IL264961B2 - Antibodies against VEGF–A and their uses - Google Patents
Antibodies against VEGF–A and their usesInfo
- Publication number
- IL264961B2 IL264961B2 IL264961A IL26496119A IL264961B2 IL 264961 B2 IL264961 B2 IL 264961B2 IL 264961 A IL264961 A IL 264961A IL 26496119 A IL26496119 A IL 26496119A IL 264961 B2 IL264961 B2 IL 264961B2
- Authority
- IL
- Israel
- Prior art keywords
- antibody
- binding
- amino acid
- acid sequence
- lcdr2
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662378391P | 2016-08-23 | 2016-08-23 | |
| PCT/EP2017/071106 WO2018037001A1 (en) | 2016-08-23 | 2017-08-22 | Anti-vegf-a antibodies and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IL264961A IL264961A (enExample) | 2019-04-30 |
| IL264961B1 IL264961B1 (en) | 2024-10-01 |
| IL264961B2 true IL264961B2 (en) | 2025-02-01 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| IL264961A IL264961B2 (en) | 2016-08-23 | 2017-08-22 | Antibodies against VEGF–A and their uses |
Country Status (10)
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| EP (2) | EP3783022A3 (enExample) |
| JP (2) | JP6949106B2 (enExample) |
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| CN (1) | CN109863172B (enExample) |
| AU (2) | AU2017315076B2 (enExample) |
| CA (1) | CA3034576A1 (enExample) |
| ES (1) | ES2836286T3 (enExample) |
| IL (1) | IL264961B2 (enExample) |
| WO (1) | WO2018037001A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP7485273B2 (ja) * | 2020-06-25 | 2024-05-16 | 国立大学法人 鹿児島大学 | 抗ｖｅｇｆ－ａ抗体による癌に対する治療応答性を予測又は決定するための方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998045331A2 (en) * | 1997-04-07 | 1998-10-15 | Genentech, Inc. | Anti-vegf antibodies |
| WO2009120922A2 (en) * | 2008-03-27 | 2009-10-01 | Zymogenetics, Inc. | Compositions and methods for inhibiting pdgfrbeta and vegf-a |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5981216A (en) | 1985-04-01 | 1999-11-09 | Alusuisse Holdings A.G. | Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same |
| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
| GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
| EP2338915A3 (en) * | 1997-04-07 | 2011-10-12 | Genentech, Inc. | Anti-VEGF antibodies |
| KR100787073B1 (ko) | 2000-06-28 | 2007-12-21 | 글리코파이, 인크. | 변형된 당단백질의 제조방법 |
| WO2007084922A2 (en) | 2006-01-17 | 2007-07-26 | Biolex Therapeutics, Inc. | Compositions and methods for humanization and optimization of n-glycans in plants |
| US20110076279A1 (en) * | 2006-10-20 | 2011-03-31 | Schering Corporation | Fully human anti-vegf antibodies and methods of using |
| EP1995309A1 (en) | 2007-05-21 | 2008-11-26 | Vivalis | Recombinant protein production in avian EBx® cells |
| WO2010124009A2 (en) * | 2009-04-21 | 2010-10-28 | Schering Corporation | Fully human anti-vegf antibodies and methods of using |
| CN102276722B (zh) * | 2011-01-14 | 2013-05-08 | 中国科学院北京基因组研究所 | 新型血管内皮生长因子人源化单克隆抗体 |
| US9527925B2 (en) * | 2011-04-01 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to VEGF and ANG2 |
| ES2749349T3 (es) * | 2011-11-07 | 2020-03-19 | Medimmune Llc | Proteínas de unión multiespecíficas y multivalentes y usos de las mismas |
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2017
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- 2017-08-22 US US16/327,362 patent/US10919958B2/en active Active
- 2017-08-22 WO PCT/EP2017/071106 patent/WO2018037001A1/en not_active Ceased
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- 2017-08-22 IL IL264961A patent/IL264961B2/en unknown
- 2017-08-22 EP EP20189960.6A patent/EP3783022A3/en active Pending
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- 2017-08-22 CA CA3034576A patent/CA3034576A1/en active Pending
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2020
- 2020-12-18 AU AU2020289850A patent/AU2020289850B2/en active Active
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2021
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998045331A2 (en) * | 1997-04-07 | 1998-10-15 | Genentech, Inc. | Anti-vegf antibodies |
| WO2009120922A2 (en) * | 2008-03-27 | 2009-10-01 | Zymogenetics, Inc. | Compositions and methods for inhibiting pdgfrbeta and vegf-a |
Non-Patent Citations (4)
| Title |
|---|
| CAI, CHENGZHONG, ET AL., DIFFERENTIAL EXPRESSION OF VEGF121, VEGF165 AND VEGF189 IN ANGIOMAS AND SQUAMOUS CELL CARCINOMA CELL LINES OF THE HEAD AND NECK., 1 March 2010 (2010-03-01) * |
| MOHAMED MUHSIN ET AL:, FRESH FROM THE PIPELINE: BEVACIZUMAB, 1 December 2004 (2004-12-01) * |
| PODAR, KLAUS, AND KENNETH C. ANDERSON., THE PATHOPHYSIOLOGIC ROLE OF VEGF IN HEMATOLOGIC MALIGNANCIES: THERAPEUTIC IMPLICATIONS., 7 October 2005 (2005-10-07) * |
| STEPHAN DU EBEL ED - STEFAN DUBEL:, HANDBOOK OF THERAPEUTIC ANTIBODIESCHAPTER 6, 1 January 2007 (2007-01-01) * |
Also Published As
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| AU2017315076B2 (en) | 2020-10-08 |
| EP3504236B1 (en) | 2020-09-23 |
| JP2019528074A (ja) | 2019-10-10 |
| AU2020289850A1 (en) | 2021-01-28 |
| US10919958B2 (en) | 2021-02-16 |
| JP7277531B2 (ja) | 2023-05-19 |
| AU2020289850B2 (en) | 2024-06-06 |
| JP6949106B2 (ja) | 2021-10-13 |
| CN109863172B (zh) | 2022-08-26 |
| US11634483B2 (en) | 2023-04-25 |
| KR20190040029A (ko) | 2019-04-16 |
| AU2017315076A1 (en) | 2019-04-04 |
| EP3783022A2 (en) | 2021-02-24 |
| JP2022008447A (ja) | 2022-01-13 |
| EP3783022A3 (en) | 2021-06-30 |
| CN109863172A (zh) | 2019-06-07 |
| IL264961A (enExample) | 2019-04-30 |
| IL264961B1 (en) | 2024-10-01 |
| US20210147531A1 (en) | 2021-05-20 |
| CA3034576A1 (en) | 2018-03-01 |
| US20190202903A1 (en) | 2019-07-04 |
| KR102538827B1 (ko) | 2023-05-31 |
| WO2018037001A1 (en) | 2018-03-01 |
| ES2836286T3 (es) | 2021-06-24 |
| EP3504236A1 (en) | 2019-07-03 |
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