IL266115A - Synp198, a promoter for specific expression of genes in renal ganglion cells with selective directionality - Google Patents
Synp198, a promoter for specific expression of genes in renal ganglion cells with selective directionalityInfo
- Publication number
- IL266115A IL266115A IL266115A IL26611519A IL266115A IL 266115 A IL266115 A IL 266115A IL 266115 A IL266115 A IL 266115A IL 26611519 A IL26611519 A IL 26611519A IL 266115 A IL266115 A IL 266115A
- Authority
- IL
- Israel
- Prior art keywords
- synp198
- promoter
- genes
- specific expression
- ganglion cells
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0619—Neurons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- C12N2015/8527—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic for producing animal models, e.g. for tests or diseases
- C12N2015/859—Animal models comprising reporter system for screening tests
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/106—Plasmid DNA for vertebrates
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Cell Biology (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16196818 | 2016-11-02 | ||
| PCT/IB2017/056792 WO2018083607A1 (en) | 2016-11-02 | 2017-11-01 | Synp198, a promoter for the specific expression of genes in direction selective retinal ganglion cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL266115A true IL266115A (en) | 2019-06-30 |
Family
ID=57223559
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL266115A IL266115A (en) | 2016-11-02 | 2019-04-17 | Synp198, a promoter for specific expression of genes in renal ganglion cells with selective directionality |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11525145B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3534966B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP7023279B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20190077471A (cg-RX-API-DMAC7.html) |
| CN (1) | CN110072557B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2017354086C1 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112019008488A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3042197A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL266115A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2766353C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2018083607A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20100136550A (ko) | 2008-04-18 | 2010-12-28 | 노파르티스 포르슝스티프퉁 쯔바이크니덜라쑹 프리드리히 미셔 인스티튜트 포 바이오메디칼 리서치 | 실명을 치료하기 위한 신규의 치료 도구 및 방법 |
| EP3289090B1 (en) | 2015-04-30 | 2019-06-26 | Friedrich Miescher Institute for Biomedical Research | Promoter for the specific expression of genes in müller cells |
| ES2926677T3 (es) | 2015-09-15 | 2022-10-27 | Friedrich Miescher Institute For Biomedical Res | Herramientas y métodos terapéuticos novedosos para tratar la ceguera mediante el direccionamiento a los fotorreceptores |
| ES2881782T3 (es) | 2015-10-14 | 2021-11-30 | Friedrich Miescher Institute For Biomedical Res | Promotor para la expresión específica de genes en células endoteliales retinianas. |
| ES2886664T3 (es) | 2015-12-03 | 2021-12-20 | Friedrich Miescher Institute For Biomedical Res | SynP162, un promotor para la expresión específica de genes en fotorreceptores de bastón |
| CN108430519B (zh) | 2015-12-03 | 2022-04-15 | 弗里德里克·米谢尔生物医学研究所 | SynP159，用于基因在视杆光感受器中特异性表达的启动子 |
| ES2761328T3 (es) | 2015-12-03 | 2020-05-19 | Friedrich Miescher Institute For Biomedical Res | SynP161, un promotor para la expresión específica de genes en fotorreceptores de bastón |
| CN108474001B (zh) | 2015-12-03 | 2022-04-08 | 弗里德里克·米谢尔生物医学研究所 | SynP160，用于基因在视杆光感受器中特异性表达的启动子 |
| CA3042197A1 (en) | 2016-11-02 | 2018-05-11 | Friedrich Miescher Institute For Biomedical Research | Synp198, a promoter for the specific expression of genes in direction selective retinal ganglion cells |
| JP7112414B2 (ja) | 2017-02-08 | 2022-08-03 | フリードリッヒ ミーシェー インスティトゥート フォー バイオメディカル リサーチ | 網膜神経節細胞中の遺伝子の特異的発現のためのプロモーターｓｙｎｐ８８ |
| CA3082080A1 (en) | 2017-11-15 | 2019-05-23 | Friedrich Miescher Institute For Biomedical Research | Primate retinal pigment epithelium cell-specific promoter |
| EP3717651A1 (en) | 2017-11-30 | 2020-10-07 | Friedrich Miescher Institute for Biomedical Research | Synpiii, a promoter for the specific expression of genes in retinal pigment epithelium |
| WO2020084541A1 (en) * | 2018-10-25 | 2020-04-30 | Friedrich Miescher Institute For Biomedical Research | Synp151 (proc29), a promoter for the specific expression of genes in retinal ganglion cells |
| CN117157091A (zh) * | 2021-02-22 | 2023-12-01 | 科罗拉多大学董事会法人团体 | 基于病毒载体的眼部病症的基因治疗 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3437473A1 (en) * | 2006-05-04 | 2019-02-06 | Wayne State University | Restoration of visual responses by in vivo delivery of rhodopsin nucleic acids |
| EP1891976A1 (en) | 2006-08-23 | 2008-02-27 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute for Biomedical Research | Use of light sensitive genes |
| KR20100136550A (ko) | 2008-04-18 | 2010-12-28 | 노파르티스 포르슝스티프퉁 쯔바이크니덜라쑹 프리드리히 미셔 인스티튜트 포 바이오메디칼 리서치 | 실명을 치료하기 위한 신규의 치료 도구 및 방법 |
| CN104857526B (zh) * | 2008-10-22 | 2019-03-05 | 夸克制药公司 | 治疗眼部疾病的方法 |
| US20140287510A1 (en) * | 2011-11-08 | 2014-09-25 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute | Rod cell-specific promoter |
| US9579399B2 (en) | 2012-08-27 | 2017-02-28 | Friedrich Miescher Institute For Biomedical Research | Retinal OFF circuit-specific promoter |
| AU2014265799B2 (en) * | 2013-05-16 | 2019-10-31 | Applied Genetic Technologies Corporation | Promoters, expression cassettes, vectors, kits, and methods for the treatment of achromatopsia and other diseases |
| EP3007730A1 (en) | 2013-06-11 | 2016-04-20 | Friedrich Miescher Institute for Biomedical Research | Retinal on bipolar cells-specific artificial promoter |
| WO2015118507A1 (en) | 2014-02-10 | 2015-08-13 | Friedrich Miescher Institute For Biomedical Research | Aii retinal amacrine cell-specific promoter |
| US10179917B2 (en) | 2014-02-11 | 2019-01-15 | Friedrich Miescher Institute For Biomedical Research | Muller cell-specific promoter |
| EP3289090B1 (en) | 2015-04-30 | 2019-06-26 | Friedrich Miescher Institute for Biomedical Research | Promoter for the specific expression of genes in müller cells |
| ES2926677T3 (es) | 2015-09-15 | 2022-10-27 | Friedrich Miescher Institute For Biomedical Res | Herramientas y métodos terapéuticos novedosos para tratar la ceguera mediante el direccionamiento a los fotorreceptores |
| ES2881782T3 (es) | 2015-10-14 | 2021-11-30 | Friedrich Miescher Institute For Biomedical Res | Promotor para la expresión específica de genes en células endoteliales retinianas. |
| ES2761328T3 (es) | 2015-12-03 | 2020-05-19 | Friedrich Miescher Institute For Biomedical Res | SynP161, un promotor para la expresión específica de genes en fotorreceptores de bastón |
| CN108474001B (zh) | 2015-12-03 | 2022-04-08 | 弗里德里克·米谢尔生物医学研究所 | SynP160，用于基因在视杆光感受器中特异性表达的启动子 |
| ES2886664T3 (es) | 2015-12-03 | 2021-12-20 | Friedrich Miescher Institute For Biomedical Res | SynP162, un promotor para la expresión específica de genes en fotorreceptores de bastón |
| CN108430519B (zh) | 2015-12-03 | 2022-04-15 | 弗里德里克·米谢尔生物医学研究所 | SynP159，用于基因在视杆光感受器中特异性表达的启动子 |
| CA3004807C (en) | 2015-12-04 | 2022-02-22 | Universite Pierre Et Marie Curie (Paris 6) | Promoters and uses thereof |
| WO2017199156A1 (en) | 2016-05-17 | 2017-11-23 | Friedrich Miescher Institute For Biomedical Research | Novel therapeutic tools and methods for treating blindness |
| CA3042197A1 (en) | 2016-11-02 | 2018-05-11 | Friedrich Miescher Institute For Biomedical Research | Synp198, a promoter for the specific expression of genes in direction selective retinal ganglion cells |
| JP2020501538A (ja) | 2016-12-01 | 2020-01-23 | フリードリッヒ ミーシェー インスティトゥート フォー バイオメディカル リサーチ | インターニューロン中の遺伝子の特異的発現のためのプロモーターｓｙｎｐｉ |
| JP7071361B2 (ja) | 2016-12-01 | 2022-05-18 | フリードリッヒ ミーシェー インスティトゥート フォー バイオメディカル リサーチ | インターニューロン中の遺伝子の特異的発現のためのプロモーターｓｙｎｐ１０７ |
| JP7112414B2 (ja) | 2017-02-08 | 2022-08-03 | フリードリッヒ ミーシェー インスティトゥート フォー バイオメディカル リサーチ | 網膜神経節細胞中の遺伝子の特異的発現のためのプロモーターｓｙｎｐ８８ |
| CA3082080A1 (en) | 2017-11-15 | 2019-05-23 | Friedrich Miescher Institute For Biomedical Research | Primate retinal pigment epithelium cell-specific promoter |
| EP3717651A1 (en) | 2017-11-30 | 2020-10-07 | Friedrich Miescher Institute for Biomedical Research | Synpiii, a promoter for the specific expression of genes in retinal pigment epithelium |
| CR20200235A (es) | 2017-11-30 | 2020-10-19 | Friedrich Miescher Institute For Biomedical Res | Synp61, un promotor específico de células del epitelio pigmentario retiniano de primates |
| EP3870240A1 (en) | 2018-10-25 | 2021-09-01 | Friedrich Miescher Institute for Biomedical Research | Synp78 (proa27), a promoter for the specific expression of genes in retinal ganglion cells |
| WO2020084537A1 (en) | 2018-10-25 | 2020-04-30 | Friedrich Miescher Institute For Biomedical Research | Synp17 (prob1), a promoter for the specific expression of genes in retinal ganglion cells |
| EP3870709A1 (en) | 2018-10-25 | 2021-09-01 | Friedrich Miescher Institute for Biomedical Research | Synp27 (prob12), a promoter for the specific expression of genes in protoplasmic astrocytes |
| WO2020084539A1 (en) | 2018-10-25 | 2020-04-30 | Friedrich Miescher Institute For Biomedical Research | Synp57 (proa14), a promoter for the specific expression of genes in photoreceptors |
| WO2020084541A1 (en) | 2018-10-25 | 2020-04-30 | Friedrich Miescher Institute For Biomedical Research | Synp151 (proc29), a promoter for the specific expression of genes in retinal ganglion cells |
| CN112912508A (zh) | 2018-10-25 | 2021-06-04 | 弗里德里克·米谢尔生物医学研究所 | 用于使基因在视网膜神经节细胞中特异性表达的启动子SynP194(ProB15) |
| US20220119841A1 (en) | 2019-01-24 | 2022-04-21 | Friedrich Miescher Instit for Biomedical Research | Synp5 (proa9), a promoter for the specific expression of genes in retinal ganglion cells |
| WO2020152626A1 (en) | 2019-01-24 | 2020-07-30 | Friedrich Miescher Institute For Biomedical Research | Synp166 (proa36), a promoter for the specific expression of genes in photoreceptors |
| CN113316643A (zh) | 2019-01-24 | 2021-08-27 | 弗里德里克·米谢尔生物医学研究所 | 用于使基因在视网膜神经节细胞中特异性表达的启动子SynP35(ProC8) |
| EP3914300A1 (en) | 2019-01-24 | 2021-12-01 | Friedrich Miescher Institute for Biomedical Research | Synp66 (proa21), a promoter for the specific expression of genes in retinal ganglion cells |
| PH12021552038A1 (en) | 2019-02-25 | 2023-01-04 | Friedrich Miescher Institute For Biomedical Res | Compositions and methods to treat bietti crystalline dystrophy |
| JP2022520875A (ja) | 2019-02-25 | 2022-04-01 | ノバルティス アーゲー | Ｂｉｅｔｔｉクリスタリン網膜症を治療するための組成物及び方法 |
-
2017
- 2017-11-01 CA CA3042197A patent/CA3042197A1/en not_active Abandoned
- 2017-11-01 JP JP2019522550A patent/JP7023279B2/ja not_active Expired - Fee Related
- 2017-11-01 EP EP17811378.3A patent/EP3534966B1/en active Active
- 2017-11-01 KR KR1020197015426A patent/KR20190077471A/ko not_active Ceased
- 2017-11-01 CN CN201780067090.8A patent/CN110072557B/zh not_active Expired - Fee Related
- 2017-11-01 RU RU2019115117A patent/RU2766353C2/ru active
- 2017-11-01 BR BR112019008488A patent/BR112019008488A2/pt not_active Application Discontinuation
- 2017-11-01 AU AU2017354086A patent/AU2017354086C1/en not_active Ceased
- 2017-11-01 US US16/346,680 patent/US11525145B2/en active Active
- 2017-11-01 WO PCT/IB2017/056792 patent/WO2018083607A1/en not_active Ceased
-
2019
- 2019-04-17 IL IL266115A patent/IL266115A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN110072557B (zh) | 2022-11-11 |
| KR20190077471A (ko) | 2019-07-03 |
| JP2019537437A (ja) | 2019-12-26 |
| AU2017354086C1 (en) | 2021-05-06 |
| RU2019115117A3 (cg-RX-API-DMAC7.html) | 2021-03-23 |
| CN110072557A (zh) | 2019-07-30 |
| WO2018083607A1 (en) | 2018-05-11 |
| JP7023279B2 (ja) | 2022-02-21 |
| EP3534966A1 (en) | 2019-09-11 |
| AU2017354086A1 (en) | 2019-05-09 |
| US11525145B2 (en) | 2022-12-13 |
| RU2019115117A (ru) | 2020-12-03 |
| RU2766353C2 (ru) | 2022-03-15 |
| EP3534966B1 (en) | 2024-06-19 |
| US20190276847A1 (en) | 2019-09-12 |
| BR112019008488A2 (pt) | 2019-07-09 |
| AU2017354086B2 (en) | 2021-01-28 |
| CA3042197A1 (en) | 2018-05-11 |
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