IL285613B2 - Improved peptide pharmaceuticals for insulin resistance - Google Patents

Improved peptide pharmaceuticals for insulin resistance

Info

Publication number
IL285613B2
IL285613B2 IL285613A IL28561321A IL285613B2 IL 285613 B2 IL285613 B2 IL 285613B2 IL 285613 A IL285613 A IL 285613A IL 28561321 A IL28561321 A IL 28561321A IL 285613 B2 IL285613 B2 IL 285613B2
Authority
IL
Israel
Prior art keywords
absent
beta
aib
peptide
lys
Prior art date
Application number
IL285613A
Other languages
English (en)
Hebrew (he)
Other versions
IL285613A (en
IL285613B1 (en
Original Assignee
Mederis Diabetes Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mederis Diabetes Llc filed Critical Mederis Diabetes Llc
Publication of IL285613A publication Critical patent/IL285613A/en
Publication of IL285613B1 publication Critical patent/IL285613B1/en
Publication of IL285613B2 publication Critical patent/IL285613B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Toxicology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Biotechnology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL285613A 2014-05-28 2015-05-28 Improved peptide pharmaceuticals for insulin resistance IL285613B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462004156P 2014-05-28 2014-05-28
PCT/US2015/033042 WO2015184177A1 (en) 2014-05-28 2015-05-28 Improved peptide pharmaceuticals for insulin resistance

Publications (3)

Publication Number Publication Date
IL285613A IL285613A (en) 2021-09-30
IL285613B1 IL285613B1 (en) 2024-07-01
IL285613B2 true IL285613B2 (en) 2024-11-01

Family

ID=54699825

Family Applications (3)

Application Number Title Priority Date Filing Date
IL285613A IL285613B2 (en) 2014-05-28 2015-05-28 Improved peptide pharmaceuticals for insulin resistance
IL249044A IL249044B (en) 2014-05-28 2016-11-17 Improved peptide pharmaceuticals for insulin resistance
IL275526A IL275526B (en) 2014-05-28 2020-06-21 Improved peptide drugs for insulin resistance

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL249044A IL249044B (en) 2014-05-28 2016-11-17 Improved peptide pharmaceuticals for insulin resistance
IL275526A IL275526B (en) 2014-05-28 2020-06-21 Improved peptide drugs for insulin resistance

Country Status (18)

Country Link
US (5) US9856306B2 (cg-RX-API-DMAC7.html)
EP (2) EP3155017B1 (cg-RX-API-DMAC7.html)
JP (4) JP6697807B2 (cg-RX-API-DMAC7.html)
KR (3) KR102542164B1 (cg-RX-API-DMAC7.html)
CN (5) CN106661097A (cg-RX-API-DMAC7.html)
AU (3) AU2015266854B2 (cg-RX-API-DMAC7.html)
BR (1) BR112016027595B1 (cg-RX-API-DMAC7.html)
CA (1) CA2949701C (cg-RX-API-DMAC7.html)
DK (1) DK3155017T3 (cg-RX-API-DMAC7.html)
ES (1) ES2985732T3 (cg-RX-API-DMAC7.html)
FI (1) FI3155017T3 (cg-RX-API-DMAC7.html)
HU (1) HUE066179T2 (cg-RX-API-DMAC7.html)
IL (3) IL285613B2 (cg-RX-API-DMAC7.html)
MX (2) MX384236B (cg-RX-API-DMAC7.html)
NZ (2) NZ726623A (cg-RX-API-DMAC7.html)
PL (1) PL3155017T4 (cg-RX-API-DMAC7.html)
PT (1) PT3155017T (cg-RX-API-DMAC7.html)
WO (1) WO2015184177A1 (cg-RX-API-DMAC7.html)

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US10010617B2 (en) 2011-05-18 2018-07-03 Eumederis Pharmaceuticals, Inc. Peptide pharmaceuticals
US10471127B2 (en) 2011-05-18 2019-11-12 Mederis Diabetes, Llc Peptide pharmaceuticals for insulin resistance
BR112015011478B1 (pt) * 2012-11-20 2022-10-25 Mederis Diabetes, Llc Produtos de peptídeo, seus usos e composição farmacêutica
DK3444281T3 (da) 2012-11-20 2022-02-07 Eumederis Pharmaceuticals Inc Forbedrede peptidlægemidler
CA2949701C (en) 2014-05-28 2023-12-12 Mederis Diabetes, Llc Improved peptide pharmaceuticals for insulin resistance
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
AU2018302022A1 (en) 2017-07-17 2020-02-27 Macregen, Inc. Topical delivery of therapeutic agents comprising cell-penetrating peptides for use for the treatment of age-related macular degeneration and other eye diseases
IL311775A (en) 2018-01-03 2024-05-01 Mederis Diabetes Llc Improved peptide drugs for the treatment of NASH and other disorders
AU2021224246A1 (en) * 2020-02-21 2022-09-15 Spitfire Pharma Llc GLP-1R and GCGR agonists, formulations, and methods of use
JP2024500324A (ja) * 2020-12-07 2024-01-09 スピットファイア ファーマ エルエルシー Ｇｌｐ－１ｒおよびｇｃｇｒ均衡アゴニストを使用した血糖および／または体重を低下させるための治療レジメンおよび方法
CN117202924A (zh) 2020-12-07 2023-12-08 斯皮特弗尔制药有限责任公司 使用glp-1r和gcgr平衡激动剂降低血糖和/或体重的治疗方案和方法
CN113461747B (zh) * 2021-07-12 2023-02-03 吉林化工学院 刺玫果中2个具有降血糖活性的化合物
CN121219311A (zh) * 2023-05-24 2025-12-26 联邦生物科技(珠海横琴)有限公司 一种胰岛素衍生物及其应用

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Publication number Priority date Publication date Assignee Title
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Also Published As

Publication number Publication date
IL285613A (en) 2021-09-30
CN113264994A (zh) 2021-08-17
CN117582516A (zh) 2024-02-23
KR20250007694A (ko) 2025-01-14
EP3155017A4 (en) 2019-03-27
KR102542164B1 (ko) 2023-06-12
BR112016027595A8 (pt) 2021-07-20
EP4397374A2 (en) 2024-07-10
US20250136656A1 (en) 2025-05-01
AU2020203609A1 (en) 2020-06-25
US9856306B2 (en) 2018-01-02
US20200277351A1 (en) 2020-09-03
EP4397374A3 (en) 2024-10-16
JP6697807B2 (ja) 2020-05-27
EP3155017B1 (en) 2024-01-10
JP2022172128A (ja) 2022-11-15
JP2017519739A (ja) 2017-07-20
US20250313604A1 (en) 2025-10-09
JP2020143066A (ja) 2020-09-10
MX2016015594A (es) 2017-03-23
AU2020203609B2 (en) 2022-11-17
PL3155017T3 (pl) 2024-06-17
CN106661097A (zh) 2017-05-10
CA2949701C (en) 2023-12-12
KR20170010412A (ko) 2017-01-31
PL3155017T4 (pl) 2024-06-17
IL275526B (en) 2021-08-31
NZ764813A (en) 2024-07-05
US20170096468A1 (en) 2017-04-06
WO2015184177A1 (en) 2015-12-03
DK3155017T3 (da) 2024-04-15
US10577405B2 (en) 2020-03-03
HUE066179T2 (hu) 2024-07-28
IL285613B1 (en) 2024-07-01
NZ757113A (en) 2022-08-26
BR112016027595B1 (pt) 2023-12-26
MX371033B (es) 2020-01-13
MX384236B (es) 2025-03-14
US20180194826A1 (en) 2018-07-12
NZ726623A (en) 2020-02-28
CN117180445A (zh) 2023-12-08
BR112016027595A2 (pt) 2017-08-15
AU2015266854A1 (en) 2016-12-15
CN109865142A (zh) 2019-06-11
FI3155017T3 (fi) 2024-04-17
JP2024102119A (ja) 2024-07-30
KR20230084337A (ko) 2023-06-12
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