IL232325A0 - 18-methyl-7,6-methylene-3-oxo-17-paragan-4-en-21, 17b-carbolactones, pharmaceutical preparations containing these compounds and their use for the treatment of endometrial disease - Google Patents
18-methyl-7,6-methylene-3-oxo-17-paragan-4-en-21, 17b-carbolactones, pharmaceutical preparations containing these compounds and their use for the treatment of endometrial diseaseInfo
- Publication number
- IL232325A0 IL232325A0 IL232325A IL23232514A IL232325A0 IL 232325 A0 IL232325 A0 IL 232325A0 IL 232325 A IL232325 A IL 232325A IL 23232514 A IL23232514 A IL 23232514A IL 232325 A0 IL232325 A0 IL 232325A0
- Authority
- IL
- Israel
- Prior art keywords
- carbolactones
- pregn
- endometriosis
- ene
- oxo
- Prior art date
Links
- 201000009273 Endometriosis Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings
- C07J53/007—3 membered carbocyclic rings in position 6-7
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2011/069464 WO2012059594A1 (en) | 2010-11-04 | 2011-11-04 | Mineralcorticoid receptor antagonists for the treatment of corticoid-induced obesity |
| DE102012212838 | 2012-07-23 | ||
| PCT/EP2012/071700 WO2013064620A1 (de) | 2011-11-04 | 2012-11-02 | 18-METHYL-6,7-METHYLEN-3-OXO-17-PREGN-4-EN-21,17β-CARBOLACTONE, PHARMAZEUTISCHE PRÄPARATE ENTHALTEND DIE GENANNTEN VERBINDUNGEN UND DEREN ANWENDUNG BEI DER THERAPIE DER ENDOMETRIOSE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL232325A0 true IL232325A0 (en) | 2014-06-30 |
Family
ID=48191408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL232325A IL232325A0 (en) | 2011-11-04 | 2014-04-29 | 18-methyl-7,6-methylene-3-oxo-17-paragan-4-en-21, 17b-carbolactones, pharmaceutical preparations containing these compounds and their use for the treatment of endometrial disease |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20140288035A1 (enExample) |
| JP (1) | JP2014532685A (enExample) |
| KR (1) | KR20140088197A (enExample) |
| CN (1) | CN103957921A (enExample) |
| AR (1) | AR088622A1 (enExample) |
| AU (1) | AU2012331089A1 (enExample) |
| BR (1) | BR112014010590A2 (enExample) |
| CA (1) | CA2854215A1 (enExample) |
| EA (1) | EA201400537A1 (enExample) |
| HK (1) | HK1199712A1 (enExample) |
| IL (1) | IL232325A0 (enExample) |
| IN (1) | IN2014CN03307A (enExample) |
| MX (1) | MX2014005367A (enExample) |
| TW (1) | TW201322986A (enExample) |
| WO (1) | WO2013064620A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| RS62297B1 (sr) | 2011-11-23 | 2021-09-30 | Therapeuticsmd Inc | Prirodne kombinovane hormonske supstitucione formulacije i terapije |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| JP2017516768A (ja) | 2014-05-22 | 2017-06-22 | セラピューティックスエムディー インコーポレーテッドＴｈｅｒａｐｅｕｔｉｃｓｍｄ， Ｉｎｃ． | 天然の併用ホルモン補充療法剤及び療法 |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
| US9931349B2 (en) | 2016-04-01 | 2018-04-03 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
| CN117417303B (zh) * | 2023-10-19 | 2024-07-09 | 黑龙江中医药大学 | 一种用于治疗子宫内膜异位症的药物及其制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1183500B (de) | 1962-10-12 | 1964-12-17 | Schering Ag | Verfahren zur Herstellung von alpha, beta-Methylenketonen der Steroidreihe |
| FR1529949A (fr) | 1966-05-19 | 1968-06-21 | American Home Prod | Composés stéroïdes tels que 10-méthylgon-4-en-3-ones et leurs dérivés |
| DE1921396C3 (de) | 1969-04-23 | 1978-04-27 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | 17 a-Hydroperoxy-16 a, 18-dimethyl-20ketosteroide, Verfahren zur Herstellung derselben, sowie weitere entsprechende Zwischenprodukte |
| DE2922500A1 (de) | 1979-05-31 | 1980-12-04 | Schering Ag | 6 beta .7 beta |
| DE19633685C1 (de) * | 1996-08-12 | 1997-10-09 | Schering Ag | Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens |
| ATE442147T1 (de) | 2000-01-18 | 2009-09-15 | Bayer Schering Pharma Ag | Pharmazeutische zubereitung enthaltend drospirenon |
| CL2004000574A1 (es) * | 2003-03-21 | 2005-02-11 | Pharmacia Corp Sa Organizada B | Proceso para preparar un compuesto 17-espirolactona o la sal de lactona abierta por carbonilacion del correspondiente 17-alquenil o alquinil derivado, los intermediarios que se usan y su proceso de obtencion. |
| DE102007011105A1 (de) | 2007-03-02 | 2008-09-04 | Bayer Schering Pharma Aktiengesellschaft | Mineralcorticoid-Rezeptor-Antagonisten zur Behandlung von Endometriose |
| WO2012059594A1 (en) * | 2010-11-04 | 2012-05-10 | Bayer Pharma Aktiengesellschaft | Mineralcorticoid receptor antagonists for the treatment of corticoid-induced obesity |
-
2012
- 2012-11-02 KR KR1020147014686A patent/KR20140088197A/ko not_active Withdrawn
- 2012-11-02 TW TW101140872A patent/TW201322986A/zh unknown
- 2012-11-02 EA EA201400537A patent/EA201400537A1/ru unknown
- 2012-11-02 MX MX2014005367A patent/MX2014005367A/es not_active Application Discontinuation
- 2012-11-02 HK HK15100197.4A patent/HK1199712A1/xx unknown
- 2012-11-02 AU AU2012331089A patent/AU2012331089A1/en not_active Abandoned
- 2012-11-02 CN CN201280054180.0A patent/CN103957921A/zh active Pending
- 2012-11-02 WO PCT/EP2012/071700 patent/WO2013064620A1/de not_active Ceased
- 2012-11-02 AR ARP120104105A patent/AR088622A1/es unknown
- 2012-11-02 IN IN3307CHN2014 patent/IN2014CN03307A/en unknown
- 2012-11-02 CA CA2854215A patent/CA2854215A1/en not_active Abandoned
- 2012-11-02 JP JP2014539339A patent/JP2014532685A/ja active Pending
- 2012-11-02 BR BR112014010590A patent/BR112014010590A2/pt not_active Application Discontinuation
- 2012-11-02 US US14/356,165 patent/US20140288035A1/en not_active Abandoned
-
2014
- 2014-04-29 IL IL232325A patent/IL232325A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2012331089A1 (en) | 2014-05-22 |
| TW201322986A (zh) | 2013-06-16 |
| CA2854215A1 (en) | 2013-05-10 |
| MX2014005367A (es) | 2014-07-09 |
| BR112014010590A2 (pt) | 2017-05-02 |
| CN103957921A (zh) | 2014-07-30 |
| IN2014CN03307A (enExample) | 2015-07-03 |
| HK1199712A1 (en) | 2015-07-17 |
| US20140288035A1 (en) | 2014-09-25 |
| EA201400537A1 (ru) | 2014-10-30 |
| AR088622A1 (es) | 2014-06-25 |
| KR20140088197A (ko) | 2014-07-09 |
| WO2013064620A1 (de) | 2013-05-10 |
| JP2014532685A (ja) | 2014-12-08 |
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