IL267430B2 - Use of anti-sclerostin antibodies to treat scleroderma - Google Patents

Use of anti-sclerostin antibodies to treat scleroderma

Info

Publication number
IL267430B2
IL267430B2 IL267430A IL26743019A IL267430B2 IL 267430 B2 IL267430 B2 IL 267430B2 IL 267430 A IL267430 A IL 267430A IL 26743019 A IL26743019 A IL 26743019A IL 267430 B2 IL267430 B2 IL 267430B2
Authority
IL
Israel
Prior art keywords
seq
sclerostin
antibody
sclerostin antibody
patient
Prior art date
Application number
IL267430A
Other languages
English (en)
Hebrew (he)
Other versions
IL267430A (en
IL267430B1 (en
Original Assignee
Mereo Biopharma 3 Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mereo Biopharma 3 Ltd filed Critical Mereo Biopharma 3 Ltd
Publication of IL267430A publication Critical patent/IL267430A/en
Publication of IL267430B1 publication Critical patent/IL267430B1/en
Publication of IL267430B2 publication Critical patent/IL267430B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IL267430A 2016-12-21 2017-12-21 Use of anti-sclerostin antibodies to treat scleroderma IL267430B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662437353P 2016-12-21 2016-12-21
PCT/GB2017/053850 WO2018115880A1 (en) 2016-12-21 2017-12-21 Use of anti-sclerostin antibodies in the treatment of osteogenesis imperfecta

Publications (3)

Publication Number Publication Date
IL267430A IL267430A (en) 2019-08-29
IL267430B1 IL267430B1 (en) 2025-09-01
IL267430B2 true IL267430B2 (en) 2026-01-01

Family

ID=60915566

Family Applications (1)

Application Number Title Priority Date Filing Date
IL267430A IL267430B2 (en) 2016-12-21 2017-12-21 Use of anti-sclerostin antibodies to treat scleroderma

Country Status (23)

Country Link
US (5) US20200179509A1 (enExample)
EP (2) EP3868780A1 (enExample)
JP (3) JP7050335B2 (enExample)
KR (3) KR20240113615A (enExample)
CN (2) CN117442720A (enExample)
AU (1) AU2017381433B2 (enExample)
BR (1) BR112019012731A2 (enExample)
CA (1) CA3047221A1 (enExample)
CL (1) CL2019001749A1 (enExample)
CY (1) CY1124238T1 (enExample)
DK (1) DK3478719T6 (enExample)
ES (1) ES2862922T7 (enExample)
FI (1) FI3478719T6 (enExample)
HR (1) HRP20210207T4 (enExample)
HU (1) HUE053436T2 (enExample)
IL (1) IL267430B2 (enExample)
LT (1) LT3478719T (enExample)
MX (1) MX2019007161A (enExample)
NZ (1) NZ754676A (enExample)
PL (1) PL3478719T6 (enExample)
PT (1) PT3478719T (enExample)
SI (1) SI3478719T2 (enExample)
WO (1) WO2018115880A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI795381B (zh) 2016-12-21 2023-03-11 比利時商健生藥品公司 作為ｍａｌｔ１抑制劑之吡唑衍生物
MX2019007161A (es) * 2016-12-21 2020-02-12 Mereo Biopharma 3 Ltd Uso de anticuerpos anti-esclerostina en el tratamiento de osteogenesis imperfecta.
US10961305B2 (en) 2016-12-21 2021-03-30 Mereo Biopharma 3 Limited Use of anti-sclerostin antibodies in the treatment of osteogenesis imperfecta
HRP20260414T1 (hr) 2018-03-30 2026-05-08 Amgen Inc. C-terminalne varijante protutijela
JP7296408B2 (ja) 2018-06-18 2023-06-22 ヤンセン ファーマシューティカ エヌ．ベー． Ｍａｌｔ１阻害剤としてのピラゾール誘導体
MA55593A (fr) 2019-04-11 2022-02-16 Janssen Pharmaceutica Nv Cycles pyridine contenant des dérivés servant d'inhibiteurs de malt1
KR102472582B1 (ko) * 2020-08-20 2022-11-30 한림대학교 산학협력단 인공관절 마모편에 의한 활막염과 골용해의 진단 및 치료 방법
MX2024003828A (es) * 2021-09-30 2024-05-10 Mereo Biopharma 3 Ltd Métodos de uso de anticuerpos antiesclerostina en el tratamiento de osteogénesis imperfecta.
TW202606715A (zh) * 2024-04-05 2026-02-16 美商安進公司 治療成骨不全之方法

Citations (2)

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Publication number Priority date Publication date Assignee Title
WO2009047356A1 (en) * 2007-10-12 2009-04-16 Novartis Ag Compositions and methods for use for antibodies against sclerostin
WO2016092101A1 (en) * 2014-12-12 2016-06-16 Amgen Inc. Anti-sclerostin antibodies and their use to treat bone disorders as part of a regimen

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US4439196A (en) 1982-03-18 1984-03-27 Merck & Co., Inc. Osmotic drug delivery system
US4447224A (en) 1982-09-20 1984-05-08 Infusaid Corporation Variable flow implantable infusion apparatus
US4487603A (en) 1982-11-26 1984-12-11 Cordis Corporation Implantable microinfusion pump system
US4486194A (en) 1983-06-08 1984-12-04 James Ferrara Therapeutic device for administering medicaments through the skin
US4596556A (en) 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
US4790824A (en) 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
US4941880A (en) 1987-06-19 1990-07-17 Bioject, Inc. Pre-filled ampule and non-invasive hypodermic injection device assembly
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JP4813660B2 (ja) 1998-11-27 2011-11-09 ダーウィン ディスカバリー リミテッド 骨鉱化作用を増加するための組成物および方法
US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
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WO2008061013A2 (en) 2006-11-10 2008-05-22 Amgen Inc. Antibody-based diagnostics and therapeutics
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CL2008002775A1 (es) 2007-09-17 2008-11-07 Amgen Inc Uso de un agente de unión a esclerostina para inhibir la resorción ósea.
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WO2009047356A1 (en) * 2007-10-12 2009-04-16 Novartis Ag Compositions and methods for use for antibodies against sclerostin
WO2016092101A1 (en) * 2014-12-12 2016-06-16 Amgen Inc. Anti-sclerostin antibodies and their use to treat bone disorders as part of a regimen

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MACNABB, CLAIRE, D. PATTON, AND J. S. HAYES., SCLEROSTIN ANTIBODY THERAPY FOR THE TREATMENT OF OSTEOPOROSIS: CLINICAL PROSPECTS AND CHALLENGES., 26 May 2016 (2016-05-26) *
OMINSKY, MICHAEL S., ET AL., TWO DOSES OF SCLEROSTIN ANTIBODY IN CYNOMOLGUS MONKEYS INCREASES BONE FORMATION, BONE MINERAL DENSITY, AND BONE STRENGTH., 31 December 2010 (2010-12-31) *

Also Published As

Publication number Publication date
IL267430A (en) 2019-08-29
CA3047221A1 (en) 2018-06-28
US20200179509A1 (en) 2020-06-11
JP2022046529A (ja) 2022-03-23
EP3478719A1 (en) 2019-05-08
ES2862922T7 (en) 2025-02-26
KR20220051269A (ko) 2022-04-26
WO2018115880A1 (en) 2018-06-28
HRP20210207T1 (hr) 2021-03-19
KR20190096409A (ko) 2019-08-19
IL267430B1 (en) 2025-09-01
US20230365669A1 (en) 2023-11-16
DK3478719T3 (da) 2021-03-01
ES2862922T3 (es) 2021-10-08
CY1124238T1 (el) 2022-07-22
RU2019118719A3 (enExample) 2021-06-01
CL2019001749A1 (es) 2019-12-27
EP3478719B3 (en) 2024-12-18
BR112019012731A2 (pt) 2019-11-26
NZ754676A (en) 2023-06-30
US20240400666A1 (en) 2024-12-05
CN110325548B (zh) 2023-11-17
CN110325548A (zh) 2019-10-11
AU2017381433A1 (en) 2019-07-04
US20200123242A1 (en) 2020-04-23
JP2020502219A (ja) 2020-01-23
PL3478719T6 (pl) 2025-01-27
FI3478719T6 (fi) 2025-01-20
DK3478719T6 (da) 2025-01-20
SI3478719T1 (sl) 2021-09-30
MX2019007161A (es) 2020-02-12
JP2025020150A (ja) 2025-02-12
LT3478719T (lt) 2021-04-12
EP3868780A1 (en) 2021-08-25
PT3478719T (pt) 2021-03-18
HUE053436T2 (hu) 2021-06-28
AU2017381433B2 (en) 2024-11-14
EP3478719B1 (en) 2021-01-20
RU2019118719A (ru) 2021-01-22
US20210253684A1 (en) 2021-08-19
CN117442720A (zh) 2024-01-26
PL3478719T3 (pl) 2021-10-25
JP7050335B2 (ja) 2022-04-08
HRP20210207T4 (hr) 2025-01-31
SI3478719T2 (sl) 2025-07-31
KR20240113615A (ko) 2024-07-22

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