IL263004B - A new crystalline form of n-[5-(5,3-difluoro-benzyl)-h1-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4 -ilamino)-benzamide - Google Patents
A new crystalline form of n-[5-(5,3-difluoro-benzyl)-h1-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4 -ilamino)-benzamideInfo
- Publication number
- IL263004B IL263004B IL263004A IL26300418A IL263004B IL 263004 B IL263004 B IL 263004B IL 263004 A IL263004 A IL 263004A IL 26300418 A IL26300418 A IL 26300418A IL 263004 B IL263004 B IL 263004B
- Authority
- IL
- Israel
- Prior art keywords
- indazol
- ylamino
- piperazin
- benzamide
- pyran
- Prior art date
Links
- HAYYBYPASCDWEQ-UHFFFAOYSA-N n-[5-[(3,5-difluorophenyl)methyl]-1h-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-2-(oxan-4-ylamino)benzamide Chemical compound C1CN(C)CCN1C(C=C1NC2CCOCC2)=CC=C1C(=O)NC(C1=C2)=NNC1=CC=C2CC1=CC(F)=CC(F)=C1 HAYYBYPASCDWEQ-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662340797P | 2016-05-24 | 2016-05-24 | |
| PCT/EP2017/061919 WO2017202674A1 (en) | 2016-05-24 | 2017-05-18 | New crystalline form of n-[5-(3,5-difluoro-benzyl)-1h-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL263004A IL263004A (en) | 2018-12-31 |
| IL263004B true IL263004B (en) | 2022-04-01 |
Family
ID=58709993
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL263004A IL263004B (en) | 2016-05-24 | 2018-11-14 | A new crystalline form of n-[5-(5,3-difluoro-benzyl)-h1-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4 -ilamino)-benzamide |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10738037B2 (enExample) |
| EP (2) | EP3464276B1 (enExample) |
| JP (2) | JP7094228B2 (enExample) |
| KR (1) | KR102441736B1 (enExample) |
| CN (1) | CN109153669B (enExample) |
| AU (1) | AU2017271458B2 (enExample) |
| CA (1) | CA3024208C (enExample) |
| ES (1) | ES2899953T3 (enExample) |
| IL (1) | IL263004B (enExample) |
| MX (1) | MX379558B (enExample) |
| PL (1) | PL3464276T3 (enExample) |
| WO (1) | WO2017202674A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX379558B (es) * | 2016-05-24 | 2025-03-11 | Nerviano Medical Sciences Srl | Nueva forma cristalina de n-[5-(3,5-difluoro-bencilo)-1h-indazol-3-il]-4-(4-metilo-piperazina-1-il)-2-(tetrahidro-pirano-4-ilamino)-benzamida. |
| JP7523521B2 (ja) | 2019-07-31 | 2024-07-26 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | 新規医薬製剤 |
| US20220372024A1 (en) * | 2019-11-01 | 2022-11-24 | Johnson Matthey Public Limited Company | Crystalline forms of entrectinib |
| CN113024521B (zh) * | 2019-12-09 | 2023-01-17 | 武汉九州钰民医药科技有限公司 | 一种制备恩曲替尼的方法 |
| CN111171009B (zh) * | 2020-01-10 | 2022-07-12 | 安礼特（上海）医药科技有限公司 | 恩曲替尼晶型及其制备方法 |
| CN113354626B (zh) * | 2020-03-04 | 2025-06-03 | 罗欣药业(上海)有限公司 | 恩曲替尼的晶型及其制备方法 |
| CN113801062B (zh) * | 2020-06-15 | 2023-05-26 | 沈阳药科大学 | 3-氨基-5-(3,5-二氟苄基)-1h-吲唑的制备方法 |
| CN112336723B (zh) * | 2020-12-11 | 2023-09-26 | 江南大学 | 制备用于降低trpv4与nox2耦联度的药物的方法 |
| WO2022166647A1 (zh) | 2021-02-03 | 2022-08-11 | 齐鲁制药有限公司 | 恩曲替尼晶型及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5506674B2 (ja) | 2007-07-20 | 2014-05-28 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | キナーゼ阻害剤として活性な置換インダゾール誘導体 |
| PL3333166T3 (pl) * | 2012-05-23 | 2020-09-07 | Nerviano Medical Sciences S.R.L. | Proces otrzymywania n-[5-(3,5-difluorobenzylo)-1h-indazol-3-ilo]- 4-(4-metylopiperazyn-1-ylo)-2-(tetrahydropiran- 4-yloamino)benzamidu |
| TWI672141B (zh) | 2014-02-20 | 2019-09-21 | 美商醫科泰生技 | 投予ｒｏｓ１突變癌細胞之分子 |
| MX379558B (es) | 2016-05-24 | 2025-03-11 | Nerviano Medical Sciences Srl | Nueva forma cristalina de n-[5-(3,5-difluoro-bencilo)-1h-indazol-3-il]-4-(4-metilo-piperazina-1-il)-2-(tetrahidro-pirano-4-ilamino)-benzamida. |
-
2017
- 2017-05-18 MX MX2018014298A patent/MX379558B/es unknown
- 2017-05-18 ES ES17724052T patent/ES2899953T3/es active Active
- 2017-05-18 CA CA3024208A patent/CA3024208C/en active Active
- 2017-05-18 AU AU2017271458A patent/AU2017271458B2/en active Active
- 2017-05-18 WO PCT/EP2017/061919 patent/WO2017202674A1/en not_active Ceased
- 2017-05-18 US US16/301,826 patent/US10738037B2/en active Active
- 2017-05-18 CN CN201780031576.6A patent/CN109153669B/zh active Active
- 2017-05-18 JP JP2018561474A patent/JP7094228B2/ja active Active
- 2017-05-18 KR KR1020187037182A patent/KR102441736B1/ko active Active
- 2017-05-18 EP EP17724052.0A patent/EP3464276B1/en active Active
- 2017-05-18 EP EP21188238.6A patent/EP3967689A1/en not_active Withdrawn
- 2017-05-18 PL PL17724052T patent/PL3464276T3/pl unknown
-
2018
- 2018-11-14 IL IL263004A patent/IL263004B/en unknown
-
2020
- 2020-06-26 US US16/912,965 patent/US11091469B2/en active Active
- 2020-11-06 JP JP2020185594A patent/JP7154271B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN109153669B (zh) | 2021-12-24 |
| US10738037B2 (en) | 2020-08-11 |
| US20200325122A1 (en) | 2020-10-15 |
| KR102441736B1 (ko) | 2022-09-13 |
| JP2019516749A (ja) | 2019-06-20 |
| ES2899953T3 (es) | 2022-03-15 |
| AU2017271458B2 (en) | 2020-11-26 |
| PL3464276T3 (pl) | 2022-04-04 |
| CN109153669A (zh) | 2019-01-04 |
| CA3024208A1 (en) | 2017-11-30 |
| EP3967689A1 (en) | 2022-03-16 |
| JP7094228B2 (ja) | 2022-07-01 |
| JP7154271B2 (ja) | 2022-10-17 |
| MX2018014298A (es) | 2019-03-14 |
| BR112018073951A2 (pt) | 2019-02-26 |
| AU2017271458A1 (en) | 2019-01-17 |
| US20190169173A1 (en) | 2019-06-06 |
| WO2017202674A1 (en) | 2017-11-30 |
| CA3024208C (en) | 2022-07-26 |
| IL263004A (en) | 2018-12-31 |
| KR20190005236A (ko) | 2019-01-15 |
| EP3464276A1 (en) | 2019-04-10 |
| JP2021042213A (ja) | 2021-03-18 |
| EP3464276B1 (en) | 2021-09-01 |
| MX379558B (es) | 2025-03-11 |
| HK1259405A1 (zh) | 2019-11-29 |
| US11091469B2 (en) | 2021-08-17 |
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