description 2
• 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 claims description 2
• 208000031814 IgA Vasculitis Diseases 0.000 claims description 2
• 208000010159 IgA glomerulonephritis Diseases 0.000 claims description 2
• 208000007031 Incontinentia pigmenti Diseases 0.000 claims description 2
• 208000032571 Infant acute respiratory distress syndrome Diseases 0.000 claims description 2
• 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 2
• 208000005615 Interstitial Cystitis Diseases 0.000 claims description 2
• 208000009319 Keratoconjunctivitis Sicca Diseases 0.000 claims description 2
• 208000008839 Kidney Neoplasms Diseases 0.000 claims description 2
• 201000008197 Laryngitis Diseases 0.000 claims description 2
• 206010024238 Leptospirosis Diseases 0.000 claims description 2
• 208000034624 Leukocytoclastic Cutaneous Vasculitis Diseases 0.000 claims description 2
• 208000032514 Leukocytoclastic vasculitis Diseases 0.000 claims description 2
• 208000004883 Lipoid Nephrosis Diseases 0.000 claims description 2
• 208000004852 Lung Injury Diseases 0.000 claims description 2
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 2
• 208000032271 Malignant tumor of penis Diseases 0.000 claims description 2
• 201000009906 Meningitis Diseases 0.000 claims description 2
• 206010027406 Mesothelioma Diseases 0.000 claims description 2
• 206010028289 Muscle atrophy Diseases 0.000 claims description 2
• 208000003926 Myelitis Diseases 0.000 claims description 2
• 208000009525 Myocarditis Diseases 0.000 claims description 2
• 206010028974 Neonatal respiratory distress syndrome Diseases 0.000 claims description 2
• 108010064641 ONX 0912 Proteins 0.000 claims description 2
• 208000008589 Obesity Diseases 0.000 claims description 2
• 206010031149 Osteitis Diseases 0.000 claims description 2
• 208000010191 Osteitis Deformans Diseases 0.000 claims description 2
• 208000005141 Otitis Diseases 0.000 claims description 2
• 206010033128 Ovarian cancer Diseases 0.000 claims description 2
• 206010061535 Ovarian neoplasm Diseases 0.000 claims description 2
• 239000012270 PD-1 inhibitor Substances 0.000 claims description 2
• 239000012668 PD-1-inhibitor Substances 0.000 claims description 2
• 102000038030 PI3Ks Human genes 0.000 claims description 2
• 108091007960 PI3Ks Proteins 0.000 claims description 2
• 208000027868 Paget disease Diseases 0.000 claims description 2
• 206010034038 Parotitis Diseases 0.000 claims description 2
• 206010034277 Pemphigoid Diseases 0.000 claims description 2
• 208000027086 Pemphigus foliaceus Diseases 0.000 claims description 2
• 208000002471 Penile Neoplasms Diseases 0.000 claims description 2
• 206010034299 Penile cancer Diseases 0.000 claims description 2
• 201000007100 Pharyngitis Diseases 0.000 claims description 2
• 206010035742 Pneumonitis Diseases 0.000 claims description 2
• 206010065159 Polychondritis Diseases 0.000 claims description 2
• 206010036105 Polyneuropathy Diseases 0.000 claims description 2
• 208000012654 Primary biliary cholangitis Diseases 0.000 claims description 2
• 206010036774 Proctitis Diseases 0.000 claims description 2
• 229940079156 Proteasome inhibitor Drugs 0.000 claims description 2
• 201000004681 Psoriasis Diseases 0.000 claims description 2
• 206010037596 Pyelonephritis Diseases 0.000 claims description 2
• 206010038389 Renal cancer Diseases 0.000 claims description 2
• 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims description 2
• 208000017442 Retinal disease Diseases 0.000 claims description 2
• 206010039085 Rhinitis allergic Diseases 0.000 claims description 2
• 208000007893 Salpingitis Diseases 0.000 claims description 2
• 208000021386 Sjogren Syndrome Diseases 0.000 claims description 2
• 201000009594 Systemic Scleroderma Diseases 0.000 claims description 2
• 206010042953 Systemic sclerosis Diseases 0.000 claims description 2
• 208000000491 Tendinopathy Diseases 0.000 claims description 2
• 206010043255 Tendonitis Diseases 0.000 claims description 2
• 229940125970 Toll-Like Receptor inhibitor Drugs 0.000 claims description 2
• 206010052779 Transplant rejections Diseases 0.000 claims description 2
• 206010069363 Traumatic lung injury Diseases 0.000 claims description 2
• 229940122429 Tubulin inhibitor Drugs 0.000 claims description 2
• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 2
• 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 2
• 208000006374 Uterine Cervicitis Diseases 0.000 claims description 2
• 206010046851 Uveitis Diseases 0.000 claims description 2
• 206010047642 Vitiligo Diseases 0.000 claims description 2
• 208000016807 X-linked intellectual disability-macrocephaly-macroorchidism syndrome Diseases 0.000 claims description 2
• VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical group CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 claims description 2
• 206010069351 acute lung injury Diseases 0.000 claims description 2
• 201000000028 adult respiratory distress syndrome Diseases 0.000 claims description 2
• 208000002205 allergic conjunctivitis Diseases 0.000 claims description 2
• 201000010105 allergic rhinitis Diseases 0.000 claims description 2
• 208000004631 alopecia areata Diseases 0.000 claims description 2
• 230000036783 anaphylactic response Effects 0.000 claims description 2
• 208000003455 anaphylaxis Diseases 0.000 claims description 2
• 201000008937 atopic dermatitis Diseases 0.000 claims description 2
• 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 claims description 2
• 208000010217 blepharitis Diseases 0.000 claims description 2
• 208000018339 bone inflammation disease Diseases 0.000 claims description 2
• 206010006451 bronchitis Diseases 0.000 claims description 2
• 208000000594 bullous pemphigoid Diseases 0.000 claims description 2
• 230000001925 catabolic effect Effects 0.000 claims description 2
• 201000010881 cervical cancer Diseases 0.000 claims description 2
• 206010008323 cervicitis Diseases 0.000 claims description 2
• 208000003167 cholangitis Diseases 0.000 claims description 2
• 201000001352 cholecystitis Diseases 0.000 claims description 2
• 208000019069 chronic childhood arthritis Diseases 0.000 claims description 2
• 208000016532 chronic granulomatous disease Diseases 0.000 claims description 2
• 208000025302 chronic primary adrenal insufficiency Diseases 0.000 claims description 2
• 229960001265 ciclosporin Drugs 0.000 claims description 2
• 206010009887 colitis Diseases 0.000 claims description 2
• 229960005168 croscarmellose Drugs 0.000 claims description 2
• 208000018261 cutaneous leukocytoclastic angiitis Diseases 0.000 claims description 2
• 229930182912 cyclosporin Natural products 0.000 claims description 2
• 201000003146 cystitis Diseases 0.000 claims description 2
• 201000004400 dacryoadenitis Diseases 0.000 claims description 2
• 208000007784 diverticulitis Diseases 0.000 claims description 2
• 239000003534 dna topoisomerase inhibitor Substances 0.000 claims description 2
• 208000019258 ear infection Diseases 0.000 claims description 2
• 206010014599 encephalitis Diseases 0.000 claims description 2
• 206010014665 endocarditis Diseases 0.000 claims description 2
• 230000002124 endocrine Effects 0.000 claims description 2
• 208000010227 enterocolitis Diseases 0.000 claims description 2
• 201000011114 epidermolysis bullosa acquisita Diseases 0.000 claims description 2
• 201000010063 epididymitis Diseases 0.000 claims description 2
• 231100000321 erythema Toxicity 0.000 claims description 2
• 208000030941 fetal growth restriction Diseases 0.000 claims description 2
• 231100000852 glomerular disease Toxicity 0.000 claims description 2
• 231100000869 headache Toxicity 0.000 claims description 2
• 208000019622 heart disease Diseases 0.000 claims description 2
• 208000014951 hematologic disease Diseases 0.000 claims description 2
• 208000007475 hemolytic anemia Diseases 0.000 claims description 2
• 208000006454 hepatitis Diseases 0.000 claims description 2
• 231100000283 hepatitis Toxicity 0.000 claims description 2
• 208000025070 hereditary periodic fever syndrome Diseases 0.000 claims description 2
• 208000002557 hidradenitis Diseases 0.000 claims description 2
• 201000007162 hidradenitis suppurativa Diseases 0.000 claims description 2
• 230000009610 hypersensitivity Effects 0.000 claims description 2
• IFSDAJWBUCMOAH-HNNXBMFYSA-N idelalisib Chemical compound C1([C@@H](NC=2C=3N=CNC=3N=CN=2)CC)=NC2=CC=CC(F)=C2C(=O)N1C1=CC=CC=C1 IFSDAJWBUCMOAH-HNNXBMFYSA-N 0.000 claims description 2
• 229960003445 idelalisib Drugs 0.000 claims description 2
• 208000016036 idiopathic nephrotic syndrome Diseases 0.000 claims description 2
• 208000015446 immunoglobulin a vasculitis Diseases 0.000 claims description 2
• 201000008319 inclusion body myositis Diseases 0.000 claims description 2
• 208000002551 irritable bowel syndrome Diseases 0.000 claims description 2
• 229960003648 ixazomib Drugs 0.000 claims description 2
• MXAYKZJJDUDWDS-LBPRGKRZSA-N ixazomib Chemical compound CC(C)C[C@@H](B(O)O)NC(=O)CNC(=O)C1=CC(Cl)=CC=C1Cl MXAYKZJJDUDWDS-LBPRGKRZSA-N 0.000 claims description 2
• 201000010982 kidney cancer Diseases 0.000 claims description 2
• 201000011486 lichen planus Diseases 0.000 claims description 2
• 201000007270 liver cancer Diseases 0.000 claims description 2
• 208000014018 liver neoplasm Diseases 0.000 claims description 2
• 201000005202 lung cancer Diseases 0.000 claims description 2
• 231100000515 lung injury Toxicity 0.000 claims description 2
• 208000020816 lung neoplasm Diseases 0.000 claims description 2
• 208000026037 malignant tumor of neck Diseases 0.000 claims description 2
• 208000027202 mammary Paget disease Diseases 0.000 claims description 2
• 208000004396 mastitis Diseases 0.000 claims description 2
• 229960004961 mechlorethamine Drugs 0.000 claims description 2
• HAWPXGHAZFHHAD-UHFFFAOYSA-N mechlorethamine Chemical class ClCCN(C)CCCl HAWPXGHAZFHHAD-UHFFFAOYSA-N 0.000 claims description 2
• 239000012022 methylating agents‎ Substances 0.000 claims description 2
• 201000006417 multiple sclerosis Diseases 0.000 claims description 2
• 201000000585 muscular atrophy Diseases 0.000 claims description 2
• SWZXEVABPLUDIO-WSZYKNRRSA-N n-[(2s)-3-methoxy-1-[[(2s)-3-methoxy-1-[[(2s)-1-[(2r)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]-2-methyl-1,3-thiazole-5-carboxamide Chemical compound N([C@@H](COC)C(=O)N[C@@H](COC)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)[C@]1(C)OC1)C(=O)C1=CN=C(C)S1 SWZXEVABPLUDIO-WSZYKNRRSA-N 0.000 claims description 2
• 201000002652 newborn respiratory distress syndrome Diseases 0.000 claims description 2
• 235000020824 obesity Nutrition 0.000 claims description 2
• 208000005963 oophoritis Diseases 0.000 claims description 2
• 229950005750 oprozomib Drugs 0.000 claims description 2
• 201000005737 orchitis Diseases 0.000 claims description 2
• 201000008482 osteoarthritis Diseases 0.000 claims description 2
• 206010057056 paraneoplastic pemphigus Diseases 0.000 claims description 2
• 229940121655 pd-1 inhibitor Drugs 0.000 claims description 2
• 201000001976 pemphigus vulgaris Diseases 0.000 claims description 2
• 208000008494 pericarditis Diseases 0.000 claims description 2
• 201000001245 periodontitis Diseases 0.000 claims description 2
• 206010034674 peritonitis Diseases 0.000 claims description 2
• 208000001297 phlebitis Diseases 0.000 claims description 2
• 208000005987 polymyositis Diseases 0.000 claims description 2
• 230000007824 polyneuropathy Effects 0.000 claims description 2
• 201000007094 prostatitis Diseases 0.000 claims description 2
• 239000003207 proteasome inhibitor Substances 0.000 claims description 2
• 208000002815 pulmonary hypertension Diseases 0.000 claims description 2
• 150000003212 purines Chemical class 0.000 claims description 2
• 206010039083 rhinitis Diseases 0.000 claims description 2
• 201000000306 sarcoidosis Diseases 0.000 claims description 2
• 239000000377 silicon dioxide Substances 0.000 claims description 2
• 108010087686 src-Family Kinases Proteins 0.000 claims description 2
• 208000003265 stomatitis Diseases 0.000 claims description 2
• 201000004595 synovitis Diseases 0.000 claims description 2
• 230000009885 systemic effect Effects 0.000 claims description 2
• 201000000596 systemic lupus erythematosus Diseases 0.000 claims description 2
• 201000004415 tendinitis Diseases 0.000 claims description 2
• 208000016595 therapy related acute myeloid leukemia and myelodysplastic syndrome Diseases 0.000 claims description 2
• 206010043778 thyroiditis Diseases 0.000 claims description 2
• 206010044008 tonsillitis Diseases 0.000 claims description 2
• 229940044693 topoisomerase inhibitor Drugs 0.000 claims description 2
• 238000002054 transplantation Methods 0.000 claims description 2
• 201000005112 urinary bladder cancer Diseases 0.000 claims description 2
• 206010046885 vaginal cancer Diseases 0.000 claims description 2
• 208000013139 vaginal neoplasm Diseases 0.000 claims description 2
• 201000005539 vernal conjunctivitis Diseases 0.000 claims description 2
• 208000002003 vulvitis Diseases 0.000 claims description 2
• 101000977771 Homo sapiens Interleukin-1 receptor-associated kinase 4 Proteins 0.000 claims 2
• 102100023533 Interleukin-1 receptor-associated kinase 4 Human genes 0.000 claims 2
• 101150053046 MYD88 gene Proteins 0.000 claims 2
• 241000237519 Bivalvia Species 0.000 claims 1
• 239000012271 PD-L1 inhibitor Substances 0.000 claims 1
• 102000001332 SRC Human genes 0.000 claims 1
• 208000024780 Urticaria Diseases 0.000 claims 1
• 235000020639 clam Nutrition 0.000 claims 1
• 230000001351 cycling effect Effects 0.000 claims 1
• 229940121656 pd-l1 inhibitor Drugs 0.000 claims 1
• 230000002568 urticarial effect Effects 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 description 27
• 208000016025 Waldenstroem macroglobulinemia Diseases 0.000 description 25
• 230000002829 reductive effect Effects 0.000 description 22
• 230000000694 effects Effects 0.000 description 21
• 208000015914 Non-Hodgkin lymphomas Diseases 0.000 description 20
• 239000003826 tablet Substances 0.000 description 18
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 16
• 101710112096 Myeloid differentiation primary response protein MyD88 Proteins 0.000 description 15
• 102100036342 Interleukin-1 receptor-associated kinase 1 Human genes 0.000 description 13
• 239000004480 active ingredient Substances 0.000 description 13
• 239000002904 solvent Substances 0.000 description 13
• 101710199015 Interleukin-1 receptor-associated kinase 1 Proteins 0.000 description 12
• 238000010521 absorption reaction Methods 0.000 description 11
• 230000004913 activation Effects 0.000 description 11
• 238000013461 design Methods 0.000 description 11
• 238000009472 formulation Methods 0.000 description 11
• 239000000463 material Substances 0.000 description 11
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
• 102000002689 Toll-like receptor Human genes 0.000 description 10
• 108020000411 Toll-like receptor Proteins 0.000 description 10
• 239000003937 drug carrier Substances 0.000 description 10
• 230000009467 reduction Effects 0.000 description 10
• 102000019223 Interleukin-1 receptor Human genes 0.000 description 9
• 108050006617 Interleukin-1 receptor Proteins 0.000 description 9
• 108091000080 Phosphotransferase Proteins 0.000 description 9
• DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
• 102000020233 phosphotransferase Human genes 0.000 description 9
• 108090000623 proteins and genes Proteins 0.000 description 9
• 239000000243 solution Substances 0.000 description 9
• 208000024891 symptom Diseases 0.000 description 9
• 231100000419 toxicity Toxicity 0.000 description 9
• 230000001988 toxicity Effects 0.000 description 9
• 241001465754 Metazoa Species 0.000 description 8
• 239000000843 powder Substances 0.000 description 8
• 235000018102 proteins Nutrition 0.000 description 8
• 102000004169 proteins and genes Human genes 0.000 description 8
• 230000001225 therapeutic effect Effects 0.000 description 8
• 239000007903 gelatin capsule Substances 0.000 description 7
• 230000019491 signal transduction Effects 0.000 description 7
• 238000009097 single-agent therapy Methods 0.000 description 7
• 235000012222 talc Nutrition 0.000 description 7
• 210000001519 tissue Anatomy 0.000 description 7
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 6
• 229930006000 Sucrose Natural products 0.000 description 6
• 239000003963 antioxidant agent Substances 0.000 description 6
• 235000006708 antioxidants Nutrition 0.000 description 6
• 230000008901 benefit Effects 0.000 description 6
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
• 235000011187 glycerol Nutrition 0.000 description 6
• 239000007788 liquid Substances 0.000 description 6
• 231100000682 maximum tolerated dose Toxicity 0.000 description 6
• 239000003921 oil Substances 0.000 description 6
• 230000037361 pathway Effects 0.000 description 6
• 229920001223 polyethylene glycol Polymers 0.000 description 6
• 229920000642 polymer Polymers 0.000 description 6
• 239000000126 substance Substances 0.000 description 6
• 239000005720 sucrose Substances 0.000 description 6
• 229940124597 therapeutic agent Drugs 0.000 description 6
• 108010010803 Gelatin Proteins 0.000 description 5
• 231100000673 dose–response relationship Toxicity 0.000 description 5
• 235000019441 ethanol Nutrition 0.000 description 5
• 230000006870 function Effects 0.000 description 5
• 239000008273 gelatin Substances 0.000 description 5
• 229920000159 gelatin Polymers 0.000 description 5
• 235000019322 gelatine Nutrition 0.000 description 5
• 235000011852 gelatine desserts Nutrition 0.000 description 5
• 239000008187 granular material Substances 0.000 description 5
• 235000019198 oils Nutrition 0.000 description 5
• 239000003755 preservative agent Substances 0.000 description 5
• 239000007787 solid Substances 0.000 description 5
• 230000004083 survival effect Effects 0.000 description 5
• 239000000725 suspension Substances 0.000 description 5
• GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 4
• CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
• 241000416162 Astragalus gummifer Species 0.000 description 4
• 102000004127 Cytokines Human genes 0.000 description 4
• 108090000695 Cytokines Proteins 0.000 description 4
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 4
• 241000699670 Mus sp. Species 0.000 description 4
• NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
• 229920002472 Starch Polymers 0.000 description 4
• 229920001615 Tragacanth Polymers 0.000 description 4
• 230000002411 adverse Effects 0.000 description 4
• 239000007864 aqueous solution Substances 0.000 description 4
• 239000000090 biomarker Substances 0.000 description 4
• 239000000969 carrier Substances 0.000 description 4
• 235000010980 cellulose Nutrition 0.000 description 4
• 229920002678 cellulose Polymers 0.000 description 4
• 239000001913 cellulose Substances 0.000 description 4
• 238000000576 coating method Methods 0.000 description 4
• 239000006071 cream Substances 0.000 description 4
• 230000003247 decreasing effect Effects 0.000 description 4
• 239000003995 emulsifying agent Substances 0.000 description 4
• 238000002347 injection Methods 0.000 description 4
• 239000007924 injection Substances 0.000 description 4
• 229960001375 lactose Drugs 0.000 description 4
• 239000008101 lactose Substances 0.000 description 4
• 239000002502 liposome Substances 0.000 description 4
• 231100000252 nontoxic Toxicity 0.000 description 4
• 230000003000 nontoxic effect Effects 0.000 description 4
• 239000002674 ointment Substances 0.000 description 4
• 239000004006 olive oil Substances 0.000 description 4
• 239000006072 paste Substances 0.000 description 4
• 239000006187 pill Substances 0.000 description 4
• 238000002360 preparation method Methods 0.000 description 4
• 239000008213 purified water Substances 0.000 description 4
• RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 4
• 239000008279 sol Substances 0.000 description 4
• 239000007921 spray Substances 0.000 description 4
• 235000019698 starch Nutrition 0.000 description 4
• 235000010487 tragacanth Nutrition 0.000 description 4
• 239000000196 tragacanth Substances 0.000 description 4
• 229940116362 tragacanth Drugs 0.000 description 4
• 239000003981 vehicle Substances 0.000 description 4
• 239000000080 wetting agent Substances 0.000 description 4
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
• 229920001817 Agar Polymers 0.000 description 3
• 201000004085 CLL/SLL Diseases 0.000 description 3
• 102000004420 Creatine Kinase Human genes 0.000 description 3
• 108010042126 Creatine kinase Proteins 0.000 description 3
• FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
• FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 3
• XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
• AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Polymers OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 3
• 229940127590 IRAK4 inhibitor Drugs 0.000 description 3
• 108010072621 Interleukin-1 Receptor-Associated Kinases Proteins 0.000 description 3
• 102000006940 Interleukin-1 Receptor-Associated Kinases Human genes 0.000 description 3
• KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
• 235000010643 Leucaena leucocephala Nutrition 0.000 description 3
• 240000007472 Leucaena leucocephala Species 0.000 description 3
• 208000008771 Lymphadenopathy Diseases 0.000 description 3
• 108091054455 MAP kinase family Proteins 0.000 description 3
• 102000043136 MAP kinase family Human genes 0.000 description 3
• 241000124008 Mammalia Species 0.000 description 3
• AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 3
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
• ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
• GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 3
• MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
• OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 3
• RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 3
• CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 3
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
• 230000003044 adaptive effect Effects 0.000 description 3
• 102000035181 adaptor proteins Human genes 0.000 description 3
• 108091005764 adaptor proteins Proteins 0.000 description 3
• 239000002671 adjuvant Substances 0.000 description 3
• 235000010419 agar Nutrition 0.000 description 3
• 235000010443 alginic acid Nutrition 0.000 description 3
• 229920000615 alginic acid Polymers 0.000 description 3
• 125000000217 alkyl group Chemical group 0.000 description 3
• 230000003110 anti-inflammatory effect Effects 0.000 description 3
• 229960005070 ascorbic acid Drugs 0.000 description 3
• 239000011668 ascorbic acid Substances 0.000 description 3
• 210000003719 b-lymphocyte Anatomy 0.000 description 3
• 239000002585 base Substances 0.000 description 3
• 235000012216 bentonite Nutrition 0.000 description 3
• WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 3
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 3
• 238000002512 chemotherapy Methods 0.000 description 3
• 208000023738 chronic lymphocytic leukemia/small lymphocytic lymphoma Diseases 0.000 description 3
• 239000011248 coating agent Substances 0.000 description 3
• 239000003086 colorant Substances 0.000 description 3
• 238000002591 computed tomography Methods 0.000 description 3
• 230000003111 delayed effect Effects 0.000 description 3
• 238000003745 diagnosis Methods 0.000 description 3
• 230000008034 disappearance Effects 0.000 description 3
• 239000006185 dispersion Substances 0.000 description 3
• 239000000839 emulsion Substances 0.000 description 3
• 230000007717 exclusion Effects 0.000 description 3
• 239000000945 filler Substances 0.000 description 3
• 239000012458 free base Substances 0.000 description 3
• 239000000499 gel Substances 0.000 description 3
• 239000008103 glucose Substances 0.000 description 3
• 230000012010 growth Effects 0.000 description 3
• FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 3
• 230000001976 improved effect Effects 0.000 description 3
• 230000006698 induction Effects 0.000 description 3
• 239000003701 inert diluent Substances 0.000 description 3
• 239000004615 ingredient Substances 0.000 description 3
• 208000018555 lymphatic system disease Diseases 0.000 description 3
• 239000011777 magnesium Substances 0.000 description 3
• 230000001404 mediated effect Effects 0.000 description 3
• 235000008390 olive oil Nutrition 0.000 description 3
• AICOOMRHRUFYCM-ZRRPKQBOSA-N oxazine, 1 Chemical compound C([C@@H]1[C@H](C(C[C@]2(C)[C@@H]([C@H](C)N(C)C)[C@H](O)C[C@]21C)=O)CC1=CC2)C[C@H]1[C@@]1(C)[C@H]2N=C(C(C)C)OC1 AICOOMRHRUFYCM-ZRRPKQBOSA-N 0.000 description 3
• 235000011007 phosphoric acid Nutrition 0.000 description 3
• 229960004063 propylene glycol Drugs 0.000 description 3
• 230000001105 regulatory effect Effects 0.000 description 3
• 235000012239 silicon dioxide Nutrition 0.000 description 3
• 239000011734 sodium Substances 0.000 description 3
• 239000012453 solvate Substances 0.000 description 3
• 235000010356 sorbitol Nutrition 0.000 description 3
• 239000000600 sorbitol Substances 0.000 description 3
• 238000011476 stem cell transplantation Methods 0.000 description 3
• 235000000346 sugar Nutrition 0.000 description 3
• 150000008163 sugars Chemical class 0.000 description 3
• 239000000375 suspending agent Substances 0.000 description 3
• 230000002459 sustained effect Effects 0.000 description 3
• 239000006188 syrup Substances 0.000 description 3
• 235000020357 syrup Nutrition 0.000 description 3
• 230000008685 targeting Effects 0.000 description 3
• 239000001993 wax Substances 0.000 description 3
• PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
• JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 2
• VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
• IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
• WXTMDXOMEHJXQO-UHFFFAOYSA-N 2,5-dihydroxybenzoic acid Chemical compound OC(=O)C1=CC(O)=CC=C1O WXTMDXOMEHJXQO-UHFFFAOYSA-N 0.000 description 2
• HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
• QCXJEYYXVJIFCE-UHFFFAOYSA-N 4-acetamidobenzoic acid Chemical compound CC(=O)NC1=CC=C(C(O)=O)C=C1 QCXJEYYXVJIFCE-UHFFFAOYSA-N 0.000 description 2
• FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
• 208000036762 Acute promyelocytic leukaemia Diseases 0.000 description 2
• QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
• 229920003084 Avicel® PH-102 Polymers 0.000 description 2
• 229940125814 BTK kinase inhibitor Drugs 0.000 description 2
• 102000004506 Blood Proteins Human genes 0.000 description 2
• 108010017384 Blood Proteins Proteins 0.000 description 2
• 241000283690 Bos taurus Species 0.000 description 2
• 239000004322 Butylated hydroxytoluene Substances 0.000 description 2
• NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 2
• VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
• WWZKQHOCKIZLMA-UHFFFAOYSA-N Caprylic acid Natural products CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 2
• 229920000858 Cyclodextrin Polymers 0.000 description 2
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
• 102000010170 Death domains Human genes 0.000 description 2
• 108050001718 Death domains Proteins 0.000 description 2
• 206010012735 Diarrhoea Diseases 0.000 description 2
• KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
• LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 description 2
• VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
• 241000206672 Gelidium Species 0.000 description 2
• 241000282412 Homo Species 0.000 description 2
• 101001059454 Homo sapiens Serine/threonine-protein kinase MARK2 Proteins 0.000 description 2
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
• 108060003951 Immunoglobulin Proteins 0.000 description 2
• XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
• WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 2
• FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
• 229930195725 Mannitol Natural products 0.000 description 2
• BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 description 2
• QIAFMBKCNZACKA-UHFFFAOYSA-N N-benzoylglycine Chemical compound OC(=O)CNC(=O)C1=CC=CC=C1 QIAFMBKCNZACKA-UHFFFAOYSA-N 0.000 description 2
• 206010061309 Neoplasm progression Diseases 0.000 description 2
• PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 2
• ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
• GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 2
• 239000002202 Polyethylene glycol Substances 0.000 description 2
• ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
• 241000288906 Primates Species 0.000 description 2
• ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
• 102100028904 Serine/threonine-protein kinase MARK2 Human genes 0.000 description 2
• QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
• DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 2
• XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
• 238000009825 accumulation Methods 0.000 description 2
• 230000003213 activating effect Effects 0.000 description 2
• WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
• 239000000783 alginic acid Substances 0.000 description 2
• 229960001126 alginic acid Drugs 0.000 description 2
• 150000004781 alginic acids Chemical class 0.000 description 2
• WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 2
• 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
• 230000001668 ameliorated effect Effects 0.000 description 2
• 230000001093 anti-cancer Effects 0.000 description 2
• 230000000118 anti-neoplastic effect Effects 0.000 description 2
• 238000013459 approach Methods 0.000 description 2
• 235000010323 ascorbic acid Nutrition 0.000 description 2
• 230000009286 beneficial effect Effects 0.000 description 2
• 239000000440 bentonite Substances 0.000 description 2
• 229910000278 bentonite Inorganic materials 0.000 description 2
• SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 2
• SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 description 2
• 229920002988 biodegradable polymer Polymers 0.000 description 2
• 239000004621 biodegradable polymer Substances 0.000 description 2
• 230000004071 biological effect Effects 0.000 description 2
• 238000001574 biopsy Methods 0.000 description 2
• 239000000872 buffer Substances 0.000 description 2
• 239000006172 buffering agent Substances 0.000 description 2
• 235000010354 butylated hydroxytoluene Nutrition 0.000 description 2
• 229940095259 butylated hydroxytoluene Drugs 0.000 description 2
• 239000011575 calcium Substances 0.000 description 2
• 229910001861 calcium hydroxide Inorganic materials 0.000 description 2
• 150000001720 carbohydrates Chemical class 0.000 description 2
• 235000014633 carbohydrates Nutrition 0.000 description 2
• 239000001768 carboxy methyl cellulose Substances 0.000 description 2
• 239000012876 carrier material Substances 0.000 description 2
• 210000003169 central nervous system Anatomy 0.000 description 2
• 239000002738 chelating agent Substances 0.000 description 2
• OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 2
• 238000013270 controlled release Methods 0.000 description 2
• 235000012343 cottonseed oil Nutrition 0.000 description 2
• 238000002425 crystallisation Methods 0.000 description 2
• 230000008025 crystallization Effects 0.000 description 2
• 229940097362 cyclodextrins Drugs 0.000 description 2
• 230000002559 cytogenic effect Effects 0.000 description 2
• 230000034994 death Effects 0.000 description 2
• 231100000517 death Toxicity 0.000 description 2
• JXTHNDFMNIQAHM-UHFFFAOYSA-N dichloroacetic acid Chemical compound OC(=O)C(Cl)Cl JXTHNDFMNIQAHM-UHFFFAOYSA-N 0.000 description 2
• 230000004069 differentiation Effects 0.000 description 2
• 239000002270 dispersing agent Substances 0.000 description 2
• POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
• 239000008298 dragée Substances 0.000 description 2
• 238000012377 drug delivery Methods 0.000 description 2
• 238000001962 electrophoresis Methods 0.000 description 2
• 150000002148 esters Chemical class 0.000 description 2
• MMXKVMNBHPAILY-UHFFFAOYSA-N ethyl laurate Chemical compound CCCCCCCCCCCC(=O)OCC MMXKVMNBHPAILY-UHFFFAOYSA-N 0.000 description 2
• LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 2
• 229940093471 ethyl oleate Drugs 0.000 description 2
• 238000013265 extended release Methods 0.000 description 2
• 230000002349 favourable effect Effects 0.000 description 2
• 239000000796 flavoring agent Substances 0.000 description 2
• 230000004907 flux Effects 0.000 description 2
• 230000037406 food intake Effects 0.000 description 2
• 210000001035 gastrointestinal tract Anatomy 0.000 description 2
• RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
• KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
• 150000002334 glycols Chemical class 0.000 description 2
• 230000036541 health Effects 0.000 description 2
• 230000002489 hematologic effect Effects 0.000 description 2
• 206010019847 hepatosplenomegaly Diseases 0.000 description 2
• IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
• UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 2
• 230000002519 immonomodulatory effect Effects 0.000 description 2
• 102000018358 immunoglobulin Human genes 0.000 description 2
• 230000006872 improvement Effects 0.000 description 2
• 238000001727 in vivo Methods 0.000 description 2
• 230000002757 inflammatory effect Effects 0.000 description 2
• 230000004054 inflammatory process Effects 0.000 description 2
• 230000005764 inhibitory process Effects 0.000 description 2
• 150000007529 inorganic bases Chemical class 0.000 description 2
• 230000003993 interaction Effects 0.000 description 2
• 239000000543 intermediate Substances 0.000 description 2
• 230000007794 irritation Effects 0.000 description 2
• SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical compound OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 description 2
• KQNPFQTWMSNSAP-UHFFFAOYSA-N isobutyric acid Chemical compound CC(C)C(O)=O KQNPFQTWMSNSAP-UHFFFAOYSA-N 0.000 description 2
• JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
• 235000010445 lecithin Nutrition 0.000 description 2
• 239000000787 lecithin Substances 0.000 description 2
• 229940067606 lecithin Drugs 0.000 description 2
• 150000002632 lipids Chemical class 0.000 description 2
• 239000008297 liquid dosage form Substances 0.000 description 2
• 239000006210 lotion Substances 0.000 description 2
• 229910052749 magnesium Inorganic materials 0.000 description 2
• 229910001862 magnesium hydroxide Inorganic materials 0.000 description 2
• 238000012423 maintenance Methods 0.000 description 2
• 239000000594 mannitol Substances 0.000 description 2
• 235000010355 mannitol Nutrition 0.000 description 2
• 239000011159 matrix material Substances 0.000 description 2
• 229910052751 metal Inorganic materials 0.000 description 2
• 239000002184 metal Substances 0.000 description 2
• BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
• 239000004530 micro-emulsion Substances 0.000 description 2
• 238000000465 moulding Methods 0.000 description 2
• 208000004235 neutropenia Diseases 0.000 description 2
• 239000012457 nonaqueous media Substances 0.000 description 2
• 108020004707 nucleic acids Proteins 0.000 description 2
• 102000039446 nucleic acids Human genes 0.000 description 2
• 150000007523 nucleic acids Chemical class 0.000 description 2
• 231100000590 oncogenic Toxicity 0.000 description 2
• 230000002246 oncogenic effect Effects 0.000 description 2
• 210000000056 organ Anatomy 0.000 description 2
• 150000007530 organic bases Chemical class 0.000 description 2
• 150000002895 organic esters Chemical class 0.000 description 2
• 238000007911 parenteral administration Methods 0.000 description 2
• 230000007170 pathology Effects 0.000 description 2
• 239000002304 perfume Substances 0.000 description 2
• 230000003285 pharmacodynamic effect Effects 0.000 description 2
• 210000004180 plasmocyte Anatomy 0.000 description 2
• 229920001983 poloxamer Polymers 0.000 description 2
• 229920005862 polyol Polymers 0.000 description 2
• 150000003077 polyols Chemical class 0.000 description 2
• 229910052700 potassium Inorganic materials 0.000 description 2
• 239000011591 potassium Substances 0.000 description 2
• 230000002265 prevention Effects 0.000 description 2
• 239000003380 propellant Substances 0.000 description 2
• 230000005855 radiation Effects 0.000 description 2
• 201000000441 refractory hematologic cancer Diseases 0.000 description 2
• YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
• CXMXRPHRNRROMY-UHFFFAOYSA-N sebacic acid Chemical compound OC(=O)CCCCCCCCC(O)=O CXMXRPHRNRROMY-UHFFFAOYSA-N 0.000 description 2
• 239000008159 sesame oil Substances 0.000 description 2
• 235000011803 sesame oil Nutrition 0.000 description 2
• 229910052708 sodium Inorganic materials 0.000 description 2
• 239000011780 sodium chloride Substances 0.000 description 2
• GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 2
• 239000007909 solid dosage form Substances 0.000 description 2
• 239000008247 solid mixture Substances 0.000 description 2
• 229940032147 starch Drugs 0.000 description 2
• 239000008107 starch Substances 0.000 description 2
• 239000008223 sterile water Substances 0.000 description 2
• 239000000829 suppository Substances 0.000 description 2
• 239000003765 sweetening agent Substances 0.000 description 2
• 230000002195 synergetic effect Effects 0.000 description 2
• 239000011975 tartaric acid Substances 0.000 description 2
• 238000012360 testing method Methods 0.000 description 2
• ZMZDMBWJUHKJPS-UHFFFAOYSA-N thiocyanic acid Chemical compound SC#N ZMZDMBWJUHKJPS-UHFFFAOYSA-N 0.000 description 2
• JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 2
• 238000011200 topical administration Methods 0.000 description 2
• 231100000331 toxic Toxicity 0.000 description 2
• 230000002588 toxic effect Effects 0.000 description 2
• VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
• GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 2
• 230000004614 tumor growth Effects 0.000 description 2
• 230000005751 tumor progression Effects 0.000 description 2
• 235000013311 vegetables Nutrition 0.000 description 2
• 238000010626 work up procedure Methods 0.000 description 2
• QIJRTFXNRTXDIP-UHFFFAOYSA-N (1-carboxy-2-sulfanylethyl)azanium;chloride;hydrate Chemical compound O.Cl.SCC(N)C(O)=O QIJRTFXNRTXDIP-UHFFFAOYSA-N 0.000 description 1
• VJLYHTOSFSGXGH-CQSZACIVSA-N (2R)-1-[3-[4-(aminomethyl)-6-(trifluoromethyl)pyridin-2-yl]oxybenzoyl]pyrrolidine-2-carboxylic acid Chemical compound NCC1=CC(=NC(=C1)C(F)(F)F)OC=1C=C(C(=O)N2[C@H](CCC2)C(=O)O)C=CC=1 VJLYHTOSFSGXGH-CQSZACIVSA-N 0.000 description 1
• QBYIENPQHBMVBV-HFEGYEGKSA-N (2R)-2-hydroxy-2-phenylacetic acid Chemical compound O[C@@H](C(O)=O)c1ccccc1.O[C@@H](C(O)=O)c1ccccc1 QBYIENPQHBMVBV-HFEGYEGKSA-N 0.000 description 1
• WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
• GVJHHUAWPYXKBD-IEOSBIPESA-N (R)-alpha-Tocopherol Natural products OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
• WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
• 229940058015 1,3-butylene glycol Drugs 0.000 description 1
• SJJCQDRGABAVBB-UHFFFAOYSA-N 1-hydroxy-2-naphthoic acid Chemical compound C1=CC=CC2=C(O)C(C(=O)O)=CC=C21 SJJCQDRGABAVBB-UHFFFAOYSA-N 0.000 description 1
• RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 description 1
• FRPZMMHWLSIFAZ-UHFFFAOYSA-N 10-undecenoic acid Chemical compound OC(=O)CCCCCCCCC=C FRPZMMHWLSIFAZ-UHFFFAOYSA-N 0.000 description 1
• FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 description 1
• KKFDCBRMNNSAAW-UHFFFAOYSA-N 2-(morpholin-4-yl)ethanol Chemical compound OCCN1CCOCC1 KKFDCBRMNNSAAW-UHFFFAOYSA-N 0.000 description 1
• WKAVKKUXZAWHDM-UHFFFAOYSA-N 2-acetamidopentanedioic acid;2-(dimethylamino)ethanol Chemical compound CN(C)CCO.CC(=O)NC(C(O)=O)CCC(O)=O WKAVKKUXZAWHDM-UHFFFAOYSA-N 0.000 description 1
• BFSVOASYOCHEOV-UHFFFAOYSA-N 2-diethylaminoethanol Chemical compound CCN(CC)CCO BFSVOASYOCHEOV-UHFFFAOYSA-N 0.000 description 1
• JNODDICFTDYODH-UHFFFAOYSA-N 2-hydroxytetrahydrofuran Chemical compound OC1CCCO1 JNODDICFTDYODH-UHFFFAOYSA-N 0.000 description 1
• BSKHPKMHTQYZBB-UHFFFAOYSA-N 2-methylpyridine Chemical compound CC1=CC=CC=N1 BSKHPKMHTQYZBB-UHFFFAOYSA-N 0.000 description 1
• KPGXRSRHYNQIFN-UHFFFAOYSA-N 2-oxoglutaric acid Chemical compound OC(=O)CCC(=O)C(O)=O KPGXRSRHYNQIFN-UHFFFAOYSA-N 0.000 description 1
• LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
• JIMDQTNPLVRAES-UHFFFAOYSA-N 3-[4-(aminomethyl)-6-(trifluoromethyl)pyridin-2-yl]oxy-N-(oxetan-3-yl)benzamide Chemical compound NCC1=CC(=NC(=C1)C(F)(F)F)OC=1C=C(C(=O)NC2COC2)C=CC=1 JIMDQTNPLVRAES-UHFFFAOYSA-N 0.000 description 1
• BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
• UOQHWNPVNXSDDO-UHFFFAOYSA-N 3-bromoimidazo[1,2-a]pyridine-6-carbonitrile Chemical compound C1=CC(C#N)=CN2C(Br)=CN=C21 UOQHWNPVNXSDDO-UHFFFAOYSA-N 0.000 description 1
• OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
• WUBBRNOQWQTFEX-UHFFFAOYSA-N 4-aminosalicylic acid Chemical compound NC1=CC=C(C(O)=O)C(O)=C1 WUBBRNOQWQTFEX-UHFFFAOYSA-N 0.000 description 1
• OFNXOACBUMGOPC-HZYVHMACSA-N 5'-hydroxystreptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](CO)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O OFNXOACBUMGOPC-HZYVHMACSA-N 0.000 description 1
• QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
• 206010067484 Adverse reaction Diseases 0.000 description 1
• 201000004384 Alopecia Diseases 0.000 description 1
• 239000005995 Aluminium silicate Substances 0.000 description 1
• 235000003276 Apios tuberosa Nutrition 0.000 description 1
• 244000105624 Arachis hypogaea Species 0.000 description 1
• 235000010777 Arachis hypogaea Nutrition 0.000 description 1
• 235000010744 Arachis villosulicarpa Nutrition 0.000 description 1
• 208000003950 B-cell lymphoma Diseases 0.000 description 1
• 208000028564 B-cell non-Hodgkin lymphoma Diseases 0.000 description 1
• 208000008035 Back Pain Diseases 0.000 description 1
• 239000005711 Benzoic acid Substances 0.000 description 1
• 208000004860 Blast Crisis Diseases 0.000 description 1
• 101710082513 C-X-C chemokine receptor type 4 Proteins 0.000 description 1
• 208000025721 COVID-19 Diseases 0.000 description 1
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
• 241000282465 Canis Species 0.000 description 1
• 241000282472 Canis lupus familiaris Species 0.000 description 1
• 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
• 229940123150 Chelating agent Drugs 0.000 description 1
• WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 description 1
• 206010010774 Constipation Diseases 0.000 description 1
• 229920002261 Corn starch Polymers 0.000 description 1
• MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 description 1
• MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 description 1
• 206010011224 Cough Diseases 0.000 description 1
• RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 1
• RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
• 108020004414 DNA Proteins 0.000 description 1
• 229920002307 Dextran Polymers 0.000 description 1
• FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
• 235000019739 Dicalciumphosphate Nutrition 0.000 description 1
• 208000000059 Dyspnea Diseases 0.000 description 1
• 206010013975 Dyspnoeas Diseases 0.000 description 1
• 241000196324 Embryophyta Species 0.000 description 1
• 241000283073 Equus caballus Species 0.000 description 1
• 239000001856 Ethyl cellulose Substances 0.000 description 1
• ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
• PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
• 241000282324 Felis Species 0.000 description 1
• 241000282326 Felis catus Species 0.000 description 1
• 239000004606 Fillers/Extenders Substances 0.000 description 1
• 241000233866 Fungi Species 0.000 description 1
• DSLZVSRJTYRBFB-UHFFFAOYSA-N Galactaric acid Natural products OC(=O)C(O)C(O)C(O)C(O)C(O)=O DSLZVSRJTYRBFB-UHFFFAOYSA-N 0.000 description 1
• IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
• 108010024636 Glutathione Proteins 0.000 description 1
• 206010019280 Heart failures Diseases 0.000 description 1
• 241000711549 Hepacivirus C Species 0.000 description 1
• 239000004705 High-molecular-weight polyethylene Substances 0.000 description 1
• 101001076418 Homo sapiens Interleukin-1 receptor type 1 Proteins 0.000 description 1
• 101000852483 Homo sapiens Interleukin-1 receptor-associated kinase 1 Proteins 0.000 description 1
• 241000701044 Human gammaherpesvirus 4 Species 0.000 description 1
• JYGXADMDTFJGBT-VWUMJDOOSA-N Hydrocortisone Natural products O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 1
• 206010061218 Inflammation Diseases 0.000 description 1
• 102100026016 Interleukin-1 receptor type 1 Human genes 0.000 description 1
• 102100023530 Interleukin-1 receptor-associated kinase 3 Human genes 0.000 description 1
• 101710199012 Interleukin-1 receptor-associated kinase 3 Proteins 0.000 description 1
• 102100036433 Interleukin-1 receptor-associated kinase-like 2 Human genes 0.000 description 1
• 101710182491 Interleukin-1 receptor-associated kinase-like 2 Proteins 0.000 description 1
• 102000004557 Interleukin-18 Receptors Human genes 0.000 description 1
• 108010017537 Interleukin-18 Receptors Proteins 0.000 description 1
• 102000015696 Interleukins Human genes 0.000 description 1
• 108010063738 Interleukins Proteins 0.000 description 1
• ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 1
• 229930064664 L-arginine Natural products 0.000 description 1
• 235000014852 L-arginine Nutrition 0.000 description 1
• 239000011786 L-ascorbyl-6-palmitate Substances 0.000 description 1
• QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 description 1
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
• KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
• 239000005639 Lauric acid Substances 0.000 description 1
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
• 102000005482 Lipopolysaccharide Receptors Human genes 0.000 description 1
• 108010031801 Lipopolysaccharide Receptors Proteins 0.000 description 1
• 240000003183 Manihot esculenta Species 0.000 description 1
• 235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 description 1
• 208000000112 Myalgia Diseases 0.000 description 1
• 102000010168 Myeloid Differentiation Factor 88 Human genes 0.000 description 1
• 108010077432 Myeloid Differentiation Factor 88 Proteins 0.000 description 1
• MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 description 1
• GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
• 208000011623 Obstructive Lung disease Diseases 0.000 description 1
• 240000007817 Olea europaea Species 0.000 description 1
• 239000005642 Oleic acid Substances 0.000 description 1
• ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
• 108700020796 Oncogene Proteins 0.000 description 1
• 235000021314 Palmitic acid Nutrition 0.000 description 1
• 206010033661 Pancytopenia Diseases 0.000 description 1
• 235000019483 Peanut oil Nutrition 0.000 description 1
• 241001494479 Pecora Species 0.000 description 1
• 206010034620 Peripheral sensory neuropathy Diseases 0.000 description 1
• 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
• 239000004952 Polyamide Substances 0.000 description 1
• 229920002732 Polyanhydride Polymers 0.000 description 1
• 229920000954 Polyglycolide Polymers 0.000 description 1
• 229920001710 Polyorthoester Polymers 0.000 description 1
• 102100023884 Probable ribonuclease ZC3H12D Human genes 0.000 description 1
• ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
• 208000033826 Promyelocytic Acute Leukemia Diseases 0.000 description 1
• XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Chemical compound CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 1
• IWYDHOAUDWTVEP-UHFFFAOYSA-N R-2-phenyl-2-hydroxyacetic acid Natural products OC(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-N 0.000 description 1
• 208000035977 Rare disease Diseases 0.000 description 1
• 241000700159 Rattus Species 0.000 description 1
• 108010081750 Reticulin Proteins 0.000 description 1
• 206010039020 Rhabdomyolysis Diseases 0.000 description 1
• 235000004443 Ricinus communis Nutrition 0.000 description 1
• 241000283984 Rodentia Species 0.000 description 1
• 235000019485 Safflower oil Nutrition 0.000 description 1
• 206010040047 Sepsis Diseases 0.000 description 1
• 235000002595 Solanum tuberosum Nutrition 0.000 description 1
• 244000061456 Solanum tuberosum Species 0.000 description 1
• 235000021355 Stearic acid Nutrition 0.000 description 1
• SSZBUIDZHHWXNJ-UHFFFAOYSA-N Stearinsaeure-hexadecylester Natural products CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCCCC SSZBUIDZHHWXNJ-UHFFFAOYSA-N 0.000 description 1
• KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
• 241000282898 Sus scrofa Species 0.000 description 1
• 208000000389 T-cell leukemia Diseases 0.000 description 1
• 208000028530 T-cell lymphoblastic leukemia/lymphoma Diseases 0.000 description 1
• 210000001744 T-lymphocyte Anatomy 0.000 description 1
• 102000003714 TNF receptor-associated factor 6 Human genes 0.000 description 1
• 108090000009 TNF receptor-associated factor 6 Proteins 0.000 description 1
• FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
• YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 1
• 102000004887 Transforming Growth Factor beta Human genes 0.000 description 1
• 108090001012 Transforming Growth Factor beta Proteins 0.000 description 1
• GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
• 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 description 1
• 206010047700 Vomiting Diseases 0.000 description 1
• 239000002250 absorbent Substances 0.000 description 1
• 230000002745 absorbent Effects 0.000 description 1
• 239000003655 absorption accelerator Substances 0.000 description 1
• 230000001133 acceleration Effects 0.000 description 1
• 230000009471 action Effects 0.000 description 1
• 239000008186 active pharmaceutical agent Substances 0.000 description 1
• 230000007059 acute toxicity Effects 0.000 description 1
• 231100000403 acute toxicity Toxicity 0.000 description 1
• 238000011374 additional therapy Methods 0.000 description 1
• 239000001361 adipic acid Substances 0.000 description 1
• 235000011037 adipic acid Nutrition 0.000 description 1
• 230000006838 adverse reaction Effects 0.000 description 1
• 239000008272 agar Substances 0.000 description 1
• 125000002723 alicyclic group Chemical group 0.000 description 1
• 125000001931 aliphatic group Chemical group 0.000 description 1
• 230000000735 allogeneic effect Effects 0.000 description 1
• 231100000360 alopecia Toxicity 0.000 description 1
• 229940087168 alpha tocopherol Drugs 0.000 description 1
• AEMOLEFTQBMNLQ-WAXACMCWSA-N alpha-D-glucuronic acid Chemical compound O[C@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-WAXACMCWSA-N 0.000 description 1
• AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 description 1
• 229910052782 aluminium Inorganic materials 0.000 description 1
• XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
• 235000012211 aluminium silicate Nutrition 0.000 description 1
• 150000001408 amides Chemical class 0.000 description 1
• 150000001412 amines Chemical class 0.000 description 1
• 229960004909 aminosalicylic acid Drugs 0.000 description 1
• 229910021529 ammonia Inorganic materials 0.000 description 1
• 230000000202 analgesic effect Effects 0.000 description 1
• JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 description 1
• 239000003242 anti bacterial agent Substances 0.000 description 1
• 230000002424 anti-apoptotic effect Effects 0.000 description 1
• 230000000844 anti-bacterial effect Effects 0.000 description 1
• 229940121375 antifungal agent Drugs 0.000 description 1
• 239000003429 antifungal agent Substances 0.000 description 1
• 239000000427 antigen Substances 0.000 description 1
• 102000036639 antigens Human genes 0.000 description 1
• 108091007433 antigens Proteins 0.000 description 1
• 125000003118 aryl group Chemical group 0.000 description 1
• 235000010385 ascorbyl palmitate Nutrition 0.000 description 1
• RQPZNWPYLFFXCP-UHFFFAOYSA-L barium dihydroxide Chemical compound [OH-].[OH-].[Ba+2] RQPZNWPYLFFXCP-UHFFFAOYSA-L 0.000 description 1
• 229910001863 barium hydroxide Inorganic materials 0.000 description 1
• 210000004082 barrier epithelial cell Anatomy 0.000 description 1
• JUHORIMYRDESRB-UHFFFAOYSA-N benzathine Chemical compound C=1C=CC=CC=1CNCCNCC1=CC=CC=C1 JUHORIMYRDESRB-UHFFFAOYSA-N 0.000 description 1
• SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 description 1
• 229940092714 benzenesulfonic acid Drugs 0.000 description 1
• 235000010233 benzoic acid Nutrition 0.000 description 1
• 229960002903 benzyl benzoate Drugs 0.000 description 1
• GONOPSZTUGRENK-UHFFFAOYSA-N benzyl(trichloro)silane Chemical compound Cl[Si](Cl)(Cl)CC1=CC=CC=C1 GONOPSZTUGRENK-UHFFFAOYSA-N 0.000 description 1
• 229960003237 betaine Drugs 0.000 description 1
• 229920000249 biocompatible polymer Polymers 0.000 description 1
• 239000012620 biological material Substances 0.000 description 1
• 229960000074 biopharmaceutical Drugs 0.000 description 1
• 230000015572 biosynthetic process Effects 0.000 description 1
• 210000004369 blood Anatomy 0.000 description 1
• 239000008280 blood Substances 0.000 description 1
• 210000000988 bone and bone Anatomy 0.000 description 1
• 210000004556 brain Anatomy 0.000 description 1
• 210000000481 breast Anatomy 0.000 description 1
• 239000007975 buffered saline Substances 0.000 description 1
• 239000001273 butane Substances 0.000 description 1
• 235000019437 butane-1,3-diol Nutrition 0.000 description 1
• KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
• 235000019282 butylated hydroxyanisole Nutrition 0.000 description 1
• 229910052791 calcium Inorganic materials 0.000 description 1
• 229910000019 calcium carbonate Inorganic materials 0.000 description 1
• 235000010216 calcium carbonate Nutrition 0.000 description 1
• AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
• 239000000920 calcium hydroxide Substances 0.000 description 1
• 229940095643 calcium hydroxide Drugs 0.000 description 1
• 239000001506 calcium phosphate Substances 0.000 description 1
• 235000012241 calcium silicate Nutrition 0.000 description 1
• CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
• 235000013539 calcium stearate Nutrition 0.000 description 1
• 239000008116 calcium stearate Substances 0.000 description 1
• LSPHULWDVZXLIL-QUBYGPBYSA-N camphoric acid Chemical compound CC1(C)[C@H](C(O)=O)CC[C@]1(C)C(O)=O LSPHULWDVZXLIL-QUBYGPBYSA-N 0.000 description 1
• KHAVLLBUVKBTBG-UHFFFAOYSA-N caproleic acid Natural products OC(=O)CCCCCCCC=C KHAVLLBUVKBTBG-UHFFFAOYSA-N 0.000 description 1
• BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
• 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
• 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
• 239000004359 castor oil Substances 0.000 description 1
• 230000015556 catabolic process Effects 0.000 description 1
• 230000004663 cell proliferation Effects 0.000 description 1
• 230000001413 cellular effect Effects 0.000 description 1
• 229920002301 cellulose acetate Polymers 0.000 description 1
• 229960000541 cetyl alcohol Drugs 0.000 description 1
• 238000006243 chemical reaction Methods 0.000 description 1
• 230000000973 chemotherapeutic effect Effects 0.000 description 1
• 229960004926 chlorobutanol Drugs 0.000 description 1
• 150000005827 chlorofluoro hydrocarbons Chemical class 0.000 description 1
• OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
• 229960001231 choline Drugs 0.000 description 1
• 230000007665 chronic toxicity Effects 0.000 description 1
• 231100000160 chronic toxicity Toxicity 0.000 description 1
• 235000013985 cinnamic acid Nutrition 0.000 description 1
• 229930016911 cinnamic acid Natural products 0.000 description 1
• 239000004927 clay Substances 0.000 description 1
• 229940110456 cocoa butter Drugs 0.000 description 1
• 235000019868 cocoa butter Nutrition 0.000 description 1
• 238000004040 coloring Methods 0.000 description 1
• 229940000425 combination drug Drugs 0.000 description 1
• 238000002648 combination therapy Methods 0.000 description 1
• 230000002301 combined effect Effects 0.000 description 1
• 239000008139 complexing agent Substances 0.000 description 1
• 239000002131 composite material Substances 0.000 description 1
• 239000007891 compressed tablet Substances 0.000 description 1
• 238000007906 compression Methods 0.000 description 1
• 230000006835 compression Effects 0.000 description 1
• 230000001276 controlling effect Effects 0.000 description 1
• 238000007796 conventional method Methods 0.000 description 1
• 235000005687 corn oil Nutrition 0.000 description 1
• 239000002285 corn oil Substances 0.000 description 1
• 239000008120 corn starch Substances 0.000 description 1
• 239000003246 corticosteroid Substances 0.000 description 1
• 125000000017 cortisol group Chemical group 0.000 description 1
• 229960004544 cortisone Drugs 0.000 description 1
• 239000002385 cottonseed oil Substances 0.000 description 1
• 239000013078 crystal Substances 0.000 description 1
• 239000000625 cyclamic acid and its Na and Ca salt Substances 0.000 description 1
• HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical compound OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 description 1
• 229960001305 cysteine hydrochloride Drugs 0.000 description 1
• 208000024389 cytopenia Diseases 0.000 description 1
• 230000002435 cytoreductive effect Effects 0.000 description 1
• 229960002887 deanol Drugs 0.000 description 1
• HABLENUWIZGESP-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O.CCCCCCCCCC(O)=O HABLENUWIZGESP-UHFFFAOYSA-N 0.000 description 1
• 230000007812 deficiency Effects 0.000 description 1
• 229920006237 degradable polymer Polymers 0.000 description 1
• 238000006731 degradation reaction Methods 0.000 description 1
• 230000001934 delay Effects 0.000 description 1
• 239000007933 dermal patch Substances 0.000 description 1
• 125000005131 dialkylammonium group Chemical group 0.000 description 1
• NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
• 229940038472 dicalcium phosphate Drugs 0.000 description 1
• 229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
• 235000014113 dietary fatty acids Nutrition 0.000 description 1
• ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
• 229940043237 diethanolamine Drugs 0.000 description 1
• HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 1
• 238000009792 diffusion process Methods 0.000 description 1
• 235000019621 digestibility Nutrition 0.000 description 1
• UGMCXQCYOVCMTB-UHFFFAOYSA-K dihydroxy(stearato)aluminium Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[Al](O)O UGMCXQCYOVCMTB-UHFFFAOYSA-K 0.000 description 1
• BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
• 238000004090 dissolution Methods 0.000 description 1
• 238000009826 distribution Methods 0.000 description 1
• 208000002173 dizziness Diseases 0.000 description 1
• 229940088679 drug related substance Drugs 0.000 description 1
• 230000004064 dysfunction Effects 0.000 description 1
• 238000002565 electrocardiography Methods 0.000 description 1
• 230000001804 emulsifying effect Effects 0.000 description 1
• 239000003623 enhancer Substances 0.000 description 1
• 239000002702 enteric coating Substances 0.000 description 1
• 238000009505 enteric coating Methods 0.000 description 1
• 230000004890 epithelial barrier function Effects 0.000 description 1
• 210000003743 erythrocyte Anatomy 0.000 description 1
• 230000000925 erythroid effect Effects 0.000 description 1
• AFAXGSQYZLGZPG-UHFFFAOYSA-N ethanedisulfonic acid Chemical compound OS(=O)(=O)CCS(O)(=O)=O AFAXGSQYZLGZPG-UHFFFAOYSA-N 0.000 description 1
• CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 description 1
• BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
• 229940093499 ethyl acetate Drugs 0.000 description 1
• 235000019325 ethyl cellulose Nutrition 0.000 description 1
• 229920001249 ethyl cellulose Polymers 0.000 description 1
• 238000011156 evaluation Methods 0.000 description 1
• 230000029142 excretion Effects 0.000 description 1
• 206010016256 fatigue Diseases 0.000 description 1
• 239000000194 fatty acid Substances 0.000 description 1
• 229930195729 fatty acid Natural products 0.000 description 1
• 239000007941 film coated tablet Substances 0.000 description 1
• 238000001914 filtration Methods 0.000 description 1
• 229960002011 fludrocortisone Drugs 0.000 description 1
• AAXVEMMRQDVLJB-BULBTXNYSA-N fludrocortisone Chemical compound O=C1CC[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 AAXVEMMRQDVLJB-BULBTXNYSA-N 0.000 description 1
• 235000019253 formic acid Nutrition 0.000 description 1
• 239000001530 fumaric acid Substances 0.000 description 1
• DSLZVSRJTYRBFB-DUHBMQHGSA-N galactaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)C(O)=O DSLZVSRJTYRBFB-DUHBMQHGSA-N 0.000 description 1
• LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 1
• 238000012252 genetic analysis Methods 0.000 description 1
• 230000037442 genomic alteration Effects 0.000 description 1
• 229960005219 gentisic acid Drugs 0.000 description 1
• 229950006191 gluconic acid Drugs 0.000 description 1
• 235000012208 gluconic acid Nutrition 0.000 description 1
• 235000013922 glutamic acid Nutrition 0.000 description 1
• 239000004220 glutamic acid Substances 0.000 description 1
• 229960003180 glutathione Drugs 0.000 description 1
• YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 description 1
• SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 description 1
• 229940093915 gynecological organic acid Drugs 0.000 description 1
• 201000005787 hematologic cancer Diseases 0.000 description 1
• 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 description 1
• 230000011132 hemopoiesis Effects 0.000 description 1
• BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
• 239000003906 humectant Substances 0.000 description 1
• XGIHQYAWBCFNPY-AZOCGYLKSA-N hydrabamine Chemical compound C([C@@H]12)CC3=CC(C(C)C)=CC=C3[C@@]2(C)CCC[C@@]1(C)CNCCNC[C@@]1(C)[C@@H]2CCC3=CC(C(C)C)=CC=C3[C@@]2(C)CCC1 XGIHQYAWBCFNPY-AZOCGYLKSA-N 0.000 description 1
• 230000036571 hydration Effects 0.000 description 1
• 238000006703 hydration reaction Methods 0.000 description 1
• 229930195733 hydrocarbon Natural products 0.000 description 1
• 150000002430 hydrocarbons Chemical class 0.000 description 1
• 229960000890 hydrocortisone Drugs 0.000 description 1
• 239000000017 hydrogel Substances 0.000 description 1
• OFNXOACBUMGOPC-UHFFFAOYSA-N hydroxystreptomycin Natural products CNC1C(O)C(O)C(CO)OC1OC1C(C=O)(O)C(CO)OC1OC1C(N=C(N)N)C(O)C(N=C(N)N)C(O)C1O OFNXOACBUMGOPC-UHFFFAOYSA-N 0.000 description 1
• RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Substances C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 1
• 230000008938 immune dysregulation Effects 0.000 description 1
• 230000001900 immune effect Effects 0.000 description 1
• 230000028993 immune response Effects 0.000 description 1
• 229940072221 immunoglobulins Drugs 0.000 description 1
• 230000001506 immunosuppresive effect Effects 0.000 description 1
• 239000007943 implant Substances 0.000 description 1
• 238000002513 implantation Methods 0.000 description 1
• 230000002779 inactivation Effects 0.000 description 1
• 238000010348 incorporation Methods 0.000 description 1
• 229910052738 indium Inorganic materials 0.000 description 1
• 208000015181 infectious disease Diseases 0.000 description 1
• 210000004969 inflammatory cell Anatomy 0.000 description 1
• 238000001802 infusion Methods 0.000 description 1
• 239000003112 inhibitor Substances 0.000 description 1
• 239000007972 injectable composition Substances 0.000 description 1
• 230000000266 injurious effect Effects 0.000 description 1
• 210000005007 innate immune system Anatomy 0.000 description 1
• 150000002484 inorganic compounds Chemical class 0.000 description 1
• 229910010272 inorganic material Inorganic materials 0.000 description 1
• 229910017053 inorganic salt Inorganic materials 0.000 description 1
• 102000002467 interleukin receptors Human genes 0.000 description 1
• 108010093036 interleukin receptors Proteins 0.000 description 1
• 230000024949 interleukin-17 production Effects 0.000 description 1
• 238000001361 intraarterial administration Methods 0.000 description 1
• 230000003834 intracellular effect Effects 0.000 description 1
• 238000007918 intramuscular administration Methods 0.000 description 1
• 238000010255 intramuscular injection Methods 0.000 description 1
• 239000007927 intramuscular injection Substances 0.000 description 1
• 238000007912 intraperitoneal administration Methods 0.000 description 1
• 238000007913 intrathecal administration Methods 0.000 description 1
• 238000001990 intravenous administration Methods 0.000 description 1
• 229910052742 iron Inorganic materials 0.000 description 1
• 238000002955 isolation Methods 0.000 description 1
• QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
• OKPOKMCPHKVCPP-UHFFFAOYSA-N isoorientaline Natural products C1=C(O)C(OC)=CC(CC2C3=CC(OC)=C(O)C=C3CCN2C)=C1 OKPOKMCPHKVCPP-UHFFFAOYSA-N 0.000 description 1
• 239000007951 isotonicity adjuster Substances 0.000 description 1
• NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
• 238000009533 lab test Methods 0.000 description 1
• 235000014655 lactic acid Nutrition 0.000 description 1
• 239000004310 lactic acid Substances 0.000 description 1
• 229940099563 lactobionic acid Drugs 0.000 description 1
• 210000000265 leukocyte Anatomy 0.000 description 1
• 239000003446 ligand Substances 0.000 description 1
• 239000006194 liquid suspension Substances 0.000 description 1
• 229910052744 lithium Inorganic materials 0.000 description 1
• WMFOQBRAJBCJND-UHFFFAOYSA-M lithium hydroxide Inorganic materials [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 description 1
• 210000004185 liver Anatomy 0.000 description 1
• 244000144972 livestock Species 0.000 description 1
• 239000007937 lozenge Substances 0.000 description 1
• 210000001165 lymph node Anatomy 0.000 description 1
• 210000004324 lymphatic system Anatomy 0.000 description 1
• 229920002521 macromolecule Polymers 0.000 description 1
• VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 1
• 239000000347 magnesium hydroxide Substances 0.000 description 1
• VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
• 239000011976 maleic acid Substances 0.000 description 1
• 239000001630 malic acid Substances 0.000 description 1
• 238000007726 management method Methods 0.000 description 1
• 229960002510 mandelic acid Drugs 0.000 description 1
• 238000005259 measurement Methods 0.000 description 1
• 238000002483 medication Methods 0.000 description 1
• 238000002844 melting Methods 0.000 description 1
• 230000008018 melting Effects 0.000 description 1
• 239000012528 membrane Substances 0.000 description 1
• 210000004379 membrane Anatomy 0.000 description 1
• 229940098779 methanesulfonic acid Drugs 0.000 description 1
• WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
• 244000005700 microbiome Species 0.000 description 1
• 239000004005 microsphere Substances 0.000 description 1
• 235000013336 milk Nutrition 0.000 description 1
• 239000008267 milk Substances 0.000 description 1
• 210000004080 milk Anatomy 0.000 description 1
• 150000007522 mineralic acids Chemical class 0.000 description 1
• 239000007932 molded tablet Substances 0.000 description 1
• CQDGTJPVBWZJAZ-UHFFFAOYSA-N monoethyl carbonate Chemical compound CCOC(O)=O CQDGTJPVBWZJAZ-UHFFFAOYSA-N 0.000 description 1
• 150000004682 monohydrates Chemical class 0.000 description 1
• 210000002200 mouth mucosa Anatomy 0.000 description 1
• 239000002324 mouth wash Substances 0.000 description 1
• 230000000869 mutational effect Effects 0.000 description 1
• WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
• IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
• OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
• KVBGVZZKJNLNJU-UHFFFAOYSA-N naphthalene-2-sulfonic acid Chemical compound C1=CC=CC2=CC(S(=O)(=O)O)=CC=C21 KVBGVZZKJNLNJU-UHFFFAOYSA-N 0.000 description 1
• 230000001537 neural effect Effects 0.000 description 1
• 230000003448 neutrophilic effect Effects 0.000 description 1
• 238000007481 next generation sequencing Methods 0.000 description 1
• 235000001968 nicotinic acid Nutrition 0.000 description 1
• 229960003512 nicotinic acid Drugs 0.000 description 1
• 239000011664 nicotinic acid Substances 0.000 description 1
• 229910017604 nitric acid Inorganic materials 0.000 description 1
• OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
• ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
• 235000021313 oleic acid Nutrition 0.000 description 1
• 230000005959 oncogenic signaling Effects 0.000 description 1
• 150000007524 organic acids Chemical class 0.000 description 1
• 235000005985 organic acids Nutrition 0.000 description 1
• 150000002894 organic compounds Chemical class 0.000 description 1
• 239000003960 organic solvent Substances 0.000 description 1
• 230000002018 overexpression Effects 0.000 description 1
• 150000003891 oxalate salts Chemical class 0.000 description 1
• 235000006408 oxalic acid Nutrition 0.000 description 1
• JMANVNJQNLATNU-UHFFFAOYSA-N oxalonitrile Chemical compound N#CC#N JMANVNJQNLATNU-UHFFFAOYSA-N 0.000 description 1
• WLJNZVDCPSBLRP-UHFFFAOYSA-N pamoic acid Chemical compound C1=CC=C2C(CC=3C4=CC=CC=C4C=C(C=3O)C(=O)O)=C(O)C(C(O)=O)=CC2=C1 WLJNZVDCPSBLRP-UHFFFAOYSA-N 0.000 description 1
• 239000012188 paraffin wax Substances 0.000 description 1
• 239000002245 particle Substances 0.000 description 1
• 235000010603 pastilles Nutrition 0.000 description 1
• 230000001575 pathological effect Effects 0.000 description 1
• 239000000312 peanut oil Substances 0.000 description 1
• 235000019371 penicillin G benzathine Nutrition 0.000 description 1
• 230000002085 persistent effect Effects 0.000 description 1
• 230000000144 pharmacologic effect Effects 0.000 description 1
• WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
• WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 description 1
• 239000008363 phosphate buffer Substances 0.000 description 1
• 150000003904 phospholipids Chemical class 0.000 description 1
• 150000003016 phosphoric acids Chemical class 0.000 description 1
• 230000026731 phosphorylation Effects 0.000 description 1
• 238000006366 phosphorylation reaction Methods 0.000 description 1
• 230000036470 plasma concentration Effects 0.000 description 1
• 229920002647 polyamide Polymers 0.000 description 1
• 229920001296 polysiloxane Polymers 0.000 description 1
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
• 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
• 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
• CHKVPAROMQMJNQ-UHFFFAOYSA-M potassium bisulfate Chemical compound [K+].OS([O-])(=O)=O CHKVPAROMQMJNQ-UHFFFAOYSA-M 0.000 description 1
• 229910000343 potassium bisulfate Inorganic materials 0.000 description 1
• KWYUFKZDYYNOTN-UHFFFAOYSA-M potassium hydroxide Inorganic materials [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 1
• 229920001592 potato starch Polymers 0.000 description 1
• 244000144977 poultry Species 0.000 description 1
• 229960005205 prednisolone Drugs 0.000 description 1
• OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
• 230000002335 preservative effect Effects 0.000 description 1
• 108090000765 processed proteins & peptides Proteins 0.000 description 1
• 238000004393 prognosis Methods 0.000 description 1
• 230000000770 proinflammatory effect Effects 0.000 description 1
• 230000035755 proliferation Effects 0.000 description 1
• 230000002035 prolonged effect Effects 0.000 description 1
• 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
• 239000001294 propane Substances 0.000 description 1
• 238000011321 prophylaxis Methods 0.000 description 1
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
• 235000013772 propylene glycol Nutrition 0.000 description 1
• 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
• 238000001959 radiotherapy Methods 0.000 description 1
• 102000005962 receptors Human genes 0.000 description 1
• 108020003175 receptors Proteins 0.000 description 1
• 230000000306 recurrent effect Effects 0.000 description 1
• 230000000241 respiratory effect Effects 0.000 description 1
• 239000003340 retarding agent Substances 0.000 description 1
• JTQHYPFKHZLTSH-UHFFFAOYSA-N reticulin Natural products COC1CC(OC2C(CO)OC(OC3C(O)CC(OC4C(C)OC(CC4OC)OC5CCC6(C)C7CCC8(C)C(CCC8(O)C7CC=C6C5)C(C)O)OC3C)C(O)C2OC)OC(C)C1O JTQHYPFKHZLTSH-UHFFFAOYSA-N 0.000 description 1
• 230000002441 reversible effect Effects 0.000 description 1
• 231100000279 safety data Toxicity 0.000 description 1
• 235000005713 safflower oil Nutrition 0.000 description 1
• 239000003813 safflower oil Substances 0.000 description 1
• 229960004889 salicylic acid Drugs 0.000 description 1
• 150000003870 salicylic acids Chemical class 0.000 description 1
• 238000004062 sedimentation Methods 0.000 description 1
• 230000001953 sensory effect Effects 0.000 description 1
• 201000005572 sensory peripheral neuropathy Diseases 0.000 description 1
• 210000002966 serum Anatomy 0.000 description 1
• 238000007493 shaping process Methods 0.000 description 1
• 230000035939 shock Effects 0.000 description 1
• 150000004760 silicates Chemical class 0.000 description 1
• 210000003491 skin Anatomy 0.000 description 1
• AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 description 1
• WBHQBSYUUJJSRZ-UHFFFAOYSA-M sodium bisulfate Chemical compound [Na+].OS([O-])(=O)=O WBHQBSYUUJJSRZ-UHFFFAOYSA-M 0.000 description 1
• 229910000342 sodium bisulfate Inorganic materials 0.000 description 1
• 229940100996 sodium bisulfate Drugs 0.000 description 1
• 229910000029 sodium carbonate Inorganic materials 0.000 description 1
• 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
• 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
• 239000001509 sodium citrate Substances 0.000 description 1
• NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
• HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
• HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Inorganic materials [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 1
• 229940001584 sodium metabisulfite Drugs 0.000 description 1
• 235000010262 sodium metabisulphite Nutrition 0.000 description 1
• 239000008109 sodium starch glycolate Substances 0.000 description 1
• 229920003109 sodium starch glycolate Polymers 0.000 description 1
• 229940079832 sodium starch glycolate Drugs 0.000 description 1
• 229940001482 sodium sulfite Drugs 0.000 description 1
• 235000010265 sodium sulphite Nutrition 0.000 description 1
• 239000008137 solubility enhancer Substances 0.000 description 1
• 235000010199 sorbic acid Nutrition 0.000 description 1
• 239000004334 sorbic acid Substances 0.000 description 1
• 229940075582 sorbic acid Drugs 0.000 description 1
• 239000003549 soybean oil Substances 0.000 description 1
• 235000012424 soybean oil Nutrition 0.000 description 1
• 210000000952 spleen Anatomy 0.000 description 1
• 102000009076 src-Family Kinases Human genes 0.000 description 1
• 239000003381 stabilizer Substances 0.000 description 1
• 238000010186 staining Methods 0.000 description 1
• 238000011272 standard treatment Methods 0.000 description 1
• 239000008117 stearic acid Substances 0.000 description 1
• 239000003206 sterilizing agent Substances 0.000 description 1
• 230000004936 stimulating effect Effects 0.000 description 1
• 230000035882 stress Effects 0.000 description 1
• 238000007920 subcutaneous administration Methods 0.000 description 1
• 238000010254 subcutaneous injection Methods 0.000 description 1
• 239000007929 subcutaneous injection Substances 0.000 description 1
• 125000000547 substituted alkyl group Chemical group 0.000 description 1
• 239000000758 substrate Substances 0.000 description 1
• 150000003460 sulfonic acids Chemical class 0.000 description 1
• 230000001629 suppression Effects 0.000 description 1
• 238000001356 surgical procedure Methods 0.000 description 1
• 238000013268 sustained release Methods 0.000 description 1
• 239000012730 sustained-release form Substances 0.000 description 1
• 208000011580 syndromic disease Diseases 0.000 description 1
• 235000002906 tartaric acid Nutrition 0.000 description 1
• PRAAPINBUWJLGA-UHFFFAOYSA-N telaglenastat Chemical compound FC(F)(F)OC1=CC=CC(CC(=O)NC=2N=NC(CCCCC=3SC(NC(=O)CC=4N=CC=CC=4)=NN=3)=CC=2)=C1 PRAAPINBUWJLGA-UHFFFAOYSA-N 0.000 description 1
• 201000002814 testicular lymphoma Diseases 0.000 description 1
• 150000005621 tetraalkylammonium salts Chemical class 0.000 description 1
• 230000004797 therapeutic response Effects 0.000 description 1
• 239000002562 thickening agent Substances 0.000 description 1
• 206010043554 thrombocytopenia Diseases 0.000 description 1
• 210000001685 thyroid gland Anatomy 0.000 description 1
• 238000004448 titration Methods 0.000 description 1
• AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 1
• 229960000984 tocofersolan Drugs 0.000 description 1
• 230000000699 topical effect Effects 0.000 description 1
• 230000002463 transducing effect Effects 0.000 description 1
• 125000005208 trialkylammonium group Chemical group 0.000 description 1
• 229960005294 triamcinolone Drugs 0.000 description 1
• GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
• 150000003628 tricarboxylic acids Chemical class 0.000 description 1
• 230000001960 triggered effect Effects 0.000 description 1
• LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
• 229960000281 trometamol Drugs 0.000 description 1
• 210000004881 tumor cell Anatomy 0.000 description 1
• 102000003298 tumor necrosis factor receptor Human genes 0.000 description 1
• 230000034512 ubiquitination Effects 0.000 description 1
• 238000010798 ubiquitination Methods 0.000 description 1
• 229960002703 undecylenic acid Drugs 0.000 description 1
• 230000003827 upregulation Effects 0.000 description 1
• 235000015112 vegetable and seed oil Nutrition 0.000 description 1
• 235000019871 vegetable fat Nutrition 0.000 description 1
• 239000008158 vegetable oil Substances 0.000 description 1
• 230000008673 vomiting Effects 0.000 description 1
• 230000003442 weekly effect Effects 0.000 description 1
• 229910052725 zinc Inorganic materials 0.000 description 1
• 239000011701 zinc Substances 0.000 description 1
• 150000003751 zinc Chemical class 0.000 description 1
• 239000011787 zinc oxide Substances 0.000 description 1
• 235000014692 zinc oxide Nutrition 0.000 description 1
• 239000002076 α-tocopherol Substances 0.000 description 1
• 235000004835 α-tocopherol Nutrition 0.000 description 1