IL217195A - Forazanobenzazimidazoles, Methods for their Preparation and Uses - Google Patents

Forazanobenzazimidazoles, Methods for their Preparation and Uses

Info

Publication number
IL217195A
IL217195A IL217195A IL21719511A IL217195A IL 217195 A IL217195 A IL 217195A IL 217195 A IL217195 A IL 217195A IL 21719511 A IL21719511 A IL 21719511A IL 217195 A IL217195 A IL 217195A
Authority
IL
Israel
Prior art keywords
formula
compound
lower alkyl
amino
lower alkoxy
Prior art date
Application number
IL217195A
Other languages
English (en)
Hebrew (he)
Other versions
IL217195A0 (en
Original Assignee
Basilea Pharmaceutica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basilea Pharmaceutica Ag filed Critical Basilea Pharmaceutica Ag
Publication of IL217195A0 publication Critical patent/IL217195A0/en
Publication of IL217195A publication Critical patent/IL217195A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245Oxadiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
IL217195A 2009-07-27 2011-12-25 Forazanobenzazimidazoles, Methods for their Preparation and Uses IL217195A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09166469 2009-07-27
PCT/EP2010/060803 WO2011012577A1 (en) 2009-07-27 2010-07-26 Furazanobenzimidazoles as prodrugs to treat neoplastic or autoimmune diseases

Publications (2)

Publication Number Publication Date
IL217195A0 IL217195A0 (en) 2012-02-29
IL217195A true IL217195A (en) 2014-03-31

Family

ID=41226617

Family Applications (1)

Application Number Title Priority Date Filing Date
IL217195A IL217195A (en) 2009-07-27 2011-12-25 Forazanobenzazimidazoles, Methods for their Preparation and Uses

Country Status (24)

Country Link
US (1) US8802858B2 (https=)
EP (1) EP2459553B1 (https=)
JP (1) JP5576485B2 (https=)
KR (1) KR101758400B1 (https=)
CN (1) CN102471329B (https=)
AU (1) AU2010277688B2 (https=)
BR (1) BR112012001817B8 (https=)
CA (1) CA2767875C (https=)
CY (1) CY1115809T1 (https=)
DK (1) DK2459553T3 (https=)
EA (1) EA021380B1 (https=)
ES (1) ES2524119T3 (https=)
HR (1) HRP20141120T1 (https=)
IL (1) IL217195A (https=)
MX (1) MX336240B (https=)
NZ (1) NZ597376A (https=)
PL (1) PL2459553T3 (https=)
PT (1) PT2459553E (https=)
RS (1) RS53679B1 (https=)
SI (1) SI2459553T1 (https=)
TW (1) TWI457337B (https=)
UA (1) UA106763C2 (https=)
WO (1) WO2011012577A1 (https=)
ZA (1) ZA201200228B (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012098203A1 (en) 2011-01-21 2012-07-26 Basilea Pharmaceutica Ag Use of glu-tubulin as a biomarker of drug response to furazanobenzimidazoles
CA2822491C (en) * 2011-01-21 2023-02-14 Basilea Pharmaceutica Ag Bubr1 as a biomarker for furazanobenzimidazoles
JP6302674B2 (ja) * 2011-01-21 2018-03-28 バジリア ファルマスーチカ アーゲーBasilea Pharmaceutica AG フラザノベンゾイミダゾールに対する薬物応答のバイオマーカーとしてのスタスミンの使用
PT2678679T (pt) 2011-02-24 2017-04-07 Basilea Pharmaceutica Ag Utilização de tubulina acetilada como um biomarcador da resposta farmacológica a furazanobenzimidazolos
EP2691533B1 (en) * 2011-03-29 2017-04-05 Basilea Pharmaceutica AG Use of phospho-akt as a biomarker of drug response
US9558575B2 (en) 2012-02-28 2017-01-31 Blackberry Limited Methods and devices for selecting objects in images
ITRM20130248A1 (it) * 2013-04-24 2014-10-25 Medivis S R L Formulazioni di riboflavina per il cross-linking transepiteliale.
WO2015173341A1 (en) * 2014-05-13 2015-11-19 Basilea Pharmaceutica Ag Dosage principle for anti-cancer furazanylbenzimidazoles
WO2017068182A1 (en) 2015-10-22 2017-04-27 Basilea Pharmaceutica Ag Use of eb1 as a biomarker of drug response
JP2020517608A (ja) * 2017-04-20 2020-06-18 ピーアイ インダストリーズ リミテッドPi Industries Ltd 新規フェニルアミン化合物
MX2021011775A (es) * 2017-04-26 2023-01-10 Basilea Pharm Int Ag Procesos para la preparacion de furazanobencimidazoles y formas cristalinas de estos.
US11633383B2 (en) * 2017-05-16 2023-04-25 Basilea Pharmaceutica International AG Dosage principle for drugs useful for treating neoplastic diseases
US11419856B2 (en) 2017-11-20 2022-08-23 Basilea Pharmaceutica International AG Pharmaceutical combinations for use in the treatment of neoplastic diseases
WO2020058405A1 (en) 2018-09-20 2020-03-26 Basilea Pharmaceutica International AG Pharmaceutical combinations for use in the treatment of neoplastic diseases
WO2021048135A1 (en) 2019-09-09 2021-03-18 Basilea Pharmaceutica International AG Pharmaceutical combinations comprising a furazanobenzimidazoles and a cd40 agonist for use in the treatment of neoplastic diseases
CN111454254B (zh) * 2020-04-26 2023-06-02 云白药征武科技(上海)有限公司 一种具有含氟取代基的苯并咪唑衍生物的制备及其应用
CN111423429A (zh) * 2020-05-19 2020-07-17 江西科技师范大学 苯并咪唑联呋咱类系列化合物及其合成方法
WO2022053549A1 (en) 2020-09-10 2022-03-17 Basilea Pharmaceutica International AG Use of c-myc as a biomarker of drug response

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6897208B2 (en) * 2001-10-26 2005-05-24 Aventis Pharmaceuticals Inc. Benzimidazoles
EP1472245A2 (en) * 2002-02-06 2004-11-03 Vertex Pharmaceuticals Incorporated Heteroaryl compounds useful as inhibitors of gsk-3
WO2004103994A1 (en) * 2003-05-23 2004-12-02 Basilea Pharmaceutica Ag Furazanobenzimidazoles
EP1723138B1 (en) * 2004-02-11 2010-07-14 Basilea Pharmaceutica AG Substituted benzimidazoles and their use for inducing apoptosis

Also Published As

Publication number Publication date
HRP20141120T1 (hr) 2015-01-30
BR112012001817B8 (pt) 2021-05-25
CA2767875C (en) 2016-03-15
MX2012000611A (es) 2012-01-27
EP2459553B1 (en) 2014-10-01
EP2459553A1 (en) 2012-06-06
CN102471329A (zh) 2012-05-23
RS53679B1 (sr) 2015-04-30
JP2013500304A (ja) 2013-01-07
JP5576485B2 (ja) 2014-08-20
DK2459553T3 (da) 2014-11-03
CY1115809T1 (el) 2017-01-25
TWI457337B (zh) 2014-10-21
US20120264792A1 (en) 2012-10-18
AU2010277688A1 (en) 2012-02-09
EA021380B1 (ru) 2015-06-30
PT2459553E (pt) 2014-11-24
WO2011012577A1 (en) 2011-02-03
MX336240B (es) 2016-01-13
CN102471329B (zh) 2014-11-05
BR112012001817A2 (pt) 2016-03-15
US8802858B2 (en) 2014-08-12
ES2524119T3 (es) 2014-12-04
HK1166316A1 (en) 2012-10-26
BR112012001817B1 (pt) 2020-09-29
UA106763C2 (uk) 2014-10-10
NZ597376A (en) 2014-01-31
ZA201200228B (en) 2012-09-26
KR20120055571A (ko) 2012-05-31
SI2459553T1 (sl) 2015-01-30
TW201107318A (en) 2011-03-01
KR101758400B1 (ko) 2017-07-14
AU2010277688B2 (en) 2013-12-05
PL2459553T3 (pl) 2015-03-31
EA201200189A1 (ru) 2012-08-30
CA2767875A1 (en) 2011-02-03
IL217195A0 (en) 2012-02-29

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