IL227487A - Bipidobacteria growth regulation used in combination of oligosaccharides found in human milk - Google Patents
Bipidobacteria growth regulation used in combination of oligosaccharides found in human milkInfo
- Publication number
- IL227487A IL227487A IL227487A IL22748713A IL227487A IL 227487 A IL227487 A IL 227487A IL 227487 A IL227487 A IL 227487A IL 22748713 A IL22748713 A IL 22748713A IL 227487 A IL227487 A IL 227487A
- Authority
- IL
- Israel
- Prior art keywords
- bifidobacteria
- modulation
- growth
- combination
- human milk
- Prior art date
Links
- 241000186000 Bifidobacterium Species 0.000 title 1
- 210000004251 human milk Anatomy 0.000 title 1
- 235000020256 human milk Nutrition 0.000 title 1
- 229920001542 oligosaccharide Polymers 0.000 title 1
- 150000002482 oligosaccharides Chemical class 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/13—Fermented milk preparations; Treatment using microorganisms or enzymes using additives
- A23C9/1307—Milk products or derivatives; Fruit or vegetable juices; Sugars, sugar alcohols, sweeteners; Oligosaccharides; Organic acids or salts thereof or acidifying agents; Flavours, dyes or pigments; Inert or aerosol gases; Carbonation methods
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pediatric Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Dairy Products (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161441451P | 2011-02-10 | 2011-02-10 | |
PCT/IB2012/050511 WO2012107865A2 (fr) | 2011-02-10 | 2012-02-03 | Modulation de la croissance de bifidobactéries à l'aide d'une combinaison d'oligosaccharides trouvés dans le lait humain |
Publications (2)
Publication Number | Publication Date |
---|---|
IL227487A0 IL227487A0 (en) | 2013-09-30 |
IL227487A true IL227487A (en) | 2015-10-29 |
Family
ID=45809349
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL227487A IL227487A (en) | 2011-02-10 | 2013-07-15 | Bipidobacteria growth regulation used in combination of oligosaccharides found in human milk |
Country Status (18)
Country | Link |
---|---|
US (3) | US20140371173A1 (fr) |
EP (2) | EP2792252B1 (fr) |
CN (2) | CN103347405A (fr) |
AU (1) | AU2012215042B2 (fr) |
BR (1) | BR112013020108A2 (fr) |
CA (1) | CA2825697A1 (fr) |
CL (1) | CL2013002210A1 (fr) |
ES (2) | ES2692533T3 (fr) |
IL (1) | IL227487A (fr) |
MX (2) | MX362129B (fr) |
MY (1) | MY161034A (fr) |
PL (1) | PL2672844T3 (fr) |
PT (1) | PT2672844E (fr) |
RU (1) | RU2586928C2 (fr) |
SG (1) | SG192095A1 (fr) |
TW (1) | TW201244640A (fr) |
WO (1) | WO2012107865A2 (fr) |
ZA (1) | ZA201306751B (fr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2825697A1 (fr) | 2011-02-10 | 2012-08-16 | Nestec S.A. | Modulation de la croissance de bifidobacteries a l'aide d'une combinaison d'oligosaccharides trouves dans le lait humain |
RU2630299C2 (ru) | 2011-06-20 | 2017-09-06 | Г.Дж. Хайнц Компани Брэндс ЛЛК | Композиции, способ и наборы для стимулирования мукозальной иммунной системы |
US20150265661A1 (en) * | 2012-04-13 | 2015-09-24 | Trustees Of Boston College | Prebiotic effect of sialyllactose |
EP2708145B1 (fr) | 2012-09-14 | 2016-05-04 | Abbott Laboratories | Compositions nutritionnelles pour utilisation dans des méthodes pour moduler les niveaux de corticostérone chez des individus psychologiquement stressés |
WO2015157098A1 (fr) | 2014-04-08 | 2015-10-15 | Abbott Laboratories | Procédés pour améliorer les réponses immunitaires innée des muqueuses à et/ou la détection d'agents pathogènes à l'aide d'oligosaccharides de lait humain |
BR112017008284A8 (pt) * | 2014-10-24 | 2023-04-11 | Evolve Biosystems Inc | Bifidobactérias ativadas e métodos para uso das mesmas |
MX2017006701A (es) * | 2014-11-26 | 2018-02-13 | Abbott Lab | Fórmula infantil con rrr-alfa-tocoferol,2'-fucosilactosa y un probiótico. |
RU2706963C2 (ru) * | 2014-11-26 | 2019-11-21 | Абботт Лаборэтриз | Молочная смесь, содержащая олигосахариды грудного молока, полиненасыщенные жирные кислоты, нуклеотиды и лютеин |
US10835544B2 (en) | 2014-12-08 | 2020-11-17 | Glycom A/S | Synthetic composition for regulating satiety |
US10881674B2 (en) | 2014-12-08 | 2021-01-05 | Glycom A/S | Synthetic composition for treating metabolic disorders |
WO2016091265A1 (fr) * | 2014-12-08 | 2016-06-16 | Glycom A/S | Composition synthétique pour le traitement de troubles métaboliques |
US10987368B2 (en) | 2014-12-08 | 2021-04-27 | Glycom A/S | Synthetic composition for preventing or treating CVD |
EP3264921A1 (fr) * | 2015-03-05 | 2018-01-10 | Nestec S.A. | Compositions aux fins d'amélioration de la consistance et de la fréquence des selles chez les nourrissons et enfants en bas âge |
EP3368047B1 (fr) | 2015-10-28 | 2023-04-26 | Glycom A/S | Composition synthétique et procédé de modulation des troubles émotionnels et de l'humeur |
EP3368046B1 (fr) | 2015-10-28 | 2022-07-27 | Glycom A/S | Composition synthétique et procédé de modulation de la fonction cérébrale et du comportement |
EP3389668A4 (fr) * | 2015-12-15 | 2019-08-21 | Glycom A/S | Mélange de hmo |
AU2017302181B2 (en) | 2016-07-28 | 2023-02-02 | Fonterra Co-Operative Group Limited | Dairy product and process |
RU2765232C1 (ru) * | 2017-06-21 | 2022-01-26 | Эбботт Лабораториз | Способ улучшения роста полезных бактерий в желудочно-кишечном тракте |
US20220241354A1 (en) * | 2019-06-05 | 2022-08-04 | Morinaga Milk Industry Co., Ltd. | Composition |
JP7474596B2 (ja) * | 2020-01-20 | 2024-04-25 | 森永乳業株式会社 | 新規ビフィドバクテリウム属細菌、および当該細菌を含む組成物、並びに当該細菌の増殖促進用の組成物 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5260280A (en) | 1989-02-07 | 1993-11-09 | Snow Brand Milk Products Co., Ltd. | Bacterial toxin neutralizer |
CA2400737C (fr) * | 2000-02-17 | 2010-12-14 | Jeffrey L. Wilson | Formulation nutritionnelle contenant des substances prebiotiques |
WO2001060246A2 (fr) * | 2000-02-18 | 2001-08-23 | Argose, Inc. | Analyse multivariable de spectres allant du vert a l'ultraviolet d'echantillons cellulaires et tissulaires |
US6913778B2 (en) | 2001-12-21 | 2005-07-05 | Wyeth | Infant formula compositions comprising increased amounts of alpha-lactalbumin |
US7867541B2 (en) | 2003-04-14 | 2011-01-11 | Mead Johnson Nutrition Company | Compositions and methods of formulation for enteral formulas containing sialic acid |
US8394370B2 (en) | 2003-06-23 | 2013-03-12 | Nestec S.A. | Nutritional formula for optimal gut barrier function |
EP2497478A3 (fr) † | 2003-12-05 | 2012-11-07 | Children's Hospital Medical Center | Composition d'oligosaccarides et leur utilisation dans le traitement d'infection |
CN101299924A (zh) | 2005-11-04 | 2008-11-05 | 阿拉乳品公司 | 一种源于富含天然存在的唾液酰乳糖的乳制品的浓缩物及其制备方法 |
WO2007114683A1 (fr) * | 2006-03-30 | 2007-10-11 | N.V. Nutricia | Oligosaccharides de lait destinés à stimuler le système immunitaire |
EP2060257A1 (fr) * | 2007-11-08 | 2009-05-20 | Nestec S.A. | Prévention et traitement d'infections secondaires à la suite d'une infection virale |
EP2072052A1 (fr) * | 2007-12-17 | 2009-06-24 | Nestec S.A. | Prévention d'infections opportunistes dans des sujets dont l'immunité est fragilisée |
NL2001377C2 (nl) † | 2008-03-14 | 2009-09-15 | Friesland Brands Bv | Werkwijze voor het isoleren van siaalzuur bevattende oligosachariden, alsmede de hiermee verkrijgbare siaalzuur bevattende oligosachariden bevatttende samenstellingen. |
BR112012002223A2 (pt) * | 2009-07-31 | 2016-06-07 | Nestec Sa | composição nutricional para lactentes ou animais de estimação com probióticos e nutrientes selecionados |
NL2004200C2 (en) * | 2010-02-05 | 2011-08-08 | Friesland Brands Bv | Use of sialyl oligosaccharides in weight management. |
CN102858191A (zh) * | 2010-04-27 | 2013-01-02 | N.V.努特里奇亚 | 6’-唾液酸化乳糖在婴儿和幼儿营养物中的用途 |
WO2012092155A1 (fr) * | 2010-12-31 | 2012-07-05 | Abbott Laboratories | Combinaison symbiotique de probiotique et d'oligosaccharides de lait humain visant à favoriser la croissance d'un microbiote bénéfique |
CA2825697A1 (fr) | 2011-02-10 | 2012-08-16 | Nestec S.A. | Modulation de la croissance de bifidobacteries a l'aide d'une combinaison d'oligosaccharides trouves dans le lait humain |
-
2012
- 2012-02-03 CA CA2825697A patent/CA2825697A1/fr not_active Abandoned
- 2012-02-03 AU AU2012215042A patent/AU2012215042B2/en active Active
- 2012-02-03 CN CN2012800083041A patent/CN103347405A/zh active Pending
- 2012-02-03 CN CN201410384571.XA patent/CN104126749A/zh active Pending
- 2012-02-03 ES ES14177597.3T patent/ES2692533T3/es active Active
- 2012-02-03 MX MX2014008513A patent/MX362129B/es unknown
- 2012-02-03 SG SG2013056064A patent/SG192095A1/en unknown
- 2012-02-03 BR BR112013020108A patent/BR112013020108A2/pt not_active Application Discontinuation
- 2012-02-03 PL PL12707135T patent/PL2672844T3/pl unknown
- 2012-02-03 RU RU2013141449/13A patent/RU2586928C2/ru active
- 2012-02-03 MX MX2013009087A patent/MX345413B/es active IP Right Grant
- 2012-02-03 US US13/984,362 patent/US20140371173A1/en not_active Abandoned
- 2012-02-03 EP EP14177597.3A patent/EP2792252B1/fr active Active
- 2012-02-03 WO PCT/IB2012/050511 patent/WO2012107865A2/fr active Application Filing
- 2012-02-03 EP EP12707135.5A patent/EP2672844B2/fr active Active
- 2012-02-03 MY MYPI2013701285A patent/MY161034A/en unknown
- 2012-02-03 ES ES12707135T patent/ES2527200T5/es active Active
- 2012-02-03 PT PT127071355T patent/PT2672844E/pt unknown
- 2012-02-08 TW TW101104099A patent/TW201244640A/zh unknown
- 2012-02-09 US US13/369,619 patent/US20120208782A1/en not_active Abandoned
-
2013
- 2013-07-15 IL IL227487A patent/IL227487A/en not_active IP Right Cessation
- 2013-08-01 CL CL2013002210A patent/CL2013002210A1/es unknown
- 2013-09-09 ZA ZA2013/06751A patent/ZA201306751B/en unknown
-
2015
- 2015-01-26 US US14/604,951 patent/US20150141367A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20150141367A1 (en) | 2015-05-21 |
EP2792252A3 (fr) | 2015-03-25 |
ZA201306751B (en) | 2015-05-27 |
RU2013141449A (ru) | 2015-03-20 |
ES2527200T5 (es) | 2022-12-29 |
US20140371173A1 (en) | 2014-12-18 |
AU2012215042B2 (en) | 2016-01-14 |
CL2013002210A1 (es) | 2014-01-10 |
EP2792252A2 (fr) | 2014-10-22 |
TW201244640A (en) | 2012-11-16 |
EP2672844B2 (fr) | 2022-10-05 |
PL2672844T3 (pl) | 2015-04-30 |
RU2586928C2 (ru) | 2016-06-10 |
MX345413B (es) | 2017-01-27 |
EP2672844A2 (fr) | 2013-12-18 |
ES2527200T3 (es) | 2015-01-21 |
WO2012107865A2 (fr) | 2012-08-16 |
ES2692533T3 (es) | 2018-12-04 |
CN104126749A (zh) | 2014-11-05 |
US20120208782A1 (en) | 2012-08-16 |
EP2672844B1 (fr) | 2014-11-19 |
SG192095A1 (en) | 2013-08-30 |
PT2672844E (pt) | 2015-02-04 |
IL227487A0 (en) | 2013-09-30 |
CA2825697A1 (fr) | 2012-08-16 |
MY161034A (en) | 2017-04-14 |
MX362129B (es) | 2019-01-07 |
MX2013009087A (es) | 2013-09-13 |
BR112013020108A2 (pt) | 2017-06-13 |
EP2792252B1 (fr) | 2018-09-12 |
CN103347405A (zh) | 2013-10-09 |
WO2012107865A3 (fr) | 2012-11-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA201306751B (en) | Modulation of growth of bifidobacteria using a combination of oligosaccharides found in human milk | |
EP2675899A4 (fr) | Biosynthèse d'oligosaccharides de lait humain dans des bactéries manipulées | |
IL254322B (en) | Dental implant | |
HK1255686A1 (zh) | 用於調節炎症的人乳寡糖 | |
HK1214479A1 (zh) | 使用人乳低聚糖的用於調節炎症的營養製劑 | |
IL228875A0 (en) | Nutritional products containing human milk uglysaccharide and methods for their production | |
HK1255687A1 (zh) | 促進有益細菌生長的人乳低聚糖 | |
HK1198625A1 (en) | Implants and methods of using the implants to fill holes in bone tissue | |
PL2632277T3 (pl) | Produkt mleczny i sposób przygotowania | |
EP2758593A4 (fr) | Produit de papier d'essuyage comportant du bambou | |
IL233235A0 (en) | Devices and methods for increasing bone growth | |
HK1205970A1 (en) | Methods for modulating cell-mediated immunity using human milk oligosaccharides | |
GB201308746D0 (en) | Patient Specific Implants | |
EP2792372A4 (fr) | Adhésif médical biodégradable et procédé de préparation et d'utilisation associé | |
EP2593466A4 (fr) | Oligosaccharides de lait bovin | |
IL228385A0 (en) | Soft crepe tissue | |
PL2563166T3 (pl) | Stosowanie oligosacharydów mleka ludzkiego w żywieniu niemowląt | |
EP2765953A4 (fr) | Implant à conduction osseuse | |
PT2522299T (pt) | Implante dentário | |
IL231185A0 (en) | Biocompatible catheter | |
PL2525768T3 (pl) | Krem mocujący do protez zębowych | |
IL229303A0 (en) | Devices and methods to fasten tissue | |
PT2685929E (pt) | Implante dentário | |
PL2627196T3 (pl) | Mleczny koktajl typu smoothie do pobudzania wzrostu u dzieci | |
PL2556806T3 (pl) | Wszczepialna proteza medyczna |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
MM9K | Patent not in force due to non-payment of renewal fees |