IL27212A - Process for the manufacture of 1,4-benzodiazepine derivatives and intermediates thereof - Google Patents

Process for the manufacture of 1,4-benzodiazepine derivatives and intermediates thereof

Info

Publication number
IL27212A
IL27212A IL27212A IL2721267A IL27212A IL 27212 A IL27212 A IL 27212A IL 27212 A IL27212 A IL 27212A IL 2721267 A IL2721267 A IL 2721267A IL 27212 A IL27212 A IL 27212A
Authority
IL
Israel
Prior art keywords
intermediates
manufacture
benzodiazepine derivatives
benzodiazepine
derivatives
Prior art date
Application number
IL27212A
Other languages
English (en)
Original Assignee
Sparamedica Ag
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sparamedica Ag, Hoffmann La Roche filed Critical Sparamedica Ag
Publication of IL27212A publication Critical patent/IL27212A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/04—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • C07D239/76—N-oxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
IL27212A 1966-01-19 1967-01-04 Process for the manufacture of 1,4-benzodiazepine derivatives and intermediates thereof IL27212A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52155166A 1966-01-19 1966-01-19

Publications (1)

Publication Number Publication Date
IL27212A true IL27212A (en) 1971-04-28

Family

ID=24077176

Family Applications (2)

Application Number Title Priority Date Filing Date
IL27189A IL27189A (en) 1966-01-19 1966-12-29 Process for the manufacture of 5-phenyl-3h-1,4-benzodiazepine 4-oxide derivatives and novel quaternary ammonium salts of quinazoline intermediates thereof
IL27212A IL27212A (en) 1966-01-19 1967-01-04 Process for the manufacture of 1,4-benzodiazepine derivatives and intermediates thereof

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL27189A IL27189A (en) 1966-01-19 1966-12-29 Process for the manufacture of 5-phenyl-3h-1,4-benzodiazepine 4-oxide derivatives and novel quaternary ammonium salts of quinazoline intermediates thereof

Country Status (16)

Country Link
US (1) US3446806A (xx)
JP (1) JPS4938814B1 (xx)
BE (2) BE692378A (xx)
CH (3) CH560692A5 (xx)
DE (2) DE1695176A1 (xx)
DK (4) DK114556B (xx)
ES (2) ES335788A1 (xx)
FI (1) FI47576C (xx)
FR (2) FR1507878A (xx)
GB (2) GB1144515A (xx)
GR (2) GR33806B (xx)
IL (2) IL27189A (xx)
MY (2) MY6900384A (xx)
NL (3) NL6700785A (xx)
OA (1) OA02391A (xx)
SE (4) SE321233B (xx)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4310429A (en) * 1978-06-19 1982-01-12 The B. F. Goodrich Company Stabilized polymers, novel stabilizers, and synthesis thereof
US4601839A (en) * 1978-06-19 1986-07-22 The B. F. Goodrich Company Stabilized polymers, novel stabilizers, and synthesis thereof
US4472435A (en) * 1980-07-31 1984-09-18 Hoffman-La Roche Inc. Benzophenone derivatives useful in treating heart failure
TW384285B (en) * 1994-03-08 2000-03-11 Takeda Chemical Industries Ltd Pharmaceutical composition containing quinoline or quinazoline derivatives and novel derivatives therefor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3267110A (en) * 1960-06-03 1966-08-16 Smith Kline French Lab Trifluoromethyl substituted o-aminophenyl ketones
US3321467A (en) * 1963-11-27 1967-05-23 Hoffmann La Roche 3-halo-1, 4-benzodiazepin-2-ones

Also Published As

Publication number Publication date
GB1144516A (en) 1969-03-05
OA02391A (fr) 1970-05-05
GR35752B (el) 1968-10-25
FR1507878A (fr) 1967-12-29
SE321233B (xx) 1970-03-02
SE335858B (xx) 1971-06-14
CH461517A (de) 1968-08-31
DE1618486A1 (de) 1971-04-01
US3446806A (en) 1969-05-27
GB1144515A (en) 1969-03-05
DE1695176A1 (de) 1970-04-16
IL27189A (en) 1971-01-28
MY6900383A (en) 1969-12-31
NL131198C (xx)
ES335789A1 (es) 1967-12-16
SE353717B (xx) 1973-02-12
BE692558A (xx) 1967-07-13
FI47576B (xx) 1973-10-01
CH560692A5 (xx) 1975-04-15
JPS4938814B1 (xx) 1974-10-21
CH553193A (en) 1974-08-30
ES335788A1 (es) 1968-03-16
DK120347B (da) 1971-05-17
DK120392B (da) 1971-05-24
SE386168B (sv) 1976-08-02
FI47576C (fi) 1974-01-10
NL6700785A (xx) 1967-07-20
NL6700786A (xx) 1967-07-20
FR1508490A (fr) 1968-01-05
DK114556B (da) 1969-07-14
BE692378A (xx) 1967-07-10
GR33806B (el) 1968-02-06
MY6900384A (en) 1969-12-31
DK119656B (da) 1971-02-08

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