IL276860A - Novel adeno-associated virus (AAV) vectors, AAV vectors with reduced capsid deamidation and uses thereof - Google Patents
Novel adeno-associated virus (AAV) vectors, AAV vectors with reduced capsid deamidation and uses thereofInfo
- Publication number
- IL276860A IL276860A IL276860A IL27686020A IL276860A IL 276860 A IL276860 A IL 276860A IL 276860 A IL276860 A IL 276860A IL 27686020 A IL27686020 A IL 27686020A IL 276860 A IL276860 A IL 276860A
- Authority
- IL
- Israel
- Prior art keywords
- aav
- vectors
- associated virus
- uses therefor
- novel adeno
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862635968P | 2018-02-27 | 2018-02-27 | |
| US201862635964P | 2018-02-27 | 2018-02-27 | |
| US201862663797P | 2018-04-27 | 2018-04-27 | |
| US201862663788P | 2018-04-27 | 2018-04-27 | |
| US201862667587P | 2018-05-06 | 2018-05-06 | |
| US201862667881P | 2018-05-07 | 2018-05-07 | |
| US201862667888P | 2018-05-07 | 2018-05-07 | |
| US201862667585P | 2018-05-29 | 2018-05-29 | |
| US201862677471P | 2018-05-29 | 2018-05-29 | |
| US201862677474P | 2018-05-29 | 2018-05-29 | |
| US201862703670P | 2018-07-26 | 2018-07-26 | |
| US201862703673P | 2018-07-26 | 2018-07-26 | |
| US201862722382P | 2018-08-24 | 2018-08-24 | |
| US201862722388P | 2018-08-24 | 2018-08-24 | |
| PCT/US2019/019861 WO2019169004A1 (fr) | 2018-02-27 | 2019-02-27 | Nouveaux vecteurs de virus adéno-associés (aav), vecteurs aav ayant une déamidation de capside réduite et leurs utilisations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL276860A true IL276860A (en) | 2020-10-29 |
Family
ID=67809202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL276860A IL276860A (en) | 2018-02-27 | 2020-08-23 | Novel adeno-associated virus (AAV) vectors, AAV vectors with reduced capsid deamidation and uses thereof |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20210123073A1 (fr) |
| EP (1) | EP3768695A4 (fr) |
| JP (1) | JP7498665B2 (fr) |
| KR (1) | KR20210006327A (fr) |
| CN (1) | CN112236443A (fr) |
| AU (1) | AU2019228504A1 (fr) |
| BR (1) | BR112020017278A2 (fr) |
| CA (1) | CA3091795A1 (fr) |
| CL (1) | CL2020002201A1 (fr) |
| IL (1) | IL276860A (fr) |
| MA (1) | MA52087A (fr) |
| MX (1) | MX2020008932A (fr) |
| SG (1) | SG11202007942YA (fr) |
| WO (1) | WO2019169004A1 (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3356390T (pt) | 2015-09-28 | 2021-04-21 | Univ Florida | Métodos e composições para vetores virais que se evadem a anticorpos |
| BR112020020266A2 (pt) | 2018-04-03 | 2021-01-19 | Stridebio, Inc. | Vetores de vírus com evasão de anticorpos |
| EP3884057A4 (fr) * | 2018-12-21 | 2022-09-07 | The University of North Carolina at Chapel Hill | Gènes galc optimisés et cassettes d'expression et leur utilisation |
| CA3133453A1 (fr) | 2019-03-21 | 2020-09-24 | Daniel Mccoy | Vecteurs viraux adeno-associes recombinants |
| BR112022006530A2 (pt) | 2019-10-17 | 2022-07-05 | Stridebio Inc | Vetores virais adenoassociados para o tratamento da doença de niemann-pick tipo c |
| WO2021080991A1 (fr) * | 2019-10-21 | 2021-04-29 | The Trustees Of The University Of Pennsylvania | Variants d'aav3b présentant un rendement de production et un tropisme hépatique améliorés |
| US20230204595A1 (en) * | 2020-01-03 | 2023-06-29 | Sarepta Therapeutics, Inc. | Methods for analyzing aav capsid proteins |
| US20230151359A1 (en) * | 2020-03-09 | 2023-05-18 | University Of Massachusetts | Gene replacement therapy for foxg1 syndrome |
| JP2023531451A (ja) | 2020-06-17 | 2023-07-24 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | 遺伝子療法患者の治療のための組成物及び方法 |
| EP4179097A1 (fr) | 2020-07-13 | 2023-05-17 | The Trustees of The University of Pennsylvania | Compositions utiles pour le traitement de la maladie de charcot-marie-tooth |
| IL302127A (en) * | 2020-10-18 | 2023-06-01 | Univ Pennsylvania | An improved adeno-associated virus (AAV) vector and its uses |
| CA3209779A1 (fr) | 2021-02-01 | 2022-08-04 | Regenxbio Inc. | Therapie genique de ceroides-lipofuscinoses neuronales |
| EP4323520A1 (fr) | 2021-04-12 | 2024-02-21 | The Trustees of The University of Pennsylvania | Compositions utiles pour le traitement de l'amyotrophie spinale et bulbaire (sbma) |
| WO2023081807A1 (fr) * | 2021-11-04 | 2023-05-11 | The Trustees of the University of Pennsylvania Penn Center for Innovation | Compositions et procédés pour réduire les taux de pcsk9 chez un sujet |
| TW202338086A (zh) | 2022-01-10 | 2023-10-01 | 賓州大學委員會 | 有用於治療異染性白質失養症之組成物 |
| TW202340467A (zh) | 2022-01-10 | 2023-10-16 | 賓州大學委員會 | 有用於治療c9orf72介導之病症之組成物及方法 |
| WO2023196892A1 (fr) | 2022-04-06 | 2023-10-12 | The Trustees Of The University Of Pennsylvania | Immunisation passive avec des anticorps neutralisants anti-aav pour empêcher la transduction hors cible de vecteurs aav administrés par voie intrathécale |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004083441A2 (fr) * | 2003-03-19 | 2004-09-30 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Bibliotheque peptidique aleatoire s'affichant sur des vecteurs aav |
| JP5054975B2 (ja) | 2003-09-30 | 2012-10-24 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | アデノ随伴ウイルス（ａａｖ）の同源系統群、配列、それらを含有するベクターおよびそれらの用途 |
| JP5702519B2 (ja) * | 2005-04-07 | 2015-04-15 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | Ａａｖベクターの機能を上げる方法 |
| PT3198018T (pt) * | 2014-09-24 | 2021-02-24 | Hope City | Variantes dos vetores de vírus adenoassociados para edição do genoma de alta eficácia e métodos da mesma |
| CA2969145A1 (fr) * | 2014-11-26 | 2016-06-02 | The Regents Of The University Of California | Compositions therapeutiques comprenant des facteurs de transcription et leurs procedes de preparation et d'utilisation |
| CN109661470A (zh) | 2016-04-15 | 2019-04-19 | 宾夕法尼亚州大学信托人 | 新型aav8突变衣壳和含有其的组合物 |
| IL305149A (en) * | 2016-07-26 | 2023-10-01 | Biomarin Pharm Inc | Novel adeno-associated virus capsid proteins |
| MX2019001938A (es) * | 2016-08-15 | 2019-07-04 | Genzyme Corp | Metodos para detectar aav. |
| JOP20190200A1 (ar) * | 2017-02-28 | 2019-08-27 | Univ Pennsylvania | تركيبات نافعة في معالجة ضمور العضل النخاعي |
| SG11201907714UA (en) * | 2017-02-28 | 2019-09-27 | Univ Pennsylvania | Adeno-associated virus (aav) clade f vector and uses therefor |
-
2019
- 2019-02-27 KR KR1020207027462A patent/KR20210006327A/ko active Search and Examination
- 2019-02-27 CA CA3091795A patent/CA3091795A1/fr active Pending
- 2019-02-27 SG SG11202007942YA patent/SG11202007942YA/en unknown
- 2019-02-27 WO PCT/US2019/019861 patent/WO2019169004A1/fr unknown
- 2019-02-27 US US16/975,545 patent/US20210123073A1/en active Pending
- 2019-02-27 MX MX2020008932A patent/MX2020008932A/es unknown
- 2019-02-27 AU AU2019228504A patent/AU2019228504A1/en active Pending
- 2019-02-27 BR BR112020017278-2A patent/BR112020017278A2/pt unknown
- 2019-02-27 JP JP2020545159A patent/JP7498665B2/ja active Active
- 2019-02-27 MA MA052087A patent/MA52087A/fr unknown
- 2019-02-27 EP EP19760152.9A patent/EP3768695A4/fr active Pending
- 2019-02-27 CN CN201980029022.1A patent/CN112236443A/zh active Pending
-
2020
- 2020-08-23 IL IL276860A patent/IL276860A/en unknown
- 2020-08-26 CL CL2020002201A patent/CL2020002201A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2019228504A1 (en) | 2020-09-10 |
| SG11202007942YA (en) | 2020-09-29 |
| US20210123073A1 (en) | 2021-04-29 |
| EP3768695A4 (fr) | 2022-04-06 |
| CL2020002201A1 (es) | 2020-12-18 |
| JP7498665B2 (ja) | 2024-06-12 |
| EP3768695A1 (fr) | 2021-01-27 |
| CN112236443A (zh) | 2021-01-15 |
| WO2019169004A9 (fr) | 2019-10-31 |
| MA52087A (fr) | 2021-06-02 |
| MX2020008932A (es) | 2020-10-01 |
| BR112020017278A2 (pt) | 2020-12-22 |
| JP2021515548A (ja) | 2021-06-24 |
| WO2019169004A8 (fr) | 2019-12-05 |
| WO2019169004A1 (fr) | 2019-09-06 |
| CA3091795A1 (fr) | 2019-09-06 |
| KR20210006327A (ko) | 2021-01-18 |
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