CN115942942A - 感染性疾病抗原和疫苗 - Google Patents

感染性疾病抗原和疫苗 Download PDF

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Publication number
CN115942942A
CN115942942A CN202180040267.1A CN202180040267A CN115942942A CN 115942942 A CN115942942 A CN 115942942A CN 202180040267 A CN202180040267 A CN 202180040267A CN 115942942 A CN115942942 A CN 115942942A
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sequence
nucleic acid
encoding nucleic
composition
acid sequence
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CN202180040267.1A
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Chinese (zh)
Inventor
A·弗格森
R·卢梭
R·耶冷斯凯
J·X·孙
M·J·戴维斯
K·朱斯
A·R·拉帕波特
C·D·斯卡伦
L·吉特林
C·D·帕尔默
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Seattle Project Co
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Millstone Biological Co
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    • C12N15/09—Recombinant DNA-technology
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
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    • A61P31/12—Antivirals
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    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
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CN202180040267.1A 2020-04-03 2021-04-05 感染性疾病抗原和疫苗 Pending CN115942942A (zh)

Applications Claiming Priority (3)

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US202063005160P 2020-04-03 2020-04-03
US63/005,160 2020-04-03
PCT/US2021/025828 WO2021203104A1 (en) 2020-04-03 2021-04-05 Infectious disease antigens and vaccines

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CN115942942A true CN115942942A (zh) 2023-04-07

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CN202180040267.1A Pending CN115942942A (zh) 2020-04-03 2021-04-05 感染性疾病抗原和疫苗

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US (1) US20240050550A1 (https=)
EP (1) EP4125944A4 (https=)
JP (1) JP2023521662A (https=)
KR (1) KR20230006825A (https=)
CN (1) CN115942942A (https=)
AU (1) AU2021247302A1 (https=)
CA (1) CA3173793A1 (https=)
IL (1) IL296752A (https=)
WO (1) WO2021203104A1 (https=)

Families Citing this family (5)

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Publication number Priority date Publication date Assignee Title
WO2023066874A1 (en) * 2021-10-18 2023-04-27 BioNTech SE Methods for determining mutations for increasing modified replicable rna function and related compositions and their use
AU2023356120A1 (en) * 2022-10-07 2025-04-17 The Trustees Of Indiana University Recombinant rotaviruses and methods and systems for producing the same
EP4604997A2 (en) * 2022-10-21 2025-08-27 PDS Biotechnology Corporation Recombinant protein vaccines formulated with enantio-specific cationic lipid r-dotap and methods of use thereof
CN116218889A (zh) * 2022-12-13 2023-06-06 浙江大学 一种表达猫细小病毒VP2蛋白的mRNA疫苗及其制备方法
CN120168624B (zh) * 2024-12-31 2025-11-04 今发制药(南京)有限公司 一种伪狂犬免疫原组合物及其用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011005799A2 (en) * 2009-07-06 2011-01-13 Novartis Ag Self replicating rna molecules and uses thereof
WO2017070626A2 (en) * 2015-10-22 2017-04-27 Modernatx, Inc. Respiratory virus vaccines
WO2018208856A1 (en) * 2017-05-08 2018-11-15 Gritstone Oncology, Inc. Alphavirus neoantigen vectors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6770283B1 (en) * 1990-12-13 2004-08-03 Bioption Ab DNA expression systems based on alphaviruses
US6015686A (en) * 1993-09-15 2000-01-18 Chiron Viagene, Inc. Eukaryotic layered vector initiation systems
ATE449105T1 (de) * 2004-01-23 2009-12-15 Angeletti P Ist Richerche Bio Impfstoffträger für schimpansen-adenovirus
SG11201706118XA (en) * 2015-01-29 2017-08-30 Agency Science Tech & Res Nanocapsules carrying chikungunya-associated peptides
JP2019511255A (ja) * 2016-01-11 2019-04-25 バーンダリ，インク． マイクロニードル組成物およびそれを使用する方法
EP3836963A2 (en) * 2018-08-17 2021-06-23 GlaxoSmithKline Biologicals S.A. Immunogenic compositions and uses thereof
IL303315A (en) * 2020-12-02 2023-07-01 Seqirus Inc Multicistronic RNA components and their uses

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011005799A2 (en) * 2009-07-06 2011-01-13 Novartis Ag Self replicating rna molecules and uses thereof
US20110300205A1 (en) * 2009-07-06 2011-12-08 Novartis Ag Self replicating rna molecules and uses thereof
WO2017070626A2 (en) * 2015-10-22 2017-04-27 Modernatx, Inc. Respiratory virus vaccines
WO2018208856A1 (en) * 2017-05-08 2018-11-15 Gritstone Oncology, Inc. Alphavirus neoantigen vectors

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US20240050550A1 (en) 2024-02-15
JP2023521662A (ja) 2023-05-25
AU2021247302A1 (en) 2022-11-10
EP4125944A1 (en) 2023-02-08
WO2021203104A1 (en) 2021-10-07
CA3173793A1 (en) 2021-10-07
IL296752A (en) 2022-11-01
EP4125944A4 (en) 2024-08-14
KR20230006825A (ko) 2023-01-11

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