IL23647A - Single stable dose vaccinator - Google Patents

Description

ARNAN PATENTS FORM δ PATENTS AND DESIGNS ORDINANCE stable SPECIFICATIO both of do hereby declare the nature of this invention and what manner the same is to be to be particularly described and ascertained in and by the invention relates to an vaccinator and more particalarly to a vaccinator which carries a single stable dose of or be of scratch type or of the are well Such instruments to utilise liquid But in the case of certain liquid for smallpox the liquid has a relatively shelf life of about 90 and then only when maintained or smallpox vaccine a longer shelf of about 18 months when in dried and furthermore does not have to be refrigerated until reactivation by a liquid the object of this invention is provide an iraproved or scarifier device wherein the scarifier provides multiple inexpensive scariication points and which device provides thereon the biological la precisely where it is to be so that application of the biological occurs eously with the effecting of and which device does not necessarily rely upon generation of lymph or blood to effect activation of the dried or Another object of this invention is to provide an improved multiple point scarifying the points are clustered closely together and a dried biological such as virus or is deposited crotches defined by pairs of multiple points to provide effective retention and desirable location of the biological substance for ease in and in application the biological and to effect production of a product that tially assures uniformity of Further objects and advantages of tMs invention will apparent aa the following description proceeds and the features of vMch characterise this invention will be pointed out with particularity in the claims annexed to and part of tMs Figure 1 is a greatly enlarged top plan view of one form of the scarifying portion of a vaccinator embodying certain of the features of my and shows the rigid pressure base and cluster of puncture points extending Figure 2 a side elevation view of the pressure base and puncture points shown in Figure 1 Figure shows use of the device of Figure 2 the puncture points loaded with liquid such as a prior to the of the Figure 4 shows the device of Figure after the liquid biological has been dried by and illustrates the dried biological retained in position between pairs of puncture Figure is an enlarged elevational view illustrating another fora of scarifier loaded with lyophilised Figure 6 is a side elevation view of the device in Figure 5 taken from the right of Figure Figure 7 is a bottom plan view of the device of Figure and Figure 8 is a side elevation view illustrating a typical sealed package enclosing the combination scariier with dried vaccine The device of this primarily intended effecting smallpox but it will be readily understood that the principles hereinafter disclosed utility in tuberculin testing and in other where a biological substance is intended to be applied to d portion of and where the device for such operation is to be a discardable instrument having an extended shelf life prior to use that does not require elaborate or uneconomical storage Referring now to the figures 1 and one basic of scarifier 18 for effecting pressure includes a generally pressure base 20 that is thin bat relatively am abruptly projecting central platform and nine closely equally puncture points 24 opposite sides aa included angle of about 12 degrees She points 24 are in three straight rows each containing three She platfora 22 is square with an edge ia the order of extended of the puncture points 24 are spaced approximately from base and the or of the 22 is approximately of the said She platform 22 serves to prevent sneering of the The border portion 21 on the base is of substantially uniform width and completely surrounds the platfora She width of the border portion 21 substantially the save the edge width of the platfora so that the area of base 20 is about nine times the area of the platform She cluster of nine elongated puncture points within a square area of than along a provides a considerable of area both along the sides of the pyramids 24 and at the surface of 22 from whence the points 24 so that when a small amount of such a portion of a is or onto the duster of points the surface tension between the vaccine and the contacted surfaces of the puncture points 24 and platform 22 is such that the scarifer 18 be to even an inverted position without the vaccine leaving the puncture features are disclosed in the earlier patent in In the present the aforenoted characteristic of holding liquid vaccine la on a point scarifier assists providing a single stable dose Each pair of adjacent scarifier points 24 therebetween a or crotch Zhe presence of a pair of closely adjacent points 24 provides structural that greatly enhance in rather than in the effect of or reactance to tension of a as compared with the ability of an unassisted single point similarly utilise effects of surface tension of a each crotch 26 defined by a pair of points 24 say be easily or fully bridged by a load of liquid vaccina by or the liquid vaccine the dry residue of the drying process remains in the crotch 26 and effects surprisingly greater tenacity to the surfaces of points 24 and to the surface of platform 22 than could be effected by forcing the dried vaccine unde pressure such a crotch scarifier has been provided with the residue of a predetermined amount of liquid vaccine retained on and between pairs of it will be aeen that additioa of sufficient distilled or in only amount to be retained by surface tension on points 24 provide the sane amount of liquid that had disappeared aa a result of the drying and hence the dried vaccine is capable of being reconstituted in the save dosage and concentration as in the original loading of liquid vaccine prior to a drying With the foregoing principles in point vaccinators of the herein disclosed vere loaded with smallpox vaccine dropped from a pipette onto the points as they faced After by aa hereinafter there was a plug of dried located in the interconnecting sockets between adjacent points 24 and against platform similar to that illustrated in Figure After reconstitution with a portion of a drop of sterile distilled as a in an sufficient to be retained on the points 24 by surface as illustrated in Figure successful vaccinations were effected by pressing the multiple points 24 with vaccine loaded thereon against a selected skin area on the individual being results obtained with use of these devices identical in and all other measurable or observable as those obtained with the use of liquid Ho ill effects devices structed and tested were afficacioue and not of the scarifier points 24 may be effected either by dropping liquid onto upwardly facing or by dipping facing points into a or of vaccine and holding it in such position until the capillary action and surface tension has operated to folly points liquid latter process has been determined to be feasible because the capillarity of the pairs of adjacen points 24 and the liquid tension of the vaccine will effect loading of the crotches as illustrated in Figure After loading of liquid vaccine onto the points it 4s subjected to a process in a refrigerated chamber talned initially at to at A drying period of 24 hoars at these conditions is sufficient to insure complete The is then evacuated and vaccine dried the frozen state in chamber teaperature is then gradually raised to by means of an neat source to complete the drying She chamber is then vented with sterile dry residual moisture of the dried vaccine should preferably be less than Figure 4 illustrates the appearance of a point scarifier with dried thereon produced by n After the device is preferably packaged under aseptic conditions in the presence of dry nitrogen to prevent the dried vaccine from absorbing device for packaged in a heat transparent envelope of cellophane or plastio a polyethylene oonraining dry nitrogen gas type of packaging provides long stability for dry device of figures 1 and 2 preferably provided with a such as a or elongated rod 28 attached to or made integral with the back side of base of manipulator 28 may be round or of the same periphery as base as long as provides a convenient grasp to A preferred form of manipulator the thumb ring mounting specifically illustrated in Figures v the of device Figures 5 7 there is provided an scarifier and manipulator molded of a plastic material including a split thumb mounting with a flattened internal for pressure by a thumb surface is back of a circular 44 having smear platform 46 from whence extend nine pressure puncture points points 48 n are clustered more tightly on platform 46 than in Figures the points 48 being spaced inwardly from the edge of platform the length of points 24 and 48 about It is believed that the preferable range of point length is said length plus or minus a fev to 5 hundredths of a Xhe spacing of the tips of a pair of points 24 ie about while the spacing of the tips of a pair of points 48 in Figures is about desirable range of spacing of the of a pair of scarifying points to effect desired about om plus a few hundredths of a while theoretically there is no lini to the spacing of the except for the practicality of insuring a suficient size of 26 to receive and retain en adequate amount of vaccine or other biological the use of the only a single dose of or is required to be reconstituted in order to provide a While the of device disclosed use of scarifying it will be that or less points may be although the theoretical considerations set oat above for obtaining an predictable result that may be duplicated requires at least two scarifying points defining a crotch that may be consistently and uniformly The loading of points is economical in the use of vaccine than in previous For present single dosage of liquid vaccine carried in a frangible glass tube is approximately to of Only about of vaccine is needed to load the nine point device of Figures less is needed with the device of Figures if less points a further reduced volume of liquid vaccine wold required for pressure points are used in the devices disclosed herein because vim that of points only a single pressure of the instrument ia required to effect substantially 100 with infante and If nore prickings scartchings are to be the number of scarifying points required nay be The scarifier points say be of any desired including plastics or the scarifiers are from points could also be While the device herein has been described for use in effecting vaccination against it will be readily apparent to those skilled in the art that the device and its of use stay be successfully used In other related fields and with other such for in effecting tuberculin use of C and in effecting virus insufficientOCRQuality

Claims (1)

While there has been shown and described a particular embodiment of this invention, it will be obvious to those skilled in the art that various changes and modifications may be made therein without departing from the invention and, therefore, it is intended in the appended clamms to cover all such changea and modi ications as fall wichin the true spirit and scope of the invention*

1. In a biological applicator of the type that includes a plurality of at least two scarifying needles projecting from a common support and a solid residue of dried biological substance carried by all said scarifying needles, the improvement comprising: the plurality of needles and the common support cooperating to define an elongated crotch space extending longitudinally between each pair of needles with one end of the crotch space adjacent the common support and with all the needles of the applicator clustered together, the spacing between the tips of the needles being in the range of 0.08 to 0.12 cm., each needle providing at least one side that bounds said crotoh space and which side is inclined along the length of the needle from the tip thereof to said common support so that the width dimension of the crotoh space is smaller adjacent the common su port than at the tips of the needles, a dried residue of a single liquid dose of biological substance carried at the common-support end of each crotch space and with the tip end of each needle from both the dried residue end the common support end being substantially free of suoh solid residue, the combined portions of each orotoh spaoe that is free of said dried residue providing a diluent-receiving-and-holding spaoe adapted to receive and hold therein an amount of liquid diluent that is retained therein by sur ace tension between the liquid diluent and the adjacent needles and is suf icient to precisely reconstitute the dried residue located at the other end of the crotch space, thereby providing an applicator that is required to be reconstituted be ore usage by an amount of liquid diluent to yield an effective and preoiee liquid dose of biologioal that is to be administered simulteneously with soarifioation by all the needles of the applioator. m A devioe as set orth in Claim 1, wherein the applioator includes at least 3 needles with each needle being common to at least each of two pairs of needles arranged in planes transverse to each other, so as to define between all the needles a orotoh spaoe whose total volume is enhanoed by a multiplicity of pairs of needles aoting An concert. Tel Aviv, this 30th day of May, 1965