IL283930A - Cell separation apparatus and methods of use - Google Patents

Cell separation apparatus and methods of use

Info

Publication number
IL283930A
IL283930A IL283930A IL28393021A IL283930A IL 283930 A IL283930 A IL 283930A IL 283930 A IL283930 A IL 283930A IL 28393021 A IL28393021 A IL 28393021A IL 283930 A IL283930 A IL 283930A
Authority
IL
Israel
Prior art keywords
methods
separation apparatus
cell separation
cell
separation
Prior art date
Application number
IL283930A
Other languages
Hebrew (he)
Inventor
Rolf Wolters
Jules Valenti
Tom Gurski
Original Assignee
Orgenesis Inc
Koligo Therapeutics Inc
Rolf Wolters
Jules Valenti
Tom Gurski
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orgenesis Inc, Koligo Therapeutics Inc, Rolf Wolters, Jules Valenti, Tom Gurski filed Critical Orgenesis Inc
Publication of IL283930A publication Critical patent/IL283930A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M45/00—Means for pre-treatment of biological substances
    • C12M45/09—Means for pre-treatment of biological substances by enzymatic treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/28—Constructional details, e.g. recesses, hinges disposable or single use
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/14—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus with filters, sieves or membranes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • C12M37/02—Filters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M45/00—Means for pre-treatment of biological substances
    • C12M45/02—Means for pre-treatment of biological substances by mechanical forces; Stirring; Trituration; Comminuting
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M45/00—Means for pre-treatment of biological substances
    • C12M45/05—Means for pre-treatment of biological substances by centrifugation
IL283930A 2018-12-13 2021-06-13 Cell separation apparatus and methods of use IL283930A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2018/065405 WO2020122916A1 (en) 2018-12-13 2018-12-13 Cell separation apparatus and methods of use

Publications (1)

Publication Number Publication Date
IL283930A true IL283930A (en) 2021-07-29

Family

ID=71076920

Family Applications (1)

Application Number Title Priority Date Filing Date
IL283930A IL283930A (en) 2018-12-13 2021-06-13 Cell separation apparatus and methods of use

Country Status (11)

Country Link
EP (1) EP3893949A4 (en)
JP (1) JP2022522323A (en)
KR (1) KR20210092324A (en)
CN (1) CN113660961A (en)
AU (1) AU2018452704A1 (en)
BR (1) BR112021011482A2 (en)
CA (1) CA3123386A1 (en)
IL (1) IL283930A (en)
MX (1) MX2021007080A (en)
WO (1) WO2020122916A1 (en)
ZA (1) ZA202104197B (en)

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5035708A (en) * 1985-06-06 1991-07-30 Thomas Jefferson University Endothelial cell procurement and deposition kit
FR2729398A1 (en) * 1995-01-17 1996-07-19 Hospal R & D Int ORGAN DIGESTION DEVICE AND METHOD FOR ISOLATING CELLS OR AMAS FROM CELLS OF BIOLOGICAL INTEREST FROM AN ORGAN
US6235534B1 (en) * 1998-04-27 2001-05-22 Ronald Frederich Brookes Incremental absorbance scanning of liquid in dispensing tips
JP2002068995A (en) * 2000-08-25 2002-03-08 Phoenix Seiyaku Kk Diabetes mellitus-treating agent
US7045349B2 (en) * 2001-01-23 2006-05-16 Benedict Daniel J Method of islet isolation using process control
US7585670B2 (en) * 2001-12-07 2009-09-08 Cytori Therapeutics, Inc. Automated methods for isolating and using clinically safe adipose derived regenerative cells
US9144583B2 (en) * 2002-03-29 2015-09-29 Tissue Genesis, Inc. Cell separation apparatus and methods of use
JP2004033006A (en) * 2002-06-28 2004-02-05 Asahi Kasei Corp Method for digesting organism-derived material/recovering cell and apparatus therefor
EP1648999A4 (en) * 2003-06-25 2006-09-06 Macropore Biosurgery Inc Systems and methods for separating and concentrating regenerative cells from tissue
US7541166B2 (en) * 2003-09-19 2009-06-02 Microfluidic Systems, Inc. Sonication to selectively lyse different cell types
EP2352533B1 (en) * 2008-12-01 2018-01-10 General Electric Company System and method for separating nucleated cells from body fluids
JP2011097878A (en) * 2009-11-06 2011-05-19 Olympus Corp Cell separation apparatus
US20110111497A1 (en) * 2009-11-06 2011-05-12 Olympus Corporation Cell separation apparatus, method for activating fat-derived cells, graft material producing process, and graft material
WO2014039697A1 (en) * 2012-09-06 2014-03-13 The Gid Group, Inc. Tissue processing apparatus and method for processing adipose tissue
US9206387B2 (en) * 2010-07-09 2015-12-08 The Gid Group, Inc. Method and apparatus for processing adipose tissue
JP6014045B2 (en) * 2010-12-16 2016-10-25 アルト，エックハルト，ユー． Method and apparatus for concentrating and recovering cells and cell enrichment matrix from tissue samples
CN103018224B (en) * 2012-12-14 2015-07-29 中国科学院上海微系统与信息技术研究所 Based on rare cells separation detecting system and the method for centrifugal microfluidic control techniques
KR101728939B1 (en) * 2012-12-14 2017-04-20 총 정 Centrifugal dynamic filtering apparatus and cell separation system using same
CN105722973A (en) * 2013-11-13 2016-06-29 斯蒂姆普优提克斯个人研究有限公司 A system and method for processing of biological tissue samples
KR101667848B1 (en) * 2014-07-08 2016-10-19 (주)시지바이오 Container for separating stem cells from fattissue and method for separating stem cells from fattissue using the same
US9695394B1 (en) * 2015-12-29 2017-07-04 Syngen, Inc. Cell separation devices, systems, and methods

Also Published As

Publication number Publication date
BR112021011482A2 (en) 2021-08-31
JP2022522323A (en) 2022-04-18
ZA202104197B (en) 2023-10-25
CN113660961A (en) 2021-11-16
WO2020122916A1 (en) 2020-06-18
EP3893949A4 (en) 2022-08-17
AU2018452704A1 (en) 2021-07-29
CA3123386A1 (en) 2020-06-18
MX2021007080A (en) 2021-10-13
EP3893949A1 (en) 2021-10-20
KR20210092324A (en) 2021-07-23

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