IL234273A - Use of compounds for the preparation of leukemia treatment drugs - Google Patents
Use of compounds for the preparation of leukemia treatment drugsInfo
- Publication number
- IL234273A IL234273A IL234273A IL23427314A IL234273A IL 234273 A IL234273 A IL 234273A IL 234273 A IL234273 A IL 234273A IL 23427314 A IL23427314 A IL 23427314A IL 234273 A IL234273 A IL 234273A
- Authority
- IL
- Israel
- Prior art keywords
- leukemia
- cells
- compounds
- optionally substituted
- ref
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
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- C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
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- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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| PCT/US2013/030748 WO2013138430A1 (en) | 2012-03-14 | 2013-03-13 | Compounds and methods for treating leukemia |
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| EP3297623B1 (en) | 2015-05-21 | 2020-10-28 | Indiana University Research & Technology Corporation | Treatment of malignant peripheral nerve sheath tumors by targeting ape1/ref-1 to inhibit hypoxia signaling genes |
| WO2018140286A1 (en) * | 2017-01-25 | 2018-08-02 | Indiana University Research And Technology Corporation | Prophylaxis and treatment of acute myeloid leukemia |
| EP3735968A1 (en) * | 2017-03-20 | 2020-11-11 | Indiana University Research & Technology Corporation | Use of ape1/ref-1 inhibitors in combination therapies for treatment of cancer |
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| BR0206036A (pt) * | 2001-09-17 | 2004-01-06 | Daiichi Suntory Pharma Co Ltd | Derivados de ácido benzóico substituìdos tendo ação de inibição de nf-kb |
| US7494997B2 (en) * | 2002-06-28 | 2009-02-24 | Nippon Shinyaku Co., Ltd. | Amide derivative |
| FR2900150B1 (fr) * | 2006-04-25 | 2012-07-06 | Fluofarma | Composes de type 1,4-naphtoquinones, compositions les comprenant et utilisation de ces composes en tant qu'agent anti-cancereux |
| WO2008073509A2 (en) * | 2006-12-11 | 2008-06-19 | Genentech, Inc. | Compositions and methods for treating a neoplasm |
| US9040505B2 (en) | 2007-09-26 | 2015-05-26 | Indiana University Research And Technology Corporation | Benzoquinone derivative E3330 in combination with chemotherapeutic agents for the treatment of cancer and angiogenesis |
| CN102215833B (zh) * | 2007-11-21 | 2014-11-05 | 印第安纳大学研究及科技有限公司 | 苯醌衍生物e3330联合化疗剂用于治疗癌症和血管生成 |
| EP2252597B1 (en) * | 2008-02-01 | 2014-03-19 | Akinion Pharmaceuticals AB | Pyrazine derivatives and their use as protein kinase inhibitors |
| CN103781753B (zh) * | 2011-05-26 | 2016-08-17 | 印第安纳大学研究及科技有限公司 | 用于治疗ape1介导的疾病的醌化合物 |
| WO2012167122A1 (en) * | 2011-06-03 | 2012-12-06 | Indiana University Research And Technology Corporation | Compounds, compositions and methods for treating oxidative dna damage disorders |
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| US9315481B2 (en) | 2016-04-19 |
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| JP2015511604A (ja) | 2015-04-20 |
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