IL265461B2 - Modulation of micrornas against myotonic dystrophy type 1 and antagonists of micrornas therefor - Google Patents
Modulation of micrornas against myotonic dystrophy type 1 and antagonists of micrornas thereforInfo
- Publication number
- IL265461B2 IL265461B2 IL265461A IL26546119A IL265461B2 IL 265461 B2 IL265461 B2 IL 265461B2 IL 265461 A IL265461 A IL 265461A IL 26546119 A IL26546119 A IL 26546119A IL 265461 B2 IL265461 B2 IL 265461B2
- Authority
- IL
- Israel
- Prior art keywords
- mir
- expression
- seq
- antagomir
- oligoribonucleotide
- Prior art date
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
- C12N2310/141—MicroRNAs, miRNAs
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- Engineering & Computer Science (AREA)
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- Biomedical Technology (AREA)
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Applications Claiming Priority (2)
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| ES201631216A ES2659845B1 (es) | 2016-09-19 | 2016-09-19 | Modulación de microRNAs contra la distrofia miotónica tipo 1 y antagonistas de microRNAs para ello |
| PCT/EP2017/073685 WO2018050930A1 (en) | 2016-09-19 | 2017-09-19 | Modulation of micrornas against myotonic dystrophy type 1 and antagonists of micrornas therefor |
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| IL265461A IL265461A (en) | 2019-05-30 |
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| IL265461A IL265461B2 (en) | 2016-09-19 | 2017-09-19 | Modulation of micrornas against myotonic dystrophy type 1 and antagonists of micrornas therefor |
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| EP (2) | EP4269587A3 (https=) |
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| JP7221275B2 (ja) | 2017-08-03 | 2023-02-13 | ボイジャー セラピューティクス インコーポレイテッド | Ａａｖを送達するための組成物および方法 |
| JP7432929B2 (ja) * | 2018-05-31 | 2024-02-19 | コリア ユニバーシティ リサーチ アンド ビジネス ファウンデーション | マイクロｒｎａの非正規標的を抑制するｒｎａ干渉誘導核酸およびその用途 |
| US20210340537A1 (en) * | 2020-04-15 | 2021-11-04 | Duquesne University Of The Holy Spirit | AN RNA G-QUADRUPLEX STRUCTURE IN PRE-miRNA-1229 AS A THERAPEUTIC TARGET FOR ALZHEIMER'S DISEASE AND VARIOUS CANCERS |
| WO2023194641A1 (es) | 2022-04-06 | 2023-10-12 | Universitat De València | Antagonistas de los microrna humanos mir-100, mir-20, mir-222, mir-181, y mir-92 y usos de los mismos |
| ES2954008A1 (es) * | 2022-04-06 | 2023-11-17 | Univ Valencia | Antagonistas de los microRNA humanos miR-100, miR-20, miR-222, miR-181, y miR-92 y usos de los mismos |
| EP4282964A1 (en) * | 2022-05-23 | 2023-11-29 | Universitat de Valéncia | Oligonucleotides conjugated to oleic acid and uses thereof |
| ES3014830A1 (es) * | 2023-10-20 | 2025-04-25 | Arthex Biotech S L | Oligonucleotidos o analogos de los mismos para el tratamiento de la distrofia del endotelio corneal de fuchs |
| CN117467664B (zh) * | 2023-11-07 | 2024-06-21 | 江苏省家禽科学研究所 | 一种靶向鸡mbnl1基因的反义寡核苷酸及其应用 |
| WO2025114442A1 (en) * | 2023-11-28 | 2025-06-05 | Arthex Biotech S.L. | Oligonucleotides conjugated to oleic acid and uses thereof |
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| WO2005013901A2 (en) * | 2003-07-31 | 2005-02-17 | Isis Pharmaceuticals, Inc. | Oligomeric compounds and compositions for use in modulation of small non-coding rnas |
| WO2008116267A1 (en) * | 2007-03-26 | 2008-10-02 | Crc For Asthma And Airways Ltd | Therapeutic targets and molecules |
| WO2013159091A2 (en) * | 2012-04-20 | 2013-10-24 | Aptamir Therapeutics, Inc. | Mirna modulators of thermogenesis |
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| US5981505A (en) | 1993-01-26 | 1999-11-09 | The Trustees Of The University Of Pennsylvania | Compositions and methods for delivery of genetic material |
| US5837533A (en) | 1994-09-28 | 1998-11-17 | American Home Products Corporation | Complexes comprising a nucleic acid bound to a cationic polyamine having an endosome disruption agent |
| US5840710A (en) | 1994-12-09 | 1998-11-24 | Genzyme Corporation | Cationic amphiphiles containing ester or ether-linked lipophilic groups for intracellular delivery of therapeutic molecules |
| US6217900B1 (en) | 1997-04-30 | 2001-04-17 | American Home Products Corporation | Vesicular complexes and methods of making and using the same |
| DE69834038D1 (de) | 1997-07-01 | 2006-05-18 | Isis Pharmaceutical Inc | Zusammensetzungen und verfahren zur verabreichung von oligonukleotiden über die speiseröhre |
| WO2003093449A2 (en) | 2002-05-06 | 2003-11-13 | Nucleonics, Inc. | Methods for delivery of nucleic acids |
| EP1723162A4 (en) * | 2004-02-13 | 2010-05-05 | Univ Rockefeller | ANTI-microRNA oligonucleotide molecules |
| WO2006069584A2 (en) * | 2004-12-29 | 2006-07-06 | Exiqon A/S | NOVEL OLIGONUCLEOTIDE COMPOSITIONS AND PROBE SEQUENCES USEFUL FOR DETECTION AND ANALYSIS OF microRNAs AND THEIR TARGET mRNAs |
| EP1984499B1 (en) * | 2006-01-27 | 2015-05-27 | Isis Pharmaceuticals, Inc. | Oligomeric compounds and compositions for the use in modulation of micrornas |
| CA2648132C (en) * | 2006-04-03 | 2019-05-28 | Santaris Pharma A/S | Pharmaceutical composition comprising anti-mirna antisense oligonucleotides |
| EP3034083B1 (en) * | 2006-09-21 | 2020-12-09 | University of Rochester | Antisense oligonucleotides for use in treating myotonic dystrophy |
| WO2009012263A2 (en) * | 2007-07-18 | 2009-01-22 | The Trustees Of Columbia University In The City Of New York | Tissue-specific micrornas and compositions and uses thereof |
| JPWO2009148137A1 (ja) | 2008-06-04 | 2011-11-04 | 協和発酵キリン株式会社 | 肥満細胞の脱顆粒を制御する核酸 |
| CA2726052A1 (en) * | 2008-06-04 | 2009-12-10 | The Board Of Regents Of The University Of Texas System | Modulation of gene expression through endogenous small rna targeting of gene promoters |
| US8609615B2 (en) * | 2008-10-15 | 2013-12-17 | Valerion Therapeutics, Llc | Methods and compositions for treatment of myotonic dystrophy |
| US8852940B2 (en) * | 2009-04-01 | 2014-10-07 | The Regents Of The University Of California | Embryonic stem cell specific microRNAs promote induced pluripotency |
| WO2010139026A1 (en) * | 2009-06-05 | 2010-12-09 | Centenary Institute Of Cancer Medicine And Cell Biology | Therapeutic and diagnostic molecules |
| EP2275545A1 (en) * | 2009-07-16 | 2011-01-19 | Julius-Maximilians-Universität Würzburg | Use of microRNA-24 and/or its targets for the treatment and prevention of ischemia and induction of angiogenesis |
| CN102869386A (zh) | 2010-01-20 | 2013-01-09 | 得克萨斯系统大学董事会 | 用于治疗红细胞增多症的antimiR-451 |
| WO2012012467A2 (en) * | 2010-07-19 | 2012-01-26 | Isis Pharmaceuticals, Inc. | Modulation of nuclear-retained rna |
| US8729046B2 (en) * | 2011-12-07 | 2014-05-20 | Albert Einstein College Of Medicine Of Yeshiva University | MIR27B is a novel target for treatment of liver fibrosis |
| KR20130083965A (ko) * | 2012-01-16 | 2013-07-24 | 김승찬 | 시험관내 배양된 세포주 에 hsa-miR-218 miRNA에 대한 DNA antisense oligomer 처리 및 신호전달체계 변경 방법 |
| GB201202228D0 (en) * | 2012-02-08 | 2012-03-28 | Queen Mary & Westfield College | Reversal of replicative senescence |
| EP3230454A1 (en) | 2014-12-09 | 2017-10-18 | Pierfrancesco Tassone | Inhibitors of mir-17-92 cluster for anti-tumor activity in multiple myeloma and other malignancies |
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2016
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2017
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- 2021-11-12 US US17/525,672 patent/US20220133774A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005013901A2 (en) * | 2003-07-31 | 2005-02-17 | Isis Pharmaceuticals, Inc. | Oligomeric compounds and compositions for use in modulation of small non-coding rnas |
| WO2008116267A1 (en) * | 2007-03-26 | 2008-10-02 | Crc For Asthma And Airways Ltd | Therapeutic targets and molecules |
| WO2013159091A2 (en) * | 2012-04-20 | 2013-10-24 | Aptamir Therapeutics, Inc. | Mirna modulators of thermogenesis |
Also Published As
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| JP2019531092A (ja) | 2019-10-31 |
| JP6919098B2 (ja) | 2021-08-18 |
| AU2017328728B2 (en) | 2021-07-29 |
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| EP3516059A1 (en) | 2019-07-31 |
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| IL265461A (en) | 2019-05-30 |
| CA3037288A1 (en) | 2018-03-22 |
| ES2659845B1 (es) | 2019-01-04 |
| WO2018050930A1 (en) | 2018-03-22 |
| AU2017328728A1 (en) | 2019-05-16 |
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| EP4269587A2 (en) | 2023-11-01 |
| CA3037288C (en) | 2024-01-16 |
| AU2021257890A1 (en) | 2021-11-18 |
| US20190231809A1 (en) | 2019-08-01 |
| EP4269587A3 (en) | 2024-07-10 |
| US11202794B2 (en) | 2021-12-21 |
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