IL28098A - Stable reagent mixtures containing polyhydric compounds - Google Patents

Stable reagent mixtures containing polyhydric compounds

Info

Publication number
IL28098A
IL28098A IL28098A IL2809867A IL28098A IL 28098 A IL28098 A IL 28098A IL 28098 A IL28098 A IL 28098A IL 2809867 A IL2809867 A IL 2809867A IL 28098 A IL28098 A IL 28098A
Authority
IL
Israel
Prior art keywords
dry
specimen
reagent
enzyme
substance
Prior art date
Application number
IL28098A
Other languages
Hebrew (he)
Original Assignee
Calbiochem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Calbiochem filed Critical Calbiochem
Publication of IL28098A publication Critical patent/IL28098A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/527—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/008—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions for determining co-enzymes or co-factors, e.g. NAD, ATP
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/50—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving creatine phosphokinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/52—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving transaminase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/58—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving urea or urease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/904—Oxidoreductases (1.) acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Claims (5)

28098/2 CLAIMSI :~
1. A dry stable reagent mixtur for assaying biological fluids* characterized by comprising at least one moisture sensitive, biologically active, enzymatic constituent, combined with a bulking-stabllizlng agent which comprises a polyhydric substance selected from the group consisting of mannitol, sorbitol and lactose*
2. Method of stabilizing a moisture sensitive enzymatic material which comprises! talcing said material while in a dry particulate state and admixing therewith a polyhydric substance selected from mannitol, sorbitol and lactose as stabilizing bulking agents, said su stances ranging for each part by weight of said material from 5 parts to 2000 parts by weight,
3. The method of claim 2, wherein the substance is mannitol.
4. A solid assay material according to claim l, for dissolving in water to create a liquid reagent for assaying a specimen for glutamate ©xaloacetate transaminase,including the combination oft substrates comprising dry aspartic acid and alpha-keto-glutaric acidI the dry enzyme malate dehydrogenases the dry coenzyme reduced diphosphopyridine nucleotidei at least one dry stabilizer from the class including mucilageneous gums, polysaccharides,hydroxyalkylaraines,ethylene diamine tetraacetic acid and its salts, and a sulfate anient a dry buffer from the class that includes the alkali metal salts and phosphates! the dry atabilizing-bulklng agent mannitoli and each substance above being present in that quantity so as to ensure a uniform rate of the reaction catalyzed by the enzyme being determined and so as to aauee said rate to be optimal or maximal.
5. The method of assaying a biological specimen for the enzyme glutamate oxaloacetate transaminase, including the steps of: dissolving in water, a substantially anhydrous solid reagent comprising: the dry substrates aspartic acid and alpha-keto-glutaric acid; the dry enzyme malate dehydrogenase; the dry coenzyme reduced diphosphopyridine nucleotide; at least one dry stabilizer from the class that includes mucilagenous gums, hydroxyalkylamines, ethylene diamine tetracetic acid and its salts, and a sulfate anion; a dry buffer from the class that includes the alkali metal salts of phosphates; the dry stabilizing-bulking agent mannitol; each substance being present in that quantity to insure a uniform rate of reaction catalyzed by the enzyme being determined, thereby to produce a liquid reagent having a measurable optical density; mixing said liquid reagent with said specimen to form a specimen reagent assay mixture; determining the rate of change of the optical density of the reacting specimen-reagent assay mixture; and obtaining a solution containing the enzyme malate dehydrogenase in aqueous ammonium sulfate; dissolving into said solution at least one stabilizer from the class of tris (hydroxymethyl)aminomethane and its sulfate salt, acacia and ethylenediamine tetraacetic acid; mixing the solution until the malate dehydrogenase and the stabilizer are uniformly distributed throughout the resultant solution; freezing the resultant solution to form a solid mass; and retaining the frozen mass under a vacuum until the moisture in the mass has been removed and the enzyme malate dehydrogenase and the stabilizers are in a dry solid form. accordipg to claim 1» 6· A solid assay materiay for dissolving in water to create a liquid reagent for assaying a specimen for lactate dehydrogenase, including the combination of? the dry substrate sodium pyruvate; the dry coenzyme reduced diphosphopyridine nucleotide; a dry buffer from the class that includes disodium hydrogen phosphate and potassium dehydrogen phosphate; the dry stabilizing-bulking agent mannitol; and each substance above being present in that quantity so as to insure a uniform rate of reaction catalyzed by the enzyme being determined and so as to cause said rate to be optimal or maximal= 7 The method of assaying a specimen for the enzyme lactate dehydrogenase, including the steps of dissolving into water, a substantially anhydrous solid reagent material, comprising^ the dry substrate sodium pyruvate; the dry coenzyme reduced diphosphopyridine nucleotide; a dry buffer comprising disodium hydrogen phosphate and potassium dihydrogen phosphate; the dry bulking-stabilizing agent mannitol; each substance being present in that quantity to insure a uniform rate of reaction catalyzed by the enzyme being determined, thereby to produce a liquid reagent having a measurable optical density; mixing said liquid reagent with said specimen to form a specimen-reagent assay mixture, and measuring the rate of change optical density of the reacting specimen-assay mixture. Λ . , . according to c.laim 1 S* A solid assay material/ for dissolving in water to create a liquid reagent for assaying a specimen for glucose, including the combination of; the dry enzymes hexokinase and glucose-6-phosphate dehydrogenase; the dry coenzymes adenosine triphosphate and triphosphopyridine nucleotide; at least one dry stabilizer selected from acacia, tris-sulfate and ammonium sulfate the dry buffer tris°succinate; the dry stabilizing-bulking agent mannitol; and each substance above being present in that quantity so as to insure a uniform rate of reaction catalyzed by the enzyme being determined and so as to cause said rate to be optimal or maximal.. . The method of assaying a specimen for glucose including the steps of dissolving into water a substantially anhydrous solid reagent comprising? the dry enzymes hexokinase and glucose-6-phosphate dehydrogenase; the dry coenzymes adenosine triphosphate and triphosphopyridine nucleotide; and the dry stabilizing-bulkifig i¾ent aannitol; each substance being present in that quantity so as to insure that the amount of reduced triphosphopyridine nucleotide formed is equivalent to the amount of glucose present, thereby to produce a liquid reagent having a measurable optical density; mixing said liquid reagent, with said specimen to form a specimen-reagent assay mixture; and determining the amount of change in the optical density of the reacted specimen reagent assay mixture. according to claim 1 40» A solid assay material/for dissolving in water to provide a liquid reagent for assaying a specimen for the unknown lactate dehydrogenase, including the combination of: the dry substrate comprising lithium lactate; the dry coenzyme comprising diphosphopyridine nucleotide; at least one dry stabilizing-bulking agent selected from the class that includes polyhydric substances; a dry buffer capable of maintaining the pH between each substance above being present in that quantity so as to insure a uniform rate of reaction catalyzed by the enzyme being determined, and so as to cause said rate to be optimal or maximal. 44» The method of assaying a specimen for the enzyme lactate dehydrogenase including the steps of dissolving a solid reagent comprising; a dry substrate lithium lactate; the dry coenzyme diphcsphopyridine nucleotide; at least one dry stabilizing-bulking agent selected from mannitol, sorbitol and lactose; a dry buffer capable of maintaining the pH between each substance being present in that quantity so as to insure a uniform rate of reaction catalyzed by the enzyme being determined, thereby to produce a liquid reagent having a measurable optical density^ mixing said liquid reagent with said specimen to form said specimen -reagent assay mixture and measuring the rate of change in optical density of the reacting specimen=reagent assay mixture,, For
IL28098A 1966-06-30 1967-06-01 Stable reagent mixtures containing polyhydric compounds IL28098A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US561757A US3413198A (en) 1966-06-30 1966-06-30 Reagents and method for assaying biological samples

Publications (1)

Publication Number Publication Date
IL28098A true IL28098A (en) 1976-02-29

Family

ID=24243318

Family Applications (1)

Application Number Title Priority Date Filing Date
IL28098A IL28098A (en) 1966-06-30 1967-06-01 Stable reagent mixtures containing polyhydric compounds

Country Status (7)

Country Link
US (1) US3413198A (en)
BE (1) BE700778A (en)
CH (1) CH514841A (en)
DE (3) DE1598321A1 (en)
GB (3) GB1192046A (en)
IL (1) IL28098A (en)
NL (1) NL6708570A (en)

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US3928137A (en) * 1971-10-20 1975-12-23 Mallinckrodt Inc Reagent formulation for uric acid assay
US3953295A (en) * 1971-10-20 1976-04-27 Mallinckrodt, Inc. Reagent formulations for glucose assay
US3926735A (en) * 1971-10-20 1975-12-16 Mallinckrodt Inc Alkaline phosphatase assay
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US3869348A (en) * 1973-02-26 1975-03-04 Pierce Chemical Co Determination of amylase
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Also Published As

Publication number Publication date
US3413198A (en) 1968-11-26
NL6708570A (en) 1968-01-02
CH514841A (en) 1971-10-31
DE1598321A1 (en) 1972-02-24
BE700778A (en) 1968-01-02
DE1598326A1 (en) 1972-03-02
GB1191697A (en) 1970-05-13
DE1598325B1 (en) 1973-01-11
GB1192046A (en) 1970-05-13
GB1163409A (en) 1969-09-04

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