IL296752A - Infectious disease antigens and vaccines - Google Patents
Infectious disease antigens and vaccinesInfo
- Publication number
- IL296752A IL296752A IL296752A IL29675222A IL296752A IL 296752 A IL296752 A IL 296752A IL 296752 A IL296752 A IL 296752A IL 29675222 A IL29675222 A IL 29675222A IL 296752 A IL296752 A IL 296752A
- Authority
- IL
- Israel
- Prior art keywords
- sequence
- nucleic acid
- epitope
- encoding nucleic
- acid sequence
- Prior art date
Links
- 208000035473 Communicable disease Diseases 0.000 title claims description 165
- 239000000427 antigen Substances 0.000 title claims description 144
- 108091007433 antigens Proteins 0.000 title claims description 143
- 102000036639 antigens Human genes 0.000 title claims description 143
- 229960005486 vaccine Drugs 0.000 title claims description 26
- 150000007523 nucleic acids Chemical group 0.000 claims description 757
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 522
- 239000002773 nucleotide Substances 0.000 claims description 385
- 125000003729 nucleotide group Chemical group 0.000 claims description 385
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 380
- 238000000034 method Methods 0.000 claims description 336
- 239000000203 mixture Substances 0.000 claims description 293
- 210000004027 cell Anatomy 0.000 claims description 245
- 208000015181 infectious disease Diseases 0.000 claims description 221
- 230000014509 gene expression Effects 0.000 claims description 204
- 241000710929 Alphavirus Species 0.000 claims description 193
- 244000052769 pathogen Species 0.000 claims description 179
- 239000013598 vector Substances 0.000 claims description 159
- 102000043129 MHC class I family Human genes 0.000 claims description 153
- 108091054437 MHC class I family Proteins 0.000 claims description 153
- 108091034057 RNA (poly(A)) Proteins 0.000 claims description 146
- 241001217856 Chimpanzee adenovirus Species 0.000 claims description 145
- 238000012217 deletion Methods 0.000 claims description 136
- 230000037430 deletion Effects 0.000 claims description 136
- 102000043131 MHC class II family Human genes 0.000 claims description 123
- 108091054438 MHC class II family Proteins 0.000 claims description 123
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 100
- 235000001014 amino acid Nutrition 0.000 claims description 93
- 108090000623 proteins and genes Proteins 0.000 claims description 89
- 238000012163 sequencing technique Methods 0.000 claims description 84
- 150000001413 amino acids Chemical class 0.000 claims description 75
- 108700028369 Alleles Proteins 0.000 claims description 64
- 102000004169 proteins and genes Human genes 0.000 claims description 64
- 235000018102 proteins Nutrition 0.000 claims description 63
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 55
- 241000701022 Cytomegalovirus Species 0.000 claims description 54
- 230000036961 partial effect Effects 0.000 claims description 49
- 241000700605 Viruses Species 0.000 claims description 45
- 241000725643 Respiratory syncytial virus Species 0.000 claims description 39
- 230000001965 increasing effect Effects 0.000 claims description 39
- 241000711549 Hepacivirus C Species 0.000 claims description 38
- 230000027455 binding Effects 0.000 claims description 36
- 150000002632 lipids Chemical class 0.000 claims description 36
- 241000701806 Human papillomavirus Species 0.000 claims description 34
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 34
- 230000001939 inductive effect Effects 0.000 claims description 34
- 229920001184 polypeptide Polymers 0.000 claims description 33
- 241001678559 COVID-19 virus Species 0.000 claims description 32
- 108090000848 Ubiquitin Proteins 0.000 claims description 32
- 102000044159 Ubiquitin Human genes 0.000 claims description 32
- 230000001717 pathogenic effect Effects 0.000 claims description 31
- 210000001519 tissue Anatomy 0.000 claims description 30
- 210000004443 dendritic cell Anatomy 0.000 claims description 29
- 239000012634 fragment Substances 0.000 claims description 29
- 241000710959 Venezuelan equine encephalitis virus Species 0.000 claims description 28
- 230000028993 immune response Effects 0.000 claims description 28
- 238000007918 intramuscular administration Methods 0.000 claims description 28
- 201000008827 tuberculosis Diseases 0.000 claims description 26
- 230000004075 alteration Effects 0.000 claims description 25
- 206010022000 influenza Diseases 0.000 claims description 25
- 230000004936 stimulating effect Effects 0.000 claims description 25
- 230000001225 therapeutic effect Effects 0.000 claims description 25
- 241000894006 Bacteria Species 0.000 claims description 24
- 108010064171 Lysosome-Associated Membrane Glycoproteins Proteins 0.000 claims description 24
- 102000014944 Lysosome-Associated Membrane Glycoproteins Human genes 0.000 claims description 24
- 102000004245 Proteasome Endopeptidase Complex Human genes 0.000 claims description 24
- 108090000708 Proteasome Endopeptidase Complex Proteins 0.000 claims description 24
- 201000011001 Ebola Hemorrhagic Fever Diseases 0.000 claims description 23
- 241000700721 Hepatitis B virus Species 0.000 claims description 23
- 238000004949 mass spectrometry Methods 0.000 claims description 23
- 230000035772 mutation Effects 0.000 claims description 23
- 230000008488 polyadenylation Effects 0.000 claims description 23
- 101150066038 E4 gene Proteins 0.000 claims description 22
- 238000007481 next generation sequencing Methods 0.000 claims description 22
- 244000045947 parasite Species 0.000 claims description 22
- 239000002105 nanoparticle Substances 0.000 claims description 21
- 241001502567 Chikungunya virus Species 0.000 claims description 20
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 20
- 238000002347 injection Methods 0.000 claims description 20
- 239000007924 injection Substances 0.000 claims description 20
- 241000725619 Dengue virus Species 0.000 claims description 19
- 210000000612 antigen-presenting cell Anatomy 0.000 claims description 19
- 230000003247 decreasing effect Effects 0.000 claims description 18
- 241000608292 Mayaro virus Species 0.000 claims description 17
- 241000710942 Ross River virus Species 0.000 claims description 17
- 241000710961 Semliki Forest virus Species 0.000 claims description 17
- 241000710960 Sindbis virus Species 0.000 claims description 17
- 125000000539 amino acid group Chemical group 0.000 claims description 17
- 238000001990 intravenous administration Methods 0.000 claims description 17
- 241000178568 Aura virus Species 0.000 claims description 16
- 206010066919 Epidemic polyarthritis Diseases 0.000 claims description 16
- 241000231322 Fort Morgan virus Species 0.000 claims description 16
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 16
- 230000005867 T cell response Effects 0.000 claims description 16
- 235000004279 alanine Nutrition 0.000 claims description 16
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims description 16
- 230000001404 mediated effect Effects 0.000 claims description 16
- 238000007920 subcutaneous administration Methods 0.000 claims description 16
- 230000008685 targeting Effects 0.000 claims description 16
- 229960000814 tetanus toxoid Drugs 0.000 claims description 16
- 241000008910 Severe acute respiratory syndrome-related coronavirus Species 0.000 claims description 15
- 108010001267 Protein Subunits Proteins 0.000 claims description 14
- 102000002067 Protein Subunits Human genes 0.000 claims description 14
- 230000003321 amplification Effects 0.000 claims description 14
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 14
- 108020001580 protein domains Proteins 0.000 claims description 14
- -1 amino lipid Chemical class 0.000 claims description 13
- 230000003362 replicative effect Effects 0.000 claims description 13
- 241000233866 Fungi Species 0.000 claims description 12
- 108010043121 Green Fluorescent Proteins Proteins 0.000 claims description 12
- 102000004144 Green Fluorescent Proteins Human genes 0.000 claims description 12
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 12
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims description 12
- 239000005090 green fluorescent protein Substances 0.000 claims description 12
- 238000013518 transcription Methods 0.000 claims description 12
- 230000035897 transcription Effects 0.000 claims description 12
- 230000009385 viral infection Effects 0.000 claims description 12
- 230000036755 cellular response Effects 0.000 claims description 11
- 230000037452 priming Effects 0.000 claims description 11
- 230000006472 autoimmune response Effects 0.000 claims description 10
- 235000012000 cholesterol Nutrition 0.000 claims description 10
- 230000002093 peripheral effect Effects 0.000 claims description 10
- 108700026244 Open Reading Frames Proteins 0.000 claims description 9
- 238000013459 approach Methods 0.000 claims description 9
- 231100000221 frame shift mutation induction Toxicity 0.000 claims description 9
- 230000037433 frameshift Effects 0.000 claims description 9
- 230000005847 immunogenicity Effects 0.000 claims description 9
- 230000005764 inhibitory process Effects 0.000 claims description 9
- 238000003780 insertion Methods 0.000 claims description 9
- 230000037431 insertion Effects 0.000 claims description 9
- 238000006467 substitution reaction Methods 0.000 claims description 9
- 230000003612 virological effect Effects 0.000 claims description 9
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims description 8
- 101710094648 Coat protein Proteins 0.000 claims description 8
- 108091035707 Consensus sequence Proteins 0.000 claims description 8
- 102000004127 Cytokines Human genes 0.000 claims description 8
- 108090000695 Cytokines Proteins 0.000 claims description 8
- 108060003951 Immunoglobulin Proteins 0.000 claims description 8
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 8
- 108060001084 Luciferase Proteins 0.000 claims description 8
- 239000005089 Luciferase Substances 0.000 claims description 8
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims description 8
- 108010076504 Protein Sorting Signals Proteins 0.000 claims description 8
- 208000036142 Viral infection Diseases 0.000 claims description 8
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims description 8
- 108010006025 bovine growth hormone Proteins 0.000 claims description 8
- 102000018358 immunoglobulin Human genes 0.000 claims description 8
- 239000002245 particle Substances 0.000 claims description 8
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims description 8
- 238000012545 processing Methods 0.000 claims description 8
- 230000032258 transport Effects 0.000 claims description 8
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 8
- 235000002374 tyrosine Nutrition 0.000 claims description 8
- 241000701161 unidentified adenovirus Species 0.000 claims description 8
- 208000035143 Bacterial infection Diseases 0.000 claims description 7
- 208000022362 bacterial infectious disease Diseases 0.000 claims description 7
- 230000001105 regulatory effect Effects 0.000 claims description 7
- 108010002350 Interleukin-2 Proteins 0.000 claims description 6
- 108091027544 Subgenomic mRNA Proteins 0.000 claims description 6
- NRLNQCOGCKAESA-KWXKLSQISA-N [(6z,9z,28z,31z)-heptatriaconta-6,9,28,31-tetraen-19-yl] 4-(dimethylamino)butanoate Chemical compound CCCCC\C=C/C\C=C/CCCCCCCCC(OC(=O)CCCN(C)C)CCCCCCCC\C=C/C\C=C/CCCCC NRLNQCOGCKAESA-KWXKLSQISA-N 0.000 claims description 6
- 230000001419 dependent effect Effects 0.000 claims description 6
- 108020005345 3' Untranslated Regions Proteins 0.000 claims description 5
- 108020003589 5' Untranslated Regions Proteins 0.000 claims description 5
- 101710128560 Initiator protein NS1 Proteins 0.000 claims description 5
- 101710144127 Non-structural protein 1 Proteins 0.000 claims description 5
- 238000003776 cleavage reaction Methods 0.000 claims description 5
- 238000000338 in vitro Methods 0.000 claims description 5
- 108020004999 messenger RNA Proteins 0.000 claims description 5
- 230000007017 scission Effects 0.000 claims description 5
- 108700026220 vif Genes Proteins 0.000 claims description 5
- OGHAROSJZRTIOK-KQYNXXCUSA-O 7-methylguanosine Chemical compound C1=2N=C(N)NC(=O)C=2[N+](C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OGHAROSJZRTIOK-KQYNXXCUSA-O 0.000 claims description 4
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims description 4
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims description 4
- 208000004293 Chikungunya Fever Diseases 0.000 claims description 4
- 206010067256 Chikungunya virus infection Diseases 0.000 claims description 4
- 206010011831 Cytomegalovirus infection Diseases 0.000 claims description 4
- 206010012310 Dengue fever Diseases 0.000 claims description 4
- 101150005585 E3 gene Proteins 0.000 claims description 4
- 206010017533 Fungal infection Diseases 0.000 claims description 4
- HVLSXIKZNLPZJJ-TXZCQADKSA-N HA peptide Chemical compound C([C@@H](C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](C)C(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 HVLSXIKZNLPZJJ-TXZCQADKSA-N 0.000 claims description 4
- 208000031886 HIV Infections Diseases 0.000 claims description 4
- 208000037357 HIV infectious disease Diseases 0.000 claims description 4
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims description 4
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims description 4
- 108010065805 Interleukin-12 Proteins 0.000 claims description 4
- 108010002586 Interleukin-7 Proteins 0.000 claims description 4
- 101150027802 L2 gene Proteins 0.000 claims description 4
- 101150084684 L3 gene Proteins 0.000 claims description 4
- 101150007425 L4 gene Proteins 0.000 claims description 4
- 208000031888 Mycoses Diseases 0.000 claims description 4
- 108091092724 Noncoding DNA Proteins 0.000 claims description 4
- 208000009608 Papillomavirus Infections Diseases 0.000 claims description 4
- 208000030852 Parasitic disease Diseases 0.000 claims description 4
- 108010029485 Protein Isoforms Proteins 0.000 claims description 4
- 102000001708 Protein Isoforms Human genes 0.000 claims description 4
- 101800001758 RNA-directed RNA polymerase nsP4 Proteins 0.000 claims description 4
- 108700008625 Reporter Genes Proteins 0.000 claims description 4
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims description 4
- 241001492404 Woodchuck hepatitis virus Species 0.000 claims description 4
- 210000000234 capsid Anatomy 0.000 claims description 4
- 210000000852 deltoid muscle Anatomy 0.000 claims description 4
- 208000025729 dengue disease Diseases 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 4
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims description 4
- 238000010348 incorporation Methods 0.000 claims description 4
- 108010074108 interleukin-21 Proteins 0.000 claims description 4
- 101150063421 l5 gene Proteins 0.000 claims description 4
- 210000004962 mammalian cell Anatomy 0.000 claims description 4
- 230000030147 nuclear export Effects 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 230000001124 posttranscriptional effect Effects 0.000 claims description 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 4
- 210000003314 quadriceps muscle Anatomy 0.000 claims description 4
- 230000008707 rearrangement Effects 0.000 claims description 4
- 238000013519 translation Methods 0.000 claims description 4
- 206010061603 Respiratory syncytial virus infection Diseases 0.000 claims description 3
- 201000003176 Severe Acute Respiratory Syndrome Diseases 0.000 claims 3
- 108090000172 Interleukin-15 Proteins 0.000 claims 2
- 241000315672 SARS coronavirus Species 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 1
- 108700018351 Major Histocompatibility Complex Proteins 0.000 description 54
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 description 54
- 101150075174 E1B gene Proteins 0.000 description 12
- 238000002649 immunization Methods 0.000 description 11
- 230000004044 response Effects 0.000 description 11
- 230000003053 immunization Effects 0.000 description 10
- 229960005386 ipilimumab Drugs 0.000 description 10
- 241000725303 Human immunodeficiency virus Species 0.000 description 9
- 102000039446 nucleic acids Human genes 0.000 description 9
- 108020004707 nucleic acids Proteins 0.000 description 9
- 210000004988 splenocyte Anatomy 0.000 description 9
- 241000282412 Homo Species 0.000 description 8
- 241000282560 Macaca mulatta Species 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 8
- 108091008874 T cell receptors Proteins 0.000 description 8
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 8
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 8
- 229960003301 nivolumab Drugs 0.000 description 7
- 239000002202 Polyethylene glycol Substances 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 229920001223 polyethylene glycol Polymers 0.000 description 6
- 108020004414 DNA Proteins 0.000 description 5
- 239000000185 hemagglutinin Substances 0.000 description 5
- 239000000523 sample Substances 0.000 description 5
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
- 102100037850 Interferon gamma Human genes 0.000 description 4
- 108010074328 Interferon-gamma Proteins 0.000 description 4
- 230000024932 T cell mediated immunity Effects 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 208000037797 influenza A Diseases 0.000 description 4
- 238000002255 vaccination Methods 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 3
- 229910052774 Proactinium Inorganic materials 0.000 description 3
- 238000003559 RNA-seq method Methods 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 238000012258 culturing Methods 0.000 description 3
- 238000013135 deep learning Methods 0.000 description 3
- 230000036039 immunity Effects 0.000 description 3
- 230000002163 immunogen Effects 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 238000005457 optimization Methods 0.000 description 3
- 210000003289 regulatory T cell Anatomy 0.000 description 3
- 238000010186 staining Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 102100036301 C-C chemokine receptor type 7 Human genes 0.000 description 2
- 108091026890 Coding region Proteins 0.000 description 2
- 108020004705 Codon Proteins 0.000 description 2
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 description 2
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 description 2
- 101000716065 Homo sapiens C-C chemokine receptor type 7 Proteins 0.000 description 2
- 101150106931 IFNG gene Proteins 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 108020004485 Nonsense Codon Proteins 0.000 description 2
- 102000035195 Peptidases Human genes 0.000 description 2
- 108091005804 Peptidases Proteins 0.000 description 2
- 239000004365 Protease Substances 0.000 description 2
- 108010026552 Proteome Proteins 0.000 description 2
- 108700012920 TNF Proteins 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 125000000129 anionic group Chemical group 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 238000009566 cancer vaccine Methods 0.000 description 2
- 229940022399 cancer vaccine Drugs 0.000 description 2
- 125000002091 cationic group Chemical group 0.000 description 2
- 108091036078 conserved sequence Proteins 0.000 description 2
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 2
- 241001493065 dsRNA viruses Species 0.000 description 2
- 239000012636 effector Substances 0.000 description 2
- 239000013604 expression vector Substances 0.000 description 2
- 238000000684 flow cytometry Methods 0.000 description 2
- 210000004602 germ cell Anatomy 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 238000010801 machine learning Methods 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 description 2
- 150000003904 phospholipids Chemical class 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 2
- 238000011179 visual inspection Methods 0.000 description 2
- 239000001993 wax Substances 0.000 description 2
- KRQUFUKTQHISJB-YYADALCUSA-N 2-[(E)-N-[2-(4-chlorophenoxy)propoxy]-C-propylcarbonimidoyl]-3-hydroxy-5-(thian-3-yl)cyclohex-2-en-1-one Chemical compound CCC\C(=N/OCC(C)OC1=CC=C(Cl)C=C1)C1=C(O)CC(CC1=O)C1CCCSC1 KRQUFUKTQHISJB-YYADALCUSA-N 0.000 description 1
- LRYZPFWEZHSTHD-HEFFAWAOSA-O 2-[[(e,2s,3r)-2-formamido-3-hydroxyoctadec-4-enoxy]-hydroxyphosphoryl]oxyethyl-trimethylazanium Chemical class CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](NC=O)COP(O)(=O)OCC[N+](C)(C)C LRYZPFWEZHSTHD-HEFFAWAOSA-O 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 208000025721 COVID-19 Diseases 0.000 description 1
- 241000282465 Canis Species 0.000 description 1
- 201000009182 Chikungunya Diseases 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 208000006825 Eastern Equine Encephalomyelitis Diseases 0.000 description 1
- 201000005804 Eastern equine encephalitis Diseases 0.000 description 1
- 206010014587 Encephalitis eastern equine Diseases 0.000 description 1
- 206010014611 Encephalitis venezuelan equine Diseases 0.000 description 1
- 102100031726 Endoplasmic reticulum junction formation protein lunapark Human genes 0.000 description 1
- 241000283073 Equus caballus Species 0.000 description 1
- 108700024394 Exon Proteins 0.000 description 1
- 241000282324 Felis Species 0.000 description 1
- 102100028972 HLA class I histocompatibility antigen, A alpha chain Human genes 0.000 description 1
- 102100028976 HLA class I histocompatibility antigen, B alpha chain Human genes 0.000 description 1
- 102100028971 HLA class I histocompatibility antigen, C alpha chain Human genes 0.000 description 1
- 108010075704 HLA-A Antigens Proteins 0.000 description 1
- 108010058607 HLA-B Antigens Proteins 0.000 description 1
- 108010052199 HLA-C Antigens Proteins 0.000 description 1
- 108010010378 HLA-DP Antigens Proteins 0.000 description 1
- 102000015789 HLA-DP Antigens Human genes 0.000 description 1
- 108010062347 HLA-DQ Antigens Proteins 0.000 description 1
- 108010058597 HLA-DR Antigens Proteins 0.000 description 1
- 102000006354 HLA-DR Antigens Human genes 0.000 description 1
- 101000941029 Homo sapiens Endoplasmic reticulum junction formation protein lunapark Proteins 0.000 description 1
- 101001043209 Homo sapiens Leukemia NUP98 fusion partner 1 Proteins 0.000 description 1
- 101150076359 Mhc gene Proteins 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 108020004711 Nucleic Acid Probes Proteins 0.000 description 1
- 208000037847 SARS-CoV-2-infection Diseases 0.000 description 1
- 108091081024 Start codon Proteins 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- 208000002847 Surgical Wound Diseases 0.000 description 1
- 241000710924 Togaviridae Species 0.000 description 1
- 208000002687 Venezuelan Equine Encephalomyelitis Diseases 0.000 description 1
- 201000009145 Venezuelan equine encephalitis Diseases 0.000 description 1
- 108020000999 Viral RNA Proteins 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000009464 antigen specific memory response Effects 0.000 description 1
- 238000013528 artificial neural network Methods 0.000 description 1
- 239000003833 bile salt Substances 0.000 description 1
- 229940093761 bile salts Drugs 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 210000000172 cytosol Anatomy 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 230000009266 disease activity Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000002222 downregulating effect Effects 0.000 description 1
- 238000003114 enzyme-linked immunosorbent spot assay Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 238000010195 expression analysis Methods 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 230000003862 health status Effects 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 230000006058 immune tolerance Effects 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 238000012886 linear function Methods 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 238000007477 logistic regression Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000037434 nonsense mutation Effects 0.000 description 1
- 239000002853 nucleic acid probe Substances 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 238000003752 polymerase chain reaction Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 235000019419 proteases Nutrition 0.000 description 1
- 230000004043 responsiveness Effects 0.000 description 1
- 238000003757 reverse transcription PCR Methods 0.000 description 1
- 238000007790 scraping Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- JAJWGJBVLPIOOH-IZYKLYLVSA-M sodium taurocholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS([O-])(=O)=O)C)[C@@]2(C)[C@@H](O)C1 JAJWGJBVLPIOOH-IZYKLYLVSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000000392 somatic effect Effects 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 241001515965 unidentified phage Species 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
- C12N2740/16334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36141—Use of virus, viral particle or viral elements as a vector
- C12N2770/36143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Oncology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063005160P | 2020-04-03 | 2020-04-03 | |
| PCT/US2021/025828 WO2021203104A1 (en) | 2020-04-03 | 2021-04-05 | Infectious disease antigens and vaccines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL296752A true IL296752A (en) | 2022-11-01 |
Family
ID=77929685
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL296752A IL296752A (en) | 2020-04-03 | 2021-04-05 | Infectious disease antigens and vaccines |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20240050550A1 (https=) |
| EP (1) | EP4125944A4 (https=) |
| JP (1) | JP2023521662A (https=) |
| KR (1) | KR20230006825A (https=) |
| CN (1) | CN115942942A (https=) |
| AU (1) | AU2021247302A1 (https=) |
| CA (1) | CA3173793A1 (https=) |
| IL (1) | IL296752A (https=) |
| WO (1) | WO2021203104A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023066874A1 (en) * | 2021-10-18 | 2023-04-27 | BioNTech SE | Methods for determining mutations for increasing modified replicable rna function and related compositions and their use |
| AU2023356120A1 (en) * | 2022-10-07 | 2025-04-17 | The Trustees Of Indiana University | Recombinant rotaviruses and methods and systems for producing the same |
| EP4604997A2 (en) * | 2022-10-21 | 2025-08-27 | PDS Biotechnology Corporation | Recombinant protein vaccines formulated with enantio-specific cationic lipid r-dotap and methods of use thereof |
| CN116218889A (zh) * | 2022-12-13 | 2023-06-06 | 浙江大学 | 一种表达猫细小病毒VP2蛋白的mRNA疫苗及其制备方法 |
| CN120168624B (zh) * | 2024-12-31 | 2025-11-04 | 今发制药(南京)有限公司 | 一种伪狂犬免疫原组合物及其用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6770283B1 (en) * | 1990-12-13 | 2004-08-03 | Bioption Ab | DNA expression systems based on alphaviruses |
| US6015686A (en) * | 1993-09-15 | 2000-01-18 | Chiron Viagene, Inc. | Eukaryotic layered vector initiation systems |
| ATE449105T1 (de) * | 2004-01-23 | 2009-12-15 | Angeletti P Ist Richerche Bio | Impfstoffträger für schimpansen-adenovirus |
| US20110300205A1 (en) * | 2009-07-06 | 2011-12-08 | Novartis Ag | Self replicating rna molecules and uses thereof |
| SG11201706118XA (en) * | 2015-01-29 | 2017-08-30 | Agency Science Tech & Res | Nanocapsules carrying chikungunya-associated peptides |
| TW201729835A (zh) * | 2015-10-22 | 2017-09-01 | 現代公司 | 呼吸道病毒疫苗 |
| JP2019511255A (ja) * | 2016-01-11 | 2019-04-25 | バーンダリ，インク． | マイクロニードル組成物およびそれを使用する方法 |
| MX2019013259A (es) * | 2017-05-08 | 2020-01-13 | Gritstone Oncology Inc | Vectores de neoantigeno de alfavirus. |
| EP3836963A2 (en) * | 2018-08-17 | 2021-06-23 | GlaxoSmithKline Biologicals S.A. | Immunogenic compositions and uses thereof |
| IL303315A (en) * | 2020-12-02 | 2023-07-01 | Seqirus Inc | Multicistronic RNA components and their uses |
-
2021
- 2021-04-05 EP EP21780767.6A patent/EP4125944A4/en active Pending
- 2021-04-05 AU AU2021247302A patent/AU2021247302A1/en active Pending
- 2021-04-05 IL IL296752A patent/IL296752A/en unknown
- 2021-04-05 JP JP2022560207A patent/JP2023521662A/ja active Pending
- 2021-04-05 WO PCT/US2021/025828 patent/WO2021203104A1/en not_active Ceased
- 2021-04-05 KR KR1020227038618A patent/KR20230006825A/ko active Pending
- 2021-04-05 CN CN202180040267.1A patent/CN115942942A/zh active Pending
- 2021-04-05 CA CA3173793A patent/CA3173793A1/en active Pending
-
2022
- 2022-10-03 US US17/937,751 patent/US20240050550A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20240050550A1 (en) | 2024-02-15 |
| JP2023521662A (ja) | 2023-05-25 |
| AU2021247302A1 (en) | 2022-11-10 |
| EP4125944A1 (en) | 2023-02-08 |
| WO2021203104A1 (en) | 2021-10-07 |
| CA3173793A1 (en) | 2021-10-07 |
| EP4125944A4 (en) | 2024-08-14 |
| KR20230006825A (ko) | 2023-01-11 |
| CN115942942A (zh) | 2023-04-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US12098383B2 (en) | Modified adenoviruses | |
| US11771747B2 (en) | Multiepitope vaccine cassettes | |
| US20240050550A1 (en) | Infectious disease antigens and vaccines | |
| US20230047979A1 (en) | Durable vaccination | |
| US20230310563A1 (en) | Antigen-encoding cassettes | |
| US20240167057A1 (en) | Modified alphavirus vectors | |
| US20240093235A1 (en) | Homologous adenoviral vaccination |