IL281771B2 - Method for selecting neoepitopes - Google Patents
Method for selecting neoepitopesInfo
- Publication number
- IL281771B2 IL281771B2 IL281771A IL28177121A IL281771B2 IL 281771 B2 IL281771 B2 IL 281771B2 IL 281771 A IL281771 A IL 281771A IL 28177121 A IL28177121 A IL 28177121A IL 281771 B2 IL281771 B2 IL 281771B2
- Authority
- IL
- Israel
- Prior art keywords
- neoepitopes
- mhc
- binding
- minimal
- score
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/30—Detection of binding sites or motifs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Evolutionary Biology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Medical Informatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pathology (AREA)
- General Engineering & Computer Science (AREA)
- Hospice & Palliative Care (AREA)
- Cell Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18197172 | 2018-09-27 | ||
| PCT/EP2019/076210 WO2020065023A1 (en) | 2018-09-27 | 2019-09-27 | Method for selecting neoepitopes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IL281771A IL281771A (en) | 2021-05-31 |
| IL281771B1 IL281771B1 (en) | 2025-04-01 |
| IL281771B2 true IL281771B2 (en) | 2025-08-01 |
Family
ID=63794302
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL281771A IL281771B2 (en) | 2018-09-27 | 2019-09-27 | Method for selecting neoepitopes |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US12462898B2 (https=) |
| EP (1) | EP3856957A1 (https=) |
| JP (1) | JP7585195B2 (https=) |
| KR (1) | KR102902460B1 (https=) |
| CN (1) | CN112771214B (https=) |
| AU (1) | AU2019346023B2 (https=) |
| BR (1) | BR112021005702A8 (https=) |
| CA (1) | CA3111903A1 (https=) |
| IL (1) | IL281771B2 (https=) |
| MX (1) | MX2021003654A (https=) |
| SG (1) | SG11202101965QA (https=) |
| WO (1) | WO2020065023A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020221783A1 (en) * | 2019-04-29 | 2020-11-05 | Vaccibody As | Methods for pre-selection of neoepitopes |
| US20230197192A1 (en) * | 2020-11-06 | 2023-06-22 | Amazon Technologies, Inc. | Selecting neoantigens for personalized cancer vaccine |
| GB202102606D0 (en) * | 2021-02-24 | 2021-04-07 | Univ Oxford Innovation Ltd | Treatment of ovarian cancer minimal residual disease |
| IL305777A (en) | 2021-03-26 | 2023-11-01 | Nykode Therapeutics ASA | Medical combination for cancer treatment |
| WO2022238420A2 (en) | 2021-05-10 | 2022-11-17 | Nykode Therapeutics ASA | Co-expression of constructs and immunostimulatory compounds |
| WO2022238381A2 (en) | 2021-05-10 | 2022-11-17 | Nykode Therapeutics ASA | Immunotherapy constructs for treatment of disease |
| WO2023244997A1 (en) * | 2022-06-13 | 2023-12-21 | The University Of North Carolina At Chapel Hill | Compositions and methods for inducing anticancer immunity |
| EP4608436A1 (en) | 2022-10-25 | 2025-09-03 | Nykode Therapeutics ASA | Constructs and their use |
| KR102857635B1 (ko) * | 2022-11-08 | 2025-09-10 | 인바이츠지노믹스 주식회사 | 면역원성이 높은 유사체를 디자인하는 방법 및 이를 이용한 장치 |
| WO2024100196A1 (en) | 2022-11-09 | 2024-05-16 | Nykode Therapeutics ASA | Co-expression of constructs and polypeptides |
| WO2024216073A1 (en) * | 2023-04-14 | 2024-10-17 | The Trustees Of Columbia University In The City Of New York | Engineered microbes comprising tumor neoantigen vectors for cancer immunotherapy |
| US20250232833A1 (en) * | 2024-01-13 | 2025-07-17 | Noergaard Anders Kaare | Cyclin D1 Based Cancer Vaccine |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016128376A1 (en) * | 2015-02-12 | 2016-08-18 | Biontech Ag | Predicting t cell epitopes useful for vaccination |
| US20160331821A1 (en) * | 2015-05-13 | 2016-11-17 | Agenus Inc. | Vaccines for treatment and prevention of cancer |
| US20170016075A1 (en) * | 2015-07-14 | 2017-01-19 | Personal Genome Diagnostics, Inc. | Neoantigen analysis |
| WO2018136664A1 (en) * | 2017-01-18 | 2018-07-26 | Ichan School Of Medicine At Mount Sinai | Neoantigens and uses thereof for treating cancer |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112012029066A2 (pt) | 2010-05-14 | 2020-09-01 | The General Hospital Corporation | composições e processos de identificação de neoantígenos específicos de tumor. |
| HRP20211595T1 (hr) | 2011-05-24 | 2022-01-21 | BioNTech SE | Individualizirana cjepiva protiv raka |
| WO2014082729A1 (en) | 2012-11-28 | 2014-06-05 | Biontech Ag | Individualized vaccines for cancer |
| CN118750591A (zh) | 2013-04-07 | 2024-10-11 | 博德研究所 | 用于个性化瘤形成疫苗的组合物和方法 |
| WO2014180490A1 (en) | 2013-05-10 | 2014-11-13 | Biontech Ag | Predicting immunogenicity of t cell epitopes |
| JP6558699B2 (ja) | 2013-10-01 | 2019-08-14 | 国立大学法人三重大学 | 抗原提示を促進するエピトープ間配列を含むｔ細胞誘導ワクチン |
| US11186640B2 (en) | 2014-07-31 | 2021-11-30 | The University Of Western Australia | Method for the identification of immunotherapy-drug combinations using a network approach |
| EP3193892A4 (en) | 2014-09-14 | 2018-09-12 | Washington University | Personalized cancer vaccines and methods therefor |
| US10317402B2 (en) | 2014-12-03 | 2019-06-11 | Verik Bio, Inc. | Identification, selection and use of high curative potential T cell epitopes |
| CA2988388C (en) * | 2015-04-23 | 2022-11-22 | Nantomics, Llc | Cancer neoepitopes |
| RU2729116C2 (ru) | 2015-12-16 | 2020-08-04 | Гритстоун Онколоджи, Инк. | Идентификация, производство и применение неоантигенов |
| EP3678699A1 (en) | 2017-09-07 | 2020-07-15 | University Of Oslo | Vaccine molecules |
-
2019
- 2019-09-27 CN CN201980063254.9A patent/CN112771214B/zh active Active
- 2019-09-27 JP JP2021517009A patent/JP7585195B2/ja active Active
- 2019-09-27 BR BR112021005702A patent/BR112021005702A8/pt unknown
- 2019-09-27 WO PCT/EP2019/076210 patent/WO2020065023A1/en not_active Ceased
- 2019-09-27 EP EP19773458.5A patent/EP3856957A1/en active Pending
- 2019-09-27 AU AU2019346023A patent/AU2019346023B2/en active Active
- 2019-09-27 KR KR1020217012734A patent/KR102902460B1/ko active Active
- 2019-09-27 CA CA3111903A patent/CA3111903A1/en active Pending
- 2019-09-27 US US17/279,946 patent/US12462898B2/en active Active
- 2019-09-27 MX MX2021003654A patent/MX2021003654A/es unknown
- 2019-09-27 SG SG11202101965QA patent/SG11202101965QA/en unknown
- 2019-09-27 IL IL281771A patent/IL281771B2/en unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016128376A1 (en) * | 2015-02-12 | 2016-08-18 | Biontech Ag | Predicting t cell epitopes useful for vaccination |
| US20160331821A1 (en) * | 2015-05-13 | 2016-11-17 | Agenus Inc. | Vaccines for treatment and prevention of cancer |
| US20170016075A1 (en) * | 2015-07-14 | 2017-01-19 | Personal Genome Diagnostics, Inc. | Neoantigen analysis |
| WO2018136664A1 (en) * | 2017-01-18 | 2018-07-26 | Ichan School Of Medicine At Mount Sinai | Neoantigens and uses thereof for treating cancer |
Non-Patent Citations (4)
| Title |
|---|
| ALEX RUBINSTEYN ET AL,, COMPUTATIONAL PIPELINE FOR THE PGV-001 NEOANTIGEN VACCINE TRIAL, 18 January 2018 (2018-01-18) * |
| D VUZMAN ET AL,, UTILITY OF COMPREHENSIVE GENOMIC PROFILING (CGP) FOR PERSONAL CANCER VACCINE DEVELOPMENT VIA NEOANTIGEN ANALYSIS., 31 December 2019 (2019-12-31) * |
| DUAN F ET AL,, GENOMIC AND BIOINFORMATIC PROFILING OF MUTATIONAL NEOEPITOPES REVEALS NEW RULES TO PREDICT ANTICANCER IMMUNOGENICITY, 31 December 2014 (2014-12-31) * |
| OTT PATRICK A ET AL,, AN IMMUNOGENIC PERSONAL NEOANTIGEN VACCINE FOR PATIENTS WITH MELANOMA, 31 December 2017 (2017-12-31) * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2022502416A (ja) | 2022-01-11 |
| BR112021005702A2 (pt) | 2021-06-22 |
| IL281771B1 (en) | 2025-04-01 |
| MX2021003654A (es) | 2021-05-28 |
| AU2019346023A1 (en) | 2021-03-25 |
| BR112021005702A8 (pt) | 2022-11-08 |
| US12462898B2 (en) | 2025-11-04 |
| WO2020065023A1 (en) | 2020-04-02 |
| US20210388438A1 (en) | 2021-12-16 |
| JP7585195B2 (ja) | 2024-11-18 |
| CA3111903A1 (en) | 2020-04-02 |
| CN112771214A (zh) | 2021-05-07 |
| KR102902460B1 (ko) | 2025-12-19 |
| EP3856957A1 (en) | 2021-08-04 |
| CN112771214B (zh) | 2025-06-13 |
| KR20210065171A (ko) | 2021-06-03 |
| AU2019346023B2 (en) | 2024-12-12 |
| SG11202101965QA (en) | 2021-04-29 |
| IL281771A (en) | 2021-05-31 |
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