IL281376B - Therapeutic neuregulin peptides for the treatment of prophylaxis of heart failure - Google Patents
Therapeutic neuregulin peptides for the treatment of prophylaxis of heart failureInfo
- Publication number
- IL281376B IL281376B IL281376A IL28137621A IL281376B IL 281376 B IL281376 B IL 281376B IL 281376 A IL281376 A IL 281376A IL 28137621 A IL28137621 A IL 28137621A IL 281376 B IL281376 B IL 281376B
- Authority
- IL
- Israel
- Prior art keywords
- days
- months
- peptide
- dose
- hours
- Prior art date
Links
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1883—Neuregulins, e.g.. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1808—Epidermal growth factor [EGF] urogastrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361773538P | 2013-03-06 | 2013-03-06 | |
| US201361774553P | 2013-03-07 | 2013-03-07 | |
| US201361900142P | 2013-11-05 | 2013-11-05 | |
| PCT/US2014/021446 WO2014138502A1 (en) | 2013-03-06 | 2014-03-06 | Therapeutic dosing of a neuregulin or a fragment thereof for treatment or prophylaxis of heart failure |
Publications (2)
| Publication Number | Publication Date |
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| IL281376A IL281376A (en) | 2021-04-29 |
| IL281376B true IL281376B (en) | 2022-08-01 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL281376A IL281376B (en) | 2013-03-06 | 2014-03-06 | Therapeutic neuregulin peptides for the treatment of prophylaxis of heart failure |
| IL241133A IL241133A0 (en) | 2013-03-06 | 2015-09-03 | Preparations containing a medicinal dose of neuragiolin or a fragment thereof for the treatment or prevention of heart failure |
| IL262522A IL262522B (en) | 2013-03-06 | 2018-10-22 | Medicinal peptides of neuregulin for the treatment or prevention of heart failure |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL241133A IL241133A0 (en) | 2013-03-06 | 2015-09-03 | Preparations containing a medicinal dose of neuragiolin or a fragment thereof for the treatment or prevention of heart failure |
| IL262522A IL262522B (en) | 2013-03-06 | 2018-10-22 | Medicinal peptides of neuregulin for the treatment or prevention of heart failure |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US20160129084A1 (enExample) |
| EP (1) | EP2964249A1 (enExample) |
| JP (4) | JP6542678B2 (enExample) |
| AU (3) | AU2014225534A1 (enExample) |
| CA (1) | CA2904055A1 (enExample) |
| IL (3) | IL281376B (enExample) |
| WO (1) | WO2014138502A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US8086315B2 (en) | 2004-02-12 | 2011-12-27 | Asap Medical, Inc. | Cardiac stimulation apparatus and method for the control of hypertension |
| US8165674B2 (en) | 2005-03-02 | 2012-04-24 | Backbeat Medical, Inc. | Methods and apparatus to increase secretion of endogenous naturetic hormones |
| US7869874B2 (en) | 2006-09-25 | 2011-01-11 | G&L Consulting, Llc | Methods and apparatus to stimulate heart atria |
| US8340763B2 (en) | 2008-09-08 | 2012-12-25 | Backbeat Medical, Inc. | Methods and apparatus to stimulate heart atria |
| WO2013053076A1 (en) | 2011-10-10 | 2013-04-18 | Zensun （Shanghai）Science & Technology Limited | Compositions and methods for treating heart failure |
| US9008769B2 (en) | 2012-12-21 | 2015-04-14 | Backbeat Medical, Inc. | Methods and systems for lowering blood pressure through reduction of ventricle filling |
| RU2015154737A (ru) | 2013-05-22 | 2017-06-27 | Цзэньсунь (Шанхай) Сайенс Энд Текнолоджи, Ко., Лтд. | Пролонгированное высвобождение нейрегулина для лечения сердечной недостаточности |
| CN104758922A (zh) | 2014-01-03 | 2015-07-08 | 上海泽生科技开发有限公司 | 纽兰格林制剂的配方 |
| CN105561298A (zh) * | 2014-10-17 | 2016-05-11 | 上海泽生科技开发有限公司 | 神经调节蛋白用于预防、治疗或延迟射血分数保留的心力衰竭的方法和组合物 |
| US10342982B2 (en) * | 2015-09-11 | 2019-07-09 | Backbeat Medical, Inc. | Methods and systems for treating cardiac malfunction |
| MX2018003780A (es) | 2015-09-25 | 2018-09-28 | B Sawyer Douglas | Metodos para tratar lesion cardiaca. |
| US10485658B2 (en) | 2016-04-22 | 2019-11-26 | Backbeat Medical, Inc. | Methods and systems for controlling blood pressure |
| CN111407881A (zh) * | 2019-01-07 | 2020-07-14 | 上海泽生科技开发股份有限公司 | 神经调节蛋白用于预防、治疗或延迟心肌损伤的方法和组合物 |
| AR121035A1 (es) | 2019-04-01 | 2022-04-13 | Lilly Co Eli | Compuestos de neuregulina-4 y métodos de uso |
| CN113289002A (zh) * | 2020-02-24 | 2021-08-24 | 上海泽生科技开发股份有限公司 | 神经调节蛋白用于预防、治疗或延缓心力衰竭的方法和组合物 |
| CN119255815A (zh) * | 2022-05-25 | 2025-01-03 | 伊莱利利公司 | 使用神经调节蛋白4化合物的方法 |
| JP2024174269A (ja) * | 2023-05-30 | 2024-12-16 | 株式会社大一商会 | 遊技機 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US5530109A (en) | 1991-04-10 | 1996-06-25 | Ludwig Institute For Cancer Research | DNA encoding glial mitogenic factors |
| US5716930A (en) | 1991-04-10 | 1998-02-10 | Ludwig Institute For Cancer Research | Glial growth factors |
| US7037888B1 (en) | 1992-04-03 | 2006-05-02 | Acorda Therapeutics, Inc. | Methods for treating muscle diseases and disorders |
| US5912326A (en) | 1995-09-08 | 1999-06-15 | President And Fellows Of Harvard College | Cerebellum-derived growth factors |
| CA2329916A1 (en) * | 1998-05-15 | 1999-11-25 | Merck & Co., Inc. | Potassium channel agonists |
| US6051401A (en) | 1998-07-28 | 2000-04-18 | Bayer Corporation | Methods and constructs for protein expression |
| US6635249B1 (en) | 1999-04-23 | 2003-10-21 | Cenes Pharmaceuticals, Inc. | Methods for treating congestive heart failure |
| BRPI0708725A2 (pt) * | 2006-03-09 | 2011-06-07 | Waratah Pharmaceuticals Inc | formulação de poliálcool de ciclohexano para o tratamento de doenças de agregação de proteìna |
| KR20100052557A (ko) * | 2007-09-12 | 2010-05-19 | 메르츠 파마 게엠베하 운트 코. 카가아 | 이명 치료를 위한 간격 치료요법 |
| WO2010030317A2 (en) * | 2008-07-17 | 2010-03-18 | Acorda Therapeutics, Inc. | Therapeutic dosing of a neuregulin or a subsequence thereof for treatment or prophylaxis of heart failure |
| JP5743898B2 (ja) * | 2008-11-28 | 2015-07-01 | ゼンサン （シャンハイ） サイエンス アンド テクノロジー リミテッド | ニューレグリンペプチド及びその使用 |
| LT3453387T (lt) * | 2008-12-22 | 2020-08-25 | Novartis Ag | S1p receptoriaus antagonisto dozavimo režimas |
| AU2010210157B2 (en) * | 2009-02-04 | 2014-08-28 | Sanofi-Aventis Deutschland Gmbh | Medical system and method for providing information for glycemic control |
| CN105147613A (zh) * | 2010-03-29 | 2015-12-16 | 阿布拉科斯生物科学有限公司 | 增强药物递送和治疗剂有效性的方法 |
| MX2014000518A (es) * | 2011-07-13 | 2014-05-30 | Pharmacyclics Inc | Inhibidores de la tirosina quinasa de bruton. |
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2014
- 2014-03-06 EP EP14712964.7A patent/EP2964249A1/en not_active Withdrawn
- 2014-03-06 AU AU2014225534A patent/AU2014225534A1/en not_active Abandoned
- 2014-03-06 WO PCT/US2014/021446 patent/WO2014138502A1/en not_active Ceased
- 2014-03-06 CA CA2904055A patent/CA2904055A1/en not_active Abandoned
- 2014-03-06 IL IL281376A patent/IL281376B/en unknown
- 2014-03-06 US US14/772,205 patent/US20160129084A1/en not_active Abandoned
- 2014-03-06 JP JP2015561687A patent/JP6542678B2/ja not_active Expired - Fee Related
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2015
- 2015-09-03 IL IL241133A patent/IL241133A0/en unknown
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2018
- 2018-04-19 US US15/957,122 patent/US20180303904A1/en not_active Abandoned
- 2018-10-22 IL IL262522A patent/IL262522B/en active IP Right Grant
- 2018-11-15 AU AU2018264093A patent/AU2018264093B9/en not_active Ceased
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2019
- 2019-06-13 JP JP2019110381A patent/JP2019194208A/ja active Pending
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- 2020-06-18 AU AU2020204070A patent/AU2020204070B2/en not_active Expired - Fee Related
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2021
- 2021-07-20 JP JP2021119288A patent/JP2021169514A/ja active Pending
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2023
- 2023-04-21 JP JP2023069875A patent/JP2023089263A/ja active Pending
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|---|---|
| US20160129084A1 (en) | 2016-05-12 |
| JP2021169514A (ja) | 2021-10-28 |
| IL241133A0 (en) | 2015-11-30 |
| AU2014225534A1 (en) | 2015-09-24 |
| IL281376A (en) | 2021-04-29 |
| AU2018264093A1 (en) | 2018-12-06 |
| AU2018264093B2 (en) | 2020-07-09 |
| EP2964249A1 (en) | 2016-01-13 |
| US20200338165A1 (en) | 2020-10-29 |
| US20180303904A1 (en) | 2018-10-25 |
| WO2014138502A1 (en) | 2014-09-12 |
| IL262522A (en) | 2018-12-31 |
| JP2023089263A (ja) | 2023-06-27 |
| AU2018264093B9 (en) | 2020-07-23 |
| IL262522B (en) | 2021-03-25 |
| JP2019194208A (ja) | 2019-11-07 |
| AU2020204070B2 (en) | 2022-06-02 |
| JP6542678B2 (ja) | 2019-07-10 |
| CA2904055A1 (en) | 2014-09-12 |
| JP2016516016A (ja) | 2016-06-02 |
| AU2020204070A1 (en) | 2020-07-09 |
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