IL285619A - תאי גזע של תורמים אוניברסליים ושיטות קשורות - Google Patents
תאי גזע של תורמים אוניברסליים ושיטות קשורותInfo
- Publication number
- IL285619A IL285619A IL285619A IL28561921A IL285619A IL 285619 A IL285619 A IL 285619A IL 285619 A IL285619 A IL 285619A IL 28561921 A IL28561921 A IL 28561921A IL 285619 A IL285619 A IL 285619A
- Authority
- IL
- Israel
- Prior art keywords
- stem cells
- related methods
- universal donor
- donor stem
- universal
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
- C12N2502/1114—T cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Gynecology & Obstetrics (AREA)
- Developmental Biology & Embryology (AREA)
- Microbiology (AREA)
- Reproductive Health (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201916277913A | 2019-02-15 | 2019-02-15 | |
| US201916596697A | 2019-10-08 | 2019-10-08 | |
| PCT/US2020/018467 WO2020168317A2 (en) | 2019-02-15 | 2020-02-16 | Universal donor stem cells and related methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL285619A true IL285619A (he) | 2021-09-30 |
Family
ID=72045137
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL285619A IL285619A (he) | 2019-02-15 | 2021-08-15 | תאי גזע של תורמים אוניברסליים ושיטות קשורות |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP3924375A4 (he) |
| JP (1) | JP2022526218A (he) |
| KR (1) | KR20210128440A (he) |
| CN (1) | CN113906048A (he) |
| AU (1) | AU2020223192A1 (he) |
| BR (1) | BR112021016178A2 (he) |
| CA (1) | CA3130398A1 (he) |
| IL (1) | IL285619A (he) |
| MX (1) | MX2021009842A (he) |
| SG (1) | SG11202108891QA (he) |
| WO (1) | WO2020168317A2 (he) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021231712A1 (en) * | 2020-05-15 | 2021-11-18 | Rxcell Inc. | Hypoimmunogenic cells and uses thereof in immune responses |
| CN114276995A (zh) * | 2020-09-28 | 2022-04-05 | 未来智人再生医学研究院(广州)有限公司 | 一种表达ctla-4阻遏分子的多能干细胞及其衍生物 |
| CN114525257A (zh) * | 2020-10-30 | 2022-05-24 | 未来智人再生医学研究院(广州)有限公司 | 一种表达Tim-3阻断物的多能干细胞或其衍生物及应用 |
| CN114525256A (zh) * | 2020-10-30 | 2022-05-24 | 未来智人再生医学研究院(广州)有限公司 | 一种表达Siglec-15阻断物的多能干细胞或其衍生物及应用 |
| CN114457021A (zh) * | 2020-10-30 | 2022-05-10 | 未来智人再生医学研究院(广州)有限公司 | 一种表达cd47抗体的多能干细胞及其衍生物与应用 |
| EP4251741A1 (en) | 2020-11-30 | 2023-10-04 | CRISPR Therapeutics AG | Gene-edited natural killer cells |
| CR20230303A (es) * | 2020-12-11 | 2023-09-01 | Intellia Therapeutics Inc | Composiciones y métodos para reducir el mhc de clase ii en una célula |
| AU2021410751A1 (en) * | 2020-12-23 | 2023-07-13 | Intellia Therapeutics, Inc. | Compositions and methods for genetically modifying ciita in a cell |
| MX2023006207A (es) | 2020-12-31 | 2023-08-09 | Sana Biotechnology Inc | Métodos y composiciones para modular la actividad de linfocitos t con receptores de antígenos quiméricos (t-car). |
| AU2022283291A1 (en) | 2021-05-27 | 2023-11-02 | Sana Biotechnology, Inc. | Hypoimmunogenic cells comprising engineered hla-e or hla-g |
| MX2024001443A (es) | 2021-08-11 | 2024-05-15 | Sana Biotechnology Inc | Sistemas inducibles para alterar la expresión génica en células hipoinmunógenas. |
| KR20240137574A (ko) | 2021-12-23 | 2024-09-20 | 사나 바이오테크놀로지, 인크. | 자가면역 질환 치료를 위한 키메라 항원 수용체[chimeric antigen receptor, car] t 세포 및 관련 방법 |
| WO2023154578A1 (en) | 2022-02-14 | 2023-08-17 | Sana Biotechnology, Inc. | Methods of treating patients exhibiting a prior failed therapy with hypoimmunogenic cells |
| WO2023191063A1 (ja) * | 2022-04-01 | 2023-10-05 | 株式会社Logomix | 遺伝子工学、細胞工学、および細胞医薬に適した細胞およびその製造方法 |
| WO2024003349A1 (en) | 2022-07-01 | 2024-01-04 | Novo Nordisk A/S | Enhancing neuronal differentiation of ventral midbrain neural progenitor cells |
| CN118406681A (zh) * | 2023-01-30 | 2024-07-30 | 南京北恒生物科技有限公司 | 用于同种异体移植的组合物及方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2016261600B2 (en) * | 2015-05-08 | 2021-09-23 | President And Fellows Of Harvard College | Universal donor stem cells and related methods |
| ES2953925T3 (es) * | 2015-11-04 | 2023-11-17 | Fate Therapeutics Inc | Ingeniería genómica de células pluripotentes |
| JP2020505025A (ja) * | 2017-01-13 | 2020-02-20 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 免疫工学的な改変をした多能性細胞 |
-
2020
- 2020-02-16 KR KR1020217029445A patent/KR20210128440A/ko unknown
- 2020-02-16 MX MX2021009842A patent/MX2021009842A/es unknown
- 2020-02-16 CN CN202080021860.7A patent/CN113906048A/zh active Pending
- 2020-02-16 AU AU2020223192A patent/AU2020223192A1/en not_active Abandoned
- 2020-02-16 EP EP20755906.3A patent/EP3924375A4/en not_active Withdrawn
- 2020-02-16 SG SG11202108891QA patent/SG11202108891QA/en unknown
- 2020-02-16 CA CA3130398A patent/CA3130398A1/en active Pending
- 2020-02-16 BR BR112021016178A patent/BR112021016178A2/pt unknown
- 2020-02-16 WO PCT/US2020/018467 patent/WO2020168317A2/en unknown
- 2020-02-16 JP JP2021547755A patent/JP2022526218A/ja active Pending
-
2021
- 2021-08-15 IL IL285619A patent/IL285619A/he unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN113906048A (zh) | 2022-01-07 |
| WO2020168317A8 (en) | 2021-02-25 |
| SG11202108891QA (en) | 2021-09-29 |
| WO2020168317A2 (en) | 2020-08-20 |
| BR112021016178A2 (pt) | 2021-11-03 |
| CA3130398A1 (en) | 2020-08-20 |
| EP3924375A2 (en) | 2021-12-22 |
| EP3924375A4 (en) | 2023-03-22 |
| KR20210128440A (ko) | 2021-10-26 |
| MX2021009842A (es) | 2021-12-10 |
| WO2020168317A3 (en) | 2020-10-29 |
| AU2020223192A1 (en) | 2021-09-09 |
| JP2022526218A (ja) | 2022-05-24 |
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