IL272163B1 - Imatelastat for use in the treatment of myelodysplastic syndrome - Google Patents

Imatelastat for use in the treatment of myelodysplastic syndrome

Info

Publication number
IL272163B1
IL272163B1 IL272163A IL27216320A IL272163B1 IL 272163 B1 IL272163 B1 IL 272163B1 IL 272163 A IL272163 A IL 272163A IL 27216320 A IL27216320 A IL 27216320A IL 272163 B1 IL272163 B1 IL 272163B1
Authority
IL
Israel
Prior art keywords
imetelstat
myelodysplastic syndrome
treating myelodysplastic
treating
syndrome
Prior art date
Application number
IL272163A
Other languages
English (en)
Hebrew (he)
Other versions
IL272163A (en
Original Assignee
Geron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=63209674&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL272163(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Geron Corp filed Critical Geron Corp
Publication of IL272163A publication Critical patent/IL272163A/en
Publication of IL272163B1 publication Critical patent/IL272163B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL272163A 2017-07-28 2020-01-21 Imatelastat for use in the treatment of myelodysplastic syndrome IL272163B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762538315P 2017-07-28 2017-07-28
US201762595329P 2017-12-06 2017-12-06
US201862685542P 2018-06-15 2018-06-15
PCT/US2018/044225 WO2019023667A1 (en) 2017-07-28 2018-07-27 METHODS OF TREATING MYELODYSPLASTIC SYNDROME

Publications (2)

Publication Number Publication Date
IL272163A IL272163A (en) 2020-03-31
IL272163B1 true IL272163B1 (en) 2025-12-01

Family

ID=63209674

Family Applications (1)

Application Number Title Priority Date Filing Date
IL272163A IL272163B1 (en) 2017-07-28 2020-01-21 Imatelastat for use in the treatment of myelodysplastic syndrome

Country Status (17)

Country Link
US (1) US12171778B2 (enExample)
EP (1) EP3658156A1 (enExample)
JP (4) JP7316261B2 (enExample)
KR (2) KR102867725B1 (enExample)
CN (1) CN110944646A (enExample)
AU (2) AU2018307983B2 (enExample)
BR (1) BR112020001749A2 (enExample)
CA (1) CA3069010A1 (enExample)
CL (2) CL2020000196A1 (enExample)
IL (1) IL272163B1 (enExample)
MA (1) MA49688A (enExample)
MX (1) MX2025005894A (enExample)
SG (1) SG11201913984RA (enExample)
TW (1) TWI879717B (enExample)
UA (1) UA127701C2 (enExample)
WO (1) WO2019023667A1 (enExample)
ZA (1) ZA202000070B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9375485B2 (en) 2012-12-07 2016-06-28 Geron Corporation Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms
EP3318276A1 (en) 2016-11-04 2018-05-09 Janssen Biotech, Inc. Combinations of a telomerase inhibitor and a bcl-2 inhibitor for the treatment of hematological cancers
TWI879717B (zh) 2017-07-28 2025-04-11 美商傑龍公司 治療骨髓增生不良症候群之方法
SG11202105573PA (en) 2018-11-29 2021-06-29 Geron Corp Methods of treating myelodysplastic syndrome
CN115776909A (zh) 2020-07-17 2023-03-10 美国杰龙生物医药公司 皮下端粒酶抑制剂组合物及其使用方法

Citations (2)

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WO2014088785A1 (en) * 2012-12-07 2014-06-12 Geron Corporation Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms
WO2015069758A1 (en) * 2013-11-06 2015-05-14 Ayalew Tefferi Methods and materials for treating hematological malignancies

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US7067497B2 (en) 1992-09-29 2006-06-27 Isis Pharmaceuticals, Inc. Modulation of telomere length by oligonucleotides having a G-core sequence
US5583016A (en) 1994-07-07 1996-12-10 Geron Corporation Mammalian telomerase
US5958680A (en) 1994-07-07 1999-09-28 Geron Corporation Mammalian telomerase
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US5656638A (en) 1995-04-18 1997-08-12 Geron Corporation Telomerase inhibitors
US5863936A (en) 1995-04-18 1999-01-26 Geron Corporation Telomerase inhibitors
US5840490A (en) 1995-06-07 1998-11-24 Mcmaster University Telomerase activity associated with hematological and colorectal malignancies
US5770613A (en) 1995-09-29 1998-06-23 Geron Corporation Telomerase inhibitors
US5767278A (en) 1995-10-06 1998-06-16 Geron Corporation Telomerase inhibitors
US6261836B1 (en) 1996-10-01 2001-07-17 Geron Corporation Telomerase
US6444650B1 (en) 1996-10-01 2002-09-03 Geron Corporation Antisense compositions for detecting and inhibiting telomerase reverse transcriptase
AU767646B2 (en) 1999-09-10 2003-11-20 Geron Corporation Oligonucleotide N3'-P5' thiophosphoramidates: their synthesis and use
WO2001053307A1 (en) 2000-01-21 2001-07-26 Geron Corporation 2'-arabino-fluorooligonucleotide n3'→p5'phosphoramidates: their synthesis and use
US6331399B1 (en) 2000-05-16 2001-12-18 Isis Pharmaceuticals, Inc. Antisense inhibition of tert expression
WO2002077184A2 (en) 2001-03-23 2002-10-03 Geron Corporation Oligonucleotide conjugates
US7563618B2 (en) 2001-03-23 2009-07-21 Geron Corporation Oligonucleotide conjugates
JP4690324B2 (ja) 2003-09-09 2011-06-01 ジェロン・コーポレーション テロメラーゼ阻害のための改変オリゴヌクレオチド
AU2004289975B2 (en) 2003-11-04 2011-11-03 Geron Corporation RNA amidates and thioamidates for RNAI
US20050282893A1 (en) 2004-01-30 2005-12-22 Au Jessie L Methods and compositions for using suramin, pentosan, polysulfate, telomerase antisense and telomerase inhibitors
RS56361B1 (sr) 2004-07-02 2017-12-29 Geron Corp Sinteza zaštićenih 3'-amino nukleozidnih monomera
FR2877013A1 (fr) 2004-10-27 2006-04-28 Assist Publ Hopitaux De Paris Indentification d'une mutation de jak2 impliquee dans la polyglobulie de vaquez
US20060166221A1 (en) 2005-01-21 2006-07-27 Bahou Wadie F Methods of diagnosing essential thrombocythemia
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PL2101789T3 (pl) 2006-10-30 2015-05-29 Geron Corp Inhibitor telomerazy skojarzony z gemcytabiną do leczenia nowotworu
US8785409B2 (en) 2007-01-30 2014-07-22 Geron Corporation Compounds having anti-adhesive effects on cancer cells
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TWI879717B (zh) 2017-07-28 2025-04-11 美商傑龍公司 治療骨髓增生不良症候群之方法

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Publication number Priority date Publication date Assignee Title
WO2014088785A1 (en) * 2012-12-07 2014-06-12 Geron Corporation Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms
WO2015069758A1 (en) * 2013-11-06 2015-05-14 Ayalew Tefferi Methods and materials for treating hematological malignancies

Non-Patent Citations (2)

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A TEFFERI ET AL,, IMETELSTAT THERAPY IN REFRACTORY ANEMIA WITH RING SIDEROBLASTS WITH OR WITHOUT THROMBOCYTOSIS, 11 March 2016 (2016-03-11) *
CLINICAL TRIALS:, STUDY TO EVALUATE IMETELSTAT (GRN163L) IN SUBJECTS WITH INTERNATIONAL PROGNOSTIC SCORING SYSTEM (IPSS) LOW OR INTERMEDIATE-1 RISK MYELODYSPLASTIC SYNDROME (MDS), 29 June 2017 (2017-06-29) *

Also Published As

Publication number Publication date
KR20200033269A (ko) 2020-03-27
TWI879717B (zh) 2025-04-11
NZ760873A (en) 2024-03-22
KR102867725B1 (ko) 2025-10-13
EP3658156A1 (en) 2020-06-03
CL2021001096A1 (es) 2021-11-12
JP7654761B2 (ja) 2025-04-01
TW201919705A (zh) 2019-06-01
JP7654615B2 (ja) 2025-04-01
JP2024015000A (ja) 2024-02-01
US20190030064A1 (en) 2019-01-31
JP2020528915A (ja) 2020-10-01
AU2018307983B2 (en) 2024-07-18
JP7316261B2 (ja) 2023-07-27
JP2025013669A (ja) 2025-01-24
IL272163A (en) 2020-03-31
CL2020000196A1 (es) 2020-11-20
UA127701C2 (uk) 2023-12-06
CA3069010A1 (en) 2019-01-31
JP2023009229A (ja) 2023-01-19
AU2018307983A1 (en) 2020-02-13
MA49688A (fr) 2020-06-03
AU2024219941A1 (en) 2024-10-10
TW202432146A (zh) 2024-08-16
CN110944646A (zh) 2020-03-31
KR20250151565A (ko) 2025-10-21
MX2025005894A (es) 2025-06-02
WO2019023667A1 (en) 2019-01-31
US12171778B2 (en) 2024-12-24
SG11201913984RA (en) 2020-02-27
ZA202000070B (en) 2025-09-25
BR112020001749A2 (pt) 2020-07-21

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